WARNING

Taking Promethazine, like any medication, carries certain risks and potential side effects. It’s crucial to use this medication under the guidance of a healthcare professional and to be aware of potential risks. Here is a brief overview of some risks associated with taking Promethazine:

• Drowsiness and Impaired Alertness: Promethazine is known for its sedative effects, and it can cause significant drowsiness. This may impair your ability to operate machinery or perform tasks that require alertness.
• Respiratory Depression: In rare cases, particularly with high doses or in sensitive individuals, promethazine can cause respiratory depression, which is a slowing of breathing. This risk is higher in young children and older adults.
• Interaction with Central Nervous System Depressants: Promethazine can enhance the sedative effects of other medications, alcohol, and central nervous system depressants, increasing the risk of drowsiness and respiratory depression.
• Extrapyramidal Symptoms: Promethazine, like other antipsychotic medications, may rarely cause extrapyramidal symptoms, such as muscle spasms, tremors, or unusual movements. This is more common with prolonged use.
• Allergic Reactions: Some individuals may be allergic to Promethazine, leading to skin reactions, itching, swelling, or more severe reactions. Anaphylaxis is a rare but serious allergic reaction that requires immediate medical attention.
• QT Prolongation: Promethazine may prolong the QT interval on the electrocardiogram (ECG), which can lead to a potentially life-threatening arrhythmia. This risk is higher in individuals with pre-existing cardiac conditions or those taking other medications that also affect the QT interval.
• Hypotension: Promethazine can cause a drop in blood pressure, leading to dizziness or fainting, particularly when standing up quickly.
• Photosensitivity: Some people may become more sensitive to sunlight while taking Promethazine, increasing the risk of sunburn.
• Neuroleptic Malignant Syndrome (NMS): Although rare, Promethazine use has been associated with NMS, a potentially fatal condition characterized by hyperthermia, muscle rigidity, altered mental status, and autonomic dysfunction.

It’s important to use Promethazine only as prescribed by a healthcare professional and to promptly report any unusual or severe side effects. Before starting this medication, discuss your medical history, current medications, and potential risks with your healthcare provider. This information is not exhaustive, and individual reactions may vary, so always rely on your healthcare professional’s advice.

Why is this medication prescribed?

Promethazine is a medication that belongs to a class of drugs known as phenothiazines. It has several uses and is commonly prescribed for the following purposes:

• Allergic Reactions: Promethazine can be used to relieve symptoms of allergy, such as itching, runny nose, sneezing, and watery eyes.
• Motion Sickness: It is often prescribed to prevent and treat motion sickness, including nausea, vomiting, and dizziness associated with travel.
• Nausea and Vomiting: Promethazine is used to alleviate nausea and vomiting, which can occur due to various reasons, including surgery, chemotherapy or certain medical conditions.
• Sedation: In some cases, promethazine may be used for its sedative effects. It can be administered to help induce sleep or provide sedation before surgical procedures.
• Insomnia: Promethazine may be prescribed to individuals experiencing difficulty sleeping.

How should this medicine be used?

The use of Promethazine should be based on the specific instructions provided by your healthcare provider. Dosage and administration can vary depending on the condition being treated, your age, weight, and overall health. Always follow your doctor’s recommendations and read the medication label carefully. Here are general guidelines for the use of Promethazine:

• Dosage: The recommended dosage of Promethazine can vary. It may be prescribed as a tablet, rectal suppository, or oral syrup. The dosage will depend on the condition being treated and individual factors. Your healthcare provider will determine the appropriate dose for you.
• Frequency of Administration: Take the medication as directed by your healthcare provider. It may be prescribed once daily, several times a day, or as needed. Follow the recommended schedule and do not exceed the prescribed dosage.
• Administration with or without Food: Promethazine can be taken with or without food. Follow your doctor’s instructions regarding food intake in relation to the medication.
• Avoiding Certain Activities: Promethazine may cause drowsiness, so it’s advisable to avoid activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
• Inform Your Healthcare Provider: Make sure to inform your healthcare provider about any other medications, supplements, or herbal products you are taking, as well as any existing medical conditions. This information will help ensure that there are no potential interactions or contraindications.
• Rectal Suppositories: If using rectal suppositories, follow the instructions provided with the medication. Wash your hands before and after inserting the suppository. Make sure to insert it as directed by your healthcare provider.
• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses to make up for a missed one.
• Storage: Store Promethazine at room temperature, away from moisture and heat. Follow the storage instructions provided on the medication packaging.

It’s essential to communicate openly with your healthcare provider about any concerns or questions you may have regarding the use of Promethazine. If you experience any unusual or severe side effects, contact your healthcare provider promptly. This information is intended for general guidance, and individual circumstances may vary, so always rely on your healthcare professional’s advice.

Other uses for this medicine

Promethazine may have other off-label uses. Off-label use refers to the use of a medication for a purpose not approved by regulatory authorities but based on medical judgment. Some healthcare providers may prescribe Promethazine for conditions beyond its FDA-approved indications. However, any such use should be discussed thoroughly with your healthcare provider.

What special precautions should I follow?

Special precautions should be taken when using Promethazine, and it’s important to inform your healthcare provider about your medical history, existing conditions, and any medications or supplements you are currently taking. Here are some general precautions for using Promethazine:

• Allergies: Inform your healthcare provider if you are allergic to promethazine or any other phenothiazines.
• Medical Conditions: Disclose any medical conditions you have, especially respiratory conditions (such as asthma or chronic obstructive pulmonary disease), liver disease, kidney disease, cardiovascular conditions, seizures, and conditions that affect the bone marrow.
• Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, discuss the risks and benefits of using Promethazine with your healthcare provider. Promethazine may pass into breast milk and may have adverse effects on a nursing infant.
• Children and Older Adults: Special considerations may apply to the use of Promethazine in children and older adults. The medication may have a higher risk of side effects, particularly respiratory depression, in young children.
• Sedation: Promethazine can cause drowsiness and impair your ability to concentrate or operate machinery. Avoid activities requiring mental alertness until you know how the medication affects you.
• Alcohol and Other Depressants: Avoid the consumption of alcohol and other central nervous system depressants while taking Promethazine, as they can enhance sedation and respiratory depression.
• Interactions with Other Medications: Inform your healthcare provider about all medications, including prescription, over-the-counter drugs, and herbal supplements, that you are taking. Promethazine may interact with certain medications, including anticholinergic drugs, CNS depressants, and opioids.
• Seizures: Promethazine may lower the seizure threshold, so use caution in individuals with a history of seizures.
• Hypersensitivity Reactions: Promethazine may cause skin reactions, and in rare cases, severe tissue damage at the injection site. Report any unusual reactions to your healthcare provider.

Always take Promethazine exactly as prescribed by your healthcare provider and follow their instructions carefully. If you have any concerns about the medication or experience unusual side effects, contact your healthcare provider promptly. This information is not exhaustive, and individual circumstances may vary, so consult with your healthcare professional for personalized advice.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with the use of Promethazine. However, it’s essential to take the medication as directed and to follow any dietary instructions provided by your healthcare provider. If you have concerns or questions about dietary interactions, discuss them with your healthcare professional.

What should I do if I forget a dose?

If you forget to take a dose of Promethazine, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one. If you are unsure about what to do, consult with your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Promethazine, like any medication, can cause side effects. Not everyone will experience these side effects, and some individuals may experience mild effects, while others may experience more severe reactions. It’s important to be aware of potential side effects and to promptly report any unusual or severe symptoms to your healthcare provider. Common side effects of Promethazine include:

• Drowsiness: Promethazine is known for its sedative effects, and drowsiness is a common side effect. It can impair your ability to concentrate or operate machinery, so it’s advisable to avoid activities requiring mental alertness.
• Dry Mouth: Promethazine may cause dry mouth, and staying hydrated or using sugarless gum or candy may help alleviate this symptom.
• Blurred Vision: Some people may experience blurred vision while taking Promethazine.
• Constipation: Promethazine can lead to constipation in some individuals.
• Urinary Retention: Difficulty urinating or incomplete emptying of the bladder may occur.
• Low Blood Pressure: Promethazine can cause a drop in blood pressure, leading to dizziness or fainting in some cases.
• Increased Sensitivity to Light: Some individuals may become more sensitive to light while taking Promethazine.
• Confusion: Especially in older adults, confusion or delirium may occur.

Serious side effects are rare, but they can occur. Seek medical attention immediately if you experience any of the following:

• Severe Dizziness or Fainting: This could be a sign of low blood pressure.
• Severe Allergic Reactions: Symptoms may include rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or difficulty breathing.
• Uncontrolled Movements or Twitching: This can be a sign of a serious movement disorder known as tardive dyskinesia.
• Seizures: Although uncommon, Promethazine may lower the seizure threshold in susceptible individuals.
• Severe Skin Reactions: This may include peeling skin, rash, or blistering, which could indicate a serious condition.

It’s important to note that this is not a comprehensive list of side effects, and individual reactions may vary. Additionally, some side effects may not be listed here. If you have any concerns about side effects or experience any unusual symptoms while taking Promethazine, contact your healthcare provider for guidance. Always take medications as directed and communicate openly with your healthcare team about your health and any concerns you may have.

What should I know about storage and disposal of this medication?

Storage and Disposal of Promethazine:

• Storage: Keep Promethazine in its original packaging, away from moisture and heat. Store it at room temperature and out of reach of children.
• Protect from Light: Some formulations of Promethazine may be light-sensitive, so it’s advisable to store them away from direct light.
• Avoid Freezing: Do not freeze Promethazine unless directed to do so by your healthcare provider or pharmacist.
• Check Expiry Date: Always check the expiration date on the medication packaging, and do not use Promethazine if it has expired.
• Disposal: Dispose of unused or expired medications properly. Do not flush them down the toilet unless instructed to do so. Consult your local pharmacy or healthcare provider for guidance on the safe disposal of medications.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms, seek emergency medical attention or contact your local poison control center at 1-800-222-1222. Symptoms of an overdose may include:

• Severe Drowsiness: Extreme drowsiness or difficulty waking up.
• Hallucinations: Seeing or hearing things that are not present.
• Seizures: Uncontrolled movements or convulsions.
• Difficulty Breathing: Shallow or difficult breathing.

What other information should I know?

• Medical and Laboratory Tests: Inform your healthcare provider about all prescription and over-the-counter medications you are taking. Promethazine may interfere with certain laboratory tests, so let your healthcare provider know if you are undergoing any medical tests.
• Avoid Alcohol: It’s advisable to avoid alcohol while taking Promethazine, as it can enhance the sedative effects of the medication.
• Inform Healthcare Providers: Before undergoing surgery or certain medical procedures, inform your healthcare providers, including dentists, about your use of Promethazine.
• Pregnancy and Breastfeeding: Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The risks and benefits of using Promethazine during pregnancy and breastfeeding should be considered.
• Interactions: Inform your healthcare provider about all medications, including prescription, over-the-counter drugs, and herbal supplements, that you are taking. Promethazine may interact with certain medications.
• Allergic Reactions: If you experience symptoms of a severe allergic reaction, such as difficulty breathing, swelling of the face/tongue/throat, or severe dizziness, seek emergency medical attention.

Always follow your healthcare provider’s instructions and seek their guidance if you have any concerns or questions about the use of Promethazine. This information is not exhaustive, and individual circumstances may vary, so consult with your healthcare professional for personalized advice.