Why is this medication prescribed?

Prezista (darunavir) is a medication used in the treatment of HIV (human immunodeficiency virus) infection. It is an antiretroviral drug that belongs to the class of protease inhibitors. Prezista, in combination with other antiretroviral medications, helps to control and manage HIV infection, slowing down the progression of the disease and improving the immune system.

How should this medicine be used?

Here are some key points about the use of Prezista:

• Prescription: Prezista is only available with a prescription from a healthcare professional. The prescribing doctor will determine the appropriate dosage and combination of medications based on the individual’s specific health condition and the stage of HIV infection.
• Combination Therapy: Prezista is typically used as part of a combination therapy, meaning it is taken alongside other antiretroviral drugs. Combining different medications helps to target the virus at various stages of its life cycle, reducing the likelihood of drug resistance.
• Dosage: The dosage of Prezista can vary depending on several factors, including the patient’s weight, other medications being taken, and overall health. It is important to follow the prescribed dosage and schedule provided by the healthcare professional.
• Administration: Prezista is usually taken orally in the form of tablets. It can be taken with or without food. The tablets should be swallowed whole with a glass of water. It’s crucial to take the medication exactly as prescribed and not to skip doses.
• Adherence: Consistent and correct adherence to the prescribed regimen is essential for the effectiveness of Prezista and the overall success of HIV treatment. Missing doses or not following the prescribed schedule can lead to the development of drug-resistant strains of HIV.
• Monitoring: Regular monitoring of HIV viral load and CD4 cell count, as well as other laboratory tests, is necessary to assess the effectiveness of the treatment and make any necessary adjustments.

It’s important for individuals taking Prezista to communicate openly with their healthcare provider about any concerns, side effects, or difficulties with adherence. Only a healthcare professional can determine the most appropriate treatment plan based on an individual’s specific circumstances.

Other uses for this medicine

Prezista (darunavir) is primarily indicated for the treatment of HIV infection, specifically in combination with other antiretroviral medications. It is not typically prescribed for purposes other than those related to the management of HIV. It is essential to use Prezista as part of a comprehensive HIV treatment plan designed and monitored by a healthcare professional.

What special precautions should I follow?

Special precautions, dietary instructions, and actions to take if you forget a dose are important aspects of managing Prezista (darunavir) and any antiretroviral medication. Here are some guidelines:

Special Precautions:

• Liver Function Monitoring: Prezista can affect liver function, and therefore, regular monitoring of liver enzymes is often necessary. If you have a history of liver problems, inform your healthcare provider.
• Allergies and Hypersensitivity: If you have a known allergy to darunavir or any of its components, inform your healthcare provider. Additionally, report any signs of hypersensitivity reactions, such as rash or difficulty breathing.
• Pregnancy and Breastfeeding: Discuss your pregnancy or breastfeeding status with your healthcare provider. The safety of Prezista during pregnancy and breastfeeding is not well established, and decisions will be made based on individual circumstances.
• Drug Interactions: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, supplements, and herbal products, that you are taking. Prezista can interact with other drugs, potentially affecting their efficacy or causing side effects.
• Side Effects: Be aware of potential side effects of Prezista, such as rash, nausea, vomiting, diarrhea, or changes in liver function. Report any unusual or severe side effects to your healthcare provider promptly.
• Regular Check-ups: Attend regular check-ups with your healthcare provider to monitor your overall health, HIV viral load, CD4 cell count, and any potential side effects or complications.

Always consult with your healthcare provider for personalized advice and guidance based on your individual health status and circumstances. If you have any concerns or questions about Prezista, do not hesitate to discuss them with your healthcare professional.

What special dietary instructions should I follow?

Special Dietary Instructions:

• Food Intake: Prezista can be taken with or without food. However, taking it with food may help improve its absorption. Follow your healthcare provider’s instructions regarding food intake.
• Grapefruit Interaction: Avoid consuming large amounts of grapefruit or grapefruit juice while taking Prezista, as it can increase the levels of darunavir in your blood, leading to potential side effects.

What should I do if I forget a dose?

• As Soon as Possible: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do Not Double Dose: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount can increase the risk of side effects.

What side effects can this medication cause?

Prezista (darunavir) is generally well-tolerated, but like any medication, it can cause side effects in some individuals. It’s important to note that not everyone will experience these side effects, and the severity can vary. Common and less serious side effects of Prezista may include:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Rash

These side effects are usually mild and may improve as your body adjusts to the medication. However, if any of these effects persist or worsen, it’s important to inform your healthcare provider.

In some cases, more serious side effects can occur. Contact your healthcare provider immediately if you experience any of the following:

• Severe Skin Reactions: This may include severe rash or blistering, which can be a sign of a serious allergic reaction.
• Liver Problems: Prezista can affect liver function, and in rare cases, it may cause severe liver problems. Seek medical attention if you notice symptoms such as yellowing of the skin or eyes (jaundice), dark urine, or persistent nausea.
• Pancreatitis: Although rare, Prezista has been associated with pancreatitis. Seek medical attention if you experience severe abdominal pain.
• Changes in Fat Distribution: Some individuals may experience changes in body fat distribution, including increased fat in the abdomen, breasts, or back of the neck. These changes can also include loss of fat in the face, arms, or legs.
• Changes in Blood Sugar Levels: Prezista may cause changes in blood sugar levels, and individuals with diabetes should monitor their blood sugar closely.

It’s important to keep in mind that this is not a comprehensive list of side effects, and individual reactions can vary. Always consult your healthcare provider if you have any concerns or experience unusual symptoms while taking Prezista. Additionally, adherence to the prescribed treatment plan and regular monitoring can help manage potential side effects and optimize the effectiveness of the medication.

What should I know about storage and disposal of this medication?

Storage and Disposal of Prezista:

• Storage: Store Prezista (darunavir) at room temperature, away from moisture and heat. Keep it in the original container, and make sure it is tightly closed. Avoid storing it in the bathroom.
• Keep Away from Children and Pets: Always keep medications, including Prezista, out of the reach of children and pets. Accidental ingestion can be harmful.
• Disposal: If you no longer need or have expired Prezista, follow your local guidelines for medication disposal. Do not flush it down the toilet or throw it in the trash without taking appropriate precautions. Many communities have specific medication disposal programs or designated drop-off locations.

In case of emergency/overdose

In case of an overdose or emergency, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention immediately. Overdose symptoms may include:

• Severe dizziness or fainting
• Nausea or vomiting
• Rapid or irregular heartbeat

What other information should I know?

• Regular Follow-ups: Attend all scheduled follow-up appointments with your healthcare provider. Regular monitoring, including blood tests, will help ensure the effectiveness of the treatment and detect any potential side effects.
• Adherence to Treatment Plan: Take Prezista exactly as prescribed by your healthcare provider. Do not skip doses or alter the dosage without consulting your healthcare professional.
• Informing Healthcare Providers: Keep your healthcare provider informed about all medications, including prescription and over-the-counter drugs, supplements, and herbal products, that you are taking. This information is crucial to avoid potential drug interactions.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The use of Prezista during pregnancy and breastfeeding will be carefully evaluated based on individual circumstances.
• Grapefruit Interaction: Avoid consuming large amounts of grapefruit or grapefruit juice while taking Prezista, as it can increase the levels of darunavir in your blood, potentially leading to side effects.
• Notify Your Doctor of Any Side Effects: If you experience any side effects or symptoms that concern you while taking Prezista, notify your healthcare provider promptly. They can provide guidance on whether any adjustments to your treatment plan are necessary.

Always follow the advice and instructions provided by your healthcare provider, and do not hesitate to reach out if you have any questions or concerns about Prezista or your HIV treatment.