Why is this medication prescribed?

Letermovir is an antiviral medication prescribed for the prevention of cytomegalovirus (CMV) infection in adult patients who have undergone allogeneic hematopoietic stem cell transplantation (HSCT). CMV is a common virus that can cause serious infections, particularly in individuals with weakened immune systems, such as those who have undergone stem cell transplantation.

The primary use of letermovir is to prevent CMV reactivation and disease in adult patients who are at risk due to their weakened immune system following allogeneic HSCT. CMV infection can lead to complications and negatively impact the outcomes of transplantation, making preventive measures crucial in these cases.

How should this medicine be used?

Here are general guidelines for the use of Letermovir:

• Dosage: The recommended dose of Letermovir is determined by the healthcare provider based on factors such as the patient’s weight, renal function, and other medical considerations.
• Administration: Letermovir tablets are taken by mouth. The tablets should be swallowed whole with water and can be taken with or without food. It’s important to take the medication at the same time each day to maintain a consistent level in the bloodstream.
• Timing: The timing of the first dose may vary depending on the specific transplant procedure and the patient’s overall health. It is usually initiated either after engraftment has occurred or when the patient is no longer receiving immunosuppressive therapy.
• Duration of Treatment: The duration of Letermovir treatment can vary. It is often continued for a certain period after the transplant procedure to provide adequate prophylaxis against CMV infection.
• Monitoring: Patients receiving Letermovir may require regular monitoring for adverse effects and to ensure that the drug is effectively preventing CMV infection.
• Precautions: It’s important for healthcare providers to consider any potential drug interactions or contraindications before prescribing Letermovir. Patients should inform their healthcare team about all medications, supplements, and medical conditions they have.

It’s crucial to note that these are general guidelines, and the specific instructions for Letermovir use should always be provided by the prescribing healthcare professional. Patients should follow their healthcare provider’s recommendations closely and report any concerns or side effects promptly. Please consult with a healthcare professional or refer to the latest medical literature and prescribing information for any updates or changes in guidelines related to Letermovir.

Other uses for this medicine

Letermovir is primarily indicated for the prevention of cytomegalovirus (CMV) infection in adult patients who have undergone allogeneic hematopoietic stem cell transplantation (HSCT). However, it’s important to note that the information provided here is based on the knowledge, and there may have been developments or new indications for letermovir. Always consult with a healthcare professional or refer to the latest medical literature for the most up-to-date information.

What special precautions should I follow?

Regarding special precautions for letermovir use, patients should be aware of the following:

• Pregnancy and Breastfeeding: Letermovir’s safety during pregnancy has not been well studied. Pregnant individuals or those planning to become pregnant should discuss the potential risks and benefits with their healthcare provider. It is not known whether letermovir passes into breast milk. Breastfeeding individuals should consult their healthcare provider before using letermovir.
• Liver Function: Letermovir is metabolized by the liver, so individuals with pre-existing liver conditions may require close monitoring during treatment. Dose adjustments may be necessary in patients with severe hepatic impairment.
• Kidney Function: Patients with impaired kidney function may also require dose adjustments, as letermovir is excreted by the kidneys.
• Drug Interactions: Letermovir may interact with other medications, including certain immunosuppressive drugs and medications that affect liver enzymes. Inform your healthcare provider about all medications, supplements, and herbal products you are taking.
• Allergic Reactions: If you have a known allergy to letermovir or any of its components, you should not use this medication.
• Driving and Operating Machinery: Letermovir may cause dizziness or other neurological side effects. Individuals should exercise caution when driving or operating machinery until they are aware of how letermovir affects them.
• Missed Doses: It’s important to take letermovir as prescribed and not to skip doses. If a dose is missed, follow the guidance provided by the healthcare provider or pharmacist.

Patients should always follow the specific instructions given by their healthcare provider and inform them of any existing medical conditions, medications, or potential concerns before starting letermovir. Regular follow-up appointments and monitoring are essential to assess the medication’s effectiveness and manage any potential side effects.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with letermovir use. However, it’s essential to follow any dietary recommendations provided by your healthcare provider or pharmacist. Always inform your healthcare provider about any dietary restrictions you may have or dietary supplements you are taking.

What should I do if I forget a dose?

If you forget to take a dose of letermovir, follow these general guidelines:

• Take the missed dose as soon as you remember, unless it’s close to the time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule.
• Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Letermovir, like any medication, may cause side effects. It’s important for individuals to be aware of potential side effects and promptly report any unusual or severe reactions to their healthcare provider. Common and serious side effects associated with Letermovir include:

Common Side Effects:

• Nausea
• Diarrhea
• Headache
• Vomiting
• Swelling or redness at the injection site

These common side effects are generally mild and may improve as the body adjusts to the medication.

Serious Side Effects:

• Liver problems: Letermovir can affect liver function, leading to elevated liver enzymes. Healthcare providers may monitor liver function through blood tests.
• Allergic reactions: In rare cases, individuals may experience allergic reactions, such as rash, itching, swelling, severe dizziness, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur.
• Kidney problems: Letermovir may impact kidney function. Regular monitoring may be required, especially in patients with pre-existing kidney issues.
• Low blood cell counts: Letermovir may cause a decrease in certain blood cell counts, such as white blood cells. Regular blood tests are typically performed to monitor for any abnormalities.

It’s important to note that the above lists are not exhaustive, and other side effects may occur. Additionally, the frequency and severity of side effects can vary from person to person.

Patients should inform their healthcare provider about their medical history, including any pre-existing conditions or medications they are taking, to help minimize the risk of adverse reactions. If any side effects are experienced, individuals should contact their healthcare provider promptly.

This information is based on knowledge, and there may have been developments or updates since then. Patients should refer to the most recent prescribing information and consult with their healthcare provider for the latest information on Letermovir.

What should I know about storage and disposal of this medication?

Storage of Letermovir:

• Temperature: Store letermovir tablets at room temperature, away from excessive heat and moisture.
• Container: Keep the medication in its original container, and ensure that it is tightly closed.
• Light: Protect the tablets from light by storing them in a dark place.
• Specific Instructions: Follow any specific storage instructions provided by your healthcare provider, pharmacist, or the medication’s packaging.

Disposal of Letermovir:

• Dispose Properly: Dispose of unused or expired letermovir in accordance with local regulations and guidelines.
• Do Not Flush: Do not flush medications down the toilet unless instructed to do so. Check with your local pharmacy or waste disposal facility for information on medication disposal.

In case of emergency/overdose

Seek Medical Attention: Contact your local poison control center (1-800-222-1222 in the United States) or emergency room immediately.
Symptom Management: If possible, provide information about the amount of letermovir ingested, and follow medical guidance for managing symptoms.

What other information should I know?

• Medical History: Inform your healthcare provider about your medical history, including any allergies, liver problems, or other medications you are taking.
• Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, discuss the potential risks and benefits of using Letermovir with your healthcare provider.
• Missed Dose: If you miss a dose of Letermovir, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule.

Always follow your healthcare provider’s instructions and ask them any specific questions you may have about the storage, disposal, or usage of Letermovir. It’s crucial to take medications as prescribed and seek medical advice in case of any concerns or emergencies.