WARNING

Abrocitinib is a medication primarily used to treat moderate to severe atopic dermatitis. While it can be effective, it does come with some risks. Key concerns include:

• Infections: Abrocitinib can suppress the immune system, increasing the risk of infections.
• Elevated Lipids: It may lead to increased cholesterol and triglyceride levels.
• Gastrointestinal Issues: Some people experience nausea or diarrhea.
• Liver Enzyme Changes: It can affect liver function, so regular monitoring is needed.
• Blood Clot Risk: There might be an increased risk of blood clots, though this is less common.

Always discuss potential risks with your healthcare provider to weigh them against the benefits for your specific situation.

Why is this medication prescribed?

Abrocitinib is a medication used primarily to treat moderate to severe atopic dermatitis (eczema) in adults and adolescents who are not adequately controlled with topical therapies. It’s a type of Janus kinase (JAK) inhibitor that works by targeting and blocking specific enzymes involved in the inflammatory process, helping to reduce the symptoms of eczema.

How should this medicine be used?

Here’s how Abrocitinib is typically used:

• Dosage: It’s usually taken orally in the form of tablets. The standard dosage is often 100 mg or 200 mg once daily, but your doctor will determine the appropriate dose based on your condition and response to the medication.
• Administration: It should be taken with or without food. Swallow the tablets whole with a glass of water, and do not crush or chew them.
• Monitoring: Regular follow-ups with your healthcare provider are important to monitor for side effects and to adjust the dose if necessary. Blood tests may be required to check for potential impacts on your blood cells, liver, and lipid levels.
• Precautions: Inform your doctor of any other medications you’re taking and any existing health conditions, especially infections, liver problems, or a history of blood clots. Avoid live vaccines during treatment.

Always follow your healthcare provider’s specific instructions regarding the use of Abrocitinib. If you have any concerns or experience side effects, consult your doctor.

Other uses for this medicine

Abrocitinib is mainly prescribed for moderate to severe atopic dermatitis, but it may have other potential uses or be explored for different conditions in clinical settings. Its role as a JAK inhibitor means it could be investigated for other inflammatory conditions or autoimmune diseases, though these uses might not be approved or well-established yet.

What special precautions should I follow?

Regarding special precautions with Abrocitinib:

• Infections: Since Abrocitinib affects the immune system, it can increase the risk of infections. Avoid contact with people who have contagious illnesses and notify your doctor if you develop symptoms of an infection.
• Liver Function: Regular monitoring of liver function is important, as Abrocitinib can impact liver health. Report any symptoms such as jaundice (yellowing of the skin or eyes), dark urine, or severe abdominal pain to your doctor.
• Blood Clots: Be aware of symptoms of blood clots, such as swelling, pain, or redness in the legs, chest pain, or shortness of breath. Inform your doctor if you have a history of blood clots or other cardiovascular issues.
• Vaccinations: Avoid live vaccines while on Abrocitinib. Inform your healthcare provider about any vaccinations you need or are considering.
• Drug Interactions: Inform your healthcare provider about all other medications and supplements you’re taking, as Abrocitinib can interact with other drugs, affecting its effectiveness or increasing side effects.
• Pregnancy and Breastfeeding: Discuss with your doctor if you’re pregnant, planning to become pregnant, or breastfeeding. The effects of Abrocitinib on pregnancy and breastfeeding are not fully known.
• Pre-existing Conditions: Inform your doctor about any other medical conditions you have, particularly those affecting the immune system or liver.

Always follow your healthcare provider’s specific instructions and report any unusual symptoms or side effects you experience.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Abrocitinib. However, maintaining a healthy diet can help manage any potential side effects and overall health. It’s always a good idea to discuss any dietary concerns or restrictions with your healthcare provider.

What should I do if I forget a dose?

• Timing: If you miss a dose and it’s almost time for your next dose, skip the missed dose and take the next one at your regular scheduled time. Do not take two doses at once to make up for a missed dose.
• Instructions: Follow any specific instructions provided by your healthcare provider regarding missed doses.
• Consult: If you’re unsure or have missed multiple doses, contact your healthcare provider for guidance.

What side effects can this medication cause?

Abrocitinib, like any medication, can cause side effects. Some common and serious side effects include:

Common Side Effects:

• Headache
• Diarrhea
• Nausea
• Fatigue
• Upper respiratory tract infections (e.g., colds)
• Elevated levels of certain liver enzymes

Serious Side Effects:

• Infections: Increased risk of serious infections, such as tuberculosis or bacterial infections.
• Liver Problems: Symptoms might include jaundice (yellowing of the skin or eyes), dark urine, severe abdominal pain, or nausea.
• Blood Clots: Risk of deep vein thrombosis, pulmonary embolism, or other blood clotting issues. Symptoms include swelling, pain, or redness in the legs, chest pain, or difficulty breathing.
• Elevated Blood Lipids: Increased levels of cholesterol or triglycerides.
• Gastrointestinal Issues: Severe stomach pain, persistent nausea or vomiting.
• Allergic Reactions: Rash, itching, swelling, severe dizziness, or trouble breathing.
• Abnormal Blood Counts: Low red blood cells (anemia), white blood cells, or platelets.
• Cancer Risk: There might be an increased risk of certain cancers, although this is still being studied.

If you experience any severe or unusual symptoms, seek medical attention immediately. Regular monitoring and follow-up with your healthcare provider can help manage and mitigate potential side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Abrocitinib:

Storage:

• Temperature: Store Abrocitinib at room temperature, typically between 68°F and 77°F (20°C and 25°C).
• Protection: Keep it in its original container, tightly closed, and away from moisture and light.
• Accessibility: Keep it out of reach of children and pets.

Disposal:

• Unused Medication: Do not dispose of Abrocitinib in the toilet or sink unless instructed to do so by your pharmacist or local waste disposal guidelines.
• Medication Take-Back Programs: Use a drug take-back program or a designated medication disposal site if available.
• Consult: If you’re unsure how to dispose of your medication, consult your pharmacist or healthcare provider for advice.

In case of emergency/overdose

• Symptoms of Overdose: Symptoms might include nausea, vomiting, or severe dizziness, but specific overdose symptoms can vary.
• What to Do: If you suspect an overdose, seek emergency medical attention immediately or contact a poison control center.
• Emergency Number: In the U.S., you can call the Poison Control Center at 1-800-222-1222. If you’re outside the U.S., call local emergency services or poison control.

What other information should I know?

• Regular Monitoring: Regular follow-ups with your healthcare provider are essential for monitoring side effects and adjusting treatment as necessary.
• Medical History: Inform your healthcare provider of your complete medical history, including any history of infections, liver issues, or blood clotting problems.
• Medication List: Keep an updated list of all medications, including over-the-counter drugs and supplements, to share with your healthcare provider to avoid interactions.
• Adherence: Take Abrocitinib exactly as prescribed. Do not alter the dose or stop taking it without consulting your healthcare provider.

Always follow your healthcare provider’s instructions and consult them with any questions or concerns regarding your medication.