WARNING

Pomalyst is a prescription medication primarily used in the treatment of multiple myeloma, a type of cancer affecting plasma cells in the bone marrow. While Pomalyst can be effective in managing the condition, it also comes with potential risks and side effects. It’s important to note that only a healthcare professional can provide personalized advice based on an individual’s health status. Here are some general risks associated with Pomalyst:

• Hematologic Toxicities: Pomalyst may cause a decrease in blood cell counts, leading to conditions such as anemia, neutropenia, and thrombocytopenia. Regular blood tests are often required to monitor these levels.
• Risk of Infections: Due to the impact on blood cell counts, there is an increased risk of infections. Patients should promptly report any signs of infection, such as fever or persistent sore throat, to their healthcare provider.
• Teratogenicity: Pomalyst can cause fetal harm, and it is advised to avoid pregnancy during treatment. Adequate contraception methods should be used, and patients should discuss family planning with their healthcare provider.
• Hepatotoxicity: Liver function may be affected, leading to elevated liver enzymes. Regular liver function tests are recommended during treatment.
• Thromboembolism: Pomalyst has been associated with an increased risk of blood clots. Patients with a history of thromboembolism should be monitored closely, and preventive measures may be necessary.
• Peripheral Neuropathy: Some patients may experience nerve damage, leading to symptoms such as numbness, tingling, or pain in the extremities.
• Hypersensitivity Reactions: Allergic reactions to Pomalyst are possible and may include rash, itching, and difficulty breathing. Immediate medical attention is necessary if such reactions occur.
• Hematologic Malignancies: There is a risk of developing new primary malignancies while taking Pomalyst.

It’s crucial for patients to communicate openly with their healthcare providers about any concerns or side effects experienced during Pomalyst treatment. This information is a brief overview, and individuals should consult their healthcare professionals for comprehensive and personalized advice.

Why is this medication prescribed?

Pomalyst (pomalidomide) is a medication prescribed for the treatment of multiple myeloma, a type of cancer that affects plasma cells in the bone marrow. It is generally used in patients who have received at least two prior therapies, including lenalidomide and a proteasome inhibitor, and have demonstrated disease progression.

Pomalyst is indicated for the treatment of multiple myeloma in the following situations:

• Relapsed or Refractory Multiple Myeloma: Pomalyst is prescribed when the disease has relapsed or is refractory (not responding) to prior treatments.
• After Previous Therapies: It is specifically used in patients who have received at least two prior therapies, which may include lenalidomide and a proteasome inhibitor, and have not responded adequately to these treatments.

How should this medicine be used?

Here are general guidelines:

• Dosage and Administration: The specific dosage of Pomalyst can vary, and it is determined by the prescribing healthcare provider based on the patient’s individual health status and response to treatment.
• Oral Administration: Pomalyst is taken orally in the form of capsules. It is usually taken once daily, with or without food.
• Continuous Treatment: Pomalyst is often administered in continuous cycles, and the treatment plan is determined by the healthcare provider. Regular monitoring, including blood tests, is essential to assess the patient’s response and manage potential side effects.
• Contraception: Due to the risk of teratogenicity (harm to the fetus), it is crucial for both males and females of reproductive potential to use effective contraception during treatment and for a certain period after discontinuing Pomalyst.
• Follow Healthcare Provider’s Instructions: Patients should strictly adhere to the healthcare provider’s instructions regarding the timing and dosage of Pomalyst. It’s important to communicate any side effects or concerns promptly.
• Regular Check-ups: Patients undergoing Pomalyst treatment will typically have regular check-ups with their healthcare providers to monitor the response to treatment and manage any potential side effects.

As with any prescription medication, the use of Pomalyst should be supervised by a qualified healthcare professional, and patients should inform their healthcare team about their medical history, ongoing medications, and any concerns they may have during the course of treatment.

Other uses for this medicine

Pomalyst (pomalidomide) is primarily approved for the treatment of multiple myeloma in specific patient populations, particularly those who have received at least two prior therapies, including lenalidomide and a proteasome inhibitor. Pomalyst doesn’t have broad approval for other uses. However, research and clinical trials may explore its potential in other conditions.

What special precautions should I follow?

Special Precautions for Pomalyst:

• Teratogenicity and Contraception: Pomalyst can cause fetal harm if taken during pregnancy. Both males and females of reproductive potential should use effective contraception during treatment and for a certain period after discontinuation. Women should undergo pregnancy testing before starting Pomalyst, and regular pregnancy tests may be required during treatment.
• Hematologic Toxicities: Pomalyst can cause a decrease in blood cell counts, leading to conditions such as anemia, neutropenia, and thrombocytopenia. Regular blood tests are essential to monitor these levels.
• Infections: Due to the impact on blood cell counts, there is an increased risk of infections. Patients should promptly report any signs of infection to their healthcare provider.
• Hepatotoxicity: Liver function may be affected, leading to elevated liver enzymes. Regular liver function tests are recommended during treatment.
• Thromboembolism: Pomalyst has been associated with an increased risk of blood clots. Patients with a history of thromboembolism should be monitored closely, and preventive measures may be necessary.
• Peripheral Neuropathy: Some patients may experience nerve damage, leading to symptoms such as numbness, tingling, or pain in the extremities.
• Hypersensitivity Reactions: Allergic reactions to Pomalyst are possible and may include rash, itching, and difficulty breathing. Immediate medical attention is necessary if such reactions occur.
• Hematologic Malignancies: There is a risk of developing new primary malignancies while taking Pomalyst.
• Renal Impairment: Pomalyst should be used with caution in patients with renal impairment, and dose adjustments may be necessary.

Patients should communicate openly with their healthcare providers about their medical history, ongoing medications, and any concerns or side effects experienced during Pomalyst treatment. This information is intended as a general overview, and individuals should consult their healthcare professionals for comprehensive and up-to-date guidance.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Pomalyst. However, it’s essential to maintain a balanced and nutritious diet to support overall health and well-being. Adequate hydration is also crucial, especially if there is a risk of renal impairment.

What should I do if I forget a dose?

If you forget to take a dose of Pomalyst, the general guidance is as follows:

• If it’s within 12 hours of the scheduled time: Take the missed dose as soon as you remember. Resume the regular dosing schedule.
• If it’s more than 12 hours after the scheduled time: Skip the missed dose. Take the next dose at the scheduled time.

What side effects can this medication cause?

Pomalyst, also known as pomalidomide, is a medication used to treat certain types of cancer, particularly multiple myeloma. Like any medication, Pomalyst can have potential side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. Some common side effects of Pomalyst include:

• Hematologic Effects:
  • Low white blood cell count (neutropenia)
  • Low red blood cell count (anemia)
  • Low platelet count (thrombocytopenia)
• Infections: Increased risk of infections due to decreased white blood cell count.
• Fatigue: Feeling tired or weak is a common side effect.
• Gastrointestinal Issues:
  • Nausea
  • Diarrhea
  • Constipation
• Peripheral Neuropathy: Numbness or tingling in the hands or feet
• Thromboembolism: Increased risk of blood clots
• Rash: Skin rash or other skin reactions
• Musculoskeletal Disorders:
  • Back pain
  • Muscle spasms
• Respiratory Issues: Shortness of breath

It’s important to inform your healthcare provider about any side effects you may experience while taking Pomalyst. Additionally, certain side effects may require immediate medical attention, so it’s crucial to seek prompt medical advice if you notice any severe or concerning symptoms.

This list is not exhaustive, and individual responses to the medication can vary. Your healthcare provider will closely monitor you during treatment to manage and mitigate potential side effects. Always follow your healthcare provider’s instructions and inform them of any changes or concerns related to your health.

What should I know about storage and disposal of this medication?

Storage and Disposal of Pomalyst:

• Storage:
  • Store Pomalyst at room temperature between 20°C to 25°C (68°F to 77°F).
  • Keep the medication in its original packaging to protect it from light.
  • Do not expose Pomalyst to excessive heat or moisture.
• Disposal:
  • Follow local regulations or guidelines for the proper disposal of unused or expired medications.
  • Do not flush Pomalyst down the toilet or throw it in the trash.
  • Check with your healthcare provider, pharmacist, or local waste disposal facility for specific instructions on how to dispose of Pomalyst safely.

In case of emergency/overdose

In the case of an emergency or suspected overdose, it’s important to seek immediate medical attention. The symptoms of an overdose can vary, and healthcare professionals will provide appropriate care based on the specific situation. It is advisable to contact your local poison control center or emergency services for guidance.

What other information should I know?

• Regular Monitoring: Regular blood tests may be required to monitor blood cell counts and other parameters during Pomalyst treatment.
• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. These appointments are crucial for monitoring treatment response and managing any potential side effects.
• Contraception: If you are of reproductive potential, use effective contraception during treatment and for a certain period after discontinuation, as Pomalyst can cause fetal harm.
• Communication with Healthcare Provider: Inform your healthcare provider about all medications, supplements, or herbal products you are taking, as they may interact with Pomalyst.
• Pregnancy and Breastfeeding: Pomalyst can cause fetal harm, so it is important to avoid pregnancy during treatment. Women should not breastfeed while taking Pomalyst.
• Allergies: Inform your healthcare provider about any known allergies or hypersensitivity reactions to medications.
• Dose Adherence: Take Pomalyst exactly as prescribed by your healthcare provider. If you miss a dose, follow the instructions provided by your healthcare professional.
• Travel: If you plan to travel, discuss your treatment plan with your healthcare provider. Carry necessary medications, and be aware of any specific precautions related to your health.

Always consult with your healthcare provider or pharmacist for the most up-to-date and relevant information regarding the storage, disposal, and usage of Pomalyst based on your individual health needs.