WARNING

Plazomicin is an antibiotic used to treat certain bacterial infections. Like any medication, it carries potential risks and side effects. It’s important to note that individual responses to medications can vary, and the following information is not exhaustive. Always consult with a healthcare professional for personalized advice.

Common side effects of Plazomicin Injection may include:

• Nausea and vomiting: Some individuals may experience gastrointestinal symptoms such as nausea and vomiting.
• Headache: Headaches are a reported side effect in some cases.
• Increased blood levels of certain enzymes: Plazomicin can affect the levels of certain enzymes in the blood, which may be monitored during treatment.
• Dizziness: Some people may experience dizziness as a side effect.
• Kidney-related issues: Plazomicin can have effects on the kidneys, so individuals with pre-existing kidney problems may be at a higher risk of complications.
• Allergic reactions: As with any medication, there is a potential for allergic reactions, including skin rash, itching, and swelling.

It’s crucial to inform your healthcare provider about your medical history, including any existing conditions or medications you are taking, before starting Plazomicin. Additionally, follow your healthcare provider’s instructions closely, complete the prescribed course of treatment, and report any unusual or severe side effects promptly.

This information is a general overview, and specific risks and recommendations may vary based on individual health factors. Always consult with a healthcare professional for the most accurate and personalized advice regarding the risks associated with Plazomicin Injection.

Why is this medication prescribed?

Plazomicin is an antibiotic medication used to treat complicated urinary tract infections (cUTIs), including pyelonephritis, caused by certain bacteria. It belongs to the aminoglycoside class of antibiotics and works by inhibiting bacterial protein synthesis, ultimately leading to the death of the bacteria.

Plazomicin is typically prescribed for the treatment of complicated urinary tract infections caused by specific bacteria, including Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, and Proteus mirabilis. It is often considered when other antibiotic options may not be suitable or effective.

How should this medicine be used?

The dosage and administration of Plazomicin Injection are determined by a healthcare professional based on the specific infection, the severity of the condition, and the patient’s individual factors. Here are some general guidelines:

• Dosage: The recommended dose and duration of treatment will be prescribed by the healthcare provider. It is usually administered intravenously (IV) over a specific period.
• Administration: Plazomicin is typically given by a healthcare professional in a hospital or clinical setting. It is administered as an intravenous infusion.
• Frequency: The frequency of administration and the total duration of treatment will depend on the severity of the infection and the response to the medication.
• Follow Instructions: It is crucial to follow the healthcare provider’s instructions precisely. Do not self-administer or alter the dosage without consulting a healthcare professional.
• Complete the Course: It’s essential to complete the entire prescribed course of Plazomicin even if symptoms improve before the medication is finished. Stopping the medication prematurely may lead to incomplete eradication of the infection and potential relapse.
• Monitoring: Regular monitoring, including kidney function tests and hearing assessments, may be necessary during treatment, as Plazomicin can impact these areas.

As with any medication, individuals should inform their healthcare provider about their medical history, existing health conditions, and other medications they are taking to ensure the safe and effective use of Plazomicin. If there are any concerns or potential side effects, individuals should promptly communicate with their healthcare provider.

Other uses for this medicine

Plazomicin is primarily indicated for the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis, caused by specific bacteria. It is important to note that antibiotics, including Plazomicin, should be used only for the conditions they are prescribed for and as directed by a healthcare professional. Using antibiotics inappropriately or without proper medical supervision can contribute to antibiotic resistance.

What special precautions should I follow?

Special Precautions for Plazomicin Injection:

• Allergies: Inform your healthcare provider about any allergies you may have, especially if you have had a previous allergic reaction to aminoglycoside antibiotics.
• Kidney Function: Plazomicin can affect kidney function, and individuals with pre-existing kidney problems may require dosage adjustments or closer monitoring during treatment.
• Hearing Impairment: Aminoglycoside antibiotics, including Plazomicin, have been associated with potential hearing and balance problems. Individuals with pre-existing hearing issues or those receiving other medications that may affect hearing should exercise caution, and hearing should be monitored during treatment.
• Neuromuscular Disorders: Caution is advised in individuals with certain neuromuscular disorders, as aminoglycosides may exacerbate muscle weakness.
• Pregnancy and Breastfeeding: Plazomicin should be used during pregnancy only if clearly needed. It is important to discuss the potential risks and benefits with a healthcare provider. The safety of Plazomicin during breastfeeding is not well established, and a decision should be made considering the importance of the medication for the mother and the potential risks to the infant.
• Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Plazomicin may interact with certain drugs.
• Superinfection: Prolonged or repeated use of Plazomicin may result in overgrowth of nonsusceptible bacteria or fungi. If superinfection occurs, appropriate measures should be taken.
• Complete the Course: It is important to complete the entire prescribed course of Plazomicin, even if symptoms improve before the medication is finished. Stopping the medication prematurely may lead to incomplete eradication of the infection and potential relapse.

Always follow the guidance of your healthcare provider and the instructions provided with the medication. If you experience any concerning side effects or have questions about Plazomicin, consult your healthcare professional promptly.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Plazomicin. However, it is important to stay well-hydrated during treatment, unless advised otherwise by your healthcare provider.

What should I do if I forget a dose?

If you miss a dose of Plazomicin, contact your healthcare provider or the medical staff overseeing your treatment as soon as possible. It’s important not to double the dose to make up for a missed one. Your healthcare provider will provide guidance on whether to resume the regular dosing schedule or if any adjustments are necessary.

What side effects can this medication cause?

Plazomicin, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary. Common side effects and adverse reactions associated with Plazomicin Injection may include:

• Nausea and Vomiting: Gastrointestinal symptoms such as nausea and vomiting can occur.
• Headache: Some individuals may experience headaches.
• Increased Blood Enzymes: Plazomicin can affect the levels of certain enzymes in the blood, which may be monitored during treatment.
• Dizziness: Dizziness may occur as a side effect.
• Kidney-related Issues: Plazomicin can have effects on kidney function, and changes in kidney function may occur. This is why kidney function is often monitored during treatment.
• Hypersensitivity Reactions: Allergic reactions can occur, leading to symptoms such as skin rash, itching, and swelling. Severe allergic reactions are rare but can occur.

It’s important to report any unusual or severe side effects to your healthcare provider promptly. Additionally, the healthcare provider will assess the overall risk-benefit profile before prescribing Plazomicin and monitor for any potential complications during the course of treatment.

Remember that this is not an exhaustive list of side effects, and individual responses to medications can vary. Always consult with your healthcare provider for personalized advice and guidance regarding the use of Plazomicin and any potential side effects you may be experiencing. If you experience a medical emergency or severe allergic reaction, seek immediate medical attention.

What should I know about storage and disposal of this medication?

Storage and Disposal of Plazomicin Injection:

• Storage:
  • Plazomicin Injection should be stored as directed by the healthcare provider or pharmacist.
  • Typically, it is stored in a cool, dry place away from direct sunlight.
  • Follow any specific storage instructions provided with the medication.
• Disposal:
  • Dispose of Plazomicin as instructed by your healthcare provider, pharmacist, or local guidelines.
  • Do not dispose of medications in household waste or sewage. Follow proper disposal procedures to minimize environmental impact.

In case of emergency/overdose

In the event of an overdose or if you suspect an adverse reaction, seek emergency medical attention immediately. Symptoms of an overdose may include severe dizziness, difficulty breathing, or other serious reactions.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Take Plazomicin exactly as prescribed by your healthcare provider. Do not alter the dosage or stop the medication without consulting them.
• Regular Monitoring: Your healthcare provider may conduct regular tests, including kidney function tests and hearing assessments, during the course of treatment. Attend all scheduled appointments to monitor your response to the medication.
• Inform Healthcare Provider: Keep your healthcare provider informed about your medical history, existing health conditions, and any other medications, supplements, or herbal products you are taking.
• Complete the Course: Finish the entire prescribed course of Plazomicin, even if symptoms improve before the medication is finished. Incomplete treatment may lead to the recurrence of infection.
• Allergic Reactions: Be aware of signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you experience these symptoms.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Plazomicin with your healthcare provider.
• Drug Interactions: Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.

Always refer to the specific instructions provided with your medication, and consult your healthcare provider for personalized advice and information. If you have any concerns or questions, do not hesitate to reach out to your healthcare professional for guidance.