WARNING

Pimavanserin is a medication primarily used to treat hallucinations and delusions associated with Parkinson’s disease psychosis. While it can be effective for some patients, like any medication, it carries potential risks and side effects. It’s essential to consult with a healthcare professional before starting any new medication, including Pimavanserin. Some potential risks and side effects associated with Pimavanserin may include:

• Increased Mortality in Elderly Patients with Dementia-Related Psychosis: Pimavanserin is not approved for use in elderly patients with dementia-related psychosis due to an increased risk of death.
• QT Interval Prolongation: Pimavanserin may prolong the QT interval, which can lead to an increased risk of serious heart rhythm abnormalities.
• Adverse Reactions: Common side effects include swelling, confusion, and peripheral edema. Less common side effects may include nausea, hallucinations, and insomnia.
• Contraindications: Pimavanserin should not be used in patients with a history of a hypersensitivity reaction to the drug.
• Interactions with Other Medications: Pimavanserin may interact with other medications, potentially affecting their efficacy or increasing the risk of side effects.

It’s crucial for individuals considering or currently taking Pimavanserin to discuss their medical history, current medications, and any concerns with their healthcare provider. The benefits and risks of the medication should be carefully evaluated on a case-by-case basis, and patients should be monitored regularly during treatment.

Why is this medication prescribed?

Pimavanserin is prescribed primarily for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. Parkinson’s disease is a neurodegenerative disorder that affects movement control, and some individuals with Parkinson’s may develop psychotic symptoms, such as visual hallucinations and delusions. Pimavanserin is an atypical antipsychotic medication designed to address these specific symptoms without worsening motor function, which is a concern with some other antipsychotic drugs.

How should this medicine be used?

As with any medication, it’s essential to follow your healthcare provider’s instructions and take Pimavanserin exactly as prescribed. Here are general guidelines for the use of Pimavanserin:

• Dosage: The recommended starting dose is typically 34 mg taken orally once daily, with or without food.
• Administration: Pimavanserin is usually taken as a tablet with water.
• Consistency: It’s important to take Pimavanserin consistently at the same time each day.
• Do not alter the dosage without consulting your healthcare provider: Changes to the dosage or discontinuation of the medication should only be done under the guidance of your healthcare professional.
• Report any side effects or concerns: If you experience any adverse effects or have concerns about the medication, contact your healthcare provider promptly.
• Compliance with other medications: If you are taking other medications for Parkinson’s disease or other conditions, inform your healthcare provider to ensure there are no potential interactions.

It’s crucial to have regular follow-up appointments with your healthcare provider to monitor the effectiveness of the medication and address any potential side effects or concerns. If you or someone you know is prescribed Pimavanserin, it’s essential to have open and ongoing communication with the healthcare team regarding the treatment plan.

Other uses for this medicine

Pimavanserin is primarily indicated for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. It is specifically designed for this purpose, and its use for other conditions may not be recommended or well-studied. Always follow your healthcare provider’s recommendations and consult them for specific information regarding the use of Pimavanserin.

What special precautions should I follow?

Regarding special precautions for Pimavanserin, it’s crucial to consider the following:

• Elderly Patients with Dementia-Related Psychosis: Pimavanserin is not approved for the treatment of elderly patients with dementia-related psychosis due to an increased risk of mortality.
• Cardiac Concerns: Pimavanserin may prolong the QT interval, which could lead to serious heart rhythm abnormalities. Caution is advised in patients with a history of QT prolongation, those taking medications that can prolong the QT interval, or those with conditions that increase the risk of QT prolongation.
• Contraindications: Pimavanserin should not be used in individuals with a known hypersensitivity or allergic reaction to the drug.
• Monitoring: Regular monitoring, including electrocardiograms (ECGs), may be recommended to assess cardiac function during treatment, especially in patients with pre-existing cardiac conditions.
• Drug Interactions: Pimavanserin may interact with other medications. Inform your healthcare provider about all the medications, supplements, or herbal products you are taking to avoid potential interactions.
• Pregnancy and Breastfeeding: The safety of Pimavanserin during pregnancy or breastfeeding is not well established. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, and breastfeeding should be avoided during treatment.

Always take Pimavanserin exactly as prescribed by your healthcare provider and inform them of any pre-existing medical conditions, ongoing treatments, or concerns you may have. Since medication guidelines may change, it’s essential to consult with your healthcare provider or refer to the most recent prescribing information for any updates or changes in recommendations.

What special dietary instructions should I follow?

Regarding dietary instructions, there are no specific dietary restrictions associated with Pimavanserin. However, it’s essential to maintain a healthy and balanced diet to support overall well-being. If you have any concerns about diet and medication interactions, it’s advisable to discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Pimavanserin, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure about what to do, consult with your healthcare provider for guidance.

What side effects can this medication cause?

Pimavanserin, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person. If you are prescribed Pimavanserin, your healthcare provider will carefully weigh the potential benefits against the risks based on your individual health and circumstances. Common side effects of Pimavanserin may include:

• Swelling: Peripheral edema or swelling in the extremities.
• Confusion: Some patients may experience confusion.
• Nausea: Feelings of discomfort or an inclination to vomit.
• Hallucinations: While Pimavanserin is used to treat hallucinations associated with Parkinson’s disease psychosis, it may, in some cases, cause hallucinations as a side effect.
• Insomnia: Difficulty falling asleep or staying asleep.

It’s important to report any side effects to your healthcare provider promptly. Additionally, there are some more serious potential side effects, and if you experience any of the following, seek immediate medical attention:

• Severe Allergic Reactions: Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• QT Prolongation: This can affect the heart’s rhythm and may lead to serious complications. Seek medical attention if you experience symptoms such as fainting, irregular heartbeat, or other cardiac issues.

Always take Pimavanserin as prescribed by your healthcare provider, and do not discontinue or change the dosage without consulting them. If you have any concerns about potential side effects or how Pimavanserin may interact with other medications you are taking, discuss them with your healthcare provider. They can provide guidance tailored to your specific health situation.

What should I know about storage and disposal of this medication?

Storage:

• Store Pimavanserin at room temperature, away from excessive heat and moisture.
• Keep the medication in its original packaging or container to protect it from light.
• Follow any specific storage instructions provided by your healthcare provider or the medication’s packaging.

Disposal:

• Dispose of unused or expired Pimavanserin in accordance with local regulations and guidelines.
• Do not flush medications down the toilet unless specifically instructed to do so.
• Check with your pharmacist or local waste disposal facility for information on safe medication disposal.

In case of emergency/overdose

In case of an overdose or emergency, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention. Symptoms of overdose may include extreme drowsiness, fainting, or irregular heartbeat.

What other information should I know?

• Keep all appointments with your healthcare provider for regular check-ups and monitoring.
• Inform healthcare professionals, including dentists and surgeons, about your use of Pimavanserin before undergoing any procedures or surgeries.
• Notify your healthcare provider of any other medications, supplements, or herbal products you are taking, as certain substances may interact with Pimavanserin.
• Attend regular follow-up appointments to assess the medication’s effectiveness and address any concerns or side effects.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Pimavanserin with your healthcare provider.

Always follow your healthcare provider’s instructions and guidelines for the safe use, storage, and disposal of Pimavanserin. If you have specific questions or concerns, consult your healthcare provider or pharmacist for personalized advice.