Why is this medication prescribed?

Pifeltro (doravirine) is a prescription medication used in the treatment of HIV-1 infection in adults who have never taken HIV medicines before (treatment-naive). It is classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI), which works by inhibiting the reverse transcriptase enzyme that the virus needs to replicate.

How should this medicine be used?

Here are general guidelines for the use of Pifeltro:

• Prescription and Supervision: Pifeltro is available only with a prescription from a healthcare provider experienced in the management of HIV infection.
• Dosage: The usual recommended dose is one 100 mg tablet taken orally once daily with a meal. It’s important to take it consistently at the same time each day.
• Administration: The tablet should be swallowed whole with a glass of water and can be taken with or without food. However, taking it with a meal is recommended to increase absorption.
• Adherence: It’s crucial to take Pifeltro exactly as prescribed by your healthcare provider. Skipping doses or not following the prescribed regimen can lead to reduced effectiveness and the development of drug-resistant HIV.
• Combination Therapy: Pifeltro is often prescribed as part of a combination regimen with other antiretroviral medications. This is known as combination antiretroviral therapy (ART), and it helps to increase its effectiveness and reduce the risk of resistance.
• Regular Monitoring: Your healthcare provider will monitor your viral load, CD4 cell count, and other relevant laboratory tests to assess the effectiveness of the treatment and make adjustments if necessary.
• Side Effects: It’s important to be aware of potential side effects and report any unusual symptoms to your healthcare provider promptly.

Remember, individual circumstances may vary, and these are general guidelines. Always follow the specific instructions provided by your healthcare provider, and consult with them regarding any questions or concerns you may have about your treatment with Pifeltro.

Other uses for this medicine

Pifeltro (doravirine) is primarily used for the treatment of HIV-1 infection in adults who have not previously taken HIV medicines (treatment-naive). It is not typically prescribed for other medical conditions. It’s important to use Pifeltro only under the supervision and guidance of a healthcare professional who is experienced in the management of HIV.

What special precautions should I follow?

Special precautions and considerations when using Pifeltro include:

• HIV Testing: Pifeltro should only be used in individuals who have confirmed HIV-1 infection. Before starting any antiretroviral therapy, including Pifeltro, it’s essential to confirm the diagnosis through HIV testing.
• Drug Interactions: Pifeltro can interact with other medications. Inform your healthcare provider about all prescription and over-the-counter medications, vitamins, and herbal supplements you are taking. Some drugs may need dosage adjustments or may need to be avoided due to potential interactions.
• Resistance: Like all antiretroviral medications, there is a risk of developing drug resistance if Pifeltro is not taken as prescribed. It’s crucial to adhere to the prescribed dosage and schedule to maintain its effectiveness.
• Pregnancy and Breastfeeding: If you are pregnant or planning to become pregnant, or if you are breastfeeding, discuss this with your healthcare provider. The potential risks and benefits of using Pifeltro during pregnancy and breastfeeding need to be considered, and alternative options may be explored.
• Liver Function: Pifeltro is metabolized by the liver, so individuals with liver impairment may need special monitoring. Your healthcare provider may perform liver function tests before starting treatment and periodically during treatment.
• Allergies: Inform your healthcare provider of any known allergies or hypersensitivity reactions to medications, including doravirine or its components.
• Rash: Skin rash is a known side effect of Pifeltro. If you develop a rash or any signs of an allergic reaction, seek medical attention promptly.
• Alcohol and Substance Use: Discuss your alcohol and substance use with your healthcare provider, as they may impact the effectiveness and safety of Pifeltro.

Always follow your healthcare provider’s instructions and attend regular follow-up appointments to monitor your progress and address any concerns. If you experience any side effects or have questions about your treatment, do not hesitate to contact your healthcare provider for guidance.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Pifeltro. However, taking the medication with a meal is recommended to increase its absorption. Pifeltro can be taken with or without food, but consistent administration with a meal may enhance its effectiveness.

What should I do if I forget a dose?

If you forget to take a dose of Pifeltro, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

If you have difficulty adhering to your medication schedule or have concerns about missed doses, it’s crucial to discuss this with your healthcare provider. They can provide guidance on what to do in specific situations and may offer strategies to help you maintain a consistent dosing routine.

What side effects can this medication cause?

Pifeltro (doravirine) may cause side effects, and it’s important to be aware of them and promptly report any unusual symptoms to your healthcare provider. Not everyone will experience these side effects, and some individuals may experience them to varying degrees. Common side effects of Pifeltro include:

• Dizziness: Some individuals may experience dizziness, especially when standing up from a sitting or lying position. It’s important to stand up slowly to minimize the risk of dizziness.
• Headache: Headache is a common side effect that may occur during the initial period of treatment.
• Rash: Skin rash can occur, and it’s important to report any rash to your healthcare provider promptly. If you develop a severe rash or signs of an allergic reaction (such as swelling, itching, or difficulty breathing), seek medical attention immediately.
• Abnormal Dreams: Some people may experience vivid or abnormal dreams as a side effect of Pifeltro.
• Nausea: Nausea or stomach discomfort may occur.
• Fatigue: Feeling tired or fatigued is a possible side effect.
• Diarrhea: Some individuals may experience diarrhea.

It’s important to note that these are not all the possible side effects of Pifeltro, and others may occur. Additionally, individual responses to medications can vary, so not everyone will experience the same side effects. Serious side effects are rare but can occur. Always follow your healthcare provider’s instructions, and inform them of any side effects or concerns you may have.

If you experience any severe or persistent side effects, or if you have concerns about your treatment, contact your healthcare provider for guidance. They can assess your situation and make any necessary adjustments to your medication or provide additional support.

What should I know about storage and disposal of this medication?

Storage and Disposal of Pifeltro:

• Storage: Store Pifeltro (doravirine) at room temperature, away from excessive heat and moisture. Keep the medication in its original container, and ensure that it is tightly closed.
• Keep Out of Reach of Children: Store Pifeltro in a location that is out of reach of children and pets.
• Do Not Use Expired Medication: Check the expiration date on the medication container, and do not use Pifeltro if it has passed the expiration date.
• Do Not Store in the Bathroom: Avoid storing medications in the bathroom, as moisture and humidity can affect their stability.
• Disposal: Dispose of any unused or expired medication properly. Do not flush medications down the toilet unless instructed to do so. Contact your local pharmacy or healthcare provider for information on proper disposal methods.

In case of emergency/overdose

In case of an overdose or emergency, contact your local poison control center (1-800-222-1222 in the United States) or emergency room immediately. If someone has collapsed or is experiencing difficulty breathing, call emergency services right away.

What other information should I know?

• Regular Follow-Up: Attend regular follow-up appointments with your healthcare provider to monitor your progress and assess the effectiveness of Pifeltro. They may conduct laboratory tests, such as viral load and CD4 cell count, to evaluate the status of your HIV infection.
• Adherence: Take Pifeltro exactly as prescribed by your healthcare provider. Adhering to the prescribed dosing schedule is crucial for the effectiveness of the medication and to prevent the development of drug-resistant HIV.
• Inform Healthcare Providers: Keep your healthcare provider informed about all medications you are taking, including Pifeltro, as well as any changes in your health or other relevant information.
• Pregnancy and Breastfeeding: If you are pregnant or planning to become pregnant, or if you are breastfeeding, discuss this with your healthcare provider. The use of Pifeltro during pregnancy and breastfeeding should be carefully considered.
• Routine Health Maintenance: Continue practicing routine health maintenance, such as vaccinations and screenings, as recommended by your healthcare provider.

Always follow the specific instructions provided by your healthcare provider and the medication’s packaging. If you have any questions or concerns, do not hesitate to contact your healthcare provider for guidance.