Why is this medication prescribed?

Phentermine and topiramate is a combination medication used for weight loss. It is typically prescribed for individuals who are overweight or obese and have weight-related medical conditions such as high blood pressure, diabetes, or high cholesterol. The combination of phentermine and topiramate works in different ways to help with weight loss.

Phentermine is an appetite suppressant that affects the central nervous system. It works by reducing appetite and increasing the feeling of fullness, which can lead to reduced food intake. Topiramate is an anticonvulsant medication that is also used to prevent migraines. It is thought to help with weight loss by affecting certain brain chemicals that control appetite and by increasing feelings of fullness.

How should this medicine be used?

When using phentermine and topiramate, it is important to follow your healthcare provider’s instructions carefully. Here are some general guidelines:

• Dosage: The dosage of phentermine and topiramate can vary based on individual factors, and your healthcare provider will determine the appropriate dose for you.
• Administration: The medication is usually taken orally, with or without food. It is typically taken once a day in the morning to avoid potential insomnia due to the stimulant effects of phentermine.
• Follow-up: Regular follow-up appointments with your healthcare provider are important to monitor your progress, adjust the dosage if needed, and address any potential side effects.
• Lifestyle Changes: Phentermine and topiramate are usually prescribed as part of a comprehensive weight loss plan that includes dietary changes and increased physical activity. It is not a standalone solution, and lifestyle modifications are essential for long-term success.
• Discontinuation: Do not stop taking phentermine and topiramate without consulting your healthcare provider. Abruptly stopping the medication may lead to withdrawal symptoms.
• Monitoring: Your healthcare provider may monitor you for potential side effects, including changes in blood pressure, heart rate, and mood.

It’s crucial to note that phentermine and topiramate, like any medication, may have potential side effects and risks. Common side effects include insomnia, dry mouth, tingling sensations, constipation, and changes in taste. Serious side effects may include an increase in heart rate and psychiatric reactions.

Always consult with your healthcare provider for personalized advice and guidance regarding the use of phentermine and topiramate, taking into account your specific health conditions and medical history.

Other uses for this medicine

Phentermine is primarily approved for the short-term treatment of obesity, but it may also be prescribed for other purposes at the discretion of a healthcare professional. It is important to note that using phentermine for any purpose other than what is specifically prescribed by a doctor can be unsafe and is not recommended.

What special precautions should I follow?

Before starting phentermine and topiramate, it’s important to discuss your medical history and any existing conditions with your healthcare provider. Here are some special precautions:

• Pregnancy and Breastfeeding: Phentermine and topiramate may harm an unborn baby, so it is important to inform your healthcare provider if you are pregnant or planning to become pregnant. The medication is generally not recommended during pregnancy. If you become pregnant while taking it, notify your doctor immediately. Breastfeeding while using this medication is also not recommended.
• Glaucoma: If you have a history of glaucoma or any other eye problems, you should inform your healthcare provider. Phentermine and topiramate can increase eye pressure, which may lead to glaucoma.
• Cardiovascular Conditions: Individuals with a history of heart problems, including heart disease, stroke, or irregular heartbeats, may need special monitoring while taking phentermine and topiramate. The medication can increase heart rate and blood pressure.
• Hyperthyroidism: Phentermine and topiramate may affect thyroid levels. If you have hyperthyroidism or any thyroid problems, your healthcare provider should be informed.
• Kidney Stones: Topiramate may increase the risk of kidney stones. If you have a history of kidney stones or other kidney problems, your healthcare provider should be aware.
• Mood Disorders: Topiramate has been associated with mood changes, including depression and suicidal thoughts. If you have a history of mood disorders, inform your healthcare provider.
• Drug Interactions: Phentermine and topiramate may interact with other medications, so it’s important to inform your healthcare provider about all the medications, supplements, and herbal products you are taking.

Always take phentermine and topiramate exactly as prescribed by your healthcare provider and follow their instructions for monitoring and potential side effects. If you experience any concerning side effects, contact your healthcare provider promptly. Regular follow-up appointments are important to assess the medication’s effectiveness and safety in your specific case.

What special dietary instructions should I follow?

While taking phentermine and topiramate, it’s essential to follow a healthy diet and lifestyle to maximize the benefits of the medication. Your healthcare provider or a registered dietitian may provide specific guidance, but here are some general tips:

• Healthy Eating: Focus on a balanced diet that includes a variety of fruits, vegetables, whole grains, and lean proteins.
• Portion Control: Be mindful of portion sizes to avoid overeating.
• Hydration: Drink an adequate amount of water throughout the day.
• Limit Caffeine and Alcohol: Both caffeine and alcohol can affect sleep and may interact with the medication. It’s advisable to limit their consumption.
• Meal Timing: Take the medication in the morning with or without food, as directed by your healthcare provider. Avoid taking it in the evening to minimize the risk of insomnia.

What should I do if I forget a dose?

If you forget to take a dose of phentermine and topiramate, take it as soon as you remember. However, if it is close to the time of your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses to make up for a missed one. If you have questions or concerns about missed doses, consult your healthcare provider for guidance.

What side effects can this medication cause?

Phentermine and topiramate, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person. Common side effects may include:

• Increased Heart Rate: Phentermine, as a stimulant, can lead to an increase in heart rate. This can be a concern for individuals with pre-existing heart conditions.
• Insomnia: Both phentermine and topiramate can cause difficulty sleeping. Taking the medication in the morning, as recommended, can help minimize this side effect.
• Dry Mouth: Phentermine may cause dry mouth, which can be alleviated by staying well-hydrated. Chewing sugarless gum or sucking on ice chips may also help.
• Constipation: This is a common side effect, and it’s important to maintain a healthy diet with an adequate intake of fiber and fluids.
• Tingling Sensations: Some individuals may experience tingling sensations or numbness in the hands or feet, which is more commonly associated with topiramate.
• Changes in Taste: Topiramate can alter the sense of taste, causing a metallic taste or other changes.
• Dizziness or Lightheadedness: This can be a side effect, especially when standing up quickly. Changing positions slowly can help minimize this.
• Mood Changes: Topiramate has been associated with mood changes, including depression, anxiety, and irritability.
• Memory and Concentration Issues: Some individuals may experience cognitive side effects, such as difficulties with memory and concentration, which are more commonly associated with topiramate.
• Vision Changes: Blurred vision or changes in vision have been reported.
• Potential for Birth Defects: Phentermine and topiramate have been associated with an increased risk of cleft lip and/or cleft palate in newborns if taken during pregnancy. It’s crucial to use effective contraception if you are of childbearing age and not planning to become pregnant.
• Increase in Blood Pressure: Phentermine can raise blood pressure, and regular monitoring is typically recommended.

It’s important to contact your healthcare provider if you experience any side effects, especially if they are severe or persistent. Additionally, if you notice any signs of an allergic reaction (e.g., rash, itching, swelling, severe dizziness), seek medical attention immediately.

This is not an exhaustive list of side effects, and individuals may experience other reactions. It’s crucial to discuss any concerns or unusual symptoms with your healthcare provider, and to attend regular follow-up appointments to monitor your response to the medication.

What should I know about storage and disposal of this medication?

Storage and Disposal of Phentermine and Topiramate:

• Storage:
  • Store phentermine and topiramate at room temperature, away from moisture and heat.
  • Keep the medication in its original container, tightly closed, and out of reach of children.
• Disposal:
  • Dispose of unused or expired medication properly. Do not flush it down the toilet or pour it into a drain unless instructed to do so.
  • Check with your local pharmacy or healthcare provider for guidance on how to dispose of medications in an environmentally friendly and safe manner.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek medical attention immediately. Symptoms of overdose may include:

• Restlessness
• Tremor
• Rapid breathing
• Confusion
• Hallucinations
• Uncontrollable movements or seizures
• Loss of consciousness

Contact your local poison control center or emergency room for guidance. Be prepared to provide information about the type and amount of medication ingested, as well as the person’s age, weight, and overall health.

What other information should I know?

• Regular Monitoring: Attend all scheduled follow-up appointments with your healthcare provider to monitor your progress and assess the effectiveness and safety of the medication.
• Contraindications: Inform your healthcare provider about any existing medical conditions or medications you are taking, as certain conditions or medications may contraindicate the use of phentermine and topiramate.
• Avoid Alcohol: Limit alcohol consumption while taking phentermine and topiramate, as alcohol can interact with the medication and increase the risk of side effects.
• Driving and Operating Machinery: Be cautious when driving or operating machinery, especially initially, as the medication may cause dizziness or impair concentration.
• Abrupt Discontinuation: Do not abruptly stop taking phentermine and topiramate without consulting your healthcare provider, as this can lead to withdrawal symptoms.
• Contraception: If you are of childbearing age and sexually active, discuss effective contraception methods with your healthcare provider, as phentermine and topiramate may pose risks during pregnancy.
• Allergies: Inform your healthcare provider of any allergies you may have, including allergies to medications or any other substances.
• Blood Pressure Monitoring: If you have a history of high blood pressure or cardiovascular issues, your blood pressure should be monitored regularly while taking phentermine and topiramate.

Always follow your healthcare provider’s instructions and ask any questions you may have about the medication. If you experience unusual or severe side effects, contact your healthcare provider promptly. This information is not exhaustive, and individual circumstances may require specific considerations.