WARNING

Pertuzumab is a medication used in the treatment of certain types of breast cancer. It is typically administered as an injection and is often used in combination with other cancer medications. While Pertuzumab can be effective in treating breast cancer, like any medication, it comes with potential risks and side effects. It’s crucial to note that individual responses to the drug can vary, and not everyone will experience the same effects.

Here are some potential risks and side effects associated with Pertuzumab:

• Cardiac Effects: Pertuzumab may lead to heart-related issues, including decreased heart function. Regular cardiac monitoring is usually recommended during treatment.
• Infusion Reactions: Some individuals may experience infusion-related reactions, such as fever, chills, or difficulty breathing, during or shortly after the administration of Pertuzumab.
• Skin and Nail Changes: Skin and nail problems, such as rash, dry skin, and nail changes, may occur as side effects of Pertuzumab.
• Gastrointestinal Issues: Nausea, diarrhea, and vomiting are among the possible gastrointestinal side effects associated with Pertuzumab.
• Respiratory Issues: Pulmonary toxicity, though rare, has been reported with Pertuzumab. Symptoms may include shortness of breath or cough.
• Neutropenia: Pertuzumab can cause a decrease in white blood cell count, leading to an increased risk of infections. Regular blood tests are often performed to monitor for this.
• Hypersensitivity Reactions: Severe allergic reactions are rare but possible with Pertuzumab. Signs may include swelling, itching, or difficulty breathing.

It’s important for individuals considering or undergoing treatment with Pertuzumab to discuss their medical history, including any pre-existing conditions, with their healthcare team. Regular monitoring and communication with healthcare providers are crucial to managing and mitigating potential risks associated with Pertuzumab treatment. This information is a brief overview, and individuals should consult their healthcare professionals for more detailed and personalized information based on their specific health circumstances.

Why is this medication prescribed?

Pertuzumab is a medication used in the treatment of certain types of cancer, particularly breast cancer. It is typically prescribed in combination with other drugs for the treatment of HER2-positive breast cancer, which is a specific subtype of breast cancer that overexpresses a protein called human epidermal growth factor receptor 2 (HER2). Pertuzumab is often used in conjunction with trastuzumab and chemotherapy to improve the effectiveness of the treatment.

How should this medicine be used?

The use of Pertuzumab is typically guided by a healthcare professional, and the medication is administered through an intravenous (IV) infusion. Here are some general guidelines:

• Dosage: The dosage of Pertuzumab can vary based on the specific treatment plan and the individual’s health status. It is determined by the healthcare provider.
• Administration: Pertuzumab is administered as an IV infusion, usually in a healthcare setting such as a hospital or clinic. The infusion is given over a specified period, and the frequency of administration depends on the overall treatment plan.
• Combination Therapy: Pertuzumab is often used in combination with other anti-cancer medications, such as trastuzumab and chemotherapy. The combination of these drugs is designed to enhance the effectiveness of treatment.
• Monitoring: Patients receiving Pertuzumab may undergo regular monitoring, including cardiac assessments, to ensure the safety of the treatment.
• Duration of Treatment: The duration of Pertuzumab treatment can vary based on the stage and type of breast cancer. It may be part of a short-term neoadjuvant treatment plan or a longer-term treatment for metastatic breast cancer.

It’s crucial for individuals to follow their healthcare provider’s instructions regarding the administration and schedule of Pertuzumab. Additionally, patients should communicate any concerns or potential side effects to their healthcare team promptly. As with any cancer treatment, the decision to use Pertuzumab is based on an individual’s specific diagnosis and overall health, and it should be made in consultation with healthcare professionals.

Other uses for this medicine

Pertuzumab is primarily used in the treatment of HER2-positive breast cancer. Its approval and recommended use may have evolved since then. It’s important to consult with healthcare professionals or refer to the latest medical literature for the most up-to-date information on Pertuzumab’s uses.

What special precautions should I follow?

When using Pertuzumab, certain precautions should be taken to ensure the safety and effectiveness of the treatment. These precautions may include:

• Cardiac Monitoring: Pertuzumab can have cardiac effects, and regular monitoring of cardiac function is typically recommended during treatment. This may involve assessments such as echocardiograms or multiple-gated acquisition (MUGA) scans.
• Hypersensitivity Reactions: Patients should be monitored for signs of hypersensitivity or infusion reactions during and after the administration of Pertuzumab. In some cases, pre-medications may be given to reduce the risk of infusion-related reactions.
• Pregnancy and Breastfeeding: The safety of Pertuzumab during pregnancy is not well established, and it may pose risks to the developing fetus. Patients should inform their healthcare provider if they are pregnant or planning to become pregnant. Breastfeeding is generally not recommended during Pertuzumab treatment.
• Infection Risk: Pertuzumab may lower the body’s ability to fight infections. Patients should report any signs of infection, such as fever or persistent cough, to their healthcare provider.
• Other Medications: Patients should inform their healthcare team about all medications, including prescription and over-the-counter drugs, as well as herbal supplements. Certain medications may interact with Pertuzumab, and dose adjustments may be necessary.
• Liver Function: Pertuzumab is metabolized by the liver, and patients with impaired liver function may require dose adjustments. Liver function should be monitored during treatment.
• Neutropenia: Pertuzumab can cause a decrease in white blood cell count (neutropenia), increasing the risk of infections. Regular blood tests are often performed to monitor for this.

It’s important for individuals receiving Pertuzumab to communicate openly with their healthcare provider about their medical history, any ongoing health issues, and any medications they are taking. This helps the healthcare team make informed decisions about the safety and appropriateness of Pertuzumab for the individual’s specific circumstances. Patients should also report any side effects or concerns promptly to their healthcare provider. As medical knowledge is continually evolving, healthcare providers will have the most current information regarding the use and precautions of Pertuzumab.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Pertuzumab. However, individual dietary considerations may vary based on the patient’s overall health and any concurrent treatments or conditions. It’s advisable to discuss any specific dietary concerns with the healthcare team, as they can provide personalized guidance based on the patient’s unique circumstances.

What should I do if I forget a dose?

As Pertuzumab is typically administered by healthcare professionals as an intravenous infusion, there is usually no concern about patients forgetting a dose. The administration is closely monitored during scheduled sessions.

What side effects can this medication cause?

Pertuzumab, like many medications, can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. The following is a list of potential side effects associated with Pertuzumab injection. This list is not exhaustive, and individuals should consult their healthcare provider for personalized information based on their specific health condition and medical history.

Common side effects of Pertuzumab may include:

• Infusion-related reactions: Symptoms may include fever, chills, nausea, vomiting, and difficulty breathing during or shortly after the infusion.
• Diarrhea: Pertuzumab may cause diarrhea, and it is important to stay hydrated. Inform your healthcare provider if diarrhea is severe or persistent.
• Nail and skin changes: This can include changes in the nails (such as discoloration or swelling) and skin problems (such as rash or dry skin).
• Fatigue: Feeling tired or weak is a common side effect of cancer treatments, including Pertuzumab.
• Decreased white blood cell count (neutropenia): This may increase the risk of infections. Regular blood tests are often performed to monitor for this.
• Decreased cardiac function: Pertuzumab, when used in combination with other medications, may affect the heart. Cardiac monitoring is usually recommended during treatment.
• Allergic reactions: In rare cases, severe allergic reactions (hypersensitivity reactions) can occur. Signs may include swelling, itching, or difficulty breathing.
• Respiratory issues: Some individuals may experience respiratory problems, such as shortness of breath or cough.

It’s important for individuals receiving Pertuzumab to communicate openly with their healthcare provider about any side effects or concerns. Healthcare providers can provide guidance on managing side effects and, if necessary, adjust the treatment plan to minimize their impact.

This list is not exhaustive, and side effects can vary. It’s crucial for patients to be aware of the potential side effects, report any new or worsening symptoms to their healthcare team, and attend regular follow-up appointments for monitoring.

What should I know about storage and disposal of this medication?

Storage and Disposal of Pertuzumab Injection:

• Storage: Pertuzumab is typically administered by healthcare professionals in a clinical setting, and the storage of the medication is the responsibility of the healthcare facility. If, for any reason, you are provided with Pertuzumab for self-administration or storage at home, follow the storage instructions provided by your healthcare provider or pharmacist. In general, medications like Pertuzumab are often stored in a refrigerator. Always check the specific storage instructions on the medication packaging.
• Disposal: Pertuzumab is usually administered in a clinical setting, and any unused medication or medical waste generated during the administration is typically handled by healthcare professionals. If you have concerns about the disposal of medical waste or unused medication, consult with your healthcare provider or pharmacist. They can provide guidance on proper disposal methods in accordance with local regulations.

In case of emergency/overdose

In the case of an emergency or suspected overdose, it is crucial to seek immediate medical attention. The symptoms of an overdose or a severe adverse reaction to Pertuzumab may include severe infusion reactions, cardiovascular issues, or other unexpected reactions.

Contact emergency services or go to the nearest emergency room if you experience severe symptoms. Be prepared to provide information about the medication, including its name (Pertuzumab), the dosage you received, and any other medications you are taking.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Always follow the instructions provided by your healthcare provider for the administration of Pertuzumab and any other medications. Attend all scheduled appointments and communicate any concerns or side effects promptly.
• Regular Monitoring: Pertuzumab treatment often involves regular monitoring of cardiac function and blood counts. Attend all recommended monitoring appointments as part of your overall cancer care.
• Inform Healthcare Providers: Keep your healthcare team informed about your overall health, any changes in medications, and any new symptoms or concerns you may have.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Pertuzumab may have potential risks to a developing fetus, and breastfeeding is generally not recommended during treatment.
• Potential Interactions: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as herbal supplements, that you are taking. Certain medications may interact with Pertuzumab, and your healthcare team can provide guidance on managing potential interactions.

Always consult with your healthcare provider or pharmacist for specific and personalized information based on your individual health status and the details of your treatment plan.