Why is this medication prescribed?

Pentasa is a medication that contains mesalamine, which is a type of anti-inflammatory drug. It is commonly used to treat inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn’s disease. These conditions involve inflammation of the gastrointestinal tract, and Pentasa works by reducing this inflammation. Here are some key points about Pentasa:

• Ulcerative Colitis: Pentasa is often prescribed to induce and maintain remission in patients with mild to moderate ulcerative colitis.
• Crohn’s Disease: Pentasa may also be used to treat and maintain remission in patients with mild to moderate Crohn’s disease, particularly when the disease affects the colon or the last part of the small intestine (ileum).

How should this medicine be used?

Here are some general guidelines:

• Dosage: The dosage of Pentasa can vary depending on the specific condition being treated and the severity of the symptoms. It is important to follow the prescribed dosage and administration schedule provided by the healthcare provider.
• Formulations: Pentasa is available in various formulations, including extended-release capsules and controlled-release granules. The choice of formulation may depend on the patient’s needs and the specific instructions of the prescribing healthcare professional.
• Administration: Pentasa is usually taken with or without food. It’s important to swallow the capsules whole and not crush or chew them. If you are taking the granules, they are typically mixed with water before ingestion.
• Consistency: To get the most benefit from Pentasa, it’s important to take it consistently as prescribed, even if symptoms improve. Missing doses may reduce the effectiveness of the treatment.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, it’s crucial to discuss the use of Pentasa with your healthcare provider to weigh the potential benefits and risks.
• Monitoring: Regular check-ups and monitoring may be necessary while taking Pentasa to assess its effectiveness and monitor for any potential side effects.

Always follow the specific instructions provided by your healthcare provider, and do not self-adjust the dosage or discontinue the medication without consulting them first. If you have any concerns or experience unusual side effects, contact your healthcare provider promptly.

Other uses for this medicine

Pentasa is primarily used for the treatment of inflammatory bowel diseases, such as ulcerative colitis and Crohn’s disease. It is not typically prescribed for other conditions. The active ingredient in Pentasa, mesalamine, acts as an anti-inflammatory agent, helping to reduce inflammation in the gastrointestinal tract.

What special precautions should I follow?

Special Precautions for Pentasa:

• Allergies: Inform your healthcare provider about any known allergies to mesalamine, aspirin, or other salicylates.
• Liver or Kidney Disease: Inform your healthcare provider if you have a history of liver or kidney disease, as Pentasa may require special consideration in such cases.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Pentasa during pregnancy and breastfeeding should be carefully considered, and the potential risks and benefits should be discussed with your healthcare provider.
• Other Medications: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as any supplements you are taking. Some medications may interact with Pentasa.
• Mesalamine Allergy: Pentasa should not be used in patients who are allergic to mesalamine or any of its components.
• Gastrointestinal Strictures: Use Pentasa with caution in patients with known or suspected gastrointestinal strictures (narrowing of the digestive tract).
• Pancreatic Disease: Patients with a history of pancreatitis should use Pentasa with caution.
• Monitoring: Regular monitoring of kidney function, liver function, and blood cell counts may be recommended during treatment with Pentasa, especially with long-term use.
• Children: The safety and effectiveness of Pentasa in children under the age of 2 have not been established.
• Immunosuppression: Exercise caution in patients who are immunosuppressed, as mesalamine has the potential to affect the immune system.

Always follow your healthcare provider’s instructions and communicate openly about your medical history and any concerns you may have. If you experience any unusual symptoms or side effects while taking Pentasa, contact your healthcare provider promptly. Do not self-adjust your medication or dosage without consulting your healthcare professional.

What special dietary instructions should I follow?

Special Dietary Instructions for Pentasa:

• Take with Food: Pentasa is usually taken with food to enhance absorption. Follow your healthcare provider’s instructions regarding the timing of medication with meals.
• Avoid Alcohol: Limit or avoid alcohol consumption, as alcohol may exacerbate gastrointestinal symptoms and interact with medications.
• Maintain a Balanced Diet: Aim for a balanced diet rich in nutrients to support overall health, especially if you have inflammatory bowel disease.

What should I do if I forget a dose?

If you forget a dose of Pentasa, follow these general guidelines:

• Take as Soon as Possible: If you forget a dose of Pentasa, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do Not Double Dose: Do not take a double dose to make up for a missed one. Taking extra medication may increase the risk of side effects.
• Consult Healthcare Provider: If you are unsure about what to do if you miss a dose, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Pentasa (mesalamine) is generally well-tolerated by many people, but like any medication, it can cause side effects. It’s important to be aware of potential side effects and to promptly inform your healthcare provider if you experience any unusual or severe symptoms. Common and uncommon side effects associated with Pentasa include:

Common Side Effects:

• Headache
• Nausea
• Abdominal Pain
• Diarrhea
• Flatulence (gas)
• Joint Pain
• Fever
• Back Pain
• Rash or Itching

Uncommon but Serious Side Effects:

• Pancreatitis: Symptoms may include severe abdominal pain, nausea, and vomiting. Seek medical attention if you experience these symptoms.
• Hypersensitivity Reactions: Rarely, Pentasa can cause severe allergic reactions. Seek emergency medical attention if you experience difficulty breathing, swelling of the face or throat, or severe rash.
• Kidney Problems: In rare cases, Pentasa may affect kidney function. Symptoms may include changes in urine output or color, swelling, or fatigue. Report these symptoms to your healthcare provider.
• Liver Problems: Pentasa may affect liver function. Symptoms of liver problems include jaundice (yellowing of the skin or eyes), dark urine, and persistent nausea. Contact your healthcare provider if you experience these symptoms.
• Blood Disorders: Rarely, Pentasa may cause changes in blood cell counts. Symptoms may include unusual fatigue, easy bruising, or bleeding. Inform your healthcare provider if you notice these symptoms.
• Lung Problems: In very rare cases, Pentasa may cause lung inflammation. Seek medical attention if you experience difficulty breathing, cough, or chest pain.

Other Considerations:

• Some patients may experience hair loss, but this is rare.
• There have been isolated reports of a condition called “mesalamine-induced acute intolerance syndrome,” which may present as cramping, acute abdominal pain, and bloody diarrhea. If you experience severe abdominal symptoms, contact your healthcare provider.

It’s important to note that individual responses to medications can vary, and not everyone will experience these side effects. Additionally, some side effects may resolve on their own as your body adjusts to the medication.

Always consult with your healthcare provider if you have concerns about side effects or if you experience any symptoms that are unusual or bothersome. They can provide guidance on whether adjustments to your medication regimen are needed. Do not stop taking Pentasa without consulting your healthcare professional, as abruptly discontinuing the medication may worsen your condition.

What should I know about storage and disposal of this medication?

Storage and Disposal of Pentasa:

• Storage:
  • Store Pentasa (mesalamine) at room temperature, away from moisture and heat.
  • Keep the medication in its original packaging or container to protect it from light.
  • Do not store Pentasa in the bathroom.
• Disposal:
  • Dispose of unused or expired medications according to local regulations and guidelines.
  • Do not flush Pentasa down the toilet unless specifically instructed to do so. Check with your local pharmacy or waste disposal facility for proper disposal methods.

In case of emergency/overdose

In case of a suspected overdose or emergency, contact your local poison control center (1-800-222-1222 in the United States) or seek emergency medical attention immediately.

What other information should I know?

• Regular Monitoring: Your healthcare provider may recommend regular monitoring of kidney function, liver function, and blood cell counts during long-term Pentasa therapy.
• Routine Check-ups: Attend regular check-ups with your healthcare provider to assess the effectiveness of Pentasa and monitor for any potential side effects.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care, including dentists and specialists, that you are taking Pentasa. They should be aware of your medication regimen to avoid potential interactions.
• Patient Assistance Programs: If you are facing financial challenges in obtaining your medication, inquire about patient assistance programs or discount cards that may be available.
• Travel Considerations: If you plan to travel, ensure that you have an adequate supply of Pentasa. Keep your medication in its original packaging, and consider carrying a copy of your prescription.
• Follow Instructions: Always follow your healthcare provider’s instructions regarding the use of Pentasa. Do not adjust the dosage or stop taking the medication without consulting your healthcare professional.
• Inform About New Medications: Inform your healthcare provider about any new medications, including over-the-counter drugs and supplements, before starting them while taking Pentasa.
• Medical Alert Bracelet: If you have a severe allergy to mesalamine or other relevant medical conditions, consider wearing a medical alert bracelet or carrying an identification card to inform healthcare providers in case of an emergency.
• Special Populations: Pregnant or breastfeeding women should discuss the potential risks and benefits of Pentasa with their healthcare provider.

Always consult with your healthcare provider or pharmacist if you have specific questions about the storage, disposal, or emergency procedures for Pentasa. They can provide personalized guidance based on your individual medical history and circumstances.