Why is this medication prescribed?

Enfuvirtide is a medication used in the treatment of HIV (human immunodeficiency virus) infection. It belongs to a class of drugs known as fusion inhibitors. Enfuvirtide is specifically prescribed for patients who have developed resistance to other HIV medications or for those who have advanced HIV infection.

Enfuvirtide works by blocking the fusion of the HIV virus with the human immune cells, preventing the virus from entering and infecting these cells. It is typically used in combination with other antiretroviral medications to create a more effective treatment regimen.

As for the administration of Enfuvirtide, it is given as a subcutaneous (under the skin) injection. The specific dosage and frequency of injections will be determined by your healthcare provider based on your individual medical condition and response to treatment. It’s important to follow the prescribed dosage and administration schedule carefully.

How should this medicine be used?

Here are general guidelines for the use of Enfuvirtide:

• Administration: Enfuvirtide is administered as a subcutaneous injection. It is usually injected into the fatty tissue of the upper arm, thigh, or abdomen.
• Frequency: The usual recommended dosage is 90 mg twice daily. Your healthcare provider will provide specific instructions on the dosage and administration schedule.
• Rotation of Injection Sites: It is important to rotate the injection sites to prevent irritation or changes in the skin at the injection site.
• Training: Patients are often provided with training on how to self-administer the injections. It’s important to follow the instructions provided by healthcare professionals.
• Storage: Enfuvirtide injections should be stored in the refrigerator. It is important to follow the storage instructions provided with the medication.

It’s crucial to inform your healthcare provider about any other medications you are taking, as well as any medical conditions you may have, before starting Enfuvirtide. Additionally, regular follow-up appointments and laboratory tests may be necessary to monitor the effectiveness of the treatment and check for any potential side effects.

As with any medication, it is important to take Enfuvirtide exactly as prescribed and to contact your healthcare provider if you have any concerns or experience side effects. Never adjust your dosage or stop taking the medication without consulting your healthcare provider.

Other uses for this medicine

Enfuvirtide is primarily used for the treatment of HIV infection, and its use is typically limited to individuals with HIV who have not responded well to other antiretroviral medications. It is not commonly prescribed for other medical conditions.

What special precautions should I follow?

Special precautions should be taken when using Enfuvirtide, and it’s important to follow the advice and instructions provided by your healthcare provider. Here are some key precautions:

• Allergies: Inform your healthcare provider if you are allergic to Enfuvirtide or any of its ingredients. This medication should not be used in individuals with known hypersensitivity to it.
• Infections: Enfuvirtide does not cure HIV infection, and individuals taking this medication may still be at risk of opportunistic infections. It is important to practice safe sex and take other precautions to prevent the transmission of HIV and other infections.
• Injection Site Reactions: Enfuvirtide is administered through subcutaneous injections, and injection site reactions (such as redness, swelling, or pain at the injection site) are common. It’s important to rotate injection sites and report any persistent or severe reactions to your healthcare provider.
• Hypersensitivity Reactions: Rare cases of severe hypersensitivity reactions, including anaphylaxis, have been reported with Enfuvirtide. Seek medical attention immediately if you experience symptoms such as difficulty breathing, swelling of the face or throat, or severe skin rash.
• Pregnancy and Breastfeeding: The safety of Enfuvirtide during pregnancy or breastfeeding is not well established. Consult with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Interactions with Other Medications: Inform your healthcare provider about all medications, including prescription, over-the-counter, and herbal supplements, that you are taking. Enfuvirtide may interact with other drugs, and adjustments to your medication regimen may be necessary.
• Monitoring: Regular monitoring of your HIV viral load and CD4 cell count will be necessary to assess the effectiveness of the treatment and make any necessary adjustments.
• Missed Doses: If you miss a dose of Enfuvirtide, contact your healthcare provider for guidance. Do not double the dose to make up for a missed one.

It’s crucial to attend regular follow-up appointments with your healthcare provider to monitor your overall health, assess the effectiveness of the treatment, and manage any potential side effects or complications. If you have any concerns or questions about Enfuvirtide or its use, don’t hesitate to discuss them with your healthcare provider.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Enfuvirtide. However, maintaining a healthy and balanced diet is generally important for overall well-being, especially for individuals living with HIV. Ensure that your diet includes a variety of nutritious foods, and stay well-hydrated.

What should I do if I forget a dose?

If you forget a dose of Enfuvirtide:

• Contact Your Healthcare Provider: Reach out to your healthcare provider for guidance on what to do next. They may advise you on whether to take the missed dose or wait until the next scheduled dose.
• Do Not Double Dose: Do not take a double dose to make up for the missed one. Taking too much medication at once can increase the risk of side effects.
• Follow Instructions: Your healthcare provider will provide specific instructions on how to handle missed doses based on your individual circumstances.

What side effects can this medication cause?

Enfuvirtide, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience only mild effects. Common side effects of Enfuvirtide injection include:

• Injection Site Reactions: Redness, swelling, pain, or nodules at the injection site are common. These reactions typically occur during the first week of treatment and may decrease over time.
• Bacterial Pneumonia: There have been reports of an increased risk of bacterial pneumonia in individuals taking Enfuvirtide.
• Hypersensitivity Reactions: Rare but severe hypersensitivity reactions, including anaphylaxis, have been reported. Seek immediate medical attention if you experience symptoms such as difficulty breathing, swelling of the face or throat, or severe skin rash.
• Increased Blood Pressure: Some individuals may experience an increase in blood pressure while taking Enfuvirtide.
• Eosinophilia: An increase in eosinophils (a type of white blood cell) has been observed in some individuals.
• Fat Redistribution: Redistribution or accumulation of body fat may occur, leading to changes in body shape.

It’s important to report any unusual or persistent side effects to your healthcare provider. Additionally, contact your healthcare provider if you experience any signs of a severe allergic reaction, such as difficulty breathing or swelling.

This is not an exhaustive list of side effects, and individuals may react differently to the medication. Your healthcare provider will provide information specific to your medical history and circumstances. They will also weigh the potential benefits of the medication in managing HIV against the potential risks of side effects. If you have concerns about the side effects of Enfuvirtide, discuss them with your healthcare provider for personalized guidance and management.

What should I know about storage and disposal of this medication?

Storage and Disposal of Enfuvirtide Injection:

• Storage:
  • Store Enfuvirtide injections in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C).
  • Do not freeze the medication.
  • Keep the medication in its original carton to protect it from light.
  • If a refrigerator is not available, Enfuvirtide can be stored at room temperature (up to 77°F or 25°C) for up to 24 hours.
• Disposal:
  • Discard any unused or expired Enfuvirtide medication according to local guidelines or regulations.
  • Do not dispose of medications in household trash unless instructed to do so.
  • Ask your healthcare provider or pharmacist about the proper disposal method for Enfuvirtide.

In case of emergency/overdose

In the event of an overdose or if you suspect an allergic reaction, seek emergency medical attention or contact your local poison control center immediately. Symptoms of an overdose or severe reaction may include difficulty breathing, swelling of the face or throat, or severe skin rash.

What other information should I know?

• Follow Instructions: Take Enfuvirtide exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your healthcare provider.
• Regular Follow-Up: Attend all scheduled follow-up appointments with your healthcare provider. These appointments are important for monitoring the effectiveness of the treatment and managing any side effects.
• Lab Tests: Your healthcare provider may order regular laboratory tests, including HIV viral load and CD4 cell count, to monitor your response to treatment.
• Medication Interactions: Inform your healthcare provider about all medications, including prescription, over-the-counter, and herbal supplements, that you are taking. Enfuvirtide may interact with other drugs.
• Safe Practices: Continue practicing safe sex and other preventive measures to reduce the risk of HIV transmission and other infections.
• Educate Yourself: Learn about HIV, its transmission, and how to manage your condition. Stay informed about your treatment plan and medications.

If you have any questions or concerns about Enfuvirtide, its storage, usage, or potential side effects, consult your healthcare provider or pharmacist for personalized guidance and support.