Why is this medication prescribed?

Parsabiv (etelcalcetide) is a medication prescribed for the treatment of secondary hyperparathyroidism (SHPT) in adult patients with chronic kidney disease (CKD) on hemodialysis. SHPT is a condition where the parathyroid glands in the neck produce too much parathyroid hormone (PTH), which can lead to imbalances in calcium and phosphorus levels in the body. Parsabiv helps lower PTH levels and regulate mineral metabolism.

How should this medicine be used?

Here are general guidelines for using Parsabiv:

• Dosage: The dosage of Parsabiv is individualized based on the patient’s PTH levels. The healthcare provider will determine the appropriate dose for each patient.
• Administration: Parsabiv is typically administered intravenously (IV) by a healthcare professional. It is given at the end of a hemodialysis session. The exact administration procedure and dosage will be determined by the prescribing healthcare provider.
• Monitoring: Regular monitoring of PTH levels and other relevant laboratory parameters is essential to adjust the Parsabiv dosage as needed. Healthcare providers will assess the patient’s response to the medication and make any necessary adjustments.
• Adherence: It is crucial for patients to follow their healthcare provider’s instructions and adhere to the prescribed dosage schedule. Missing doses or altering the dosage without medical guidance can affect the effectiveness of treatment.
• Side Effects: Patients should be aware of potential side effects and promptly report any unusual or severe symptoms to their healthcare provider. Common side effects may include hypocalcemia (low blood calcium levels), nausea, and vomiting.
• Calcium and Phosphorus Management: Patients taking Parsabiv may also be advised to manage their dietary intake of calcium and phosphorus. This may include dietary restrictions and the use of phosphate binders.

Always consult with a healthcare professional for specific information about your medical condition and the appropriate use of Parsabiv. The information provided here is general and may not cover all aspects of your individual treatment plan.

Other uses for this medicine

Parsabiv (etelcalcetide) is primarily indicated for the treatment of secondary hyperparathyroidism (SHPT) in adult patients with chronic kidney disease (CKD) on hemodialysis. It is important to note that new information may have emerged since then, so it’s recommended to consult with a healthcare professional or refer to updated medical resources for the latest information.

What special precautions should I follow?

Regarding special precautions for Parsabiv, it’s crucial to follow the advice and instructions provided by your healthcare provider. Here are some general precautions and considerations:

• Medical History: Before starting Parsabiv, inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, and medications you are currently taking. This information helps the healthcare provider assess the potential risks and benefits of Parsabiv for your specific situation.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The safety of Parsabiv during pregnancy and breastfeeding is an important consideration.
• Calcium Levels: Parsabiv can lower blood calcium levels, so your healthcare provider will monitor your calcium levels regularly. It’s important to follow any dietary recommendations related to calcium intake and to inform your healthcare provider of any symptoms of low calcium, such as muscle spasms or tingling sensations.
• Phosphorus Levels: Parsabiv may also affect phosphorus levels. Your healthcare provider will monitor these levels and may provide dietary advice or prescribe phosphate binders to manage phosphorus levels effectively.
• Adherence to Treatment Plan: Adhere to the prescribed dosage and administration schedule as directed by your healthcare provider. Do not adjust the dose or stop taking Parsabiv without consulting your healthcare provider.
• Interaction with Other Medications: Inform your healthcare provider about all medications, including over-the-counter drugs, supplements, and herbal products, that you are taking. Some medications may interact with Parsabiv, affecting its effectiveness or increasing the risk of side effects.
• Regular Monitoring: Regular monitoring of laboratory parameters, including PTH, calcium, and phosphorus levels, is essential to assess your response to Parsabiv and make any necessary adjustments to the treatment plan.

These precautions are general guidelines, and individual considerations may vary. Always consult with your healthcare provider for personalized advice based on your specific medical condition and needs.

What special dietary instructions should I follow?

• Calcium Intake: Follow your healthcare provider’s recommendations regarding dietary calcium intake. Your doctor may advise you to modify your diet based on your calcium levels.
• Phosphorus Restriction: If your healthcare provider advises phosphorus restriction, adhere to dietary recommendations and take any prescribed phosphate binders.

What should I do if I forget a dose?

If you forget to take a dose of Parsabiv:

• Contact Your Healthcare Provider: If you forget a dose, contact your healthcare provider or the healthcare team promptly. They can provide guidance on whether you should take the missed dose or adjust your treatment plan.
• Do Not Double Dose: Do not take a double dose to make up for a missed one unless instructed to do so by your healthcare provider.
• Follow Instructions: Follow any specific instructions provided by your healthcare provider for managing missed doses.

What side effects can this medication cause?

Parsabiv (etelcalcetide) may cause side effects, and it’s important to be aware of them. Not everyone will experience these side effects, and some individuals may experience side effects that are not listed here. If you are prescribed Parsabiv, your healthcare provider will monitor you for potential side effects. Common side effects and adverse reactions associated with Parsabiv may include:

• Hypocalcemia: Parsabiv can lower blood calcium levels. Symptoms of low calcium may include muscle spasms, tingling sensations, and numbness. Your healthcare provider will monitor your calcium levels and adjust your treatment plan accordingly.
• Nausea: Some people may experience nausea as a side effect of Parsabiv.
• Vomiting: Vomiting can occur in some individuals taking Parsabiv.
• Hypophosphatemia: Low levels of phosphorus in the blood (hypophosphatemia) may occur. Your healthcare provider will monitor your phosphorus levels and manage them as needed.
• Muscle Spasms: Muscle spasms or cramps may occur, especially if calcium levels are low.
• Headache: Some individuals may experience headaches as a side effect of Parsabiv.
• Diarrhea: Diarrhea can occur in some people taking Parsabiv.
• Upper Respiratory Tract Infection: Infections of the upper respiratory tract, such as the common cold, may be reported as a side effect.

It’s essential to report any unusual or severe symptoms to your healthcare provider promptly. Additionally, individual responses to medications can vary, and not everyone will experience the same side effects.

If you are prescribed Parsabiv, your healthcare provider will carefully consider the potential benefits and risks based on your medical history and current health status. They will monitor you regularly and adjust the treatment plan as needed to ensure the medication is both effective and well-tolerated. Always consult with your healthcare provider for personalized information and guidance related to your specific situation.

What should I know about storage and disposal of this medication?

Storage and Disposal of Parsabiv:

• Storage:
  • Store Parsabiv as directed by your healthcare provider or as indicated on the medication packaging.
  • Keep it in its original packaging to protect it from light.
  • Store at the recommended temperature, and avoid exposing it to extreme heat or cold.
• Disposal:
  • Follow your local guidelines or regulations for the proper disposal of unused or expired medications.
  • Do not dispose of Parsabiv in household trash or wastewater unless instructed to do so.
  • Consult with your pharmacist or healthcare provider for specific instructions on how to safely dispose of Parsabiv.

In case of emergency/overdose

In case of an emergency or overdose, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention immediately. The symptoms of an overdose may include severe hypocalcemia (low calcium levels), which can manifest as muscle spasms, seizures, and other serious complications. Provide emergency medical personnel with information about the medication and the amount taken.

What other information should I know?

• Follow Healthcare Provider Instructions: Adhere to your healthcare provider’s instructions regarding the administration, dosage, and monitoring of Parsabiv. Attend regular check-ups to assess your response to the medication.
• Lab Tests: Your healthcare provider will likely conduct regular blood tests to monitor your calcium, phosphorus, and parathyroid hormone (PTH) levels. Attend these tests as scheduled.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care (including dentists and surgeons) that you are taking Parsabiv. This helps them make informed decisions about your treatment.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Parsabiv with your healthcare provider.
• Missed Doses: If you miss a dose, contact your healthcare provider for guidance. Do not double up on doses unless instructed to do so.
• Potential Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.

Always consult with your healthcare provider or pharmacist for the most accurate and up-to-date information based on your individual health circumstances. The information provided here is general and may not cover all aspects of your specific situation.