WARNING

Panitumumab is a monoclonal antibody used in the treatment of certain types of cancer, such as colorectal cancer. Like any medication, it comes with potential risks and side effects. It’s important to note that individual responses to medications can vary, and not everyone will experience these side effects. Here are some potential risks associated with Panitumumab injection:

• Skin Reactions: Panitumumab can cause skin-related side effects, including rash, itching, and dry skin. In some cases, more severe skin reactions such as acne-like rash or skin infections may occur.
• Gastrointestinal Issues: Some patients may experience diarrhea and other gastrointestinal issues. In severe cases, dehydration can occur, requiring medical attention.
• Infusion Reactions: Like many monoclonal antibodies, Panitumumab can cause infusion reactions during or after the administration of the drug. Symptoms may include fever, chills, and difficulty breathing. Patients are typically closely monitored during the infusion to manage these reactions.
• Hypomagnesemia: Low levels of magnesium in the blood (hypomagnesemia) can occur with Panitumumab treatment. This may lead to symptoms such as muscle spams, irregular heartbeat, and seizures.
• Electrolyte Imbalance: Panitumumab may lead to electrolyte imbalances, including changes in calcium and potassium levels. Monitoring these levels is important during treatment.
• Eye Disorders: Some patients may experience eye-related side effects, including changes in vision, conjunctivitis, and dry eyes.
• Pulmonary Disorders: Interstitial lung disease, a serious and potentially fatal lung disorder, has been reported in some patients receiving Panitumumab. Symptoms may include cough, difficulty breathing, and chest pain.
• Infections: There is an increased risk of infections, including respiratory and skin infections, with Panitumumab treatment.

It’s crucial for patients to discuss their medical history and any existing health conditions with their healthcare provider before starting Panitumumab or any other medication. The benefits and risks should be carefully considered, and patients should be monitored for potential side effects during treatment. As with any medical treatment, individual responses can vary, and healthcare professionals will tailor their approach based on the specific needs and conditions of each patient.

Why is this medication prescribed?

Panitumumab is a monoclonal antibody medication that is prescribed for the treatment of certain types of cancer. Specifically, it is used in the treatment of metastatic colorectal cancer (cancer that has spread to other parts of the body) that has not responded to other chemotherapy medications.

Panitumumab targets and inhibits a protein called epidermal growth factor receptor (EGFR), which is found on the surface of some cancer cells. By blocking EGFR, panitumumab interferes with the growth and spread of cancer cells.

How should this medicine be used?

Panitumumab is typically administered as an intravenous (IV) infusion by a healthcare professional, usually in a hospital or clinic setting. Here are general guidelines on how Panitumumab is typically used:

• Administration: The medication is given through a vein, usually in the arm. The infusion process may take some time, and you will be monitored during and after the infusion to watch for any potential side effects or reactions.
• Dosage: The specific dosage of Panitumumab can vary based on factors such as the type of cancer being treated, the patient’s weight, overall health, and other individual considerations. Your healthcare provider will determine the appropriate dosage for you.
• Frequency: Panitumumab infusions are usually given once every two weeks, but the exact schedule can vary. Your healthcare team will establish the appropriate treatment plan for your specific situation.
• Preparation: Panitumumab is supplied as a liquid concentrate that needs to be diluted before administration. This preparation is done by healthcare professionals prior to the infusion.
• Pre-Medication: Before the infusion, your healthcare provider may administer medications to help prevent or manage potential infusion reactions.
• Monitoring: During the infusion, you will be closely monitored for any signs of an allergic reaction or other side effects. After the infusion, you may continue to be monitored for a period to ensure there are no delayed reactions.
• Duration of Treatment: The duration of Panitumumab treatment can vary depending on the individual’s response to the medication and the progression of the cancer. Your healthcare team will assess your response to treatment and adjust the plan accordingly.

It’s essential to follow your healthcare provider’s instructions and attend all scheduled appointments. If you have any concerns about the medication or experience side effects, it’s crucial to communicate with your healthcare team promptly.

Remember that this information provides a general overview, and individual circumstances may vary. Always consult with your healthcare provider for personalized advice and guidance based on your specific health condition.

Other uses for this medicine

As of last update, there were no widely accepted alternative uses or indications for Panitumumab beyond metastatic colorectal cancer with wild-type RAS. The decision to use Panitumumab or any other medication for off-label purposes should be made in consultation with a healthcare professional.

What special precautions should I follow?

Special Precautions for Panitumumab Injection:

• Infusion Reactions: Be aware of the signs of infusion reactions, such as fever, chills, difficulty breathing, or chest pain. Report any symptoms immediately to your healthcare provider. Infusions are typically administered in a healthcare setting where staff is trained to manage potential reactions.
• Skin Reactions: Monitor your skin for any changes, rash, itching, or dryness. Report severe skin reactions promptly to your healthcare provider.
• Gastrointestinal Issues: Be vigilant for diarrhea, dehydration, or other gastrointestinal problems. Report severe or persistent symptoms to your healthcare provider.
• Eye Disorders: If you experience changes in vision, eye irritation, or dry eyes, inform your healthcare provider.
• Electrolyte Imbalance: Attend regular check-ups and laboratory tests to monitor electrolyte levels, including magnesium, calcium, and potassium.
• Pulmonary Disorders: Pay attention to respiratory symptoms, such as cough, difficulty breathing, or chest pain. Report these symptoms to your healthcare provider.
• Infections: Be alert to signs of infection, and promptly report any symptoms such as fever or persistent infections.
• Hypomagnesemia: Inform your healthcare provider about muscle spasms, irregular heartbeat, or other symptoms of low magnesium levels.
• Pre-existing Conditions: Communicate any pre-existing conditions, especially skin disorders, lung diseases, or cardiovascular issues, to your healthcare provider.
• Pregnancy and Breastfeeding: Discuss the risks and benefits with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Panitumumab. However, it’s essential to maintain a balanced and healthy diet to support overall well-being during cancer treatment. Ensure adequate hydration and discuss any specific dietary concerns with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

Since Panitumumab is typically administered by healthcare professionals as an intravenous infusion, the concern of “forgetting a dose” may not apply in the same way as with oral medications. The schedule for infusions is usually determined by your healthcare team, and missing a scheduled infusion could impact the effectiveness of the treatment.

What side effects can this medication cause?

Panitumumab, like many medications, can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. Additionally, the side effects may be influenced by factors such as the specific cancer being treated, the patient’s overall health, and other medications they may be taking. Here are some common side effects associated with Panitumumab:

Common Side Effects:

• Skin-related issues: One of the most common side effects is skin-related problems, including rash, itching, dryness, and redness. In some cases, skin reactions may become severe and require medical attention.
• Gastrointestinal issues: Diarrhea and nausea are common side effects. In some cases, diarrhea may be severe.
• Fatigue: Feeling tired or fatigued is a common side effect.
• Abdominal pain: Some individuals may experience abdominal pain or discomfort.
• Electrolyte imbalance: Panitumumab can affect magnesium levels, leading to hypomagnesemia. This can cause symptoms such as muscle spasms, irregular heartbeat, or seizures.

Serious Side Effects:

While less common, Panitumumab may also cause more serious side effects, including:

• Infusion reactions: Some people may experience allergic or infusion reactions during or shortly after the infusion. These reactions can include difficulty breathing, chest pain, fever, chills, and low blood pressure. It’s essential to report any symptoms to your healthcare provider immediately.
• Infections: Panitumumab may increase the risk of infections. Notify your healthcare provider if you develop signs of an infection, such as fever or persistent sore throat.
• Eye problems: In rare cases, Panitumumab has been associated with eye disorders, including inflammation and damage to the cornea.
• Pulmonary issues: Interstitial lung disease has been reported in some patients receiving Panitumumab. Symptoms may include difficulty breathing, cough, or chest pain.

It’s crucial to report any side effects or concerns to your healthcare provider promptly. They can help assess the severity of the side effects and determine the appropriate course of action. It’s also important to attend all scheduled appointments for monitoring and follow-up during the course of treatment. This information is not exhaustive, and individual experiences may vary, so always consult with your healthcare provider for personalized advice.

What should I know about storage and disposal of this medication?

Storage and Disposal of Panitumumab Injection:

• Storage:
  • Panitumumab is typically stored in a healthcare setting, and the healthcare provider will ensure proper storage conditions.
  • If you are given Panitumumab for home use, follow the specific storage instructions provided by your healthcare provider or pharmacist.
• Disposal:
  • Proper disposal of unused or expired medication is important to prevent accidental exposure. Follow your local guidelines or consult with your healthcare provider or pharmacist on the appropriate disposal method.
  • Do not dispose of Panitumumab in household trash unless instructed to do so. Ask your healthcare provider or pharmacist about the proper disposal procedure.

In case of emergency/overdose

In case of an emergency or suspected overdose, contact your healthcare provider or seek emergency medical attention immediately. The specific management of an overdose will depend on the symptoms and severity, and healthcare professionals are best equipped to provide appropriate care.

What other information should I know?

• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. Regular monitoring is essential to assess your response to treatment and manage any potential side effects.
• Patient Education: Understand the importance of adhering to the prescribed treatment plan and reporting any unusual symptoms or side effects to your healthcare provider promptly.
• Lab Tests: Your healthcare provider may order regular lab tests to monitor your blood counts, electrolyte levels, and other parameters. Attend these tests as scheduled.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Panitumumab.
• Pregnancy/Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Panitumumab with your healthcare provider.
• Allergies: Inform your healthcare provider of any allergies or hypersensitivity reactions you may have, as Panitumumab may contain ingredients that could cause allergic reactions.
• Medical History: Provide a comprehensive medical history to your healthcare provider, including any pre-existing conditions or a history of skin disorders, lung diseases, or cardiovascular issues.

Always follow your healthcare provider’s instructions and ask for clarification if there’s anything you don’t understand. Open communication with your healthcare team is essential for a safe and effective treatment experience. If you have specific questions or concerns about Panitumumab, consult with your healthcare provider or pharmacist for personalized advice.