Why is this medication prescribed?

Palifermin is a medication prescribed to reduce the risk of severe oral mucositis in patients undergoing high-dose chemotherapy and total body irradiation before hematopoietic stem cell transplant (HSCT). Mucositis is a common side effect of these treatments and involves inflammation and ulceration of the mucous membranes lining the digestive tract, particularly in the mouth and throat.

Palifermin is a recombinant human keratinocyte growth factor (KGF), and it works by stimulating the growth and development of cells lining the mouth and digestive tract. This stimulation is thought to help protect the mucosal lining from the damaging effects of chemotherapy and radiation therapy.

How should this medicine be used?

Dosage and administration of Palifermin:

• Dosage: The recommended dose of Palifermin is typically based on the patient’s weight and is administered intravenously (IV) over a short period. The dosage and schedule will be determined by the healthcare provider.
• Timing: Palifermin is usually administered for three consecutive days before the start of the conditioning therapy (chemotherapy and/or radiation) used in preparation for HSCT. The goal is to provide protection to the oral mucosa during the period of high treatment intensity.
• Administration: It is essential to follow the healthcare provider’s instructions regarding the proper administration of Palifermin. The medication is administered by a healthcare professional, such as a nurse or doctor, in a clinical setting.
• Preparation: Healthcare providers will prepare and administer Palifermin according to the recommended guidelines. Patients should not attempt to self-administer this medication.
• Monitoring: Patients receiving Palifermin will be closely monitored for any adverse reactions or side effects. It’s crucial to report any unexpected symptoms to the healthcare team promptly.

As with any medication, it’s essential for patients to discuss their medical history, current medications, and any concerns with their healthcare provider before starting Palifermin. This ensures that the treatment plan is tailored to the individual patient’s needs and circumstances.

Other uses for this medicine

Palifermin is primarily used to prevent severe oral mucositis in patients undergoing high-dose chemotherapy and total body irradiation before hematopoietic stem cell transplant (HSCT). However, it’s important to note that new uses or indications for medications may emerge over time, and you should consult with a healthcare professional or check more recent sources for the latest information.

What special precautions should I follow?

Special precautions for Palifermin use:

• Allergies: Before using Palifermin, inform your healthcare provider about any allergies you may have, especially if you have had a previous allergic reaction to Palifermin or any of its components.
• Pregnancy and breastfeeding: If you are pregnant or planning to become pregnant, or if you are breastfeeding, discuss the potential risks and benefits of Palifermin with your healthcare provider. The use of Palifermin during pregnancy or breastfeeding should be carefully considered based on the individual situation.
• Medical history: Provide your healthcare provider with a comprehensive medical history, including any pre-existing conditions, ongoing treatments, and medications you are currently taking. Certain medical conditions may require special consideration when using Palifermin.
• Interactions: Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as Palifermin may interact with other drugs. This includes both prescription and over-the-counter medications.
• Adverse reactions: Be aware of potential side effects or adverse reactions associated with Palifermin. Common side effects may include rash, erythema, edema, and taste alteration. Report any unusual or severe symptoms to your healthcare provider promptly.
• Administration: Palifermin is typically administered by a healthcare professional in a clinical setting. Do not attempt to self-administer the medication.
• Regular check-ups: Attend regular follow-up appointments with your healthcare provider to monitor your response to Palifermin and assess for any potential complications.

Always follow your healthcare provider’s instructions regarding the use of Palifermin, and do not make any changes to your treatment plan without consulting them. They can provide personalized guidance based on your specific health condition and needs.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Palifermin. However, it’s essential to follow your healthcare provider’s advice regarding your overall nutrition and hydration during the treatment period. Maintaining good oral hygiene and staying hydrated may be important in managing potential side effects.

What should I do if I forget a dose?

If you miss a dose of Palifermin, contact your healthcare provider immediately. They will provide guidance on whether the missed dose needs to be rescheduled or if any adjustments to the treatment plan are necessary. It’s crucial to follow your healthcare provider’s recommendations to ensure the effectiveness of the treatment.

What side effects can this medication cause?

Palifermin, like any medication, may cause side effects. Not everyone will experience these side effects, and the severity can vary. It’s important to be aware of potential side effects and to promptly report any unusual or severe symptoms to your healthcare provider. Common side effects associated with Palifermin include:

• Skin reactions: This may include rash, redness (erythema), and swelling (edema) around the mouth.
• Taste changes: Altered taste perception may occur during Palifermin treatment.
• Minor respiratory symptoms: Some individuals may experience coughing or shortness of breath.

It’s important to note that these side effects are not an exhaustive list, and individual responses to medications can vary. Additionally, new information about side effects may have emerged since last update.

If you experience any unexpected or severe side effects while using Palifermin, contact your healthcare provider immediately. They can provide guidance on how to manage side effects and may adjust the treatment plan if necessary.

Keep in mind that healthcare providers weigh the potential benefits of a medication against the risk of side effects when prescribing it. The information provided here is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with your healthcare provider for personalized guidance based on your specific health condition and needs.

What should I know about storage and disposal of this medication?

Storage and disposal of Palifermin:

• Storage: Palifermin is typically stored in a healthcare setting by healthcare professionals. If you are given the medication for at-home use, follow your healthcare provider’s instructions regarding storage. Generally, it should be stored at controlled room temperature.
• Disposal: Unused or expired Palifermin should be disposed of properly. Consult with your healthcare provider or pharmacist for guidance on the appropriate disposal method. Do not dispose of medications in household trash or wastewater unless instructed to do so.

In case of emergency/overdose

If you suspect an overdose or experience severe side effects, seek emergency medical attention or contact your local poison control center immediately. It’s important to have the medication’s packaging or label information available when seeking help.

What other information should I know?

• Follow-up appointments: Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to Palifermin and address any concerns.
• Lab tests: Your healthcare provider may perform regular lab tests to monitor your condition and check for any potential side effects or complications.
• Informing healthcare providers: Ensure that all healthcare providers involved in your care are aware of your Palifermin treatment, including dentists and specialists.
• Informing pharmacists: Inform your pharmacist about all the medications you are currently taking, including Palifermin, to check for potential drug interactions.
• Patient assistance programs: If you face challenges affording your medication, inquire about patient assistance programs or financial assistance options that may be available.
• Educational resources: Seek information from reliable sources, such as your healthcare provider or reputable medical websites, to enhance your understanding of Palifermin and its use.

Always follow your healthcare provider’s instructions and recommendations for the safe and effective use of Palifermin. If you have any questions or concerns, don’t hesitate to discuss them with your healthcare team. This information is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with your healthcare provider for guidance on your specific situation.