Why is this medication prescribed?

Pacritinib is a drug that was being investigated for the treatment of certain types of blood disorders, particularly myelofibrosis. Myelofibrosis is a rare bone marrow disorder characterized by the excessive production of fibrous tissue in the bone marrow, leading to the displacement of normal blood-forming cells.

Pacritinib is a tyrosine kinase inhibitor, and it was designed to target specific enzymes involved in the abnormal signaling pathways associated with myelofibrosis. Tyrosine kinase inhibitors are a class of drugs that interfere with the signals that promote the growth and survival of abnormal cells.

How should this medicine be used?

The usage and dosage of pacritinib should be determined by a healthcare professional based on the specific needs and condition of the individual patient. The information provided here is general and may not cover all possible scenarios. Always follow the instructions provided by the prescribing healthcare provider and the medication’s official prescribing information. Below are general guidelines for the use of pacritinib:

• Dosage: The recommended dosage can vary, and it is determined by the healthcare provider based on factors such as the patient’s overall health, the severity of the condition, and any other medications the patient may be taking.
• Administration: Pacritinib is typically taken orally, with or without food. The tablets should be swallowed whole with a glass of water. It’s important not to crush, break, or chew the tablets unless advised otherwise by the healthcare provider.
• Schedule: Patients should adhere to the prescribed dosing schedule. It’s important to take the medication regularly and at the same time each day. If a dose is missed, patients should follow the healthcare provider’s instructions for what to do next.
• Monitoring: Regular medical check-ups and laboratory tests may be necessary to monitor the patient’s response to pacritinib and to check for any potential side effects. It’s important to attend all scheduled appointments.
• Adverse Effects: Patients should be aware of potential side effects and promptly report any unusual or severe symptoms to their healthcare provider. Common side effects may include fatigue, nausea, diarrhea, anemia, and low platelet count.
• Special Instructions: Some patients may require dosage adjustments or special considerations based on their individual health status, age, or other factors. The healthcare provider will provide specific instructions tailored to the patient’s needs.

Always consult with the prescribing healthcare provider or pharmacist if there are any questions or concerns about the use of pacritinib. It’s crucial to communicate openly with the healthcare team to ensure the safe and effective use of the medication. Additionally, information on dosing and administration may have changed since last update, so referring to the latest prescribing information is recommended.

Other uses for this medicine

Pacritinib is primarily indicated for the treatment of myelofibrosis, a rare bone marrow disorder. It is a selective Janus kinase (JAK) inhibitor. However, the approved uses of medications can change, and new indications may emerge over time. Therefore, it’s important to check with a healthcare professional or refer to the most recent prescribing information for the latest and most accurate information.

What special precautions should I follow?

Regarding special precautions for pacritinib, it’s crucial for patients to discuss their medical history and any existing health conditions with their healthcare provider before starting the medication. Special precautions and considerations may include:

• Liver Function: Pacritinib may affect liver function, and periodic liver function tests may be required during treatment. Patients with pre-existing liver conditions should be closely monitored, and the dosage may need adjustment.
• Blood Counts: Pacritinib can affect blood counts, including platelet and red blood cell counts. Regular blood tests are usually conducted to monitor these levels. Dose adjustments may be necessary based on blood count results.
• Cardiovascular Effects: There have been reports of cardiovascular events with pacritinib use. Patients with a history of cardiovascular issues should be carefully evaluated before starting the medication, and regular cardiovascular monitoring may be necessary during treatment.
• Infections: Pacritinib may increase the risk of infections. Patients should promptly report any signs of infection to their healthcare provider.
• Prior Treatment: Pacritinib is often used in patients with myelofibrosis who have had inadequate responses or intolerance to other treatments. The healthcare provider will consider the patient’s treatment history when prescribing pacritinib.
• Pregnancy and Breastfeeding: The safety of pacritinib during pregnancy and breastfeeding is not well established. Patients should inform their healthcare provider if they are pregnant, planning to become pregnant, or breastfeeding.
• Drug Interactions: Pacritinib may interact with other medications, including those metabolized by certain enzymes. Patients should provide a complete list of all medications, including over-the-counter drugs and supplements, to their healthcare provider to check for potential interactions.

It’s important to note that the information provided here is general, and individual circumstances may vary. Patients should rely on the guidance of their healthcare provider and carefully follow their recommendations and instructions. Additionally, any updates or changes to the prescribing information may not be reflected in this response, so consulting the latest medical literature or a healthcare professional is advisable.

What special dietary instructions should I follow?

As of last update, there were no specific dietary restrictions associated with pacritinib use. However, dietary considerations can vary, and it’s essential to discuss any concerns with the prescribing healthcare provider. They can provide guidance based on the individual’s overall health and medical history.

What should I do if I forget a dose?

If a dose of pacritinib is missed, patients should follow the guidance provided by their healthcare provider or the prescribing information. In general:

• Take the Missed Dose as Soon as Possible: If the patient remembers shortly after missing the dose, they should take it as soon as possible.
• Skip the Missed Dose if It’s Almost Time for the Next Dose: If it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed.
• Do Not Double Up on Doses: Patients should not take a double dose to make up for a missed one.

What side effects can this medication cause?

Pacritinib, like many medications, can cause side effects. It’s important to note that the severity and occurrence of side effects can vary from person to person, and not everyone will experience them. If you are prescribed pacritinib, your healthcare provider will monitor your response to the medication and manage any potential side effects. Common side effects and less common, but more serious, side effects associated with pacritinib may include:

Common Side Effects:

• Low Blood Cell Counts: Pacritinib can lead to decreases in red blood cell counts (anemia), white blood cell counts, and platelet counts. Regular blood tests are typically done to monitor these levels.
• Nausea: Some individuals may experience nausea or an upset stomach.
• Diarrhea: Diarrhea is a common side effect and should be reported to your healthcare provider if it becomes severe or persistent.
• Fatigue: Feeling tired or fatigued is a common side effect.
• Headache: Some individuals may experience headaches while taking pacritinib.
• Bruising or Bleeding: Due to its effect on platelet counts, pacritinib may increase the risk of bruising or bleeding.

Less Common, Serious Side Effects:

• Cardiovascular Events: Some patients may experience serious cardiovascular events such as heart attack, stroke, or other cardiac complications.
• Liver Problems: Liver enzyme elevations have been reported, and severe liver toxicity is a potential but rare side effect.
• Infections: Pacritinib may increase the risk of infections, and serious infections have been reported.
• Gastrointestinal Perforations: In rare cases, gastrointestinal perforations have occurred.

It’s important to promptly report any unusual or severe symptoms to your healthcare provider. If you experience signs of an allergic reaction, such as difficulty breathing, swelling, or severe rash, seek immediate medical attention.

This list is not exhaustive, and there may be other side effects associated with pacritinib. It is crucial to consult with your healthcare provider for personalized information and guidance. If you have specific concerns or questions about your medication, contact your healthcare provider promptly. They can provide the most accurate and up-to-date information based on your individual health profile.

What should I know about storage and disposal of this medication?

Storage and Disposal of Pacritinib:

• Storage: Pacritinib should be stored at room temperature, away from excessive heat and moisture. It is typically recommended to keep the medication in its original packaging, and it should be stored out of reach of children.
• Disposal: Proper disposal of medication is important to prevent accidental ingestion by others and to minimize environmental impact. Follow any specific disposal instructions provided by your healthcare provider or pharmacist. Do not flush medications down the toilet unless instructed to do so. Instead, consider using a drug take-back program or a medication disposal pouch.

In case of emergency/overdose

In the event of a suspected overdose or emergency, contact your local poison control center (1-800-222-1222 in the United States) or emergency medical services immediately. Symptoms of overdose may include severe dizziness, fainting, or difficulty breathing.

What other information should I know?

• Follow-up Appointments: Regular follow-up appointments with your healthcare provider are important to monitor your response to pacritinib, assess for any potential side effects, and adjust the treatment plan as needed.
• Lab Tests: Pacritinib treatment may require periodic blood tests to monitor blood cell counts and other parameters. Attend all scheduled lab appointments as advised by your healthcare provider.
• Inform Healthcare Providers: Make sure all healthcare providers (including dentists and specialists) are aware that you are taking pacritinib. This includes providing a comprehensive list of all medications, supplements, and over-the-counter drugs you are taking.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The safety of pacritinib during pregnancy and breastfeeding is not well established.
• Drug Interactions: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as any herbal supplements you are taking. Pacritinib may interact with other medications.
• Allergic Reactions: If you experience signs of an allergic reaction, such as difficulty breathing, swelling, or severe rash, seek immediate medical attention.
• Patient Assistance Programs: If you face financial challenges in obtaining your medication, inquire about patient assistance programs or support services that may be available.

Always consult with your healthcare provider or pharmacist for personalized advice and information regarding pacritinib. The information provided here is general and may not cover all individual circumstances. If you have specific questions or concerns, it’s crucial to discuss them with your healthcare team.