Why is this medication prescribed?

Oxervate (cenegermin) is prescribed for the treatment of neurotrophic keratitis (NK), a rare eye condition characterized by corneal damage and impaired corneal healing due to a deficiency in corneal nerve growth factor. The primary purpose of Oxervate is to promote corneal healing by stimulating the regeneration of corneal nerves.

How should this medicine be used?

When using Oxervate, it’s important to follow the instructions provided by your healthcare professional and the medication’s packaging. Here are general guidelines for the use of Oxervate:

• Wash your hands thoroughly before handling the medication or touching your eyes.
• Gently remove any contact lenses before applying Oxervate. You may reinsert them 15 minutes after using the medication.
• Tilt your head back and look up.
• Carefully pull down your lower eyelid to create a small pocket.
• Hold the single-dose container vertically and squeeze a drop of Oxervate into the pocket of the lower eyelid. Avoid touching the tip of the container to any surface, including your eye.
• Release the lower eyelid and close your eyes gently for a few seconds to allow the medication to spread evenly over the surface of the eye.
• If your healthcare professional has instructed you to use multiple drops, wait at least 10 minutes before applying additional drops.
• Dispose of the single-dose container after each use, even if there is remaining solution.
• Repeat the process for each eye if both eyes are being treated.
• Avoid blinking excessively or rubbing your eyes immediately after applying Oxervate.

It is essential to follow your doctor’s specific instructions regarding the dosage and frequency of Oxervate application. They will determine the appropriate treatment duration based on your individual condition.

As always, it is recommended to consult with your healthcare professional or eye specialist for detailed instructions tailored to your specific situation.

Other uses for this medicine

Regarding other uses of Oxervate, cenegermin is currently approved only for the treatment of neurotrophic keratitis. There is no documented evidence or approved indications for its use in other eye conditions or diseases. It is essential to consult with a healthcare professional to determine the appropriate treatment for any specific eye condition.

What special precautions should I follow?

Regarding special precautions for Oxervate, it’s crucial to follow the instructions provided by your healthcare provider and the medication’s packaging. Here are some general precautions that might apply:

• Administration: Oxervate is for ocular use (in the eyes) only. Avoid touching the dropper tip to any surface to prevent contamination.
• Allergies: Inform your doctor if you have any known allergies, especially related to eye medications or any of the components of Oxervate.
• Pregnancy and breastfeeding: It is essential to discuss the potential risks and benefits of using Oxervate during pregnancy or while breastfeeding with your healthcare provider.
• Eye conditions: Inform your doctor about any other eye conditions or diseases you have before using Oxervate. They can evaluate whether it is appropriate for you.
• Adverse reactions: Be aware of possible side effects, such as eye pain, eye redness, eye inflammation, and increased lacrimation (tearing). If you experience any unusual or severe reactions, contact your doctor promptly.
• Use with other eye medications: Inform your doctor about all the medications you are using, including prescription drugs, over-the-counter products, and herbal supplements. Some medications may interact with Oxervate, so it’s important to disclose all relevant information to your healthcare provider.

Remember, these precautions are not exhaustive, and it is crucial to consult your healthcare provider or refer to the most recent prescribing information for comprehensive guidance specific to your situation.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with the use of Oxervate (cenegermin). However, it is always a good practice to maintain a healthy and balanced diet to support overall well-being, including eye health.

What should I do if I forget a dose?

If you forget a dose of Oxervate, it is generally recommended to take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

What side effects can this medication cause?

Oxervate (cenegermin) is generally well-tolerated, but like any medication, it can potentially cause side effects. The most commonly reported side effects associated with the use of Oxervate include:

• Eye pain: Some individuals may experience mild to moderate eye pain after using Oxervate.
• Eye redness: Redness or irritation of the eyes is a possible side effect.
• Increased lacrimation (tearing): Excessive tearing or increased production of tears may occur.
• Eyelid reactions: Swelling, itching, or inflammation of the eyelids are potential side effects.
• Foreign body sensation: Some people may feel a sensation of having a foreign object in their eye.
• Blurred vision: Transient blurred vision or changes in vision have been reported.
• Eye discharge: Discharge from the eye, such as watery or sticky discharge, can occur.

These side effects are generally mild to moderate in severity and tend to improve over time. However, it is important to inform your healthcare provider if you experience any persistent or bothersome side effects while using Oxervate. They can provide guidance and determine the best course of action.

It’s worth noting that this list may not be exhaustive, and there may be other potential side effects associated with Oxervate. For the most accurate and up-to-date information, it is recommended to consult the prescribing information or discuss any concerns with your healthcare provider.

What should I know about storage and disposal of this medication?

Storage and disposal:

• Oxervate should be stored in a refrigerator between 2°C and 8°C (36°F and 46°F). Do not freeze it.
• Keep the bottle tightly closed when not in use.
• Protect the bottle from light.
• Do not use Oxervate if it has been frozen or if the expiration date has passed.
• If your doctor advises you to stop using Oxervate, follow their instructions on how to dispose of the remaining medication. Do not flush it down the toilet or pour it into a drain unless specifically instructed to do so.

In case of emergency/overdose

• In the event of an emergency or accidental ingestion of Oxervate, contact your local poison control center or seek immediate medical attention.
• The National Poison Control Center can be reached at 1-800-222-1222 in the United States.

What other information should I know?

• It is crucial to follow your doctor’s instructions regarding the dosage and duration of Oxervate treatment.
• Regularly visit your healthcare provider for follow-up examinations and evaluations of your eye condition.
• Inform your doctor about all medications, including eye drops and supplements, that you are currently taking, as they can potentially interact with Oxervate.
• Attend all scheduled appointments and assessments to monitor your response to Oxervate therapy.
• If you experience any new or worsening symptoms while using Oxervate, contact your doctor for further evaluation.

It is essential to consult the most recent prescribing information or contact your healthcare provider for comprehensive and up-to-date instructions, guidelines, and emergency procedures specific to Oxervate.