Why is this medication prescribed?

Oxbryta (voxelotor) is a prescription medication used for the treatment of sickle cell disease (SCD) in adults and pediatric patients aged 12 years and older. SCD is an inherited blood disorder characterized by the presence of abnormal hemoglobin molecules in red blood cells, which can cause the cells to become rigid and assume a sickle shape. This can lead to various complications, including pain crises, anemia, and organ damage.

Oxbryta works by increasing the amount of hemoglobin in the blood that can carry oxygen. It helps prevent the sickling of red blood cells, which reduces the frequency of pain crises and improves anemia associated with SCD.

How should this medicine be used?

Oxbryta (voxelotor) is an oral medication used for the treatment of sickle cell disease (SCD) in adults and pediatric patients aged 12 years and older. Here are the general guidelines for how Oxbryta should be used:

• Dosage: The recommended dosage of Oxbryta is 1500 mg (three tablets of 500 mg) taken orally once daily.
• Administration: Take Oxbryta tablets by mouth with or without food. Swallow the tablets whole with water, without crushing, chewing, or breaking them.
• Timing: Oxbryta should be taken at the same time every day to maintain a consistent level of the medication in your body. It is recommended to establish a routine to help remember to take it.
• Compliance: Follow your healthcare provider’s instructions regarding the duration of treatment and continue taking Oxbryta even if you start feeling better. Do not stop or adjust the dosage without consulting your healthcare provider.
• Missed Dose: If you forget to take a dose of Oxbryta, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
• Additional Medications: Oxbryta can be taken with or without other SCD therapies or medications. It is important to inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.
• Regular Check-ups: Attend all scheduled appointments with your healthcare provider for monitoring your condition, assessing the effectiveness of Oxbryta, and making any necessary adjustments to your treatment plan.

Remember to consult your healthcare provider or pharmacist for personalized instructions and recommendations on how to use Oxbryta. They can provide you with specific guidance based on your individual condition and medical history.

Other uses for this medicine

Oxbryta (voxelotor) is currently approved by the U.S. Food and Drug Administration (FDA) specifically for the treatment of sickle cell disease (SCD) in adults and pediatric patients aged 12 years and older. There are no other approved uses for Oxbryta. It is always important to consult with a healthcare professional or refer to the latest prescribing information for the most up-to-date and accurate information regarding approved uses of any medication.

What special precautions should I follow?

Regarding special precautions for Oxbryta, it is crucial to consider the following:

• Allergic Reactions: Some individuals may experience allergic reactions to Oxbryta. If you develop signs of an allergic reaction such as hives, rash, itching, swelling, dizziness, or difficulty breathing, seek medical attention immediately.
• Laboratory Monitoring: Oxbryta can interfere with certain laboratory tests, such as the measurement of bilirubin levels. Inform healthcare providers that you are taking Oxbryta if you require any laboratory tests.
• Drug Interactions: Oxbryta may interact with other medications, including strong CYP3A inducers (such as rifampin, phenytoin, and St. John’s wort) and strong CYP3A inhibitors (such as ketoconazole, clarithromycin, and ritonavir). Inform your healthcare provider about all medications, supplements, and herbal products you are taking to ensure there are no potential interactions.
• Pregnancy and Breastfeeding: The safety and effectiveness of Oxbryta during pregnancy and breastfeeding have not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits with your healthcare provider.
• Adverse Reactions: Common side effects of Oxbryta may include headache, diarrhea, abdominal pain, nausea, fatigue, rash, and fever. Report any persistent or severe side effects to your healthcare provider.

It is important to remember that these precautions are not exhaustive, and it is essential to consult a healthcare professional or refer to the prescribing information and medication guide for Oxbryta for a comprehensive list of precautions, warnings, and possible side effects.

What special dietary instructions should I follow?

Regarding special dietary instructions for Oxbryta (voxelotor), there are no specific dietary restrictions or instructions associated with its use. Oxbryta can be taken with or without food, so you can take it with your regular meals or on an empty stomach according to your preference.

What should I do if I forget a dose?

If you happen to miss a dose of Oxbryta, you should take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for the missed one. If you have any concerns about missed doses or need further guidance, it is advisable to consult your healthcare provider or pharmacist for specific instructions based on your individual situation.

What side effects can this medication cause?

Oxbryta (voxelotor) may cause side effects in some individuals. Common side effects that have been reported include:

• Headache
• Diarrhea
• Abdominal pain
• Nausea
• Fatigue
• Rash
• Pyrexia (fever)

These side effects are generally mild to moderate in nature and may subside over time as your body adjusts to the medication. However, if any of these side effects persist or become bothersome, it is important to inform your healthcare provider.

In addition to the common side effects, there may be other, less common side effects or serious adverse reactions associated with Oxbryta. It is crucial to be aware of any unusual symptoms or changes in your health and promptly report them to your healthcare provider. They are in the best position to assess your situation and determine the appropriate course of action.

It is important to note that this is not an exhaustive list of side effects, and others may occur. Each individual may react differently to medication. For a comprehensive list of side effects, including rare or serious adverse reactions, it is recommended to consult the prescribing information or medication guide provided with Oxbryta or consult your healthcare provider.

If you experience any severe or life-threatening symptoms after taking Oxbryta, seek immediate medical attention or contact emergency services.

What should I know about storage and disposal of this medication?

• Storage: Oxbryta should be stored at room temperature, between 20°C and 25°C (68°F and 77°F). It should be kept in its original container, tightly closed, and away from excessive heat, moisture, and direct light. Do not freeze the medication.
• Disposal: It is important to properly dispose of unused or expired Oxbryta tablets. Follow any specific disposal instructions provided by your healthcare provider or local waste disposal regulations. Do not dispose of medications in wastewater or household waste. Instead, consult with a pharmacist or local disposal facility to determine the proper disposal method.

In case of emergency/overdose

In case of an emergency or suspected overdose of Oxbryta, contact your local emergency services (such as calling 911 in the United States) or seek immediate medical attention. It is helpful to provide healthcare professionals with as much information as possible, including the medication name, strength, and the amount ingested.

What other information should I know?

• Keep all appointments: It is important to attend all scheduled medical appointments and laboratory tests as recommended by your healthcare provider. These appointments allow monitoring of your condition and response to Oxbryta treatment.
• Inform other healthcare providers: Make sure to inform other healthcare providers, including dentists and specialists, that you are taking Oxbryta. This helps them have a complete understanding of your medication regimen and manage any potential interactions or considerations.
• Compliance with dosing: Take Oxbryta as prescribed by your healthcare provider. It is important to adhere to the recommended dosage and follow the instructions for administration. Do not adjust the dose or stop taking the medication without consulting your healthcare provider.
• Medication interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as certain medications can interact with Oxbryta. This includes both prescription and over-the-counter medications.
• Updated information: Stay informed about any updates or changes in the prescribing information, warnings, or precautions related to Oxbryta. Regularly consult with your healthcare provider or pharmacist to ensure you have the most up-to-date information.

It is crucial to follow the specific instructions provided by your healthcare provider or refer to the prescribing information and medication guide for comprehensive guidance on storage, disposal, emergency procedures, and other relevant information related to Oxbryta.