WARNING

Otrexup, which contains methotrexate, can have various risks and potential side effects. It’s important to note that these risks should be evaluated in the context of your individual medical condition and discussed with your healthcare provider. Here are some of the potential risks associated with taking Otrexup:

• Gastrointestinal effects: Methotrexate can cause nausea, vomiting, diarrhea, and loss of appetite. In some cases, it may lead to more serious gastrointestinal problems such as ulcers or bleeding.
• Liver toxicity: Otrexup can affect liver function, leading to liver damage or inflammation. Regular monitoring of liver function through blood tests is typically recommended during treatment.
• Bone marrow suppression: Methotrexate can suppress the bone marrow, which may result in decreased production of blood cells. This can lead to an increased risk of infection, anemia, or bleeding. Regular blood tests are often performed to monitor blood cell counts.
• Lung problems: Rarely, methotrexate can cause lung-related complications such as interstitial pneumonitis or pulmonary fibrosis. Symptoms may include cough, shortness of breath, or chest pain.
• Increased risk of infections: Methotrexate can suppress the immune system, making individuals more susceptible to infections. It is important to monitor for signs of infection and seek prompt medical attention if any symptoms arise.
• Skin reactions: Some individuals may experience skin reactions such as rash, itching, or photosensitivity while taking Otrexup.
• Potential for birth defects: Methotrexate is known to be harmful to a developing fetus, so it should be avoided during pregnancy.

It’s crucial to remember that the risks and side effects of Otrexup may vary from person to person. Your healthcare provider will carefully consider the potential benefits and risks before prescribing this medication and will closely monitor your condition during treatment to minimize any adverse effects.

Why is this medication prescribed?

Otrexup is a prescription medication that contains methotrexate, which is an antimetabolite and immunosuppressant drug. It is primarily prescribed for the treatment of certain autoimmune conditions, including:

• Rheumatoid arthritis: Otrexup can help reduce inflammation and joint pain associated with rheumatoid arthritis. It may be used when other medications have not been effective.
• Psoriasis: Otrexup is sometimes prescribed for severe psoriasis that has not responded to other treatments. It can help reduce the excessive growth of skin cells and alleviate symptoms such as scaling, redness, and itching.
• Polyarticular juvenile idiopathic arthritis: Otrexup may be used in children with this form of arthritis to manage symptoms and improve joint function.
• Non-Hodgkin’s lymphoma: Methotrexate, the active ingredient in Otrexup, is also used as a part of chemotherapy regimens for certain types of non-Hodgkin’s lymphoma.

How should this medicine be used?

Otrexup is a prescription medication that is typically administered by subcutaneous injection (under the skin). However, it is essential to follow the specific instructions provided by your healthcare provider. Here is a general overview of how Otrexup is commonly used:

• Administration: Otrexup is available as a prefilled, single-dose autoinjector. It is designed for self-administration or administration by a caregiver after proper training. Always follow the instructions provided with the medication and consult your healthcare provider if you have any questions or concerns.
• Dosing: The dosage of Otrexup can vary depending on the condition being treated and individual factors. Your healthcare provider will determine the appropriate dose for you. It is crucial to follow the prescribed dosage and schedule exactly as instructed.
• Injection site: Otrexup is typically injected into the fatty tissue just beneath the skin, commonly in the thigh or abdomen. Your healthcare provider will advise you on the recommended injection site and any specific instructions.
• Injection technique: Proper injection technique is important to ensure accurate and safe administration. Your healthcare provider will provide detailed instructions on how to use the autoinjector correctly. It is important to rotate injection sites to minimize irritation or other injection-related issues.
• Compliance and monitoring: It is important to use Otrexup regularly as prescribed, even if you start feeling better. Do not alter the dosage or frequency without consulting your healthcare provider. Regular follow-up appointments and blood tests may be necessary to monitor your response to the medication and detect any potential side effects.

Remember, this information is a general guideline, and it is crucial to follow the specific instructions provided by your healthcare provider or the medication’s packaging. If you have any questions or concerns about the administration of Otrexup, it is best to consult with your healthcare provider or pharmacist for personalized guidance.

Other uses for this medicine

Otrexup, which contains methotrexate, is primarily prescribed for the treatment of certain autoimmune conditions such as rheumatoid arthritis, psoriasis, and polyarticular juvenile idiopathic arthritis. However, there may be other off-label uses of Otrexup as determined by healthcare providers. Off-label use refers to the use of a medication for a purpose not specifically approved by regulatory authorities but supported by medical literature or clinical experience.

What special precautions should I follow?

Regarding special precautions for Otrexup, it is important to consider the following:

• Pregnancy and breastfeeding: Otrexup should not be used during pregnancy, as it may cause harm to the developing fetus. If you are pregnant or planning to become pregnant, it is essential to discuss alternative treatment options with your healthcare provider. Methotrexate can also pass into breast milk, so breastfeeding is generally not recommended while taking Otrexup.
• Pre-existing medical conditions: Inform your healthcare provider about any pre-existing medical conditions you have, such as liver disease, kidney disease, lung disease, or any blood disorders. These conditions may require special monitoring or adjustments to the dosage of Otrexup.
• Immunosuppression: Otrexup can suppress the immune system, making you more susceptible to infections. If you have any current or recent infections, it is important to inform your healthcare provider. Additionally, vaccinations with live vaccines should generally be avoided while taking Otrexup.
• Interaction with other medications: Otrexup may interact with other medications, including certain antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), and other immunosuppressive drugs. It is important to inform your healthcare provider about all the medications, supplements, and herbal products you are taking to avoid potential interactions.
• Regular monitoring: Your healthcare provider will monitor your response to Otrexup and assess any potential side effects or complications. This may involve periodic blood tests to check liver function, kidney function, blood cell counts, and other relevant parameters.

It’s crucial to have a detailed discussion with your healthcare provider about your medical history, any current medications, and potential risks and precautions specific to your situation before starting treatment with Otrexup. They will be able to provide personalized advice and guidance based on your individual needs.

What special dietary instructions should I follow?

When it comes to special dietary instructions for Otrexup, there are no specific dietary restrictions associated with the medication. However, it is generally recommended to follow a healthy and balanced diet to support your overall well-being, especially if you are being treated for conditions such as rheumatoid arthritis or psoriasis. A nutritious diet that includes a variety of fruits, vegetables, whole grains, lean proteins, and adequate hydration can help promote general health.

What should I do if I forget a dose?

If you forget to take a dose of Otrexup, it is important to consult your healthcare provider or pharmacist for guidance. The specific actions to take may depend on the dosage schedule and how much time has passed since the missed dose. In general:

• If it is close to the time for your next scheduled dose: Skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for the missed one.
• If there is a significant time gap until your next dose: Contact your healthcare provider or pharmacist for advice. They may recommend taking the missed dose as soon as you remember, or they may provide specific instructions based on your treatment plan.

What side effects can this medication cause?

Otrexup, which contains methotrexate, can potentially cause various side effects. It’s important to note that not everyone experiences these side effects, and their severity can vary from person to person. Here are some common side effects associated with Otrexup:

• Gastrointestinal effects: Nausea, vomiting, diarrhea, and loss of appetite are common side effects of methotrexate. These symptoms can often be managed by taking the medication with food or as directed by your healthcare provider.
• Liver toxicity: Methotrexate can affect liver function. It may cause elevated liver enzyme levels, liver damage, or inflammation. Regular monitoring of liver function through blood tests is typically recommended during treatment.
• Bone marrow suppression: Methotrexate can suppress the bone marrow, leading to decreased production of blood cells. This can result in an increased risk of infection, anemia, or bleeding. Regular blood tests are often performed to monitor blood cell counts.
• Fatigue: Feeling tired or fatigued is a common side effect of Otrexup. It is advisable to get plenty of rest and inform your healthcare provider if fatigue becomes persistent or severe.
• Mouth sores: Some individuals may experience mouth sores or ulcers while taking Otrexup. Maintaining good oral hygiene and consulting your healthcare provider for suitable mouth care strategies may help alleviate these symptoms.
• Skin reactions: Otrexup can cause skin reactions such as rash, itching, or photosensitivity (increased sensitivity to sunlight). It is important to protect your skin from excessive sun exposure and inform your healthcare provider if you develop any skin abnormalities.
• Lung problems: Although rare, methotrexate can cause lung-related complications such as interstitial pneumonitis or pulmonary fibrosis. Symptoms may include cough, shortness of breath, or chest pain. Prompt medical attention should be sought if any respiratory symptoms occur.

These are not the only possible side effects of Otrexup, and others may occur. It’s important to report any unexpected or bothersome side effects to your healthcare provider for further evaluation and guidance.

What should I know about storage and disposal of this medication?

• Storage: Keep Otrexup in its original packaging at room temperature, away from excessive heat, moisture, and light. Avoid freezing the medication. Follow any specific storage instructions provided by the manufacturer or your healthcare provider.
• Disposal: Properly dispose of used Otrexup autoinjectors and any unused medication. It is recommended to consult your healthcare provider or pharmacist for guidance on safe disposal methods. They can provide information on local regulations and resources for medication disposal.

In case of emergency/overdose

• Emergency assistance: If you or someone else is experiencing severe symptoms or an emergency situation, immediately call your local emergency number or go to the nearest emergency room.
• Overdose symptoms: Symptoms of an overdose may include severe nausea, vomiting, diarrhea, dizziness, mouth sores, blood in the urine, or unusual bruising or bleeding. Contact a poison control center or seek medical attention right away if you suspect an overdose.
• Inform healthcare providers: It is important to inform healthcare providers about the overdose or emergency situation. This will help them provide appropriate medical treatment and guidance.

What other information should I know?

• Regular monitoring: Your healthcare provider will likely schedule regular appointments and blood tests to monitor your response to Otrexup, check for any side effects, and adjust the treatment plan as needed.
• Medication interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking. Some medications may interact with Otrexup, potentially affecting its effectiveness or increasing the risk of side effects.
• Compliance: It is important to take Otrexup as prescribed and adhere to the recommended dosage schedule. If you have any concerns or difficulties with the medication, discuss them with your healthcare provider.
• Pregnancy and contraception: If you are of childbearing age and taking Otrexup, it is crucial to use reliable contraception to avoid pregnancy. Methotrexate can cause harm to a developing fetus.
• Follow-up care: Continue to follow up with your healthcare provider as directed and inform them about any changes in your health or any new symptoms that arise during treatment.

It’s important to consult your healthcare provider or pharmacist for the most up-to-date and accurate information regarding the storage, disposal, emergency procedures, and other important details specific to your situation and treatment plan.