WARNING

Oramorph SR (sustained-release) is a medication that contains morphine, which is a potent opioid analgesic used for the management of severe pain. While it can be an effective pain reliever, there are potential risks associated with taking Oramorph SR. Here are some of the key risks:

• Addiction and dependence: Oramorph SR belongs to the opioid class of medications, which can be highly addictive. Prolonged use or misuse of Oramorph SR can lead to physical and psychological dependence, requiring higher doses to achieve the same pain relief.
• Respiratory depression: One of the most significant risks of taking Oramorph SR is respiratory depression, which refers to slow and shallow breathing. Opioids can suppress the respiratory system, leading to breathing difficulties or even respiratory failure, particularly in individuals with compromised lung function.
• Sedation and drowsiness: Oramorph SR can cause drowsiness, sedation, and impaired cognitive function. This effect can impact a person’s ability to operate machinery, drive a vehicle, or perform tasks that require alertness and concentration.
• Constipation: Opioids like Oramorph SR commonly cause constipation, as they slow down the movement of the digestive tract. This can lead to discomfort, bloating, and other gastrointestinal issues. Adequate hydration, dietary fiber, and the use of stool softeners can help alleviate this side effect.
• Nausea and vomiting: Oramorph SR can cause nausea and vomiting, especially when starting the medication or with higher doses. These side effects may improve over time or with the use of antiemetic medications.
• Central nervous system effects: Opioids can have various effects on the central nervous system, including dizziness, confusion, and mood changes. These effects can be particularly pronounced in older adults.
• Overdose and potential fatalities: Taking high doses of Oramorph SR or combining it with other central nervous system depressants (such as alcohol or sedatives) significantly increases the risk of overdose. An opioid overdose can be life-threatening, leading to respiratory failure and cardiac arrest.

It is crucial to take Oramorph SR exactly as prescribed by a healthcare professional, closely monitor its effects, and report any concerning symptoms promptly. Regular communication with a healthcare provider is essential to manage the risks and ensure the medication’s appropriate use.

Why is this medication prescribed?

Oramorph SR is a prescription medication primarily prescribed for the management of severe pain that requires around-the-clock, long-term treatment. It contains the active ingredient morphine sulfate, which is a potent opioid analgesic.

The extended-release formulation of Oramorph SR is designed to provide a sustained release of morphine over an extended period, typically 12 to 24 hours. This allows for consistent pain relief and reduces the need for frequent dosing compared to immediate-release formulations of morphine.

Oramorph SR is often used when other pain medications, such as non-opioid analgesics or immediate-release opioids, have been insufficient in providing adequate pain relief. It may be prescribed for chronic conditions, such as cancer-related pain or severe pain associated with other medical conditions.

How should this medicine be used?

Oramorph SR should be used exactly as prescribed by a healthcare professional. It is essential to follow the specific instructions provided on the prescription label. The dosing regimen for Oramorph SR may vary depending on the individual’s pain severity, medical condition, and response to the medication. Here are some general guidelines:

• Dosage: Oramorph SR is available in different strengths, and the prescribed dosage will depend on your specific needs. The medication is typically taken once or twice daily.
• Administration: Oramorph SR is an oral medication that is swallowed whole with water. Do not crush, chew, or break the tablets, as it can alter the drug’s extended-release mechanism and lead to an overdose.
• Timing: Oramorph SR is usually taken at the same time(s) every day to maintain consistent pain control. Follow your doctor’s instructions regarding the exact timing of each dose.
• Avoid sudden discontinuation: Oramorph SR should not be stopped abruptly without consulting your healthcare provider. Suddenly discontinuing an opioid medication can lead to withdrawal symptoms. If you need to stop taking Oramorph SR, your doctor will provide a gradual tapering schedule.
• Adjustments: The dosage of Oramorph SR may need to be adjusted over time based on your response to the medication and changes in your pain levels. Regularly communicate with your doctor to evaluate the effectiveness of the medication and make any necessary adjustments.
• Safety precautions: Oramorph SR can cause drowsiness, dizziness, and impaired judgment. Avoid driving or operating heavy machinery until you know how the medication affects you. It is also important to avoid consuming alcohol or other sedatives while taking Oramorph SR, as it can enhance the sedative effects and increase the risk of respiratory depression.

Always consult your healthcare provider if you have any questions or concerns about the proper use of Oramorph SR. They can provide you with personalized instructions based on your condition and medical history.

Other uses for this medicine

Oramorph SR, which contains morphine sulfate, is primarily prescribed for the management of severe pain. However, there may be certain off-label uses or situations where it could be considered, but it is important to note that any use beyond its approved indications should be discussed with a healthcare professional. Off-label use refers to the use of a medication for a purpose other than those officially approved by regulatory authorities.

What special precautions should I follow?

Regarding special precautions, here are some important considerations when using Oramorph SR:

• Respiratory depression: Oramorph SR is an opioid medication and can cause respiratory depression, which is a potentially life-threatening condition involving slowed or shallow breathing. This risk is higher when starting treatment, with increasing doses, or when combined with other medications that have sedating effects. It is crucial to follow the prescribed dosage and closely monitor breathing patterns while using Oramorph SR.
• Sedation and drowsiness: Oramorph SR can cause drowsiness and impair cognitive and physical abilities. It is important to avoid activities that require alertness, such as driving or operating machinery, until you understand how the medication affects you. Alcohol and other sedatives should be avoided, as they can intensify these effects.
• Dependence and addiction: Oramorph SR is an opioid with the potential for dependence, tolerance, and addiction. Misuse or prolonged use can lead to physical and psychological dependence. It is important to use Oramorph SR only as prescribed and to follow your healthcare provider’s instructions regarding the duration of treatment.
• Interactions and contraindications: Oramorph SR can interact with other medications, including sedatives, tranquilizers, certain antidepressants, and monoamine oxidase inhibitors (MAOIs). It is crucial to inform your healthcare provider about all medications, supplements, or herbal products you are taking to avoid potential drug interactions. Oramorph SR is contraindicated in individuals with respiratory depression, acute or severe bronchial asthma, and paralytic ileus (intestinal obstruction).
• Pregnancy and breastfeeding: Oramorph SR can pass into breast milk and may harm a nursing baby. It should be used with caution during pregnancy and breastfeeding, and the potential risks and benefits should be discussed with a healthcare professional.

These precautions are not exhaustive, and it is important to consult with your healthcare provider before using Oramorph SR to ensure it is appropriate and safe for your specific situation.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with taking Oramorph SR (morphine sulfate). However, it is generally recommended to take the medication with food or milk to help reduce the likelihood of stomach upset.

What should I do if I forget a dose?

If you forget to take a dose of Oramorph SR, the best course of action depends on the timing and instructions provided by your healthcare provider. Here are some general guidelines:

• Regular dosing schedule: If you realize that you missed a dose close to the next scheduled dose, it is generally recommended to skip the missed dose and resume your regular dosing schedule. Do not double up on doses to make up for the missed one, as this can increase the risk of side effects and overdose.
• Extended delay: If a significant amount of time has passed since the missed dose, it is important to consult your healthcare provider for guidance. They may recommend either taking the missed dose or adjusting your dosing schedule.

What side effects can this medication cause?

Oramorph SR (morphine sulfate) can cause various side effects, ranging from common to rare. It’s important to note that not all individuals will experience these side effects, and their severity can vary. Common side effects may include:

• Constipation: Oramorph SR can cause constipation, which is a common side effect of opioid medications. Increasing fluid intake, incorporating dietary fiber, and using over-the-counter laxatives (under medical guidance) can help manage this side effect.
• Nausea and vomiting: Some individuals may experience nausea or vomiting while taking Oramorph SR. Taking the medication with food or adjusting the dosage may help alleviate these symptoms.
• Drowsiness and sedation: Oramorph SR can cause drowsiness, sedation, and reduced alertness. It is important to avoid activities that require mental or physical alertness until you know how the medication affects you.
• Dizziness: Oramorph SR may cause dizziness, especially when getting up quickly from a sitting or lying position. Taking precautions such as rising slowly can help minimize this side effect.
• Respiratory depression: Oramorph SR is an opioid medication and can depress the respiratory system, leading to slowed or shallow breathing. This is more likely at higher doses or when combined with other sedating medications. It is important to follow the prescribed dosage and closely monitor breathing patterns.
• Itching or rash: Some individuals may experience itching or develop a rash while taking Oramorph SR. If this occurs and becomes bothersome, it should be reported to a healthcare professional.
• Other side effects: Additional side effects that may occur with Oramorph SR include dry mouth, sweating, urinary retention, headache, confusion, mood changes, and decreased blood pressure.

It is important to note that this is not an exhaustive list of side effects, and some individuals may experience rare or more severe reactions. If you experience any concerning or persistent side effects, it is crucial to contact your healthcare provider for further evaluation and guidance.

Furthermore, it’s important to follow up with your healthcare provider regularly to monitor the effectiveness of the medication, manage side effects, and discuss any concerns or questions you may have.

What should I know about storage and disposal of this medication?

• Storage of Oramorph SR: Keep Oramorph SR in a secure location that is out of reach of children, pets, and anyone who should not have access to the medication. Store it at room temperature, away from direct sunlight, moisture, and heat.
• Disposal of Oramorph SR: Do not flush Oramorph SR down the toilet or throw it in the trash. Properly dispose of unused or expired Oramorph SR by following local guidelines for medication disposal. Contact your local pharmacy, law enforcement agency, or waste management facility to inquire about available drug take-back programs or other appropriate disposal methods.

In case of emergency/overdose

In case of an emergency or suspected overdose, immediately call emergency services or the relevant poison control center in your country. Provide them with all the necessary information, including the name of the medication (Oramorph SR) and the dosage taken, if known. Follow their instructions carefully.

What other information should I know?

• Oramorph SR is a potent opioid medication and should only be used as prescribed by a healthcare professional. Follow the prescribed dosage and instructions closely.
• Do not abruptly stop taking Oramorph SR without consulting your healthcare provider, as it may lead to withdrawal symptoms. Gradual dose reduction may be necessary under medical supervision.
• Inform your doctor about any other medications, substances, or medical conditions you have, as they may interact with Oramorph SR and affect its efficacy or increase the risk of side effects.
• Oramorph SR can cause drowsiness, dizziness, and impaired judgment. Avoid driving, operating machinery, or engaging in activities that require alertness until you know how the medication affects you.
• Keep regular appointments with your healthcare provider to monitor your response to Oramorph SR and adjust the dosage if necessary.
• Store Oramorph SR in its original packaging or in a child-resistant container to prevent accidental ingestion by children.
• If you have any questions or concerns about Oramorph SR, consult your healthcare provider or pharmacist for further guidance.

Remember, this information is not exhaustive, and it’s crucial to consult your healthcare provider or pharmacist for specific instructions and advice regarding the safe use, storage, and disposal of Oramorph SR.