Why is this medication prescribed?

Ongentys (opicapone) is a prescription medication that is used in the treatment of Parkinson’s disease. It is specifically prescribed as an adjunctive therapy to levodopa/carbidopa in patients with Parkinson’s disease who experience “off” episodes.

“Off” episodes refer to periods of time when the symptoms of Parkinson’s disease, such as tremors, stiffness, and difficulty with movement, become more pronounced or re-emerge despite the regular use of levodopa/carbidopa therapy. These episodes can significantly impact a patient’s quality of life and daily functioning.

Ongentys belongs to a class of drugs called COMT inhibitors (catechol-O-methyltransferase inhibitors). It works by blocking the enzyme COMT, which is responsible for the breakdown of levodopa in the body. By inhibiting COMT, Ongentys prolongs the effect of levodopa, thereby reducing “off” episodes and improving motor function in patients with Parkinson’s disease.

How should this medicine be used?

Ongentys (opicapone) should be used exactly as prescribed by your healthcare professional. It is usually taken once daily, orally, and in combination with levodopa/carbidopa therapy. Here are some general guidelines for using Ongentys:

• Follow the prescribed dosage: Take Ongentys exactly as instructed by your doctor. Do not take more or less than the recommended dose, and do not stop or change the dosage without consulting your healthcare provider.
• Timing: Ongentys is typically taken once daily, in the morning. It is important to take it at the same time each day to maintain a consistent level of medication in your system.
• Combination with levodopa/carbidopa: Ongentys is used as an adjunctive therapy to levodopa/carbidopa. Continue taking your levodopa/carbidopa medication as prescribed by your doctor. Ongentys should not replace or alter your levodopa/carbidopa dosage.
• Take with or without food: Ongentys can be taken with or without food. Follow your doctor’s instructions regarding food intake when taking Ongentys.
• Swallow whole: Take the Ongentys capsules whole with a glass of water. Do not crush, chew, or break the capsules before swallowing.
• Adherence: It is important to take Ongentys consistently and as prescribed to maximize its effectiveness. If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
• Regular check-ups: Attend scheduled follow-up appointments with your healthcare provider to monitor your response to Ongentys and make any necessary adjustments to your treatment plan.

Always consult your healthcare professional for specific instructions on how to use Ongentys, as individual dosing and administration may vary based on your condition and medical history.

Other uses for this medicine

Ongentys (opicapone) is primarily used for the treatment of Parkinson’s disease as an adjunctive therapy to levodopa/carbidopa. However, it is important to note that Ongentys should only be used for its approved indications and as prescribed by a healthcare professional. There are currently no other approved uses for Ongentys beyond its intended purpose in Parkinson’s disease management.

What special precautions should I follow?

When taking Ongentys, it is crucial to observe certain precautions:

• Allergies: Inform your healthcare provider if you have any known allergies to opicapone or any other ingredients in Ongentys. This medication may contain inactive ingredients that can cause allergic reactions or other complications.
• Medication interactions: Ongentys may interact with other medications, including over-the-counter drugs, herbal supplements, and prescription medications. It is important to provide your doctor with a complete list of all the medications you are taking to minimize the risk of potential drug interactions.
• Liver function: Ongentys is primarily metabolized by the liver. Therefore, individuals with liver problems or impaired liver function should exercise caution when using Ongentys. Your doctor may need to adjust your dosage or monitor your liver function more closely.
• Dyskinesia: Ongentys may potentially exacerbate dyskinesia, which refers to involuntary, uncontrollable movements. If you experience worsening or bothersome dyskinesia while taking Ongentys, inform your doctor.
• Impulse control disorders: Some patients with Parkinson’s disease may experience impulse control disorders, such as compulsive gambling, overeating, or excessive shopping. If you notice any changes in your behavior or the development of unusual urges, report them to your healthcare provider.
• Pregnancy and breastfeeding: The safety of Ongentys during pregnancy or breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Ongentys with your doctor.
• Surgery: If you are scheduled for surgery, including dental procedures, inform your healthcare provider about your use of Ongentys. It may be necessary to adjust your medication regimen temporarily.
• Adverse effects: Ongentys may cause side effects such as dyskinesia, constipation, dizziness, nausea, hallucinations, or orthostatic hypotension (low blood pressure upon standing). If you experience any unusual or persistent side effects, notify your doctor promptly.

It is important to follow your healthcare professional’s guidance and discuss any concerns or questions you have regarding Ongentys. They can provide personalized advice based on your specific medical condition and history.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with taking Ongentys (opicapone). You can generally take this medication with or without food. However, it’s always a good idea to follow a balanced and healthy diet as recommended by your healthcare provider to support overall well-being.

What should I do if I forget a dose?

If you forget to take a dose of Ongentys, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

What side effects can this medication cause?

Ongentys (opicapone) may cause side effects in some individuals. Not everyone who takes the medication will experience these side effects, and their severity can vary. Common side effects of Ongentys include:

• Dyskinesia: Involuntary, uncontrollable movements, such as twitching or jerking.
• Constipation: Difficulty or infrequent bowel movements.
• Orthostatic hypotension: A drop in blood pressure upon standing, which can cause dizziness or lightheadedness.
• Nausea: Feeling of discomfort or queasiness in the stomach.
• Hallucinations: Sensations of seeing, hearing, or feeling things that are not present.
• Urine discoloration: Ongentys may cause a harmless discoloration of urine (dark yellow to brown). This effect is due to the active metabolite of Ongentys and is not a cause for concern.

It’s important to note that this list is not exhaustive, and other side effects may occur. If you experience any unusual or persistent side effects while taking Ongentys, it is recommended to contact your healthcare provider. They can evaluate your symptoms and provide guidance on managing any adverse effects.

Remember to report any severe or concerning side effects immediately, as they may require medical attention. Your doctor can provide personalized advice and make adjustments to your treatment plan if needed.

What should I know about storage and disposal of this medication?

• Storage: Store Ongentys at room temperature, away from excessive heat, moisture, and direct sunlight. Follow the specific storage instructions provided on the medication packaging.
• Keep out of reach of children and pets: Ensure that Ongentys is stored in a secure location where children and pets cannot access it. Accidental ingestion can be harmful.
• Do not transfer: Do not transfer Ongentys to any other container. Keep it in its original container with the label intact to avoid confusion.
• Disposal: Dispose of unused or expired Ongentys in accordance with local regulations and guidelines. Do not flush it down the toilet or pour it into drains unless specifically instructed to do so. Consult your pharmacist or healthcare provider for proper disposal methods.

In case of emergency/overdose

In the case of an emergency or overdose, promptly seek medical attention or contact a poison control center. You can also call the emergency services hotline in your country for immediate assistance. Be prepared to provide information about the medication involved, the dosage taken, and the time of ingestion.

What other information should I know?

It is essential to communicate with your healthcare provider about any other medications or supplements you are taking to avoid potential drug interactions or complications. Additionally, inform all healthcare professionals involved in your care that you are taking Ongentys.

Regularly attend follow-up appointments with your doctor to monitor your response to the medication and discuss any concerns or questions you may have. They can provide you with personalized advice and guidance based on your specific medical condition and needs.

Lastly, always read the medication guide and follow the instructions provided by your healthcare professional and the packaging for the most accurate and up-to-date information on Ongentys.