WARNING

Onfi is the brand name for clobazam, which is a prescription medication primarily used to treat seizures associated with Lennox-Gastaut syndrome (LGS) in children and adults. While Onfi can be effective in managing seizures, like any medication, it carries certain risks. Here are some of the potential risks and side effects associated with taking Onfi:

• Sedation and drowsiness: Onfi can cause drowsiness, fatigue, and sedation. This can impair your ability to concentrate, operate machinery, or drive a vehicle.
• Cognitive and motor impairment: Onfi may cause difficulties with thinking, memory, and coordination. It can affect your ability to perform tasks that require mental alertness and physical coordination.
• Behavioral changes: Some individuals may experience changes in behavior, mood swings, irritability, aggression, or other psychiatric symptoms while taking Onfi. These effects should be monitored closely, especially in children.
• Withdrawal symptoms: Suddenly stopping Onfi can lead to withdrawal symptoms, such as seizures or increased seizures, anxiety, insomnia, and irritability. It is important to gradually reduce the dosage under medical supervision if the medication needs to be discontinued.
• Drug interactions: Onfi may interact with other medications, including some antidepressants, antifungal drugs, and certain seizure medications. These interactions can affect the effectiveness of Onfi or increase the risk of side effects.
• Allergic reactions: In rare cases, Onfi can cause severe allergic reactions, including rash, itching, swelling, dizziness, and difficulty breathing. If you experience any signs of an allergic reaction, seek immediate medical attention.

It’s crucial to consult with a healthcare professional before starting or adjusting any medication, including Onfi. They can evaluate your specific situation, medical history, and potential risks to determine the most appropriate treatment plan for you.

Why is this medication prescribed?

Onfi (clobazam) is primarily prescribed for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS), a severe form of epilepsy that typically starts in childhood. LGS is characterized by multiple types of seizures and cognitive impairment.

Onfi is an antiepileptic medication that helps reduce the frequency and severity of seizures in individuals with LGS. It belongs to a class of drugs called benzodiazepines, which work by affecting the chemicals in the brain that may become unbalanced and contribute to seizures.

How should this medicine be used?

The specific dosage and administration instructions for Onfi will vary depending on individual factors such as age, weight, and overall health. It is important to follow the instructions provided by your healthcare professional and the information on the prescription label. Generally, the following guidelines apply:

• Dosage: The initial dosage of Onfi is usually low and gradually increased based on the individual’s response and tolerance. The exact dosage will be determined by the prescribing doctor.
• Administration: Onfi is typically taken orally in the form of tablets or suspension. The medication can be taken with or without food, as directed by the healthcare provider.
• Timing: Onfi is usually taken twice daily, with a consistent interval between doses. It is important to maintain a regular dosing schedule and not skip doses.
• Avoid abrupt discontinuation: If Onfi needs to be discontinued, it should be done gradually under the guidance of a healthcare professional. Abruptly stopping Onfi can lead to withdrawal symptoms and increased seizure activity.
• Regular monitoring: While taking Onfi, it is important to have regular check-ups with your doctor to monitor its effectiveness, adjust the dosage if necessary, and manage any potential side effects.

Remember to always consult your healthcare professional for personalized advice on dosing, usage, and any specific concerns you may have regarding the use of Onfi.

Other uses for this medicine

Onfi (clobazam) is primarily approved for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS). However, it may also be prescribed off-label for other seizure disorders or conditions that involve seizures, as determined by a healthcare professional. It is important to note that off-label use should only be done under the guidance and supervision of a qualified healthcare provider.

What special precautions should I follow?

When using Onfi, it is essential to take certain precautions to ensure safe and effective use. Here are some special precautions to consider:

• Allergic reactions: Inform your healthcare provider if you have a history of hypersensitivity or allergic reactions to clobazam or other benzodiazepines. Allergic reactions can be serious and may require immediate medical attention.
• Respiratory issues: Onfi may cause respiratory depression, especially when combined with other medications that suppress the central nervous system. Inform your doctor if you have a history of respiratory problems, such as chronic obstructive pulmonary disease (COPD) or sleep apnea.
• Suicidal thoughts and behavior: Like many antiepileptic drugs, Onfi carries a risk of causing suicidal thoughts or behaviors. Individuals taking Onfi should be closely monitored for any changes in mood, behavior, or signs of depression. Contact your healthcare provider immediately if you or a loved one experiences worsening depression, suicidal thoughts, or any unusual changes in behavior.
• Withdrawal seizures: Abruptly stopping Onfi can lead to withdrawal seizures, especially in individuals with a history of seizures. If you and your doctor decide to discontinue Onfi, it should be done gradually and under medical supervision.
• Dependence and addiction: Onfi, like other benzodiazepines, has the potential for dependence and addiction. It is important to use the medication as prescribed and not exceed the recommended dosage. If you develop a pattern of increasing tolerance or dependence, inform your healthcare provider.
• Interaction with other medications: Onfi can interact with other medications, including other antiepileptic drugs, central nervous system depressants, and certain antibiotics or antifungal medications. These interactions can affect the effectiveness of Onfi or increase the risk of side effects. Inform your doctor about all the medications, supplements, or herbal products you are taking to avoid potential interactions.

It is crucial to discuss your medical history, current medications, and any specific concerns with your healthcare provider before starting or adjusting the use of Onfi. They can provide personalized guidance and monitor your progress to ensure the safest and most effective treatment.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with taking Onfi (clobazam). However, it is generally recommended to take the medication with or without food, as directed by your healthcare provider. If you have any concerns or questions about dietary instructions while taking Onfi, it is best to consult with your doctor or pharmacist for personalized advice based on your specific situation.

What should I do if I forget a dose?

If you forget to take a dose of Onfi, follow these general guidelines:

• Timing: Take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule.
• Do not double dose: Do not take a double dose to make up for the missed one. Taking more than the prescribed amount can increase the risk of side effects and complications.
• Consult your healthcare provider: If you frequently forget to take your doses or have concerns about missed doses, it is important to discuss this with your healthcare provider. They can provide guidance on managing missed doses and may offer strategies to help you remember your medication schedule.

What side effects can this medication cause?

Onfi (clobazam) can cause various side effects. While not everyone experiences these side effects, it is important to be aware of the potential risks. Common side effects of Onfi include:

• Sedation and drowsiness: Onfi can cause drowsiness, sleepiness, or fatigue. This can affect your ability to concentrate, operate machinery, or drive a vehicle safely.
• Cognitive and motor impairment: Onfi may lead to difficulties with thinking, memory, coordination, or balance. It can impact your mental alertness and physical abilities.
• Behavior and mood changes: Some individuals may experience changes in behavior, mood swings, irritability, agitation, aggression, or restlessness while taking Onfi. These effects should be monitored closely, particularly in children.
• Drooling: Onfi may cause excessive drooling or increased saliva production.
• Constipation: Onfi can sometimes lead to constipation, causing difficulty or infrequent bowel movements.
• Upper respiratory tract infection: In clinical trials, upper respiratory tract infections, such as the common cold, were reported as common side effects of Onfi.
• Nasopharyngitis: Nasopharyngitis, which refers to inflammation of the nose and throat, can occur as a side effect of Onfi.
• Cough: Some individuals may experience a cough as a side effect of Onfi.
• Rash: Onfi can rarely cause skin rashes or allergic reactions. Seek medical attention if you develop a rash while taking the medication.
• Increased liver enzymes: Onfi can lead to elevated levels of liver enzymes, which can be detected through blood tests.

It is important to note that this list does not encompass all possible side effects. Some individuals may experience side effects not mentioned here. If you encounter any concerning or severe side effects while taking Onfi, it is essential to contact your healthcare provider for further evaluation and guidance.

What should I know about storage and disposal of this medication?

• Storage: Keep Onfi in its original packaging at room temperature, away from excessive heat, moisture, and direct sunlight. Follow any specific storage instructions provided by the manufacturer.
• Keep out of reach of children: Store Onfi in a secure location out of the reach of children and pets to prevent accidental ingestion.
• Disposal: Properly dispose of unused or expired Onfi. Do not flush it down the toilet or pour it into drains unless instructed to do so. Consult your pharmacist or local waste disposal authority for guidelines on medication disposal in your area.

In case of emergency/overdose

In case of emergency or overdose, take the following steps:

• Seek immediate medical attention: If you or someone else may have taken too much Onfi or is experiencing severe symptoms, call emergency services or go to the nearest emergency room immediately.
• Contact a poison control center: If you suspect an overdose but the person is conscious and alert, you can also contact your local poison control center for guidance. They can provide specific instructions based on the situation.

What other information should I know?

• Regular monitoring: Your healthcare provider may conduct regular check-ups and monitor your response to Onfi. This can involve evaluating the effectiveness of the medication, adjusting the dosage if necessary, and monitoring for any potential side effects.
• Medication interactions: Inform your healthcare provider about all the medications, supplements, or herbal products you are taking. Onfi may interact with certain medications, and your doctor can help determine if any adjustments or precautions are necessary.
• Medical ID: Consider wearing a medical identification bracelet or carrying a card that indicates you are taking Onfi. This can be helpful in emergency situations where you may be unable to communicate your medical information.
• Compliance: Take Onfi as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your doctor. It is important to follow the prescribed regimen to maintain its effectiveness.

Remember to consult your healthcare provider or pharmacist for specific instructions regarding storage, disposal, and what to do in case of emergencies or overdose. They can provide personalized advice based on your individual circumstances.