WARNING

Omalizumab is a medication used to treat allergic asthma and chronic idiopathic urticaria (chronic hives) in certain individuals. While it can be effective in managing these conditions, like any medication, it carries some potential risks. Here are some of the known risks associated with taking Omalizumab:

• Allergic reactions: Some individuals may experience severe allergic reactions to Omalizumab, which can include symptoms such as difficulty breathing, chest tightness, swelling of the face or throat, and hives. If such a reaction occurs, immediate medical attention is necessary.
• Increased risk of infection: Omalizumab may potentially weaken the immune system, making individuals more susceptible to infections. This can include respiratory tract infections, sinusitis, and urinary tract infections. It is important to monitor for any signs of infection and seek medical treatment if necessary.
• Malignancies: There have been rare cases of malignancies, including certain types of cancer, reported in individuals treated with Omalizumab. However, the relationship between the medication and these cases is not fully understood, and further research is needed.
• Cardiovascular effects: Omalizumab has been associated with an increased risk of cardiovascular events such as heart attacks, angina (chest pain), and hypertension (high blood pressure). Individuals with pre-existing cardiovascular conditions should be closely monitored while taking this medication.
• Local injection site reactions: Some individuals may experience injection site reactions such as pain, redness, swelling, or itching at the site of injection. These reactions are generally mild and temporary.

It’s important to note that these risks vary in terms of frequency and severity. Before starting Omalizumab or any medication, it’s crucial to consult with a healthcare professional who can assess your specific situation, discuss potential risks and benefits, and provide personalized advice.

Why is this medication prescribed?

Omalizumab injection is prescribed for the treatment of two main conditions:

• Allergic asthma: Omalizumab is used for the management of moderate to severe allergic asthma in individuals whose symptoms are not adequately controlled by other asthma medications such as inhaled corticosteroids. It is specifically indicated for individuals aged 6 years and older who have a positive skin test or blood test for allergens and have symptoms that are triggered by these allergens.
• Chronic idiopathic urticaria: Omalizumab is also used to treat chronic idiopathic urticaria (CIU), which is a type of chronic hives. CIU is characterized by the presence of hives on the skin for six weeks or more without a known cause. Omalizumab can be considered as a treatment option for individuals who do not respond well to antihistamines, which are the first-line therapy for CIU.

In both of these conditions, Omalizumab works by targeting and blocking immunoglobulin E (IgE), which is involved in allergic reactions. By reducing the levels of IgE, Omalizumab helps to alleviate symptoms associated with asthma and chronic hives, such as wheezing, coughing, shortness of breath, and skin itching.

How should this medicine be used?

Omalizumab injection should be used exactly as prescribed by a healthcare professional. Here are some general guidelines for using Omalizumab:

• Administration: Omalizumab is given as a subcutaneous injection, which means it is injected under the skin. The injection is usually administered by a healthcare professional. It is important to follow the recommended injection technique and use sterile equipment to minimize the risk of infection.
• Dosage: The dosage of Omalizumab can vary depending on the individual’s specific condition, weight, and IgE levels. The healthcare professional will determine the appropriate dosage for each patient. It is important to adhere to the prescribed dosage and not adjust or stop the medication without consulting a healthcare professional.
• Schedule: Omalizumab is typically administered every 2 or 4 weeks. The healthcare professional will determine the appropriate dosing schedule based on the individual’s condition and response to treatment. It is important to follow the recommended schedule and not miss any doses.
• Monitoring: Regular monitoring may be necessary while using Omalizumab. This may include assessments of asthma symptoms, lung function tests, or monitoring of allergic reactions. Follow-up appointments with the healthcare professional should be scheduled as advised to evaluate the effectiveness of the treatment.
• Additional medications: Omalizumab is often used in conjunction with other asthma medications or antihistamines for chronic hives. It is important to continue using other prescribed medications unless instructed otherwise by the healthcare professional.

It’s important to note that these are general guidelines, and the specific instructions for using Omalizumab may vary depending on the individual’s condition and the healthcare professional’s recommendations. It is essential to follow the instructions provided by the healthcare professional and seek clarification if there are any uncertainties about the proper use of Omalizumab.

Other uses for this medicine

Omalizumab injection is primarily used for the treatment of allergic asthma and chronic idiopathic urticaria (chronic hives). However, there have been some off-label uses reported for Omalizumab, which means it has been used in ways not specifically approved by regulatory authorities. These off-label uses may include conditions such as nasal polyps, food allergies, and allergic rhinitis, among others. Off-label use should be done under the guidance and supervision of a healthcare professional who can assess the potential risks and benefits.

What special precautions should I follow?

Regarding special precautions for Omalizumab injection, here are some important considerations:

• Allergic reactions: Omalizumab itself can cause allergic reactions, including severe anaphylaxis. Individuals should be closely monitored for any signs of an allergic reaction during and after the injection. Immediate medical attention should be sought if symptoms such as difficulty breathing, swelling, or hives occur.
• Pre-existing conditions: It is important to inform the healthcare professional about any pre-existing medical conditions, especially cardiovascular conditions, before starting Omalizumab. The medication has been associated with an increased risk of cardiovascular events, so caution is required in individuals with a history of heart disease or hypertension.
• Immunizations: Omalizumab may affect the response to certain vaccines. It is recommended to consult with a healthcare professional regarding immunization schedules and the effectiveness of vaccines while using Omalizumab.
• Pregnancy and breastfeeding: The safety of Omalizumab during pregnancy and breastfeeding has not been fully established. It is important to discuss the potential risks and benefits with a healthcare professional if considering Omalizumab in these situations.
• Monitoring and follow-up: Regular monitoring and follow-up appointments with a healthcare professional are necessary while using Omalizumab. This is to assess the effectiveness of the medication, monitor for any adverse effects or complications, and adjust the treatment plan if needed.

It is crucial to communicate openly and honestly with the healthcare professional, provide a comprehensive medical history, and follow their guidance and instructions regarding the use of Omalizumab. They will be able to assess individual circumstances and provide personalized precautions based on the specific needs of the patient.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Omalizumab injection. Generally, you can continue with your regular diet while using Omalizumab. However, it’s always a good idea to maintain a healthy and balanced diet to support overall health and well-being.

What should I do if I forget a dose?

If you forget a dose of Omalizumab, it is important to contact your healthcare professional for guidance. They will be able to provide specific instructions based on your individual treatment plan. In some cases, the missed dose may be rescheduled, or your healthcare professional may advise you on the appropriate course of action. It is not recommended to double the dose to make up for a missed one without consulting a healthcare professional first.

What side effects can this medication cause?

Omalizumab injection, like any medication, can cause side effects. While not everyone experiences these side effects, it is important to be aware of them. Common side effects of Omalizumab may include:

• Injection site reactions: These can include pain, redness, swelling, itching, or bruising at the injection site. These reactions are usually mild and temporary.
• Headache: Some individuals may experience headaches while using Omalizumab.
• Viral infections: Omalizumab may slightly increase the risk of upper respiratory tract infections, such as the common cold.
• Sinusitis: Sinusitis, which is inflammation of the sinuses, can occur in some individuals taking Omalizumab.
• Throat pain or irritation: Sore throat or irritation in the throat may occur as a side effect of Omalizumab.
• Joint or muscle pain: Some individuals may experience joint pain or muscle pain while using Omalizumab.

It’s important to note that these are not all the possible side effects of Omalizumab. Some individuals may experience rare or more severe side effects. If you experience any unusual or bothersome symptoms while taking Omalizumab, it is essential to contact your healthcare professional for further evaluation and guidance.

Additionally, it’s worth mentioning that the benefits of Omalizumab in controlling allergic asthma or chronic idiopathic urticaria generally outweigh the potential risks of side effects. Your healthcare professional will closely monitor your response to treatment and help manage any side effects that may occur.

What should I know about storage and disposal of this medication?

• Storage: Omalizumab injections should be stored in the refrigerator between 2°C and 8°C (36°F and 46°F). Do not freeze the medication. Protect it from light by keeping it in the original packaging or a dark container. Do not use Omalizumab that has been frozen or exposed to extreme temperatures. If you are traveling and need to transport Omalizumab, consult with your healthcare professional for specific instructions.
• Disposal: It is recommended to follow local regulations and guidelines for the proper disposal of Omalizumab injection. Unused or expired Omalizumab should not be flushed down the toilet or thrown into regular household trash. Contact your local pharmacy or healthcare facility for guidance on the safe disposal of unused medications.

In case of emergency/overdose

In case of an emergency or overdose, it is crucial to seek immediate medical assistance by calling your local emergency services or going to the nearest emergency room. It is helpful to provide healthcare professionals with information about the medication taken, including the name (Omalizumab) and the dosage. If possible, take the medication packaging with you for reference.

What other information should I know?

• Omalizumab is a prescription medication and should only be used under the supervision of a healthcare professional.
• Inform your healthcare professional about any other medications, supplements, or herbal products you are taking before starting Omalizumab, as they may interact with each other.
• Attend all scheduled appointments with your healthcare professional for regular monitoring and evaluation of your condition.
• Carry a medical alert identification card or bracelet to inform healthcare providers about your Omalizumab treatment in case of an emergency.

It is important to carefully follow the instructions provided by your healthcare professional for the storage, disposal, and handling of Omalizumab to ensure its effectiveness and maintain safety. If you have any specific questions or concerns regarding these aspects, it is advisable to consult with your healthcare professional or pharmacist for detailed guidance.