WARNING

Olumiant, whose generic name is baricitinib, is a medication used to treat certain autoimmune conditions such as rheumatoid arthritis. While it can be beneficial for many patients, it’s important to be aware of potential risks associated with taking Olumiant. Here are some of the main risks:

• Infections: Olumiant can increase the risk of developing serious infections. It may lower your body’s ability to fight off infections, including bacterial, viral, and fungal infections. It is crucial to monitor for any signs of infection while taking this medication.
• Allergic reactions: Some individuals may experience allergic reactions to Olumiant, which can range from mild to severe. If you develop symptoms such as rash, itching, swelling, dizziness, or difficulty breathing, seek immediate medical attention.
• Blood clotting: There have been reports of blood clots in individuals taking Olumiant. Blood clots can be dangerous and may lead to serious conditions such as deep vein thrombosis (DVT) or pulmonary embolism (PE). If you experience symptoms like swelling, pain, or tenderness in your limbs, or have difficulty breathing, inform your healthcare provider immediately.
• Liver problems: Olumiant may cause liver function abnormalities, including elevated liver enzymes. Regular monitoring of liver function is typically recommended while using this medication.
• Increased risk of malignancies: There have been observations of an increased risk of certain types of cancers, such as lymphoma, in patients treated with Olumiant. However, the absolute risk is generally low.

It’s important to note that these risks may vary from person to person, and not everyone experiences them. Before starting Olumiant, it is essential to discuss your medical history and any current medications with your healthcare provider to ensure it is a suitable option for you. Additionally, regular monitoring and follow-up appointments are typically recommended to manage these potential risks.

Why is this medication prescribed?

Olumiant, also known by its generic name baricitinib, is prescribed for the treatment of certain autoimmune conditions, most notably rheumatoid arthritis. Rheumatoid arthritis is a chronic inflammatory disorder that primarily affects the joints, causing pain, swelling, and stiffness. Olumiant is classified as a disease-modifying antirheumatic drug (DMARD) and works by inhibiting the activity of certain enzymes in the body that are involved in the inflammation process.

Olumiant is typically prescribed when other conventional treatments for rheumatoid arthritis, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or methotrexate, have not provided sufficient relief or are not well tolerated. It can be used as a monotherapy (as the sole treatment) or in combination with methotrexate or other DMARDs.

The main goals of prescribing Olumiant for rheumatoid arthritis are to reduce joint pain and swelling, improve physical function, prevent joint damage, and slow down the progression of the disease. It is important to note that Olumiant is prescribed under the supervision of a healthcare professional, and the dosage and treatment duration are determined based on the individual’s condition and response to the medication.

How should this medicine be used?

Olumiant (baricitinib) is available as tablets for oral administration. It is important to follow the instructions provided by your healthcare provider regarding the dosage and duration of treatment. Here are some general guidelines on how Olumiant is typically used:

• Dosage: The recommended starting dose of Olumiant for rheumatoid arthritis is usually 4 mg once daily. However, your healthcare provider may adjust the dosage based on your individual condition and response to treatment.
• Administration: Olumiant tablets are taken orally with or without food. You can swallow the tablet whole with a glass of water. Avoid crushing, splitting, or chewing the tablets unless specifically instructed by your healthcare provider.
• Regular Use: Olumiant is usually taken on a daily basis at the same time each day to maintain consistent levels of the medication in your body. It is important to adhere to the prescribed schedule and not skip doses.
• Combinations: Olumiant may be prescribed as a monotherapy or in combination with other medications such as methotrexate or other disease-modifying antirheumatic drugs (DMARDs). If you are taking other medications, make sure to inform your healthcare provider to ensure there are no potential drug interactions.
• Follow-up: Regular monitoring and follow-up appointments with your healthcare provider are typically recommended to evaluate the response to treatment and assess any potential side effects. Your healthcare provider may adjust the dosage or treatment plan as needed.

It is important to strictly follow the prescribed dosage and any additional instructions provided by your healthcare provider. If you have any questions or concerns regarding the use of Olumiant, it is best to consult with your healthcare provider for personalized guidance.

Other uses for this medicine

While Olumiant (baricitinib) is primarily used for the treatment of rheumatoid arthritis, it is also being investigated for its potential effectiveness in other autoimmune conditions, such as psoriatic arthritis and systemic lupus erythematosus (SLE). However, it’s important to note that the use of Olumiant for these conditions is still under investigation, and its effectiveness and safety in these indications have not been fully established.

What special precautions should I follow?

Regarding special precautions for Olumiant, here are some important points to consider:

• Infections: Olumiant can increase the risk of infections. It’s crucial to inform your healthcare provider about any existing infections or a history of recurrent infections before starting treatment. Avoid starting Olumiant if you have an active infection, and monitor for signs of infection while taking the medication.
• Tuberculosis (TB): Prior to initiating Olumiant, it’s essential to screen for latent TB infection and, if necessary, treat it appropriately. Patients with active TB should not start Olumiant.
• Vaccinations: Prior to starting Olumiant, it’s recommended to ensure that all immunizations, including live vaccines, are up to date. However, specific vaccines may be contraindicated during Olumiant treatment. Consult with your healthcare provider regarding appropriate vaccination strategies.
• Blood clotting: Olumiant may increase the risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (PE). Individuals with a history of blood clots or known risk factors for blood clots should use Olumiant with caution. Seek medical attention if you experience signs or symptoms of blood clots, such as swelling, pain, or difficulty breathing.
• Laboratory monitoring: Regular monitoring of liver function tests and complete blood counts is typically recommended during treatment with Olumiant. This helps to assess any potential liver abnormalities or changes in blood cell counts.
• Pregnancy and breastfeeding: The safety of Olumiant during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits with your healthcare provider.

It is important to communicate with your healthcare provider about your medical history, current medications, and any concerns you may have before starting Olumiant. They can provide personalized guidance and ensure that the medication is appropriate for your specific situation.

What special dietary instructions should I follow?

There are no specific dietary instructions that need to be followed while taking Olumiant (baricitinib). However, it’s generally recommended to maintain a healthy and balanced diet to support overall well-being.

What should I do if I forget a dose?

If you forget to take a dose of Olumiant, here are some general guidelines to follow:

• Timing: If you realize that you missed a dose and it is close to the time of your next scheduled dose, you can simply skip the missed dose. Take the next dose at the regular scheduled time. Do not take a double dose to make up for the missed one.
• Reminder: To help you remember taking your medication on time, you can set alarms or use medication reminder apps or devices.
• Consult your healthcare provider: If you frequently forget to take your medication or are unsure about what to do when you miss a dose, it’s best to consult your healthcare provider. They can provide specific instructions based on your treatment plan and condition.

What side effects can this medication cause?

Olumiant (baricitinib) may cause various side effects. Not everyone experiences these side effects, and their severity can vary from person to person. It’s important to note that while some side effects may be common, others are rare but potentially serious. Here are some of the possible side effects associated with Olumiant:

• Infections: Olumiant can increase the risk of developing infections, including upper respiratory tract infections, urinary tract infections, and shingles. Symptoms of infection may include fever, cough, sore throat, and painful urination.
• Allergic reactions: Some individuals may experience allergic reactions to Olumiant, which can manifest as rash, itching, swelling, dizziness, or difficulty breathing. Seek immediate medical attention if you experience these symptoms.
• Blood clotting: Olumiant may increase the risk of blood clots, which can lead to serious conditions such as deep vein thrombosis (DVT) or pulmonary embolism (PE). Symptoms may include swelling, pain, or tenderness in the limbs, or difficulty breathing.
• Liver problems: Olumiant can cause abnormalities in liver function, resulting in elevated liver enzymes. Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, or abdominal pain.
• Gastrointestinal issues: Common side effects of Olumiant include nausea, diarrhea, and abdominal pain. These symptoms are usually mild and temporary.
• Changes in blood cell counts: Olumiant may cause changes in blood cell counts, such as a decrease in white blood cells or platelets. This can increase the risk of infections or bleeding.
• Increased cholesterol levels: Olumiant may lead to elevated cholesterol levels, so regular monitoring of cholesterol levels is generally recommended.
• Malignancies: There have been reports of an increased risk of certain types of cancers, such as lymphoma, in patients treated with Olumiant. However, the absolute risk is generally low.

It is important to discuss any side effects or concerns with your healthcare provider. They can provide guidance, monitor your condition, and adjust the treatment plan if needed.

What should I know about storage and disposal of this medication?

• Storage: Keep Olumiant tablets in their original container at room temperature, away from excessive heat and moisture. Avoid storing them in the bathroom or any area prone to high humidity.
• Childproofing: Store Olumiant out of reach of children and pets to prevent accidental ingestion.
• Disposal: Follow local regulations or guidelines for the proper disposal of unused or expired medications. Do not flush Olumiant down the toilet or pour it into drains unless instructed to do so.

In case of emergency/overdose

• Emergency assistance: If you or someone else experiences severe symptoms, exhibits signs of an allergic reaction, or if an overdose is suspected, immediately call emergency services or your local poison control center.
• Symptoms: Symptoms of an overdose may include severe headache, dizziness, confusion, or an increased risk of infections. It is important to seek medical attention promptly.

What other information should I know?

• Regular monitoring: Your healthcare provider may schedule regular appointments to monitor your response to Olumiant, assess any potential side effects, and perform necessary laboratory tests.
• Medication interactions: Inform your healthcare provider about all medications, supplements, or herbal products you are taking, as they may interact with Olumiant and affect its effectiveness or increase the risk of side effects.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Olumiant with your healthcare provider. The safety of Olumiant during pregnancy and breastfeeding has not been established.
• Allergy to ingredients: If you have known allergies or sensitivities to any of the ingredients in Olumiant, inform your healthcare provider before starting treatment.
• Adherence to dosage: Take Olumiant as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting them first.

Remember to consult your healthcare provider or pharmacist for any specific instructions or information regarding the storage, disposal, emergency procedures, and any other concerns you may have about Olumiant. They can provide personalized guidance based on your individual situation.