WARNING

Nayzilam is a medication used for the treatment of seizures in adults. The active ingredient in Nayzilam is midazolam, which belongs to the benzodiazepine class of drugs. Like all medications, Nayzilam carries certain risks and potential side effects. Some of the risks associated with taking Nayzilam include:

• Drowsiness and Sedation: Nayzilam can cause drowsiness, sedation, and reduced alertness. It may impair your ability to drive or operate heavy machinery, making tasks that require full attention potentially dangerous.
• Respiratory Depression: As a benzodiazepine, Nayzilam can slow down breathing in some individuals, especially if taken in large doses or in combination with other central nervous system depressants like alcohol or opioids. This can be particularly concerning for individuals with respiratory issues or breathing disorders.
• Potential for Abuse and Dependence: Benzodiazepines like midazolam have a risk of abuse and dependence, especially when used recreationally or for extended periods. It’s essential to take Nayzilam only as prescribed by a healthcare professional.
• Memory Impairment: Some people may experience memory problems or difficulty recalling events while taking Nayzilam.
• Allergic Reactions: In rare cases, Nayzilam can cause allergic reactions, which may manifest as skin rashes, itching, swelling, or difficulty breathing.
• Drug Interactions: Nayzilam may interact with other medications, including prescription drugs, over-the-counter medications, and herbal supplements, leading to adverse effects or reduced efficacy.
• Tolerance and Withdrawal: Prolonged use of Nayzilam may lead to tolerance, requiring higher doses to achieve the same effect. Abruptly stopping the medication can result in withdrawal symptoms, including anxiety, irritability, insomnia, and seizures in some cases.

It’s crucial to discuss your medical history and any other medications or substances you are taking with your healthcare provider before starting Nayzilam or any other medication. Your doctor will weigh the potential benefits against the risks to determine if this medication is suitable for your specific condition. Always follow your doctor’s instructions and report any concerning side effects promptly.

Why is this medication prescribed?

Nayzilam is prescribed for the treatment of seizure clusters in adults who have been diagnosed with epilepsy. A seizure cluster refers to a series of seizures that occur close together and may not fully resolve between episodes. It is designed as a rescue medication to provide rapid relief during a seizure cluster when other seizure medications may not be sufficient to control the seizures.

The active ingredient in Nayzilam is midazolam, which belongs to the benzodiazepine class of drugs. Midazolam works by calming and slowing down the activity in the brain, which helps to stop or reduce the intensity and frequency of seizures.

How should this medicine be used?

• Administration by Caregiver: Nayzilam is intended to be used by a caregiver to treat someone experiencing a seizure cluster. It comes in a nasal spray form, and the caregiver should administer it to the person having the seizure.
• Proper Positioning: Place the person on their side if possible before administering the medication. This helps to prevent choking in case of vomiting and ensures a clear airway.
• Dosage: The dosage of Nayzilam should be determined by a healthcare professional based on the individual’s weight and medical condition. Always use the dose prescribed by the doctor and do not exceed the recommended amount.
• Nasal Administration: Nayzilam is sprayed into the nostril of the person having the seizure. The caregiver should insert the nozzle of the nasal spray into one nostril while holding the person’s head still, and then spray the medication.
• Second Dose: In some cases, a second dose of Nayzilam may be given if the seizure continues or recurs after the first dose. However, this should only be done as directed by a healthcare professional.
• Medical Attention: After administering Nayzilam, seek immediate medical attention, even if the seizure stops. It is essential to have the person evaluated by a healthcare provider to ensure their safety and determine the cause of the seizure cluster.

It’s important to note that Nayzilam is specifically for the treatment of seizure clusters and is not intended for routine seizure management. It should only be used as prescribed and under the guidance of a healthcare professional. If you or someone you know is prescribed Nayzilam, be sure to receive proper training from a healthcare provider on its administration and usage.

Other uses for this medicine

Nayzilam (midazolam) is primarily used for the treatment of seizure clusters in adults with epilepsy. It is a rescue medication intended for use during seizure clusters when other seizure medications may not be sufficient to control the seizures. There are no other approved uses for Nayzilam, and it should not be used for any other purposes without the explicit recommendation and prescription of a healthcare professional.

What special precautions should I follow?

Special Precautions for Nayzilam:

• Allergic Reactions: Before using Nayzilam, individuals should inform their healthcare provider about any known allergies, especially to benzodiazepines or other medications. Allergic reactions to Nayzilam can be serious and may require immediate medical attention.
• Respiratory Conditions: Nayzilam can cause respiratory depression (slowed breathing), especially when used with other central nervous system depressants like opioids or alcohol. Individuals with respiratory conditions, such as chronic obstructive pulmonary disease (COPD) or asthma, may be at higher risk and should use Nayzilam with caution.
• Impairment of Activities: Nayzilam may cause drowsiness, dizziness, and reduced alertness. It is essential for individuals to avoid activities that require mental alertness, such as driving or operating machinery, until the effects of the medication wear off.
• Tolerance and Dependence: Prolonged use of Nayzilam can lead to tolerance, where higher doses may be needed to achieve the same effect. It can also result in physical and psychological dependence. It’s crucial to use Nayzilam only as prescribed and for the specified purpose.
• Interactions with Other Medications: Nayzilam may interact with other medications, including prescription drugs, over-the-counter medications, and herbal supplements. Some drug interactions can be dangerous or reduce the efficacy of Nayzilam. Always inform your healthcare provider about all the medications you are taking before starting Nayzilam.
• Pregnancy and Breastfeeding: The safety of Nayzilam during pregnancy and breastfeeding has not been well-established. It should only be used in pregnant or breastfeeding individuals if the benefits outweigh the potential risks, and under the close supervision of a healthcare provider.
• Medical History: Before using Nayzilam, individuals should inform their healthcare provider about their medical history, especially if they have a history of liver or kidney problems, respiratory disorders, substance abuse, or any other significant medical condition.
• Pediatric Use: Nayzilam is not approved for use in pediatric patients, and its safety and efficacy in children have not been established.

These are general precautions associated with the use of Nayzilam, but it is essential to consult a healthcare professional for personalized guidance and to discuss specific concerns or conditions. Always follow your doctor’s instructions and report any concerning side effects promptly.

What special dietary instructions should I follow?

There were no specific dietary instructions related to Nayzilam (midazolam) usage. However, it is essential to follow a balanced and healthy diet as part of your overall health management, especially if you are taking any medications.

What should I do if I forget a dose?

If you forget to use Nayzilam during a seizure cluster, follow these general steps:

• Administer the medication as soon as you remember that a seizure cluster is occurring.
• If the person’s seizure cluster continues or worsens after using Nayzilam, seek immediate medical attention.
• Do not use a double dose to make up for a missed dose.

What side effects can this medication cause?

Nayzilam (midazolam) may cause various side effects in some individuals. Not everyone who takes Nayzilam will experience these side effects, and their severity can vary. If you are prescribed Nayzilam, it’s essential to be aware of the potential side effects and discuss any concerns with your healthcare provider. Some of the common side effects of Nayzilam may include:

• Drowsiness and Sedation: Feeling drowsy, sleepy, or having reduced alertness is a common side effect of Nayzilam.
• Headache: Some individuals may experience headaches as a side effect of the medication.
• Dizziness: Nayzilam can cause dizziness or a sensation of feeling lightheaded.
• Nasal Discomfort: Since Nayzilam is administered as a nasal spray, some people may experience mild irritation, burning, or discomfort in the nasal passages.
• Memory Problems: Some individuals may experience memory impairment or difficulty recalling events while taking Nayzilam.
• Respiratory Depression: In some cases, Nayzilam can cause respiratory depression, characterized by slowed breathing. This is more likely to occur when used in high doses or in combination with other central nervous system depressants.
• Allergic Reactions: Although rare, allergic reactions to Nayzilam can occur. Symptoms may include skin rashes, itching, swelling, or difficulty breathing. If you experience any signs of an allergic reaction, seek immediate medical attention.
• Tolerance and Dependence: Prolonged use of Nayzilam may lead to tolerance, requiring higher doses to achieve the same effect, and can also result in physical and psychological dependence.

It’s important to note that this list is not exhaustive, and other side effects may occur. Additionally, not everyone will experience these side effects. If you notice any concerning or persistent side effects while taking Nayzilam, contact your healthcare provider for evaluation and guidance.

What should I know about storage and disposal of this medication?

Storage and Disposal of Nayzilam:

• Storage: Store Nayzilam at room temperature, away from light and moisture. Follow the specific storage instructions provided by the manufacturer or pharmacist.
• Keep Out of Reach of Children: Keep Nayzilam and all medications out of the reach of children and pets.
• Protect from Heat: Do not store Nayzilam in areas with high heat or direct sunlight, as it may affect the medication’s effectiveness.
• Do Not Freeze: Avoid freezing Nayzilam nasal spray.
• Do Not Use Expired Medication: Check the expiration date on the packaging and do not use Nayzilam after it has expired. Properly dispose of expired or unused medication.
• Disposal: If you have unused or expired Nayzilam, consult with your local pharmacy or healthcare provider for safe disposal instructions. Do not flush medications down the toilet or drain unless instructed to do so by the proper authorities.

In case of emergency/overdose

In the event of an emergency or suspected overdose of Nayzilam, immediately seek medical attention or contact your local poison control center at 1-800-222-1222 (United States). If possible, inform the medical professionals about the medication and its dosage that was taken.

What other information should I know?

• Avoid Alcohol and Other Depressants: Do not consume alcohol or take other medications that can cause central nervous system depression while using Nayzilam, as it may increase the risk of severe side effects and respiratory depression.
• Medication List: Keep a list of all your current medications, including Nayzilam, and share it with your healthcare provider to prevent potential drug interactions.
• Medical ID or Alert Bracelet: If you have epilepsy or are at risk of experiencing seizure clusters, consider wearing a medical identification bracelet or carrying a medical ID card indicating your condition and the medications you are taking. This can be helpful in emergency situations.
• Regular Check-ups: Attend regular check-ups with your healthcare provider to monitor the effectiveness of Nayzilam and any potential side effects.
• Inform Other Healthcare Providers: Let any other healthcare providers or specialists you visit know that you are taking Nayzilam to ensure coordinated care and avoid potential drug interactions.
• Avoid Abrupt Discontinuation: Do not stop taking Nayzilam suddenly without consulting your healthcare provider. Abrupt discontinuation can lead to withdrawal symptoms and potential seizures in individuals with epilepsy.

Always follow your healthcare provider’s instructions regarding the use of Nayzilam and any other medications. If you have any questions or concerns about Nayzilam or its usage, consult your healthcare provider for personalized advice and guidance.