WARNING

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, inflammation, and stiffness caused by conditions such as arthritis. While it can be effective in managing these symptoms, like any medication, nabumetone carries certain risks. Here are some potential risks associated with taking nabumetone:

• Gastrointestinal Effects: NSAIDs, including nabumetone, can irritate the lining of the stomach and increase the risk of developing ulcers, bleeding, or gastrointestinal perforation. Individuals with a history of stomach ulcers or digestive system issues are at a higher risk.
• Cardiovascular Risks: Prolonged use of nabumetone may increase the chances of cardiovascular events such as heart attack or stroke. This risk is more pronounced in individuals with pre-existing heart conditions or those who have already experienced cardiovascular events.
• Kidney Issues: NSAIDs can affect kidney function and may lead to kidney damage or worsen existing kidney problems. Individuals with pre-existing kidney disease, dehydration, or taking other medications that affect kidney function may be more susceptible.
• Allergic Reactions: Some people may experience allergic reactions to nabumetone, ranging from mild to severe. Symptoms can include rash, hives, swelling, difficulty breathing, or dizziness. Immediate medical attention is necessary if an allergic reaction occurs.
• Interactions with Other Medications: Nabumetone can interact with other medications, such as blood thinners, diuretics, or certain high blood pressure medications. These interactions can alter the effectiveness or increase the risk of side effects of either medication.
• Other Side Effects: Common side effects of nabumetone include upset stomach, indigestion, headache, dizziness, and drowsiness. Less frequently, it may cause more serious side effects, such as liver damage, blood disorders, or fluid retention.

It is essential to consult with a healthcare professional before starting or changing any medication regimen. They can assess your specific situation, medical history, and individual risk factors to determine the suitability and potential risks associated with nabumetone or any other medication.

Why is this medication prescribed?

Nabumetone is prescribed to relieve pain, inflammation, and stiffness associated with conditions such as osteoarthritis and rheumatoid arthritis. It belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) and works by reducing the production of certain chemicals in the body that cause pain and inflammation.

How should this medicine be used?

The dosage and usage instructions for nabumetone may vary depending on the individual’s condition and their response to the medication. It is important to follow the instructions provided by the prescribing healthcare professional and the medication’s label. Here are some general guidelines:

• Dosage: The typical starting dose for nabumetone is 1,000 to 2,000 milligrams per day, divided into two doses. The total daily dosage should not exceed 2,000 milligrams unless specifically directed by the healthcare professional.
• Administration: Nabumetone is usually taken orally with a full glass of water, preferably with food or milk to minimize the risk of stomach upset. It is important not to crush, chew, or break the tablets, as they are designed to release the medication slowly.
• Duration: The duration of nabumetone treatment varies depending on the condition being treated and individual response. It is typically used for short-term relief of symptoms or for longer periods in chronic conditions under medical supervision.
• Regular Use: Nabumetone should be taken regularly as prescribed by the healthcare professional to achieve the best results. It is not intended for immediate relief of pain, and its effects may take time to build up.
• Avoiding Interactions: It is important to inform your healthcare professional about any other medications, supplements, or herbal products you are taking, as they can interact with nabumetone and affect its effectiveness or increase the risk of side effects.
• Regular Check-ups: Regular follow-up appointments with the prescribing healthcare professional are important to monitor the response to nabumetone, assess its effectiveness, and manage any potential side effects or risks.

Remember, the information provided here is a general overview, and it is crucial to consult with a healthcare professional for personalized advice regarding the appropriate dosage, duration, and usage of nabumetone based on your specific condition and medical history.

Other uses for this medicine

While nabumetone is primarily used for arthritis-related conditions, it may occasionally be prescribed for other purposes determined by your doctor.

What special precautions should I follow?

Regarding special precautions, here are some important considerations when taking nabumetone:

• Allergies and Sensitivities: Individuals who are allergic to nabumetone or any other NSAIDs should avoid its use. Allergic reactions can range from mild symptoms like rash or itching to severe reactions requiring immediate medical attention.
• Pre-existing Medical Conditions: Inform your healthcare professional about any pre-existing medical conditions, such as cardiovascular disease, liver disease, kidney disease, asthma, or gastrointestinal disorders. These conditions may require additional monitoring or adjustments to the dosage or choice of medication.
• Drug Interactions: Nabumetone may interact with other medications, including other NSAIDs, blood thinners, diuretics, certain antidepressants, and some antihypertensive medications. Inform your healthcare professional about all medications, supplements, and herbal products you are taking to minimize the risk of interactions.
• Gastrointestinal Effects: NSAIDs, including nabumetone, can increase the risk of gastrointestinal ulcers, bleeding, and perforation. Individuals with a history of stomach ulcers or gastrointestinal issues are at higher risk and may require additional precautions.
• Renal Function: Nabumetone can affect kidney function, and individuals with pre-existing kidney disease or those taking medications that affect the kidneys should be closely monitored.
• Cardiovascular Risks: Prolonged use of nabumetone may increase the risk of cardiovascular events, especially in individuals with pre-existing heart conditions or those who have previously experienced cardiovascular events. The lowest effective dose for the shortest duration should be used in such cases.

It is important to consult with a healthcare professional before taking nabumetone, as they can provide personalized guidance, assess your specific medical situation, and determine the appropriate precautions based on your individual needs.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with nabumetone. However, it is generally recommended to take nabumetone with food or milk to help minimize the risk of stomach upset or gastrointestinal side effects. Having a meal or snack before taking the medication can provide a protective layer for the stomach lining.

What should I do if I forget a dose?

• If you forget to take a dose of nabumetone, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Nabumetone, like other nonsteroidal anti-inflammatory drugs (NSAIDs), can cause side effects. The severity and frequency of these side effects can vary from person to person. Here are some potential side effects associated with nabumetone:

• Gastrointestinal Effects: Common side effects include upset stomach, heartburn, indigestion, nausea, and abdominal pain. In some cases, nabumetone can cause more serious gastrointestinal issues such as stomach ulcers, bleeding, or perforation, although these are less common.
• Cardiovascular Risks: Long-term use of nabumetone or other NSAIDs may increase the risk of cardiovascular events, including heart attack or stroke. This risk is more significant in individuals with pre-existing heart conditions or those who have previously experienced cardiovascular events.
• Kidney Effects: NSAIDs, including nabumetone, can impair kidney function, leading to fluid retention, edema, or worsening of pre-existing kidney problems. It is important to monitor kidney function regularly, especially in individuals with underlying kidney disease.
• Allergic Reactions: Some individuals may experience allergic reactions to nabumetone. Allergic symptoms can range from mild to severe and may include rash, hives, itching, swelling, difficulty breathing, or dizziness. Immediate medical attention is necessary if an allergic reaction occurs.
• Liver Effects: Although rare, nabumetone can cause liver damage or abnormal liver function. Signs of liver problems include yellowing of the skin or eyes (jaundice), dark urine, persistent nausea or vomiting, or abdominal pain. If any of these symptoms occur, medical attention should be sought promptly.
• Blood Disorders: In rare cases, nabumetone may affect blood cells, leading to conditions such as anemia, leukopenia (low white blood cell count), or thrombocytopenia (low platelet count). Symptoms can include unexplained fatigue, pale skin, frequent infections, or easy bruising or bleeding.
• Central Nervous System Effects: Some individuals may experience headache, dizziness, drowsiness, or confusion while taking nabumetone. These symptoms are generally mild and resolve on their own, but if they persist or worsen, it is advisable to consult a healthcare professional.

It is important to note that this is not an exhaustive list of side effects, and others may occur. If you experience any unusual or persistent side effects while taking nabumetone, it is crucial to seek medical advice. Your healthcare professional can provide guidance, assess your individual situation, and determine the appropriate steps to manage any side effects effectively.

What should I know about storage and disposal of this medication?

• Storage: Nabumetone should be stored at room temperature, away from moisture and heat. It is recommended to keep it in its original packaging, tightly closed, and out of reach of children and pets.
• Disposal: When disposing of nabumetone, it is important to follow local regulations and guidelines for medication disposal. Do not flush the medication down the toilet or pour it down the drain unless instructed to do so. Instead, consult with your local pharmacy or healthcare provider for proper disposal methods.

In case of emergency/overdose

In case of an emergency or overdose, contact your local emergency services (such as 911) or go to the nearest emergency room immediately. It is helpful to have the medication packaging or label available to provide information to healthcare professionals about the specific medication and dosage taken.

What other information should I know?

It is important to inform your healthcare provider about any other medications you are taking, including prescription, over-the-counter, and herbal supplements, as they may interact with nabumetone. Additionally, discuss your medical history, including any allergies, liver or kidney problems, heart conditions, or gastrointestinal issues, as these factors may affect the suitability of nabumetone for you. Follow your healthcare provider’s instructions regarding the use of nabumetone, and if you have any concerns or questions, consult them for further guidance.

Always consult with your healthcare professional for comprehensive and personalized guidance regarding the storage, disposal, emergency procedures, and other important information specific to your situation.