WARNING

Taking Myorisan (isotretinoin) comes with several potential risks, which is why it is typically reserved for severe cases of recalcitrant nodular acne and prescribed under strict monitoring. Some of the main risks associated with Myorisan include:

• Birth Defects: Myorisan is known to cause severe birth defects if taken during pregnancy. It is essential for females of reproductive age to use two reliable forms of contraception throughout the course of treatment and for at least one month after stopping the medication.
• Mental Health Effects: Myorisan has been associated with mood changes, including feelings of sadness or depression. While not everyone will experience these effects, it is crucial to monitor for any signs of mental health changes and inform your healthcare provider if they occur.
• Increased Sun Sensitivity: Myorisan can make the skin more sensitive to the sun, leading to an increased risk of sunburn. Patients should avoid excessive sun exposure and use sunscreen and protective clothing when outdoors.
• Dryness and Irritation: Myorisan can cause dryness of the skin, lips, mouth, and eyes, leading to chapped lips, dry skin, and dryness or irritation in the eyes.
• Elevated Liver Enzymes: Myorisan can affect liver function, leading to elevated liver enzymes in blood tests. Regular monitoring of liver function is essential during treatment.
• Musculoskeletal Effects: Some individuals may experience muscle and joint pain while taking Myorisan.
• Temporary Worsening of Acne: In some cases, acne may worsen initially before improving with Myorisan treatment. This is typically temporary and resolves as the medication takes effect.
• Gastrointestinal Effects: Myorisan can cause gastrointestinal discomfort, such as stomach pain or nausea, in some individuals.
• Vision Changes: Although rare, Myorisan has been linked to changes in vision, including blurred vision.

It’s important to recognize that the decision to use Myorisan should be carefully weighed against the potential benefits and risks, and it should only be prescribed by healthcare professionals experienced in its usage. Patients should be informed about these risks and closely monitored during treatment.

If you have any concerns or experience any side effects while taking Myorisan, promptly contact your healthcare provider for further evaluation and guidance.

Why is this medication prescribed?

Myorisan (isotretinoin) is a prescription medication primarily used to treat severe recalcitrant nodular acne. It belongs to a class of drugs known as retinoids and is one of the most potent and effective treatments for severe acne that has not responded well to other forms of therapy.

The exact reason why Myorisan is prescribed is at the discretion of a healthcare professional, typically a dermatologist, who will evaluate the severity of the acne and assess whether other treatments have been unsuccessful or are not suitable for the patient. Myorisan is not typically used for mild to moderate acne due to its potential side effects and the availability of other less potent treatment options.

How should this medicine be used?

• Dosage: The dosage of Myorisan varies based on the individual’s weight, the severity of their acne, and the specific prescription provided by the healthcare provider.
• Timing: Myorisan is usually taken twice daily with meals. Absorbing the medication with food can help improve its absorption and reduce the risk of stomach upset.
• Duration: Treatment with Myorisan usually lasts several months, depending on the response and severity of the acne. In some cases, a second course of treatment may be necessary.
• Compliance: It is crucial to take Myorisan exactly as prescribed by the healthcare professional. Do not alter the dosage or stop the medication prematurely, as doing so may affect its effectiveness.
• Contraception: Myorisan is known to cause severe birth defects if taken during pregnancy. Hence, it is essential to use two reliable forms of contraception (e.g., birth control pills and condoms) while taking the medication, even if the patient is not sexually active.
• Monitoring: During the course of treatment, patients may need to have regular follow-up visits with their healthcare provider to monitor their progress and check for any potential side effects.
• Side Effects: Myorisan can cause various side effects, including dry skin, chapped lips, nosebleeds, muscle or joint pain, increased sensitivity to the sun, and changes in mood. Some patients may experience more severe side effects, and it is crucial to report any concerning symptoms to the healthcare provider promptly.

Always follow the instructions provided by your prescribing healthcare professional and carefully read the medication guide that comes with Myorisan. If you have any questions or concerns about the medication or its usage, consult your doctor or pharmacist for clarification. Note that drug information may change over time, so it’s best to refer to the most recent guidelines and package inserts.

Other uses for this medicine

Myorisan (isotretinoin) is primarily prescribed for the treatment of severe recalcitrant nodular acne that has not responded to other forms of therapy. While it is mainly used for acne, there have been some off-label uses reported, meaning it has been used for other conditions, although these uses may not have been officially approved by regulatory authorities. Off-label use may be prescribed by healthcare professionals based on their clinical judgment and the patient’s individual circumstances. However, you should always follow your healthcare provider’s recommendations and use the medication only as prescribed for your specific condition.

What special precautions should I follow?

Special Precautions for Myorisan:

• Birth Control: As previously mentioned, Myorisan is known to cause severe birth defects if taken during pregnancy. It is essential for females of reproductive age to use two reliable forms of contraception throughout the course of treatment and for at least one month after stopping the medication.
• Pregnancy Test: Prior to starting Myorisan and each month during treatment, females of reproductive age must have a negative pregnancy test to ensure they are not pregnant before continuing with the medication.
• Avoid Blood Donation: Patients taking Myorisan should not donate blood during treatment and for at least one month after stopping the medication. This is to avoid the risk of the medication being given to a pregnant woman through a blood transfusion.
• Monitoring and Follow-up: Regular follow-up visits with the prescribing healthcare professional are crucial to monitor progress, check for potential side effects, and make any necessary adjustments to the treatment plan.
• Liver Function: Myorisan can affect liver function, so patients may need to undergo periodic blood tests to monitor liver enzymes.
• Mental Health: Some patients may experience changes in mood or other mental health effects while taking Myorisan. It’s important to inform the healthcare provider of any mood changes or signs of depression during treatment.
• Sun Sensitivity: Myorisan can make the skin more sensitive to the sun, increasing the risk of sunburn. Patients should avoid excessive sun exposure and use sunscreen and protective clothing when outdoors.
• Interactions with Other Medications: Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as Myorisan may interact with certain medications, potentially affecting their efficacy or safety.
• Allergic Reactions: If you have a known allergy to isotretinoin or any of its components, inform your healthcare provider before starting the medication.

Always follow your healthcare provider’s instructions, and do not hesitate to discuss any concerns or questions you may have about Myorisan or its precautions.  Consult your healthcare provider or refer to the most recent prescribing information for the latest guidelines and precautions.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Myorisan (isotretinoin) usage. However, taking the medication with food is generally recommended to improve absorption and reduce the risk of stomach upset. Therefore, it is advisable to take Myorisan with a meal or snack.

What should I do if I forget a dose?

If you forget to take a dose of Myorisan, follow these general guidelines:

• Take it as Soon as Possible: If you remember the missed dose relatively soon after the scheduled time, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do Not Double Dose: Do not take a double dose to make up for the missed one. Taking two doses close together can increase the risk of side effects without providing any additional benefit.
• Consult Your Healthcare Provider: If you are unsure about what to do or if you have any concerns, contact your healthcare provider for guidance.

What side effects can this medication cause?

Myorisan (isotretinoin) can cause various side effects, ranging from mild to severe. Not everyone will experience these side effects, and their severity can vary from person to person. Some common side effects include:

• Dryness: Myorisan can cause dryness of the skin, lips, mouth, and eyes. This may lead to chapped lips, dry or itchy skin, and dryness or irritation in the eyes.
• Nosebleeds: Some individuals may experience increased sensitivity and dryness in the nasal passages, leading to nosebleeds.
• Muscle and Joint Pain: Myorisan can cause muscle and joint pain, which may be mild to moderate in intensity.
• Increased Sun Sensitivity: The medication can make the skin more sensitive to the sun, leading to an increased risk of sunburn. It is essential to use sunscreen and protective clothing when exposed to sunlight.
• Mood Changes: In some cases, Myorisan has been associated with mood changes, including feelings of sadness or depression.
• Temporary Worsening of Acne: Some individuals may experience an initial worsening of their acne before it starts to improve. This is a temporary effect, and the acne usually begins to clear up after a few weeks of treatment.
• Vision Changes: Although rare, Myorisan has been linked to changes in vision, including blurred vision.
• Hair Thinning: Some individuals may experience temporary hair thinning while on Myorisan.
• Gastrointestinal Issues: Myorisan can cause gastrointestinal discomfort, such as stomach pain or nausea, in some individuals.
• Elevated Liver Enzymes: Myorisan can affect liver function, leading to elevated liver enzymes in blood tests.

It’s important to note that Myorisan carries a significant risk of causing severe birth defects if taken during pregnancy. Therefore, women of reproductive age must use effective contraception during treatment and for at least one month after discontinuing the medication.

It is crucial to report any unusual or severe side effects to your healthcare provider promptly. If you experience any symptoms that cause concern or interfere with your daily life, do not hesitate to seek medical advice.

Remember that the list above is not exhaustive, and other side effects may occur. The occurrence of side effects may also be influenced by factors such as the dosage, treatment duration, and individual health characteristics. Always follow your healthcare provider’s instructions and discuss any concerns or questions you have about Myorisan and its potential side effects with them.

What should I know about storage and disposal of this medication?

Storage and Disposal of Myorisan:

• Storage: Keep Myorisan at room temperature, away from moisture, heat, and direct light. Do not store it in the bathroom. Follow any specific storage instructions provided by your pharmacist or on the medication packaging.
• Childproof Container: Store Myorisan in a childproof container and keep it out of the reach of children and pets.
• Proper Disposal: Do not flush Myorisan down the toilet or pour it into a drain unless instructed to do so. Properly discard any unused or expired medication through a drug take-back program if available in your area. If a take-back program is not available, consult your pharmacist or local waste disposal authorities on how to safely dispose of the medication.

In case of emergency/overdose

In case of an emergency or suspected overdose of Myorisan, immediately contact your local emergency services or go to the nearest emergency room. Overdosing on Myorisan can lead to serious side effects, and prompt medical attention is crucial.

What other information should I know

• Medication Interactions: Inform your healthcare provider about all the medications, vitamins, and supplements you are taking, as Myorisan may interact with certain drugs, potentially affecting their efficacy or safety.
• Follow Up: Attend all follow-up appointments with your healthcare provider while taking Myorisan to monitor your progress, check for potential side effects, and make any necessary adjustments to the treatment plan.
• Birth Control: Females of reproductive age must use two reliable forms of contraception throughout the course of treatment and for at least one month after stopping Myorisan, due to the risk of severe birth defects if taken during pregnancy.
• Mental Health: Be aware of any mood changes or signs of depression during treatment, and promptly inform your healthcare provider if you experience any such issues.
• Avoid Waxing and Cosmetic Procedures: While on Myorisan treatment, it is recommended to avoid waxing or undergoing certain cosmetic procedures like dermabrasion, as the skin may be more sensitive and susceptible to damage.
• Blood Donation: Do not donate blood during treatment with Myorisan and for at least one month after discontinuing the medication.
• Sun Exposure: Myorisan can increase sun sensitivity. Protect your skin from excessive sun exposure and use sunscreen with at least SPF 30 when outdoors.
• Alcohol: Avoid excessive alcohol consumption while on Myorisan, as it may exacerbate certain side effects and put additional strain on the liver.
• Pregnancy and Breastfeeding: Myorisan is not safe for use during pregnancy or breastfeeding. Women should avoid becoming pregnant while taking the medication and consult their healthcare provider for guidance if planning to breastfeed.

Always follow your healthcare provider’s instructions regarding the usage of Myorisan and adhere to the prescribed dosage. If you have any specific concerns or questions about the medication, its storage, or potential interactions, consult your healthcare provider or pharmacist for personalized advice.