WARNING

Myfembree is a medication that combines three active ingredients: relugolix, estradiol, and norethindrone acetate. It is primarily used as a treatment for heavy menstrual bleeding associated with uterine fibroids in premenopausal individuals. Like any medication, Myfembree carries certain risks and potential side effects. Here is a brief overview of some of the risks associated with taking Myfembree:

• Cardiovascular Risks: Myfembree contains estrogen (estradiol) and progestin (norethindrone acetate), which can increase the risk of blood clots, stroke, and heart attack. This risk may be higher in individuals with a history of cardiovascular problems or those who smoke.
• Breast Cancer Risk: Hormone replacement therapy, which includes estrogen and progestin, has been associated with an increased risk of breast cancer. Myfembree contains these hormones, so there may be a similar risk, especially if taken over an extended period.
• Bone Health: Long-term use of Myfembree may lead to a decrease in bone mineral density, potentially increasing the risk of osteoporosis or fractures.
• Liver Problems: There is a risk of liver problems, including liver function abnormalities, while taking Myfembree. If you experience symptoms like yellowing of the skin or eyes, abdominal pain, or dark urine, you should contact a healthcare provider.
• Headache and Nausea: Common side effects of Myfembree include headaches and nausea. These side effects may decrease over time but can be bothersome.
• Mood Changes: Some individuals may experience mood changes, such as depression or anxiety, while taking Myfembree.
• Other Side Effects: Myfembree may cause other side effects like irregular vaginal bleeding, breast tenderness, weight gain, and decreased libido.

It’s essential to discuss the potential risks and benefits of Myfembree with your healthcare provider before starting this medication. Your healthcare provider can help assess whether Myfembree is a suitable treatment option for your specific medical condition and provide guidance on managing and monitoring any potential risks associated with its use. Regular follow-up appointments are typically recommended while taking Myfembree to evaluate its effectiveness and monitor for any adverse effects.

Why is this medication prescribed?

Myfembree is a medication prescribed for various medical reasons, primarily related to gynecological and hormonal health. It is a combination medication that contains three active ingredients: estradiol (an estrogen), norethindrone acetate (a progestin), and elagolix (a gonadotropin-releasing hormone receptor antagonist). Myfembree is primarily prescribed for the following purposes:

• Management of Heavy Menstrual Bleeding: Myfembree is often prescribed to treat heavy menstrual bleeding (menorrhagia) in premenopausal individuals. The combination of estradiol and norethindrone helps regulate the menstrual cycle and reduce excessive bleeding.
• Uterine Fibroids: Uterine fibroids are noncancerous growths in the uterus that can cause symptoms like heavy bleeding and pelvic pain. Myfembree may be prescribed to manage these symptoms and shrink the size of uterine fibroids.
• Endometriosis Pain: Endometriosis is a condition where tissue similar to the lining of the uterus grows outside the uterus, leading to pain and other symptoms. Myfembree, with its combination of elagolix and hormonal components, can help manage pain and reduce the growth of endometrial tissue.
• Contraception: The combination of estradiol and norethindrone in Myfembree also makes it a contraceptive option. It can be prescribed for birth control purposes.
• Hormone Replacement Therapy (HRT): In some cases, Myfembree may be prescribed as hormone replacement therapy for postmenopausal women. It can help relieve menopausal symptoms such as hot flashes and vaginal dryness.

How should this medicine be used?

here are some general guidelines for using Myfembree:

• Take as Prescribed: Always take Myfembree exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking it without consulting your healthcare provider.
• Timing: Myfembree tablets are typically taken once daily, with or without food. The timing of the dose may vary, so follow your healthcare provider’s instructions on when to take it.
• Swallow Whole: Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
• Contraceptive Use: If you are using Myfembree as a contraceptive, follow the instructions carefully. It’s important to take the tablets at the same time each day to maintain its effectiveness.
• Uterine Fibroids and Menorrhagia: If prescribed for uterine fibroids or heavy menstrual bleeding, your healthcare provider will determine the duration of treatment. Follow their guidance closely, even if your symptoms improve.
• Endometriosis: If prescribed for endometriosis, your healthcare provider will also determine the duration of treatment. Follow the prescribed schedule, and report any changes in your symptoms or any side effects to your provider.
• Hormone Replacement Therapy (HRT): If Myfembree is prescribed as HRT, follow your healthcare provider’s instructions for the duration of treatment.
• Missed Doses: If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses to make up for a missed one.
• Side Effects: Be aware of potential side effects and report any unusual or severe side effects to your healthcare provider promptly.
• Regular Check-ups: Your healthcare provider may schedule regular check-ups while you are taking Myfembree to monitor your progress and assess the medication’s effectiveness and safety for your specific condition.

It’s crucial to have open communication with your healthcare provider about any questions or concerns you have regarding Myfembree, its use, and its potential side effects. They can provide personalized guidance based on your medical history and current health status.

Other uses for this medicine

Myfembree is primarily prescribed for conditions such as heavy menstrual bleeding, uterine fibroids, endometriosis, contraception, and hormone replacement therapy. Some off-label uses may be determined by a healthcare provider based on clinical judgment and evidence. These may include managing hormonal imbalances, certain menstrual disorders, or hormone therapy in transgender healthcare.

What special precautions should I follow?

Special precautions for using Myfembree:

• Consult with a Healthcare Provider: Before starting Myfembree or any medication, it’s essential to consult with a healthcare provider who can assess your medical history, perform necessary tests, and provide guidance on its use.
• Pregnancy and Breastfeeding: Myfembree should not be used during pregnancy or while breastfeeding. It may harm an unborn baby or pass into breast milk, potentially affecting a nursing infant.
• Liver Function: Inform your healthcare provider about any liver problems you may have or a history of liver disease. Myfembree may affect liver function.
• Contraindications: Myfembree should not be used if you have known or suspected breast cancer or other hormone-sensitive cancers, as it contains hormones that could stimulate the growth of these cancers.
• Blood Clot Risk: Like other hormonal medications, Myfembree may increase the risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism. Inform your healthcare provider if you have a history of blood clotting disorders or a family history of such disorders.
• High Blood Pressure: Myfembree can lead to an increase in blood pressure. It is essential to monitor blood pressure regularly and inform your healthcare provider if you have hypertension or a history of it.
• Interactions with Other Medications: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as some drugs may interact with Myfembree.
• Adverse Effects: Be aware of potential side effects, which can include headache, breast tenderness, nausea, vomiting, abdominal pain, changes in menstrual bleeding patterns, and others. If you experience severe or persistent side effects, contact your healthcare provider.
• Regular Check-ups: Your healthcare provider will likely schedule regular check-ups to monitor your response to Myfembree and assess any potential side effects or complications.
• Follow Instructions: Take Myfembree exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking it without consulting them.

Remember that Myfembree is a prescription medication, and its use should be closely supervised by a healthcare provider who can provide personalized guidance and monitor your health throughout the treatment. Always follow your healthcare provider’s recommendations and inform them of any changes in your health status or any concerns you may have.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Myfembree. However, it’s generally a good idea to maintain a balanced and healthy diet. Some individuals may experience mild nausea when taking medications like Myfembree. If this occurs, taking the medication with food or a small snack may help alleviate the nausea.

What should I do if I forget a dose?

If you forget to take a dose of Myfembree, follow these guidelines:

• Take It as Soon as You Remember: If you miss a dose, take it as soon as you remember, even if it means taking two doses on the same day.
• Continue Your Regular Schedule: Continue taking Myfembree at your regular dosing schedule. Do not take two doses at once to make up for the missed dose.
• Use Backup Contraception: If you miss more than one dose or forget to take your medication for an extended period, consult your healthcare provider. You may need to use backup contraception to prevent pregnancy.
• Contact Your Healthcare Provider: If you have any concerns or questions about missed doses or the medication in general, contact your healthcare provider for guidance.

What side effects can this medication cause?

Myfembree, like any medication, can cause side effects. Not everyone will experience these side effects, and some individuals may experience them to a greater or lesser degree. Common side effects of Myfembree may include:

• Hot Flashes: Flushing, warmth, or sudden feelings of heat, often experienced in the face and chest.
• Headache: Mild to moderate headaches are a common side effect.
• Nausea: Some individuals may experience nausea while taking Myfembree.
• Insomnia: Difficulty falling asleep or staying asleep may occur.
• Fatigue: Feeling tired or having low energy levels.
• Mood Changes: Changes in mood, including mood swings, irritability, or feelings of sadness.
• Decreased Libido: Some individuals may experience a decrease in sexual desire.
• Weight Gain: Weight gain is a possible side effect, although not everyone will experience it.
• Joint Pain: Musculoskeletal pain, including joint pain, has been reported.
• Breast Tenderness: Some individuals may experience breast tenderness or swelling.
• Menstrual Changes: Changes in menstrual bleeding patterns, including spotting, irregular bleeding, or amenorrhea (absence of menstruation).
• Bone Density: Long-term use of Myfembree may affect bone density, potentially leading to a decrease in bone mineral density.
• Elevated Liver Enzymes: In some cases, Myfembree may lead to elevated liver enzyme levels, which can indicate liver function changes.
• Menopausal Symptoms: Some individuals may experience symptoms similar to those of menopause, such as vaginal dryness.
• Blood Pressure Changes: Myfembree may affect blood pressure in some individuals.

It’s important to note that not everyone will experience these side effects, and some individuals may tolerate Myfembree well with minimal or no side effects. Additionally, the severity and duration of side effects can vary from person to person.

If you experience any severe or concerning side effects while taking Myfembree, or if you have any questions or concerns about the medication, it’s crucial to contact your healthcare provider. They can provide guidance, adjust your treatment plan if necessary, or explore alternative medications or therapies to manage your specific condition. Your healthcare provider will consider the benefits and risks of Myfembree in the context of your overall health and medical history.

What should I know about storage and disposal of this medication?

Storage:

• Store Myfembree as directed: Keep Myfembree at room temperature, typically between 68°F to 77°F (20°C to 25°C).
• Protect from Light and Moisture: Store the medication in its original container or packaging, and keep it away from direct light and moisture.
• Keep Out of Reach of Children and Pets: Store Myfembree in a location that is inaccessible to children and pets to prevent accidental ingestion.
• Check Expiry Date: Ensure that you check the expiration date on the medication packaging, and do not use it if it has expired.

Disposal:

• Dispose of Unused Medication Properly: If you have unused or expired Myfembree tablets, do not flush them down the toilet or throw them in the trash. Instead, follow your local guidelines or regulations for the safe disposal of medications.
• Take-Back Programs: Many communities have drug take-back programs or events where you can safely dispose of unused or expired medications. Check with your local pharmacy or healthcare provider for information on disposal options in your area.

In case of emergency/overdose

If you suspect an overdose or experience severe adverse reactions while taking Myfembree, seek immediate medical attention or call your local poison control center at 1-800-222-1222 (USA) for guidance. Symptoms of an overdose may include severe nausea, vomiting, or signs of excessive estrogen exposure.

What other information should I know

• Follow Prescribing Instructions: Always follow your healthcare provider’s prescribing instructions for Myfembree. Do not adjust your dosage or stop taking the medication without consulting your healthcare provider.
• Regular Check-ups: Your healthcare provider may recommend regular check-ups while you are taking Myfembree to monitor your progress and assess its effectiveness and safety for your specific condition.
• Medication Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking to check for potential interactions with Myfembree.
• Adverse Effects: If you experience any unusual or severe side effects while taking Myfembree, contact your healthcare provider promptly.
• Inform Your Healthcare Providers: Make sure all of your healthcare providers are aware that you are taking Myfembree, including your primary care physician, specialists, and any other healthcare professionals involved in your care.
• Patient Information Leaflet: Read the patient information leaflet provided with Myfembree, which contains important information about the medication, its uses, side effects, and precautions.

It’s essential to have open communication with your healthcare provider about any questions or concerns you have regarding Myfembree. They can provide personalized guidance based on your medical history and current health status, helping ensure that you use the medication safely and effectively.