Why is this medication prescribed?

Movantik (generic name: naloxegol) is a medication prescribed to treat opioid-induced constipation (OIC) in adults who are taking opioid pain medications on a regular basis and are experiencing constipation as a side effect. Opioid pain medications, such as morphine, oxycodone, and others, can slow down the movement of the gastrointestinal tract, leading to constipation. Movantik works by blocking the effects of opioids in the gut, which helps to relieve constipation without reducing the pain-relieving effects of the opioids.

How should this medicine be used?

Here are general guidelines on how Movantik should be used, but always follow your doctor’s specific instructions:

• Dosage: Movantik is typically available in tablet form, and the recommended starting dose is usually 25 milligrams (mg) taken once daily. Your doctor may adjust the dose based on your individual response to the medication.
• Timing: It is usually taken at the same time each day, with or without food. Follow your doctor’s recommendations for the best time to take it.
• Swallow whole: Swallow the tablet whole with water. Do not crush, break, or chew the tablet.
• Avoid grapefruit: Avoid consuming grapefruit or grapefruit juice while taking Movantik, as it may interact with the medication.
• Stay hydrated: Make sure to drink plenty of fluids while taking Movantik to help prevent constipation.
• Continue opioid pain medication: Continue taking your prescribed opioid pain medication as directed by your doctor. Movantik is designed to relieve constipation without reducing the pain relief provided by opioids.
• Monitor for side effects: Be aware of any side effects or adverse reactions while taking Movantik. Common side effects may include abdominal pain, diarrhea, nausea, and headache. If you experience severe or persistent side effects, contact your healthcare provider.
• Follow your doctor’s advice: It’s essential to follow your doctor’s instructions and not change the dose or stop taking Movantik without consulting them.

Remember that Movantik is specifically intended to treat opioid-induced constipation, and it should not be used for other types of constipation unless recommended by your healthcare provider. If you have any questions or concerns about the use of Movantik, discuss them with your healthcare provider for personalized guidance.

Other uses for this medicine

Movantik is primarily indicated for the treatment of opioid-induced constipation. It is not typically used for other purposes. Always use this medication as prescribed by your healthcare provider.

What special precautions should I follow?

Before taking Movantik, it’s essential to discuss your medical history and any other medications or conditions with your doctor. Here are some special precautions to consider:

• Allergies: Inform your doctor if you are allergic to naloxegol or any other medications.
• Medical Conditions: Notify your healthcare provider if you have a history of bowel blockage or other gastrointestinal disorders.
• Pregnancy and Breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Movantik during pregnancy and breastfeeding is not well established.
• Drug Interactions: Movantik may interact with other medications, including certain opioids. Inform your healthcare provider about all the medications, vitamins, and supplements you are taking.
• Side Effects: Be aware of potential side effects such as stomach pain, diarrhea, nausea, and vomiting. If you experience severe or persistent side effects, contact your doctor.
• Driving and Machinery: Movantik may cause dizziness, so use caution when driving or operating machinery until you know how it affects you.
• Abuse and Dependence: Movantik itself is not an opioid, but it should be used with caution in individuals with a history of opioid use disorder.

Always follow your healthcare provider’s guidance and take Movantik as prescribed to manage opioid-induced constipation safely and effectively. If you have any questions or concerns about this medication, discuss them with your doctor or pharmacist.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with taking Movantik (naloxegol). You can generally continue with your normal diet while using this medication. However, it’s essential to maintain good hydration, as constipation can be exacerbated by dehydration. Drinking an adequate amount of fluids and consuming a high-fiber diet may also help manage constipation.

What should I do if I forget a dose?

If you forget to take a dose of Movantik, here are some general guidelines:

• Timing: Take the missed dose as soon as you remember it.
• Next Dose: If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
• Consult Your Healthcare Provider: If you frequently forget doses or have concerns about missed doses, it’s a good idea to discuss this with your healthcare provider. They can provide guidance on how to manage missed doses effectively.

What side effects can this medication cause?

Movantik (naloxegol) can cause side effects, as can most medications. Not everyone will experience these side effects, and some people may experience them to a greater degree than others. Common side effects of Movantik may include:

• Abdominal pain: Pain or discomfort in the abdomen is a common side effect.
• Diarrhea: Diarrhea can occur while taking Movantik. In some cases, it can be severe.
• Nausea: You may experience feelings of nausea while using this medication.
• Headache: Headaches are another common side effect.
• Gas: Some individuals may experience increased gas or flatulence.
• Vomiting: Vomiting can occur in some cases.
• Dizziness: Movantik may cause dizziness, which could increase the risk of falls.
• Peripheral Edema: Swelling of the hands, ankles, or feet may occur in some individuals.
• Pain or Discomfort in the Back or Muscles: Some people may experience back pain or muscle discomfort.
• Fatigue: Feeling tired or fatigued is another potential side effect.

It’s important to note that while these side effects are possible, not everyone will experience them. Additionally, if you are taking Movantik to treat opioid-induced constipation, the benefits of relieving constipation may outweigh the potential side effects.

If you experience severe or persistent side effects while taking Movantik, or if you have concerns about the medication’s side effects, contact your healthcare provider. They can provide guidance, adjust your treatment if necessary, or recommend other approaches to managing constipation.

In rare cases, severe allergic reactions to medications can occur. Seek immediate medical attention if you experience symptoms such as difficulty breathing, rash, itching, swelling of the face, lips, tongue, or throat, or severe dizziness.

This is not an exhaustive list of side effects, and there may be other potential side effects associated with Movantik. Always consult your healthcare provider or pharmacist for a complete list of side effects and for guidance on how to manage them.

What should I know about storage and disposal of this medication?

Storage:

• Store Movantik at room temperature, away from excessive heat and moisture. Avoid storing it in the bathroom or kitchen where humidity can affect the medication.
• Keep the medication in its original container with the lid tightly closed, and out of reach of children and pets.
• Do not share Movantik with others, even if they have similar symptoms, as it is prescribed specifically for your condition.

Disposal:

• When you no longer need Movantik or it has expired, do not flush it down the toilet or throw it in the trash. Properly dispose of it in accordance with local guidelines or through a medication take-back program if available in your area.
• If you’re unsure about how to dispose of the medication, consult your pharmacist or healthcare provider for guidance.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms while taking Movantik, seek immediate medical attention or call your local poison control center at 1-800-222-1222. Symptoms of an overdose may include:

• Severe diarrhea
• Vomiting
• Severe stomach pain or cramping
• Dizziness
• Fainting
• Unresponsiveness

What other information should I know

• Keep all of your healthcare appointments while taking Movantik to monitor your condition and any potential side effects.
• Inform all healthcare providers, including dentists and surgeons, about your use of Movantik, as it may interact with other medications or anesthesia during medical procedures.
• If you experience new or worsening abdominal pain, as it may be a sign of a bowel obstruction, contact your healthcare provider promptly.
• Be cautious when driving or operating heavy machinery, as Movantik may cause dizziness.
• Inform your healthcare provider of any other medical conditions you have and all medications you are taking to ensure there are no potential interactions or contraindications.
• Do not change the dose or stop taking Movantik without consulting your healthcare provider.

Always follow your healthcare provider’s instructions for the safe and proper use of Movantik. If you have any questions or concerns about the medication, its storage, disposal, or potential emergencies, consult your healthcare provider or pharmacist for guidance.