Why is this medication prescribed?

Monjuvi (tafasitamab-cxix) is a prescription medication used to treat certain types of lymphoma, specifically diffuse large B-cell lymphoma (DLBCL). DLBCL is a type of non-Hodgkin lymphoma, and Monjuvi is indicated for use in combination with lenalidomide in patients who have previously received at least two prior therapies.

How should this medicine be used?

Here’s how Monjuvi is typically used:

• Prescription: Monjuvi is a prescription medication, and it should only be used under the supervision of a healthcare professional who is experienced in the treatment of lymphoma.
• Combination Therapy: Monjuvi is often used in combination with lenalidomide, another medication. The specific dosage and treatment regimen will be determined by your healthcare provider based on your individual medical history and the severity of your condition.
• Administration: Monjuvi is usually administered as an intravenous (IV) infusion. This means that it is delivered directly into your bloodstream through a vein. The infusion is typically given in a healthcare setting, such as a clinic or hospital, by a trained healthcare professional.
• Treatment Schedule: The treatment schedule will vary depending on your specific treatment plan. Your healthcare provider will determine the frequency and duration of your Monjuvi infusions.
• Monitoring: While receiving Monjuvi, you will be closely monitored by your healthcare team for any potential side effects and to assess the effectiveness of the treatment.
• Follow-Up: It’s important to follow your healthcare provider’s instructions closely and attend all scheduled follow-up appointments to track your progress and make any necessary adjustments to your treatment plan.
• Side Effects: Like all medications, Monjuvi can have side effects. Common side effects may include fatigue, diarrhea, fever, and decreased white blood cell counts. Your healthcare provider will discuss potential side effects with you and how to manage them.

It’s essential to have open communication with your healthcare team about your treatment, any side effects you may experience, and any concerns or questions you may have. They can provide you with the most up-to-date and personalized information about Monjuvi and its use in your specific case.

Other uses for this medicine

Monjuvi (tafasitamab-cxix) is primarily approved for the treatment of diffuse large B-cell lymphoma (DLBCL) in combination with lenalidomide. It is not typically prescribed for other medical conditions unless specifically recommended by a healthcare provider as part of an off-label use, which should only occur after careful consideration of the potential risks and benefits.

What special precautions should I follow?

Special precautions to follow when using Monjuvi include:

• Medical Supervision: Monjuvi should only be administered under the supervision of a healthcare professional who is experienced in the treatment of lymphoma.
• Allergies: Inform your healthcare provider of any allergies or hypersensitivities you may have, especially if you have had an allergic reaction to Monjuvi or any of its components in the past.
• Pregnancy and Breastfeeding: Monjuvi can harm an unborn baby. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Monjuvi with your healthcare provider. It may not be recommended during pregnancy or breastfeeding.
• Infections: Monjuvi can lower your body’s ability to fight infections. Inform your healthcare provider if you have a history of infections or if you develop signs of infection while taking Monjuvi, such as fever, chills, cough, or sore throat.
• Blood Counts: Monjuvi can affect blood cell counts, particularly white blood cells. Your healthcare provider will monitor your blood counts regularly during treatment to check for any abnormalities. If your white blood cell count becomes too low, it may increase your risk of infection.
• Interactions: Inform your healthcare provider of all the medications, supplements, and herbal products you are currently taking, as they can interact with Monjuvi and affect its effectiveness or increase the risk of side effects.
• Side Effects: Be aware of potential side effects of Monjuvi, such as fatigue, diarrhea, fever, and decreased blood cell counts. Report any side effects to your healthcare provider promptly, as they can provide guidance on managing them.
• Follow-Up: Attend all scheduled follow-up appointments with your healthcare team to monitor your progress and adjust your treatment plan as needed.
• Driving and Operating Machinery: Monjuvi may cause dizziness or fatigue. If you experience these side effects, avoid activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.

It’s essential to have open and honest communication with your healthcare provider about your medical history, any medications you are taking, and any concerns or questions you may have about Monjuvi. They can provide personalized guidance and ensure your safety while undergoing treatment.

What special dietary instructions should I follow?

There are no specific dietary instructions that are typically associated with taking Monjuvi (tafasitamab-cxix). However, it’s essential to follow your healthcare provider’s guidance on any dietary restrictions or recommendations that may be related to your overall health or any other medications you are taking in combination with Monjuvi.

In general, maintaining a well-balanced and nutritious diet can support your overall health during cancer treatment. It’s important to stay hydrated and eat a variety of foods that provide essential nutrients to help your body cope with the effects of cancer and treatment.

What should I do if I forget a dose?

Regarding missed doses of Monjuvi:

• Timing: If you forget to take a dose of Monjuvi, it’s essential to contact your healthcare provider or nurse as soon as possible to discuss the situation and get guidance on how to proceed.
• Don’t Double Up: Do not take a double dose to make up for the missed one. Taking more medication than prescribed can increase the risk of side effects.
• Follow Instructions: Your healthcare provider will provide specific instructions on what to do if you miss a dose based on your treatment plan. They may adjust your schedule or provide further guidance on the next steps.

What side effects can this medication cause?

Monjuvi (tafasitamab-cxix) can cause a range of side effects, and it’s important to be aware of these potential adverse reactions. Not everyone will experience these side effects, and some individuals may experience them to a greater or lesser degree. Common side effects of Monjuvi may include:

• Fatigue: Feeling tired or weak is a common side effect of Monjuvi treatment.
• Diarrhea: Some people may experience diarrhea while taking Monjuvi.
• Fever: A fever is another possible side effect.
• Low Blood Cell Counts: Monjuvi can affect blood cell counts, particularly white blood cells. This can increase the risk of infections. Your healthcare provider will monitor your blood counts regularly during treatment.
• Infusion-Related Reactions: Infusion-related reactions such as fever, chills, nausea, headache, and low blood pressure can occur during or shortly after the infusion of Monjuvi. Healthcare providers typically take steps to manage and minimize these reactions.
• Nausea: Nausea, which may be mild to moderate, can occur as a side effect.
• Respiratory Tract Infections: Upper respiratory tract infections and other infections can occur more frequently when taking Monjuvi.
• Cough: Some individuals may develop a cough as a side effect.
• Skin Rash: Skin rashes and itching can occur in some cases.
• Low Platelet Counts: Monjuvi can lead to low platelet counts, which may result in increased bleeding or bruising.
• Low Red Blood Cell Counts: Anemia, characterized by low red blood cell counts, can occur as a side effect.
• Headache: Headaches are reported by some individuals taking Monjuvi.

It’s important to note that not all individuals will experience these side effects, and some people may experience side effects that are not listed here. Additionally, the severity of side effects can vary from person to person. Your healthcare provider will closely monitor your health during treatment and can provide guidance on managing and mitigating side effects. It’s crucial to report any side effects you experience promptly so that your healthcare team can provide appropriate care and make any necessary adjustments to your treatment plan.

What should I know about storage and disposal of this medication?

Storage:

• Storage Temperature: Monjuvi is typically provided by a healthcare facility and administered by healthcare professionals. It should be stored and handled by healthcare providers according to manufacturer recommendations. However, if you are given a supply to take home, follow your healthcare provider’s instructions regarding storage.
• Keep Out of Reach: Keep Monjuvi out of the reach of children and pets. It is a prescription medication meant for your treatment only.

Disposal:

• Unused Medication: Do not keep or use Monjuvi that is no longer needed or has expired. Ask your healthcare provider or pharmacist about proper disposal methods for unused medications.
• Dispose of Sharps Safely: If you are using needles or syringes as part of your treatment, follow your healthcare provider’s instructions on how to safely dispose of sharps containers.

In case of emergency/overdose

In the case of an emergency or suspected overdose, take the following steps:

• Seek Immediate Medical Attention: Contact your healthcare provider or go to the nearest emergency room or poison control center.
• Provide Information: Be prepared to provide information about the medication, including its name (Monjuvi), the dose taken, and the time of ingestion.
• Do Not Drive: If you or someone else has taken an overdose, do not attempt to drive to the hospital. Call for emergency medical assistance or have someone else take you.

What other information should I know

• Follow Healthcare Provider’s Guidance: Always follow your healthcare provider’s instructions regarding the use of Monjuvi. This includes the dosing schedule, infusion appointments, and any other specific guidance they provide.
• Communication: Maintain open and clear communication with your healthcare provider throughout your treatment. Inform them of any side effects, concerns, or questions you may have.
• Medication Records: Keep a record of your Monjuvi treatments, including dates and any side effects or symptoms you experience. This information can be helpful during discussions with your healthcare team.
• Medication Guide: Your healthcare provider and pharmacist may provide you with a medication guide that includes important information about Monjuvi. Review this guide carefully and keep it for reference.
• Regular Follow-Up: Attend all scheduled follow-up appointments with your healthcare provider. These appointments are essential for monitoring your progress and making any necessary adjustments to your treatment plan.

It’s crucial to prioritize your safety and the proper use of Monjuvi. If you have any questions or concerns about your medication, storage, disposal, or what to do in case of emergencies or overdose, consult your healthcare provider or pharmacist for guidance. They can provide you with personalized information and support.