WARNING

Mobocertinib is a medication used to treat certain types of non-small cell lung cancer (NSCLC) with specific genetic mutations, such as EGFR exon 20 insertion mutations. While it can be effective in managing the disease, like all medications, it carries some potential risks and side effects. Here is a brief overview of the risks associated with Mobocertinib:

• Gastrointestinal Issues: Some individuals may experience nausea, diarrhea, vomiting, or abdominal pain while taking Mobocertinib. These side effects should be reported to a healthcare provider.
• Skin Reactions: Skin rashes and other dermatological issues, such as itching or dry skin, may occur. Serious skin reactions are rare but can happen.
• Interactions with Other Medications: Mobocertinib can interact with other medications you may be taking, potentially affecting their effectiveness or increasing the risk of side effects. It’s important to inform your healthcare provider about all the medications you are using.
• Liver Problems: In some cases, Mobocertinib can lead to abnormal liver function test results. Regular monitoring of liver function is usually recommended during treatment.
• Interstitial Lung Disease (ILD): ILD is a rare but potentially serious side effect of Mobocertinib. Symptoms may include difficulty breathing, cough, or fever. It’s essential to report any respiratory symptoms to your healthcare provider promptly.
• Eye Problems: Some patients may experience eye problems, such as dry eyes or changes in vision. Regular eye exams may be recommended during treatment.
• Cardiovascular Effects: Mobocertinib can lead to QT interval prolongation, a heart rhythm disorder. Patients with a history of heart problems or those taking medications that affect heart rhythm should be closely monitored.
• Fertility and Pregnancy: Mobocertinib may harm a developing fetus. Patients should use effective contraception during treatment and avoid pregnancy. It’s crucial to discuss family planning with your healthcare provider.
• Allergic Reactions: While rare, severe allergic reactions can occur. Signs of an allergic reaction include difficulty breathing, hives, or swelling of the face, lips, tongue, or throat. Seek immediate medical attention if you experience these symptoms.

It’s essential to take Mobocertinib exactly as prescribed by your healthcare provider and to keep regular follow-up appointments for monitoring and managing potential side effects. Always communicate any new or unusual symptoms to your healthcare team, as early detection and management of side effects can be crucial for your overall well-being during treatment. Your healthcare provider will weigh the potential risks and benefits of Mobocertinib and consider your individual health circumstances when determining its suitability for your cancer treatment.

Why is this medication prescribed?

Mobocertinib is prescribed to treat specific types of non-small cell lung cancer (NSCLC) in patients who have a particular genetic mutation known as EGFR exon 20 insertion mutations. These mutations are responsible for driving the growth of cancer cells, and Mobocertinib is designed to target and inhibit these mutations, thereby slowing down or stopping the growth of the cancer cells. It is classified as a tyrosine kinase inhibitor (TKI) and is used as a targeted therapy for NSCLC with EGFR exon 20 insertion mutations.

How should this medicine be used?

Here are some key points on how Mobocertinib should be used:

• Prescription: Mobocertinib should only be prescribed by a qualified oncologist or healthcare provider who has determined that it is the appropriate treatment for a patient with NSCLC and EGFR exon 20 insertion mutations.
• Dosage: The dosage of Mobocertinib can vary depending on individual patient factors and the specific treatment plan developed by the healthcare provider. It is typically taken orally in the form of tablets.
• Administration: Mobocertinib tablets should be taken with or without food, as directed by the prescribing healthcare provider. It’s essential to follow the dosing instructions carefully.
• Duration of Treatment: The duration of treatment with Mobocertinib will depend on the patient’s response to the medication and the progression of the cancer. It may be used as long as it continues to be effective and well-tolerated.
• Regular Monitoring: Patients receiving Mobocertinib will undergo regular medical check-ups and monitoring to assess the medication’s effectiveness and to watch for any potential side effects or complications. This may include blood tests, imaging scans, and other assessments.
• Adherence: It’s crucial to take Mobocertinib exactly as prescribed by your healthcare provider. Missing doses or altering the dosage without medical guidance can affect the treatment’s effectiveness.
• Side Effects: Patients should be aware of possible side effects, including gastrointestinal issues, skin reactions, liver problems, eye problems, and more, as mentioned in the previous response. Report any side effects promptly to your healthcare team.
• Contraception: If you are of childbearing potential, it is important to use effective contraception during treatment with Mobocertinib, as it can harm a developing fetus. Discuss family planning with your healthcare provider.
• Interaction with Other Medications: Inform your healthcare provider about all the medications and supplements you are taking to avoid potential interactions that could affect the effectiveness or safety of Mobocertinib.
• Follow-Up Care: Patients should maintain regular follow-up appointments with their oncologist to discuss treatment progress and any changes in their condition.

Always consult with your healthcare provider for specific guidance on how to use Mobocertinib, as individual treatment plans can vary based on the patient’s overall health and the stage of their cancer. Adherence to the prescribed treatment plan and open communication with your healthcare team are essential for the best possible outcomes.

Other uses for this medicine

Mobocertinib is primarily prescribed for the treatment of non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations, as it specifically targets these mutations. It is considered a targeted therapy for this specific type of cancer, and its use outside of this context is limited. It is not typically used for other conditions or cancer types.

What special precautions should I follow?

Special precautions should be taken when using Mobocertinib, and it’s crucial to follow your healthcare provider’s guidance closely. Here are some important precautions to keep in mind:

• Prescription Only: Mobocertinib should only be prescribed by a qualified oncologist or healthcare provider who has determined that it is the appropriate treatment for your specific type of NSCLC with EGFR exon 20 insertion mutations.
• Pregnancy and Contraception: Mobocertinib may harm a developing fetus, so it’s essential to use effective contraception during treatment if you are of childbearing potential. Discuss family planning with your healthcare provider.
• Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking. Some medications can interact with Mobocertinib, potentially affecting its effectiveness or safety.
• Liver Function: Mobocertinib can affect liver function, and your healthcare provider may monitor your liver with regular blood tests during treatment. Inform your provider of any pre-existing liver conditions.
• Cardiovascular Health: Mobocertinib can lead to QT interval prolongation, a heart rhythm disorder. If you have a history of heart problems or are taking medications that affect heart rhythm, discuss this with your healthcare provider. They may monitor your heart health during treatment.
• Eye Health: Some patients may experience eye problems while taking Mobocertinib. Regular eye exams may be recommended, so inform your healthcare provider of any changes in your vision or eye discomfort.
• Allergic Reactions: Although rare, severe allergic reactions can occur. Be aware of signs of an allergic reaction, such as difficulty breathing, hives, or swelling of the face, lips, tongue, or throat. Seek immediate medical attention if these symptoms occur.
• Regular Follow-Up: Maintain regular follow-up appointments with your oncologist to discuss your treatment progress, any side effects you may be experiencing, and any changes in your condition.
• Adherence: Take Mobocertinib exactly as prescribed by your healthcare provider. Missing doses or altering the dosage without medical guidance can affect the treatment’s effectiveness.
• Side Effects: Be aware of potential side effects, which can include gastrointestinal issues, skin reactions, and more. Promptly report any side effects to your healthcare team.
• Patient Assistance Programs: If you have concerns about the cost of Mobocertinib or accessing the medication, ask your healthcare provider about patient assistance programs or resources that may be available to help.

Always consult with your healthcare provider for specific precautions and recommendations based on your individual health and treatment plan. Open communication and collaboration with your healthcare team are essential for managing your condition effectively and safely while using Mobocertinib.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Mobocertinib. However, it’s essential to take the medication as prescribed by your healthcare provider and follow any instructions they provide regarding food and medication interactions.

What should I do if I forget a dose?

If you forget to take a dose of Mobocertinib, here’s what you should do:

• Take it as soon as you remember: If you remember within a few hours of the scheduled dose, take it right away. If it’s close to the time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Don’t double up: Do not take two doses at the same time to make up for the missed dose. Taking extra medication can increase the risk of side effects without providing any additional benefits.
• Notify your healthcare provider: It’s a good practice to inform your healthcare provider about the missed dose during your next appointment or contact them for guidance on what to do.

What side effects can this medication cause?

Mobocertinib is a medication used in the treatment of certain types of non-small cell lung cancer (NSCLC) that have specific genetic mutations, such as EGFR exon 20 insertion mutations. Like all medications, Mobocertinib can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. Common side effects of Mobocertinib may include:

• Diarrhea
• Rash or skin problems
• Nausea
• Vomiting
• Fatigue
• Abdominal pain
• Decreased appetite
• Dry skin
• Mouth sores
• Cough

It’s important to promptly report any side effects you experience to your healthcare provider, as they can provide guidance on managing these side effects and may adjust your treatment plan if necessary. Additionally, Mobocertinib can cause more serious side effects, including:

• Interstitial lung disease (ILD): ILD is a serious lung condition that can lead to symptoms such as shortness of breath, cough, and difficulty breathing. If you experience any of these symptoms, you should contact your healthcare provider immediately.
• Liver problems: Mobocertinib can affect liver function, leading to symptoms like yellowing of the skin or eyes (jaundice), dark urine, and abdominal pain. These could be signs of liver problems and should be reported to your healthcare provider.
• Gastrointestinal perforation: Although rare, Mobocertinib can increase the risk of gastrointestinal perforation, which is a hole or tear in the stomach or intestine. Symptoms may include severe abdominal pain, fever, and vomiting. Seek medical attention if you experience these symptoms.
• High blood pressure (hypertension): Your healthcare provider will monitor your blood pressure regularly during treatment with Mobocertinib. If you develop high blood pressure, they may prescribe medication to manage it.
• Heart problems: Mobocertinib may lead to heart-related issues, including QT interval prolongation, which can cause irregular heartbeats. Your healthcare provider will monitor your heart function during treatment.
• Blood disorders: Mobocertinib may cause changes in blood cell counts, leading to conditions such as anemia, neutropenia (low white blood cell count), or thrombocytopenia (low platelet count).
• Eye problems: Some patients may experience eye problems, including dry eyes or blurred vision, while taking Mobocertinib.

It’s essential to communicate openly with your healthcare provider about any side effects or concerns you may have while taking Mobocertinib. They can provide guidance on managing side effects and make adjustments to your treatment plan if needed. Additionally, it’s crucial to follow your healthcare provider’s instructions and attend regular check-ups to monitor for any potential side effects or complications.

What should I know about storage and disposal of this medication?

Storage:

• Keep in its original container: Store Mobocertinib tablets in their original container to protect them from light and moisture.
• Room temperature: Store Mobocertinib at room temperature, typically between 20°C to 25°C (68°F to 77°F).
• Keep out of reach of children and pets: Ensure that the medication is stored in a place inaccessible to children and pets.
• Do not share: Mobocertinib is prescribed for your specific medical condition and should not be shared with others.

Disposal:

• Follow healthcare provider’s instructions: Dispose of any unused or expired Mobocertinib tablets according to your healthcare provider’s recommendations or local guidelines.
• Community disposal programs: Some areas have programs or facilities for the safe disposal of medications. Check with your local pharmacy or healthcare provider for information on such programs.

In case of emergency/overdose

In case of an emergency or suspected overdose of Mobocertinib, you should:

• Seek immediate medical attention: Call 911 or go to the nearest emergency room for immediate medical assistance.
• Inform healthcare provider: Notify your healthcare provider as soon as possible to report the overdose and receive guidance on managing any potential side effects or complications.

What other information should I know

• Regular follow-up: Continue to attend regular follow-up appointments with your oncologist or healthcare provider. They will monitor your progress, assess the effectiveness of Mobocertinib, and manage any side effects or concerns.
• Medication interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions with Mobocertinib.
• Patient assistance programs: If you have concerns about the cost of Mobocertinib or accessing the medication, ask your healthcare provider about patient assistance programs or resources that may be available to help.
• Patient education: Stay informed about your treatment plan, potential side effects, and any changes in your condition. Ask your healthcare provider for educational materials or resources to help you better understand your treatment.
• Supportive care: Consider seeking support from patient advocacy groups, counseling services, or support networks to help you cope with the emotional and practical aspects of your cancer diagnosis and treatment.

Always follow your healthcare provider’s guidance and recommendations regarding Mobocertinib and your overall cancer treatment plan. Open communication with your healthcare team is crucial for the safe and effective management of your condition.