Why is this medication prescribed?

Mirabegron is a medication that is prescribed to treat certain bladder conditions, primarily overactive bladder (OAB). Overactive bladder is a medical condition characterized by frequent and sudden urges to urinate, often accompanied by urinary incontinence (involuntary loss of urine). Mirabegron is classified as a beta-3 adrenergic agonist and works by relaxing the bladder muscles, which helps to reduce the frequency and urgency of urination.

How should this medicine be used?

Here are some general guidelines on how Mirabegron should be used:

• Dosage: The recommended dose of Mirabegron may vary depending on your specific medical condition and your healthcare provider’s instructions. Typically, the starting dose is 25 milligrams (mg) once daily, which can be increased to 50 mg once daily if necessary.
• Timing: Mirabegron can be taken with or without food, but it’s essential to take it at the same time each day to help you remember and maintain consistent blood levels of the medication.
• Swallowing: Mirabegron tablets should be swallowed whole and should not be crushed, broken, or chewed.
• Follow your doctor’s instructions: It’s crucial to follow your healthcare provider’s instructions regarding the dosage and duration of Mirabegron treatment. Do not change the dose or stop taking the medication without consulting your healthcare provider.
• Monitoring: Your doctor may monitor your response to Mirabegron and make adjustments to your treatment plan as necessary.
• Adherence: Be sure to take Mirabegron as prescribed. If you miss a dose, take it as soon as you remember, but skip it if it’s close to your next scheduled dose. Do not take a double dose to make up for a missed one.
• Side effects: Like all medications, Mirabegron may have side effects. Common side effects can include increased blood pressure, headache, constipation, and urinary tract infection. If you experience any unusual or severe side effects, contact your healthcare provider.
• Precautions: Inform your doctor about any other medications, supplements, or medical conditions you have, as Mirabegron may interact with other drugs and may not be suitable for everyone. Additionally, it’s important to let your healthcare provider know if you are pregnant, planning to become pregnant, or breastfeeding.

Remember that Mirabegron should only be used under the guidance of a healthcare professional who can assess your specific condition and determine the most appropriate treatment plan for you. This information is provided as a general overview and should not replace the advice and instructions provided by your healthcare provider.

Other uses for this medicine

While Mirabegron is primarily indicated for treating overactive bladder, it may have off-label uses or be under investigation for other conditions. Some potential other uses include:

• Interstitial Cystitis/Bladder Pain Syndrome: Mirabegron may be considered for individuals with interstitial cystitis or bladder pain syndrome who have not responded to other treatments.
• Neurogenic Bladder: In some cases, it may be used in individuals with neurogenic bladder dysfunction, which can occur due to conditions like spinal cord injury or multiple sclerosis.
• Chronic Pelvic Pain: There is some research exploring the use of Mirabegron for the management of chronic pelvic pain, especially in women.

What special precautions should I follow?

As for special precautions when using Mirabegron, here are some important considerations:

• Allergies: Inform your healthcare provider if you are allergic to Mirabegron or any of its components.
• Medical History: Provide your doctor with a complete medical history, including any heart problems (e.g., arrhythmias, heart failure), liver or kidney disease, high blood pressure, or other medical conditions.
• Medications: Let your healthcare provider know about all the medications, supplements, and herbal products you are currently taking, as Mirabegron can interact with certain drugs.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using Mirabegron with your doctor. The safety of Mirabegron during pregnancy and breastfeeding is not well established.
• Blood Pressure: Mirabegron may increase blood pressure in some individuals. Your doctor may monitor your blood pressure regularly during treatment.
• Liver and Kidney Function: Mirabegron is metabolized by the liver and excreted by the kidneys. If you have impaired liver or kidney function, your doctor may need to adjust the dosage or monitor you more closely.
• Alcohol: Limit alcohol consumption while taking Mirabegron, as alcohol can increase the risk of certain side effects, such as dizziness or drowsiness.

Always follow your healthcare provider’s instructions and guidance regarding the use of Mirabegron. They can provide you with specific recommendations based on your medical history and needs, and they will monitor your progress while on the medication to ensure its safety and effectiveness.

What special dietary instructions should I follow?

Special Dietary Instructions:

• There are typically no specific dietary restrictions associated with Mirabegron. However, it’s essential to maintain a balanced diet and stay hydrated, as adequate hydration is essential for managing bladder issues.
• If you have any concerns about potential interactions between Mirabegron and specific foods or supplements, consult your healthcare provider or pharmacist.

What should I do if I forget a dose?

If you forget to take a dose of calcium carbonate:

• If you forget to take a dose of Mirabegron, take it as soon as you remember, unless it’s close to the time for your next scheduled dose.
• If it’s near the time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Do not double the dose to make up for a missed one, as this can increase the risk of side effects

What side effects can this medication cause?

Mirabegron, like all medications, can cause side effects in some individuals. Not everyone will experience these side effects, and the severity and frequency of side effects can vary from person to person. Common side effects of Mirabegron may include:

• Increased Blood Pressure: One of the most common side effects of Mirabegron is an increase in blood pressure. Your doctor may monitor your blood pressure regularly while you are taking this medication.
• Headache: Some people may experience headaches while taking Mirabegron.
• Urinary Tract Infections (UTIs): UTIs, including symptoms like pain or a burning sensation during urination, increased frequency of urination, and cloudy or bloody urine, may occur.
• Constipation: Mirabegron can slow down the movement of the digestive system, leading to constipation in some individuals.
• Nasopharyngitis: This term refers to inflammation or irritation of the nose and throat, which may cause symptoms like a runny or stuffy nose, sore throat, and sneezing.
• Dizziness: Some people may experience dizziness, especially when changing positions quickly.
• Bladder Pain: Rarely, Mirabegron can cause bladder pain or discomfort.
• Back Pain: Back pain may occur as a side effect in some individuals.
• Nausea: Nausea, or a feeling of queasiness in the stomach, can occur in some cases.
• Diarrhea: While less common, diarrhea has been reported as a side effect.
• Fatigue: Some people may feel more tired than usual when taking Mirabegron.
• Rash: Skin rash or itching is a rare side effect.

It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed here. If you notice any unusual or severe side effects while taking Mirabegron, it’s essential to contact your healthcare provider promptly. They can evaluate your symptoms, provide guidance, and determine whether any adjustments to your treatment plan are necessary.

Additionally, if you have a history of heart problems, including arrhythmias or high blood pressure, or if you are taking other medications that can affect blood pressure, your healthcare provider will carefully consider the risks and benefits of using Mirabegron and monitor your condition accordingly. Always follow your doctor’s instructions and communicate any concerns or changes in your health while taking this medication.

What should I know about storage and disposal of this medication?

Storage:

• Store Mirabegron in its original container or packaging.
• Keep the medication out of reach of children and pets.
• Store Mirabegron at room temperature, away from excessive heat and moisture. Avoid storing it in the bathroom, as moisture can degrade the medication.

Disposal:

• Do not keep expired or unused Mirabegron tablets. Follow your healthcare provider’s instructions or local regulations for proper disposal.
• Do not flush Mirabegron down the toilet or pour it down the drain unless specifically instructed to do so. This is typically not recommended to prevent environmental contamination.
• Many communities offer medication take-back programs or designated drop-off locations for safe disposal of unused medications. Check with your local pharmacy or law enforcement agency to find a disposal program near you.

In case of emergency/overdose

If you suspect an overdose or experience severe side effects after taking Mirabegron, seek immediate medical attention or contact your local poison control center at 1-800-222-1222 (in the United States). Symptoms of an overdose may include:

• Severe dizziness
• Fainting
• Rapid or irregular heartbeat
• High blood pressure
• Difficulty breathing
• Seizures
• Nausea and vomiting

What other information should I know

• Keep all of your healthcare appointments to monitor your progress while taking Mirabegron.
• Inform your healthcare provider about all medications, supplements, and herbal products you are taking to check for potential drug interactions.
• If you experience any new or unusual symptoms while taking Mirabegron, report them to your healthcare provider promptly.
• Mirabegron is prescribed to you based on your specific medical condition and needs. Do not share this medication with others, even if they have similar symptoms.
• Do not change your dosage or stop taking Mirabegron without consulting your healthcare provider, as it may affect the effectiveness of your treatment.

Always follow your healthcare provider’s instructions regarding the use, storage, and disposal of Mirabegron. If you have any questions or concerns about your medication, don’t hesitate to discuss them with your healthcare provider or pharmacist for clarification and guidance.