Why is this medication prescribed?

Mesalamine is a medication primarily prescribed to treat inflammatory bowel diseases (IBD), specifically ulcerative colitis and Crohn’s disease. It belongs to a class of drugs called aminosalicylates, which have anti-inflammatory properties and work to reduce the inflammation in the lining of the gastrointestinal tract. Here’s why Mesalamine is prescribed:

• Ulcerative Colitis: Mesalamine is commonly used to treat mild to moderate cases of ulcerative colitis. It helps to reduce symptoms such as diarrhea, abdominal pain, and rectal bleeding. In some cases, it may also be used to maintain remission and prevent flare-ups in people with this condition.
• Crohn’s Disease: Mesalamine is sometimes used in the treatment of mild to moderate Crohn’s disease, particularly when the inflammation is limited to the colon or lower parts of the small intestine (ileum). It may help alleviate symptoms and maintain remission.

How should this medicine be used?

The usage of Mesalamine can vary depending on the specific product (e.g., oral tablets, capsules, suppositories, enemas) and the individual’s medical condition. Therefore, it’s crucial to follow your doctor’s instructions and the information provided on the medication label. Here are some general guidelines for how Mesalamine is typically used:

Oral Tablets/Capsules:

• Dosage: Take Mesalamine orally as directed by your healthcare provider. The dosage and frequency will depend on the severity of your condition, and it may be taken once or multiple times a day.
• Take with or without food: Mesalamine can be taken with or without food, but some people find that taking it with food can help reduce stomach upset. Follow your doctor’s recommendations regarding food.
• Swallow whole: Swallow the tablets or capsules whole with a full glass of water. Do not crush, chew, or break them unless your doctor instructs you otherwise.
• Consistency: Try to take Mesalamine at the same times each day to maintain a consistent level of the medication in your system.

General Tips:

• Continue Treatment: It’s crucial to continue taking Mesalamine as prescribed by your healthcare provider, even if you start to feel better. Stopping the medication prematurely could lead to a relapse of symptoms.
• Regular Monitoring: While using Mesalamine, you may need to undergo regular check-ups with your healthcare provider. They will assess the effectiveness of the medication and monitor for any potential side effects or changes in your condition.
• Other Medications: If you are taking other medications for your inflammatory bowel disease or other conditions, discuss the timing and potential interactions with your healthcare provider.
• Patient Information Leaflet: Read and keep the patient information leaflet that comes with your medication. It provides essential information about the medication’s uses, potential side effects, and safety considerations.

Always consult with your healthcare provider if you have any questions or concerns about how to use Mesalamine or if you experience any side effects. They can provide you with personalized guidance based on your specific medical condition and needs.

Other uses for this medicine

While Mesalamine is primarily used to treat inflammatory bowel diseases like ulcerative colitis and Crohn’s disease, it may also have off-label uses. These uses are less common and should only be pursued under the guidance of a healthcare professional. Some potential off-label uses include:

• Treating diverticulitis
• Managing pouchitis (inflammation of an ileal pouch after ileal pouch-anal anastomosis surgery)
• Preventing colorectal cancer in certain high-risk individuals

What special precautions should I follow?

Special precautions to consider when using Mesalamine include:

• Allergies: Inform your healthcare provider if you are allergic to Mesalamine or any other medications, as this can affect your suitability for treatment.
• Kidney Function: Mesalamine can affect kidney function, so if you have a history of kidney problems, your doctor may need to adjust the dose or monitor your kidney function regularly during treatment.
• Liver Function: Liver problems have been reported in some individuals taking Mesalamine. Regular liver function tests may be necessary if you have a history of liver disease or experience symptoms like jaundice (yellowing of the skin or eyes).
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Mesalamine with your healthcare provider. The safety of Mesalamine during pregnancy and breastfeeding is not fully established, and the decision to use it should be made with careful consideration of the potential risks and benefits.
• Interactions: Inform your healthcare provider of all the medications, supplements, and herbal products you are taking, as Mesalamine may interact with other drugs. Some interactions can affect the effectiveness or safety of Mesalamine.
• Side Effects: Be aware of potential side effects of Mesalamine, which may include headache, nausea, diarrhea, and abdominal pain. If you experience severe side effects, contact your healthcare provider promptly.
• Monitoring: Regular monitoring by your healthcare provider is crucial while taking Mesalamine to assess the effectiveness of the treatment and manage any potential side effects.

Always follow your doctor’s instructions and discuss any concerns or questions you may have about Mesalamine. This medication should only be used under the guidance and supervision of a qualified healthcare professional, and its use should be tailored to your specific medical condition and needs.

What special dietary instructions should I follow?

• Mesalamine is generally taken with or without food, depending on the specific formulation prescribed. Follow your doctor’s instructions on whether to take it with meals or on an empty stomach.
• It’s important to maintain a well-balanced and nutritious diet when managing inflammatory bowel disease. Avoid trigger foods that worsen your symptoms, and consider working with a registered dietitian to create a diet plan that suits your needs.
• Stay well-hydrated, as diarrhea and frequent bowel movements can lead to dehydration. Drink plenty of water throughout the day.

What should I do if I forget a dose?

As for what to do if you forget a dose of Mesalamine:

• If you miss a dose: Take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and return to your regular dosing schedule.
• Do not double up: Do not take two doses at the same time to make up for a missed dose. Taking extra doses can increase the risk of side effects without providing additional benefit.
• Consult your healthcare provider: If you frequently forget doses or have concerns about your dosing schedule, talk to your doctor. They can provide guidance on how to manage missed doses and may consider alternative dosing strategies if necessary.

What side effects can this medication cause?

Mesalamine, like any medication, can cause side effects in some individuals. It’s essential to be aware of potential side effects and report them to your healthcare provider if they occur. Common side effects of Mesalamine may include:

• Headache: Headaches are a relatively common side effect of Mesalamine.
• Nausea and Vomiting: Some people may experience nausea or vomiting when taking Mesalamine.
• Abdominal Pain or Cramps: Abdominal discomfort, cramps, or pain can occur.
• Diarrhea: Ironically, one of the symptoms Mesalamine is used to treat (diarrhea in inflammatory bowel diseases) can also be a side effect in some individuals.
• Flatulence (Gas): Increased gas production can occur as a side effect.
• Joint Pain: Some individuals may experience joint pain.
• Skin Rash: Skin rashes or itching are possible side effects, although they are less common.
• Hair Loss: Hair loss has been reported in some cases.
• Dizziness: Dizziness can occur in some individuals taking Mesalamine.
• Elevated Liver Enzymes: In rare cases, Mesalamine can cause abnormal liver function test results.
• Kidney Function Changes: Mesalamine can affect kidney function, which may lead to elevated levels of creatinine or other markers of kidney function in some individuals.

It’s important to note that not everyone will experience these side effects, and some people may experience different or more severe reactions. Additionally, many individuals tolerate Mesalamine well with minimal side effects.

If you experience any severe or persistent side effects, it’s crucial to contact your healthcare provider promptly. They can assess your condition, adjust your treatment if necessary, or provide guidance on managing side effects. In some cases, your doctor may need to consider alternative medications or treatment approaches if side effects are severe or intolerable.

It’s also essential to inform your healthcare provider of any pre-existing medical conditions or medications you are taking, as these factors can influence the likelihood and severity of side effects when using Mesalamine. Your doctor will weigh the benefits of treatment against the potential risks and make recommendations based on your individual health profile.

What should I know about storage and disposal of this medication?

Storage:

• Store as Directed: Follow the storage instructions provided on the medication label or as given by your healthcare provider. Typically, Mesalamine should be stored at room temperature, away from moisture and direct sunlight.
• Keep Out of Reach: Ensure that Mesalamine is stored in a location that is out of the reach of children and pets. Accidental ingestion can be dangerous.
• Proper Container: Keep the medication in its original container, tightly closed, to protect it from air and moisture.

Disposal:

• Dispose of Unused Medication: Do not keep or use Mesalamine beyond its expiration date. If you have unused or expired medication, follow your local regulations for safe disposal.
• Dispose Safely: Do not flush Mesalamine tablets down the toilet or pour them down the drain unless instructed to do so by your healthcare provider or the medication’s label. Instead, check with your local pharmacy or healthcare facility for safe medication disposal options, such as medication take-back programs.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms while taking Mesalamine, seek immediate medical attention or contact your local poison control center. Overdose symptoms can include:

• Severe stomach pain
• Vomiting
• Diarrhea
• Rapid heart rate
• Confusion
• Unconsciousness

What other information should I know

• Regular Monitoring: While taking Mesalamine, you may need to undergo regular check-ups with your healthcare provider. They will assess the effectiveness of the medication and monitor for any potential side effects or changes in your condition.
• Keep Appointments: Attend all scheduled appointments with your doctor. These appointments are essential for tracking your progress and making any necessary adjustments to your treatment plan.
• Inform Your Healthcare Provider: Always inform your healthcare provider of any new medications, supplements, or herbal products you plan to take while on Mesalamine, as there can be potential interactions.
• Follow Instructions: Adhere to your doctor’s instructions regarding the dosage and timing of Mesalamine. Do not alter your dose or discontinue the medication without consulting your healthcare provider.
• Patient Information: Read and keep the patient information leaflet that comes with your medication. It provides essential information about the medication’s uses, potential side effects, and safety considerations.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Mesalamine with your healthcare provider, as the risks and benefits should be carefully evaluated.

Always consult with your healthcare provider if you have any questions or concerns about the use, storage, disposal, or any other aspect of your Mesalamine medication. They can provide you with personalized guidance and address any specific concerns related to your medical condition.