Why is this medication prescribed?

Mayzent (siponimod) is a prescription medication used to treat relapsing forms of multiple sclerosis (MS) in adults. Multiple sclerosis is a chronic autoimmune disease that affects the central nervous system, leading to various neurological symptoms and disability. Mayzent helps reduce the frequency of relapses and delay the progression of physical disability associated with MS.

How should this medicine be used?

Here are some key points about how Mayzent is prescribed and used:

• Prescription: Mayzent is available by prescription only and should be prescribed by a healthcare provider experienced in the treatment of multiple sclerosis.
• Indication: Mayzent is specifically indicated for adults with relapsing forms of MS, including clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), and active secondary progressive MS (SPMS). It is not intended for the treatment of primary progressive MS.
• Dosage: The recommended starting dose of Mayzent is typically taken orally as a 2-milligram (mg) tablet once daily. Your healthcare provider may adjust the dose based on your individual response and tolerability.
• Titration: To minimize the risk of side effects, Mayzent is often initiated with a titration regimen. This means that you may start with a lower dose and gradually increase it over several days or weeks until you reach the target maintenance dose.
• Monitoring: While taking Mayzent, your healthcare provider will likely monitor your condition regularly. This may include assessing your neurological function and conducting blood tests to check for potential side effects, such as changes in liver function or a decrease in certain white blood cell counts.
• Adherence: It’s crucial to take Mayzent as prescribed by your healthcare provider. Missing doses or discontinuing the medication without medical guidance may reduce its effectiveness.
• Side Effects: Mayzent may cause various side effects, and some can be serious. Common side effects may include headache, high blood pressure, and an increased risk of infections. Less common but more serious side effects may include macular edema (a vision problem), liver problems, and a decrease in white blood cell counts. Your healthcare provider will discuss the risks and benefits of Mayzent with you.
• Contraindications: Mayzent is contraindicated in individuals with certain medical conditions, such as recent heart attack or stroke, certain types of heart problems, and severe liver disease. Your healthcare provider will assess your medical history before prescribing Mayzent.
• Pregnancy and Contraception: Mayzent may harm an unborn baby, so it’s important for women of childbearing potential to use effective contraception during treatment and for at least 10 days after stopping the medication.

Always follow your healthcare provider’s instructions and guidance regarding the use of Mayzent. If you have questions or concerns about this medication, discuss them with your healthcare provider to ensure safe and effective treatment for your multiple sclerosis.

Other uses for this medicine

Mayzent is primarily approved for the treatment of relapsing forms of multiple sclerosis. It is not typically used for other medical conditions unless specifically prescribed by a healthcare provider for an off-label use, which should be based on a careful evaluation of the potential benefits and risks.

What special precautions should I follow?

Regarding special precautions for Mayzent, here are some important considerations:

• Medical History: Before starting Mayzent, inform your healthcare provider of your complete medical history, including any preexisting conditions, allergies, or medications you are currently taking.
• Contraindications: Mayzent is contraindicated in individuals with certain medical conditions, such as recent heart attack or stroke, certain types of heart problems, and severe liver disease. Your healthcare provider will assess your eligibility for Mayzent based on your medical history.
• Infections: Mayzent can increase the risk of infections, including serious ones. Inform your healthcare provider if you develop any signs of infection, such as fever, sore throat, or persistent cough, while taking the medication.
• Liver Function: Mayzent may affect liver function. Regular liver function tests may be conducted while you are on Mayzent. Inform your healthcare provider if you have a history of liver problems.
• Macular Edema: Mayzent may cause macular edema, a condition that affects the eye and can lead to vision problems. You may undergo eye exams before starting Mayzent and during treatment. Report any changes in vision to your healthcare provider.
• Cardiovascular Effects: Mayzent can affect heart rate and blood pressure. Your healthcare provider may monitor these parameters and may advise against using Mayzent if you have certain heart conditions.
• Pregnancy and Contraception: Mayzent may harm an unborn baby. Women of childbearing potential should use effective contraception during treatment and for at least 10 days after stopping Mayzent.
• Vaccinations: It is generally recommended to be up to date with vaccinations before starting Mayzent, as some vaccines may be less effective while on this medication.
• Driving and Activities: Mayzent may cause dizziness or blurred vision. Be cautious when engaging in activities that require alertness, such as driving, until you are confident about how the medication affects you.

Always follow your healthcare provider’s instructions and advice when taking Mayzent. They will carefully evaluate your medical history and monitor your progress to ensure your safety while using this medication. If you have specific concerns or questions about Mayzent or its potential side effects, discuss them with your healthcare provider.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Mayzent. However, it’s essential to maintain a balanced and healthy diet to support your overall well-being while managing your MS. Speak with a registered dietitian or nutritionist for personalized dietary guidance if needed.

What should I do if I forget a dose?

If you forget to take your Mayzent dose at the scheduled time, follow these steps:

• Take It As Soon As You Remember: If it’s within 24 hours of the missed dose, take it as soon as you remember. You can take it with or without food.
• If More Than 24 Hours Have Passed: If it’s been more than 24 hours since you missed the dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for the missed one.
• Notify Your Healthcare Provider: It’s essential to inform your healthcare provider about the missed dose and follow their guidance.

What side effects can this medication cause?

Mayzent (siponimod) can cause a range of side effects, some of which can be common, while others may be less common but more serious. It’s important to be aware of potential side effects and discuss them with your healthcare provider before starting the medication. Not everyone will experience these side effects, and some individuals may tolerate Mayzent well. Common side effects of Mayzent may include:

• Headache: Headaches are a common side effect and can occur when you start taking Mayzent.
• High Blood Pressure: Mayzent can increase blood pressure. Your healthcare provider will monitor your blood pressure and may adjust your treatment as needed.
• Upper Respiratory Infections: Infections of the upper respiratory tract, such as the common cold or sinusitis, are common side effects.
• Increased Risk of Infections: Mayzent can suppress the immune system, increasing the risk of infections. You should promptly report any signs of infection to your healthcare provider, such as fever, sore throat, or persistent cough.
• Liver Function Changes: Mayzent may affect liver function. Regular liver function tests may be performed to monitor for any abnormalities.
• Edema (Swelling): Swelling in the extremities, such as the ankles or feet, can occur while taking Mayzent.
• Dizziness: Some individuals may experience dizziness or lightheadedness when taking Mayzent.
• Blurred Vision: Mayzent may cause blurred vision. It’s important to report any changes in vision to your healthcare provider.
• Difficulty Sleeping (Insomnia): Trouble sleeping can be a side effect of Mayzent for some individuals.
• Back Pain: Back pain is another potential side effect that may occur.
• Abnormal Liver Enzymes: Mayzent can lead to elevated levels of certain liver enzymes, which may indicate liver function changes.

While the above side effects are relatively common, Mayzent also has some less common but more serious side effects. These include:

• Bradyarrhythmia: Mayzent can slow down the heart rate, leading to bradyarrhythmia (slow heart rhythms). This can be serious, especially in individuals with a history of heart problems.
• Macular Edema: Mayzent may cause macular edema, which affects the central part of the retina and can lead to vision problems.
• Respiratory Effects: In rare cases, Mayzent can lead to a decrease in lung function, which may cause shortness of breath.
• Increased Blood Pressure: Mayzent can significantly increase blood pressure in some individuals, which may require treatment.
• Infections: While infections are common side effects, some infections may be serious. Be vigilant about reporting any signs of infection to your healthcare provider.

It’s crucial to discuss potential side effects with your healthcare provider before starting Mayzent, and you should inform them promptly if you experience any unusual or severe symptoms while taking the medication. Your healthcare provider will monitor your health and adjust your treatment plan as necessary to manage side effects and ensure your safety.

What should I know about storage and disposal of this medication?

Storage and Disposal of Mayzent:

Storage:

• Store as Directed: Follow the storage instructions provided with your Mayzent medication. Typically, it should be stored at room temperature, away from moisture and heat.
• Keep Out of Reach of Children and Pets: Store Mayzent in a secure location where it cannot be accessed by children or pets.
• Original Container: Keep the medication in its original container with the label intact. This helps ensure you are taking the correct medication.
• Protect from Light: Some medications are sensitive to light. Check the labeling to see if Mayzent should be protected from light, and store it accordingly.

Disposal:

• Do not flush Mayzent down the toilet or pour it down the drain unless instructed to do so.
• Ask your pharmacist or healthcare provider about the proper disposal method for unused or expired medication. They may recommend using a medication take-back program or a designated disposal container.
• Follow any specific disposal instructions provided with your Mayzent medication.

In case of emergency/overdose

In case of emergency or overdose, take the following steps:

• Seek Medical Attention: If you suspect an overdose or experience severe side effects, contact emergency medical services or go to the nearest emergency room immediately.
• Provide Information: Be prepared to provide information about the medication, including its name (Mayzent), the dose you took, and the time of ingestion.
• Do Not Wait: Do not delay seeking medical help if you suspect an overdose, as prompt medical attention is crucial.

What other information should I know

• Follow Your Healthcare Provider’s Instructions: Always take Mayzent exactly as prescribed by your healthcare provider. Do not alter the dose or stop taking the medication without their guidance.
• Regular Monitoring: Your healthcare provider will likely schedule regular check-ups and tests to monitor your response to Mayzent and any potential side effects.
• Interactions: Inform your healthcare provider of all medications, supplements, and herbal products you are taking, as they can interact with Mayzent.
• Pregnancy and Contraception: If you are of childbearing potential, discuss effective contraception methods with your healthcare provider, as Mayzent can harm an unborn baby.
• Medical Alert Card: Your healthcare provider may provide you with a medical alert card that contains essential information about your treatment. Carry this card with you in case of emergencies.
• Patient Education: Educate yourself about Mayzent and its potential side effects. Ask your healthcare provider any questions you may have about the medication.
• Communication: Maintain open communication with your healthcare provider about your MS symptoms and any concerns or changes in your health.

Remember that this information is provided as a general guideline, and specific instructions may vary depending on your individual circumstances and the recommendations of your healthcare provider. Always consult with your healthcare provider for personalized guidance on the use, storage, and disposal of Mayzent.