Why is this medication prescribed?

Kynamro (mipomersen) is used for the treatment of a specific rare genetic disorder called homozygous familial hypercholesterolemia (HoFH). HoFH is a condition characterized by extremely high levels of low-density lipoprotein cholesterol (LDL-C), commonly known as “bad” cholesterol, which can lead to premature cardiovascular disease.

Kynamro is prescribed as an adjunct to lipid-lowering medications and diet in patients with HoFH who have not responded adequately to other treatments. It works by inhibiting the production of apolipoprotein B-100, a protein necessary for the formation of LDL-C particles.

How should this medicine be used?

Kynamro is administered as a subcutaneous injection, which means it is injected under the skin. The medication should only be prescribed by a healthcare professional who has experience in the management of HoFH.

Here are some general guidelines for using Kynamro:

• Administration: Kynamro is usually injected once a week. It is important to follow the specific instructions provided by your healthcare provider regarding the injection technique, the dose, and the injection site.
• Injection site: Kynamro is injected into the fatty tissue just under the skin, typically in the abdomen or thigh. Rotate the injection sites to help prevent injection site reactions.
• Compliance: It is crucial to adhere to the prescribed dosing schedule and not miss any doses. If you forget to take a dose, contact your healthcare provider for guidance.
• Monitoring: Your healthcare provider will closely monitor your cholesterol levels and liver function while you are taking Kynamro. Regular blood tests will be conducted to assess the effectiveness of the medication and to monitor for any potential side effects.
• Dietary changes: Kynamro is usually used in combination with other cholesterol-lowering therapies and lifestyle modifications, such as a low-fat diet. Follow your healthcare provider’s recommendations regarding dietary changes and other lifestyle adjustments.
• Side effects: Kynamro may cause side effects, including injection site reactions, flu-like symptoms, liver problems, and a potential risk of liver toxicity. It is essential to promptly report any unusual symptoms or side effects to your healthcare provider.

Remember, these are general guidelines, and individual instructions may vary. Always consult with your healthcare provider for specific dosing instructions and any concerns you may have about using Kynamro.

Other uses for this medicine

Kynamro (mipomersen sodium) is primarily used for the treatment of homozygous familial hypercholesterolemia (HoFH). However, it’s important to note that Kynamro is not approved for other uses or conditions. The information I provide here is based on its approved use, and any use of Kynamro beyond its approved indication would be considered off-label.

What special precautions should I follow?

Regarding special precautions for Kynamro, here are some important points to consider:

• Liver function: Kynamro has the potential to cause liver problems, including liver toxicity. Before starting Kynamro, your healthcare provider will likely conduct liver function tests to evaluate your liver health. Regular monitoring of liver function is essential throughout the treatment. If you experience symptoms such as yellowing of the skin or eyes, dark urine, abdominal pain, or unusual fatigue, it is important to notify your healthcare provider immediately.
• Potential interactions: Kynamro may interact with other medications or substances. Inform your healthcare provider about all the medications, including over-the-counter drugs, supplements, and herbal products, that you are currently taking. Certain medications, such as immunosuppressants and certain lipid-lowering drugs, may increase the risk of liver problems when used with Kynamro.
• Pregnancy and breastfeeding: Kynamro is not recommended during pregnancy as it may cause harm to the developing fetus. If you are pregnant or planning to become pregnant, discuss the risks and benefits of Kynamro with your healthcare provider. It is also not known if Kynamro passes into breast milk, so it is important to consult your healthcare provider regarding its use while breastfeeding.
• Injection site reactions: Kynamro may cause injection site reactions, such as redness, pain, swelling, or itching. Rotate injection sites and follow proper injection techniques as instructed by your healthcare provider to minimize these reactions. If you experience severe or persistent injection site reactions, contact your healthcare provider.
• Flu-like symptoms: Some individuals taking Kynamro may experience flu-like symptoms, including fever, headache, muscle aches, and fatigue. These symptoms are usually temporary and tend to improve over time. If you experience severe or persistent symptoms, notify your healthcare provider.
• Allergic reactions: Allergic reactions, though rare, can occur with the use of Kynamro. Seek immediate medical attention if you experience signs of an allergic reaction, such as difficulty breathing, swelling of the face or throat, or severe rash.

It is important to discuss all potential risks, precautions, and side effects of Kynamro with your healthcare provider before starting treatment. They can provide personalized guidance based on your specific medical history and condition.

What special dietary instructions should I follow?

Regarding dietary instructions for Kynamro, there are no specific dietary restrictions associated with the medication. However, it is essential to follow a heart-healthy diet and lifestyle, which typically includes a low-cholesterol and low-saturated fat diet. Your healthcare provider or a registered dietitian can provide personalized dietary recommendations based on your specific needs.

What should I do if I forget a dose?

If you forget a dose of Kynamro, follow these steps:

• Inject the missed dose as soon as you remember, unless it is almost time for your next scheduled dose.
• Do not double the dose to make up for the missed one.
• Continue with your regular dosing schedule.

What side effects can this medication cause?

Kynamro (mipomersen sodium) can cause various side effects. Some of the common side effects include:

• Injection site reactions: Redness, pain, swelling, itching, or bruising at the injection site are common side effects of Kynamro. It is important to follow proper injection techniques and rotate injection sites to minimize these reactions.
• Flu-like symptoms: Many individuals taking Kynamro may experience flu-like symptoms, such as fever, headache, muscle aches, chills, and fatigue. These symptoms are usually temporary and tend to improve over time.
• Liver problems: Kynamro has the potential to cause liver problems, including liver enzyme abnormalities and liver toxicity. Regular monitoring of liver function is essential during treatment. If you experience symptoms such as yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or unusual fatigue, it is important to notify your healthcare provider immediately.
• Increased risk of bleeding: Kynamro can increase the risk of bleeding. Inform your healthcare provider if you have a history of bleeding disorders or if you are taking medications that can increase the risk of bleeding, such as anticoagulants (blood thinners).
• Allergic reactions: Although rare, allergic reactions can occur with the use of Kynamro. Seek immediate medical attention if you experience signs of an allergic reaction, such as difficulty breathing, swelling of the face or throat, or severe rash.

These are not all the possible side effects of Kynamro. Other less common or rare side effects may occur. It is important to consult with your healthcare provider for a comprehensive list of potential side effects and to report any unusual symptoms or side effects promptly.

What should I know about storage and disposal of this medication?

• Storage: Kynamro should be stored in the refrigerator at a temperature of 36°F to 46°F (2°C to 8°C). It should be kept in its original carton to protect it from light. Do not freeze Kynamro. Avoid storing it near the freezer compartment or in the freezer.
• Handling and disposal: It is important to handle Kynamro with care and follow proper procedures for disposal. If you are unsure about how to handle or dispose of Kynamro, consult your healthcare provider, pharmacist, or local waste disposal authorities for guidance. They can provide specific instructions for safe disposal to protect others from accidental exposure.

In case of emergency/overdose

In the case of an emergency or potential overdose, contact your local emergency services (such as 911 in the United States) or go to the nearest emergency room immediately. It is important to inform the healthcare professionals about the medication you have taken, including Kynamro, and provide them with any relevant information.

What other information should I know?

• Do not share Kynamro with others, as it is prescribed specifically for your condition.
• Keep all follow-up appointments with your healthcare provider for monitoring your progress and adjusting your treatment plan if necessary.
• Inform all healthcare professionals involved in your care, including dentists and surgeons, that you are taking Kynamro.
• Carry an identification card or wear a medical alert bracelet indicating that you are taking Kynamro in case of emergencies.
• Keep a record of the dates and injection sites for each Kynamro dose for proper rotation and to monitor for any injection site reactions.

Always consult with your healthcare provider or pharmacist for specific instructions and any additional information regarding the storage, disposal, emergency procedures, and other aspects of using Kynamro.