Why is this medication prescribed?

Adagrasib (also known as MRTX849) is a targeted therapy medication used in the treatment of non-small cell lung cancer (NSCLC) that carries a specific genetic mutation called KRAS G12C.

KRAS is a gene that plays a role in cell growth and division. The KRAS G12C mutation is a specific genetic alteration found in some NSCLC tumors. Adagrasib works by inhibiting the activity of the mutated KRAS protein, thereby interfering with the signaling pathways that promote cancer cell growth and survival.

How should this medicine be used?

Here is some information on how Adagrasib should be used:

• Prescription: Adagrasib is available by prescription only and should be used under the supervision of a healthcare professional who is experienced in the treatment of cancer.
• Dosage: The dosage of Adagrasib may vary depending on individual factors, such as the patient’s overall health, the stage of cancer, and other medications they may be taking. The specific dosage and treatment schedule will be determined by the prescribing doctor.
• Administration: Adagrasib is taken orally in the form of capsules. The capsules should be swallowed whole with a glass of water, and it can be taken with or without food, as directed by the healthcare professional.
• Compliance: It is important to take Adagrasib exactly as prescribed by the doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider.
• Follow-up: Regular follow-up appointments with the doctor are essential to monitor the effectiveness of the treatment and to manage any potential side effects.
• Side effects: Adagrasib may cause side effects, which can vary from person to person. Common side effects may include diarrhea, fatigue, nausea, vomiting, rash, decreased appetite, and muscle or joint pain. It is important to report any side effects to your doctor for appropriate management.

It’s worth noting that the information provided here is a general overview, and individual circumstances may vary. It is important to consult with a healthcare professional or refer to the medication’s prescribing information for specific instructions regarding the use of Adagrasib.

Other uses for this medicine

Adagrasib (MRTX849) is primarily being investigated and developed for the treatment of non-small cell lung cancer (NSCLC) with the KRAS G12C mutation. However, it’s important to note that clinical trials and research studies may explore other potential uses for Adagrasib in the future.

What special precautions should I follow?

Regarding special precautions for Adagrasib, it’s crucial to consider the following:

• KRAS G12C mutation: Adagrasib is specifically targeted for NSCLC patients who have the KRAS G12C mutation. Genetic testing is necessary to confirm the presence of this mutation before prescribing Adagrasib.
• Medical history: It’s important to inform your healthcare provider about your complete medical history, including any other medical conditions, ongoing treatments, and medications you are taking. Certain medical conditions or medications may interact with Adagrasib or require additional monitoring.
• Pregnancy and breastfeeding: Adagrasib may potentially harm unborn babies, so it is important to discuss the risks and benefits with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Side effects: Adagrasib may cause side effects, some of which can be serious. Common side effects include diarrhea, fatigue, nausea, vomiting, rash, decreased appetite, and muscle or joint pain. It’s essential to report any side effects to your doctor and follow their guidance for managing them.
• Drug interactions: Adagrasib may interact with other medications, including over-the-counter drugs, herbal supplements, and prescription medications. Inform your healthcare provider about all the medications you are taking to avoid potential drug interactions.
• Regular monitoring: Your doctor will likely schedule regular follow-up appointments to monitor the effectiveness of the treatment and assess any potential side effects or complications. It’s important to attend these appointments as scheduled.

These precautions are not exhaustive, and specific precautions and instructions may vary based on individual circumstances. It is crucial to consult with a healthcare professional or refer to the prescribing information for Adagrasib for comprehensive and up-to-date information regarding its use and precautions.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with taking Adagrasib (MRTX849). However, it is always a good idea to follow a balanced and healthy diet as recommended by your healthcare provider. Eating a nutritious diet can support overall health and well-being, which is important during cancer treatment.

What should I do if I forget a dose?

If you forget to take a dose of Adagrasib, it is recommended to follow these general guidelines:

• Promptly take the missed dose: If you realize that you have missed a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule.
• Do not double dose: Do not take a double dose of Adagrasib to make up for the missed dose. Taking more than the prescribed amount can increase the risk of side effects without providing any additional benefit.
• Consult your healthcare provider: If you have any concerns or questions about missed doses or how to manage your medication schedule, it is best to consult your healthcare provider. They can provide specific guidance based on your individual circumstances.

What side effects can this medication cause?

Adagrasib (MRTX849) may cause side effects, which can vary from person to person. Here are some common side effects associated with Adagrasib:

• Diarrhea: Diarrhea is one of the most frequently reported side effects of Adagrasib. It may range from mild to severe. It is important to stay hydrated and inform your healthcare provider if you experience persistent or severe diarrhea.
• Fatigue: Fatigue, or feeling tired or weak, is another common side effect of Adagrasib. It is advisable to get adequate rest and conserve energy during the treatment period.
• Nausea and vomiting: Some individuals may experience nausea and vomiting while taking Adagrasib. Your healthcare provider may prescribe anti-nausea medications to help manage these symptoms.
• Rash: Adagrasib can cause skin rash, which may be mild or more severe. It is important to notify your doctor if you develop a rash or any skin abnormalities.
• Decreased appetite: Adagrasib can sometimes cause a decrease in appetite, leading to weight loss. It is essential to maintain proper nutrition during treatment, so discussing this side effect with your healthcare provider is important.
• Muscle and joint pain: Adagrasib may cause muscle or joint pain. Inform your healthcare provider if you experience persistent or severe pain, as they may be able to recommend pain management strategies.

It is important to remember that these side effects are not exhaustive, and some individuals may experience different or additional side effects. It is recommended to discuss any concerns or side effects you experience with your healthcare provider. They can provide personalized guidance, monitor your progress, and help manage any side effects that arise during treatment.

What should I know about storage and disposal of this medication?

Storage and disposal of Adagrasib:

• Storage: Adagrasib should be stored at room temperature, typically between 20°C to 25°C (68°F to 77°F). It should be kept in its original container and protected from light and moisture. Ensure that the medication is stored out of reach of children and pets.
• Disposal: It is important to dispose of Adagrasib properly and responsibly. Follow your local regulations and guidelines for medication disposal. Do not dispose of Adagrasib in household trash or flush it down the toilet unless specifically instructed to do so.

In case of emergency/overdose

In the case of an emergency or suspected overdose, immediately contact your local emergency services or go to the nearest emergency room. It is also recommended to inform the healthcare professionals about the medication taken and the dosage to receive appropriate assistance.

What other information should I know?

• Adagrasib is a prescription medication and should be used only under the guidance and supervision of a healthcare professional experienced in treating cancer.
• Inform your healthcare provider about any other medications, supplements, or treatments you are taking to avoid potential drug interactions.
• Attend all scheduled appointments with your doctor for monitoring, follow-up, and evaluation of the treatment.
• Report any new or worsening symptoms, side effects, or concerns to your healthcare provider promptly.
• Adagrasib is specific to non-small cell lung cancer (NSCLC) patients with the KRAS G12C mutation. Genetic testing is necessary to determine if Adagrasib is appropriate for your condition.
• Keep a list of emergency contact numbers, including your healthcare provider’s information, readily available.

Remember, the information provided here is a general overview, and specific instructions and guidelines may vary. It is crucial to consult with your healthcare provider or refer to the medication’s prescribing information for comprehensive and up-to-date instructions regarding storage, disposal, emergencies, and other relevant information.