WARNING

Kineret, also known as anakinra, is a medication used to treat certain inflammatory conditions such as rheumatoid arthritis and neonatal-onset multisystem inflammatory disease (NOMID). While Kineret can be effective for some patients, like any medication, it carries certain risks. Here are some potential risks associated with taking Kineret:

• Infections: Kineret can suppress the immune system, making individuals more susceptible to infections. Serious infections, including bacterial, fungal, and viral infections, have been reported in some patients taking Kineret. It is important to monitor for any signs of infection while using this medication.
• Allergic reactions: Some individuals may develop allergic reactions to Kineret. These reactions can range from mild to severe and may include symptoms like rash, itching, swelling, dizziness, and difficulty breathing. If any allergic reaction occurs, immediate medical attention should be sought.
• Injection site reactions: Kineret is typically administered through subcutaneous injections, which may cause local skin reactions at the injection site. These reactions can include redness, pain, swelling, or bruising. Proper injection techniques and site rotation can help minimize these reactions.
• Blood disorders: Rarely, Kineret may cause changes in blood cell counts, such as decreased white blood cells or platelets. Regular blood tests may be necessary to monitor for any abnormalities.
• Other side effects: Some individuals may experience common side effects while taking Kineret, including headache, nausea, diarrhea, or flu-like symptoms. These side effects are generally mild and tend to improve over time.

It is important to note that this is not an exhaustive list of all possible risks associated with Kineret. Different individuals may react differently to the medication, and the prescribing physician should provide comprehensive information about the potential risks and benefits based on the individual’s specific situation. It is crucial to discuss any concerns or questions with a healthcare professional before starting or stopping any medication.

Why is this medication prescribed?

Kineret is prescribed for the treatment of certain autoimmune disorders, particularly rheumatoid arthritis and neonatal-onset multisystem inflammatory disease (NOMID). Here’s a brief explanation of why Kineret is prescribed for these conditions:

• Rheumatoid arthritis: Rheumatoid arthritis (RA) is a chronic inflammatory disorder that primarily affects the joints. It occurs when the immune system mistakenly attacks the body’s own tissues, leading to joint inflammation, pain, and damage. Kineret, which contains the active ingredient anakinra, is used as a disease-modifying antirheumatic drug (DMARD) in the treatment of moderate to severe active rheumatoid arthritis in adults. It works by blocking the activity of a specific protein called interleukin-1 (IL-1), which plays a role in the inflammatory process. By inhibiting IL-1, Kineret helps reduce joint inflammation and symptoms associated with rheumatoid arthritis.
• Neonatal-onset multisystem inflammatory disease (NOMID): NOMID, also known as chronic infantile neurologic, cutaneous, articular (CINCA) syndrome, is a rare autoinflammatory disorder that usually begins in infancy. It is characterized by chronic inflammation in multiple body systems, including the skin, joints, and central nervous system. Kineret is approved for the treatment of NOMID/CINCA syndrome in children and adults. By blocking IL-1, Kineret helps alleviate the symptoms and reduce the frequency and severity of flare-ups associated with this condition.

How should this medicine be used?

Kineret is a medication that contains the active ingredient anakinra, which is used to treat certain autoimmune disorders such as rheumatoid arthritis and neonatal-onset multisystem inflammatory disease (NOMID). It is important to note that I am an AI language model and not a medical professional. Therefore, I can provide general information, but it is always best to consult with a healthcare provider for specific instructions on how to use Kineret or any other medication.

Here are some general guidelines on how Kineret is typically used:

• Administration: Kineret is usually administered as a subcutaneous injection, which means it is injected under the skin. The injection is typically given in the thigh or abdomen. The injection site should be rotated to different areas to prevent irritation or skin reactions.
• Dosage: The dosage of Kineret will be determined by your healthcare provider based on factors such as the specific condition being treated, your body weight, and your response to the medication. Always follow the prescribed dosage and schedule provided by your healthcare provider.
• Storage: Kineret should be stored in a refrigerator at a temperature between 36°F to 46°F (2°C to 8°C). It should not be frozen. If you are traveling and need to take Kineret with you, it can be stored at room temperature (up to 77°F or 25°C) for up to 30 days. However, it should be protected from light and excessive heat.
• Preparation: Kineret is available in pre-filled syringes or pre-filled pens, which are designed for self-administration. Follow the instructions provided by the manufacturer on how to prepare the syringe or pen for injection. It is important to use aseptic techniques to maintain cleanliness and reduce the risk of infection.
• Injection technique: Your healthcare provider will provide instructions on the specific injection technique for Kineret. It is important to follow these instructions carefully to ensure proper administration. If you have any concerns or questions about the injection technique, consult your healthcare provider or a nurse for guidance.
• Adherence to treatment: It is important to use Kineret as prescribed and adhere to the recommended treatment schedule. Missing doses or stopping the medication abruptly without medical advice may reduce its effectiveness.

Other uses for this medicine

Kineret (generic name: anakinra) is a medication used for the treatment of certain autoimmune conditions, particularly rheumatoid arthritis. However, it may also have off-label uses for other autoimmune disorders.

Other uses for Kineret can include:

• Cryopyrin-Associated Periodic Syndromes (CAPS): Kineret is approved for the treatment of CAPS, which is a group of rare autoinflammatory disorders, including familial cold autoinflammatory syndrome, Muckle-Wells syndrome, and neonatal-onset multisystem inflammatory disease.
• Still’s Disease: Kineret has been used off-label for the treatment of adult-onset Still’s disease, a rare inflammatory disorder characterized by high spiking fevers, joint pain, and rash.
• Gout: In some cases, Kineret has been used off-label for the treatment of gout, a form of arthritis caused by the buildup of uric acid crystals in the joints.

What special precautions should I follow?

Regarding special precautions, here are some important considerations when using Kineret:

• Infections: Kineret may increase the risk of infections, including serious or potentially life-threatening infections. It’s important to avoid using Kineret if you have an active infection. Pre-existing infections should be adequately treated before starting Kineret. Regular monitoring for signs of infection is necessary during treatment.
• Allergic reactions: Some individuals may experience allergic reactions to Kineret. If you develop signs of an allergic reaction, such as hives, swelling, difficulty breathing, or severe itching, seek medical attention immediately.
• Tuberculosis: Prior to starting Kineret, a thorough evaluation for tuberculosis (TB) should be conducted, as it can be reactivated during treatment. If you have a history of TB or have been in close contact with someone with TB, inform your healthcare provider.
• Vaccinations: Live vaccines should be avoided while using Kineret, as it may interfere with the effectiveness of the vaccines. Consult your healthcare provider for guidance on vaccinations while on Kineret.
• Pregnancy and breastfeeding: The use of Kineret during pregnancy or breastfeeding should be discussed with a healthcare provider. The potential risks and benefits need to be carefully evaluated before making a decision.

These are just a few precautions associated with Kineret. It’s crucial to follow the instructions provided by your healthcare provider and consult them for personalized advice on precautions, potential drug interactions, and other considerations specific to your situation.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with the use of Kineret. However, it’s always a good idea to maintain a balanced and healthy diet to support overall well-being, especially if you have a condition such as rheumatoid arthritis or NOMID.

What should I do if I forget a dose?

Regarding missed doses of Kineret, here are some general guidelines:

• If you forget to take a dose at the scheduled time, try to take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
• If you frequently forget doses, consider setting reminders or alarms to help you remember to take your medication as prescribed.
• It’s important to discuss missed doses with your healthcare provider, as they can provide specific guidance based on your condition and treatment plan. They may advise adjustments to the dosing schedule or any necessary precautions.

What side effects can this medication cause?

Kineret (anakinra) may cause certain side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. It’s recommended to discuss potential side effects with your healthcare provider before starting Kineret. Here are some common side effects associated with Kineret:

• Injection site reactions: The most common side effects of Kineret are injection site reactions, such as redness, swelling, bruising, itching, pain, or irritation at the injection site. These reactions are usually mild to moderate and tend to improve over time. It is advised to rotate injection sites to minimize these reactions.
• Infections: Kineret can increase the risk of infections, including upper respiratory tract infections, urinary tract infections, and skin infections. Serious or potentially life-threatening infections, such as pneumonia or sepsis, are possible but rare. If you experience symptoms of infection, such as fever, chills, cough, or unusual discharge, contact your healthcare provider immediately.
• Allergic reactions: Some individuals may have an allergic reaction to Kineret. Symptoms may include hives, rash, itching, swelling (especially of the face, tongue, or throat), dizziness, or difficulty breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Blood disorders: Rare cases of decreases in white blood cell counts, including neutropenia, have been reported with Kineret. This can increase the risk of infections. Regular blood tests may be performed to monitor your blood cell counts during treatment.
• Hypersensitivity reactions: In rare cases, hypersensitivity reactions such as angioedema (swelling under the skin) and anaphylaxis (severe allergic reaction) have been reported with Kineret.
• Other side effects: Additional side effects that have been reported with Kineret include headache, dizziness, nausea, diarrhea, abdominal pain, fatigue, and flu-like symptoms.

It’s important to promptly report any side effects or concerns to your healthcare provider. They can provide guidance, monitor your progress, and determine the appropriate course of action.

This is not an exhaustive list of side effects. For a more comprehensive understanding of potential side effects associated with Kineret, please consult the medication’s package insert or speak directly with your healthcare provider.

What should I know about storage and disposal of this medication?

• Storage of Kineret: It is important to store Kineret as directed by the manufacturer or your healthcare provider. Generally, it should be stored in a refrigerator between 36°F (2°C) and 46°F (8°C). However, do not freeze the medication. Protect it from light by keeping it in the original carton until ready to use. Do not shake the medication vigorously.
• Disposal of Kineret: When disposing of Kineret, it is recommended to follow local guidelines for medication disposal. You can consult with your pharmacist or healthcare provider to get specific instructions. Avoid throwing the medication in the trash or flushing it down the toilet unless specifically advised to do so.

In case of emergency/overdose

In the case of an emergency or suspected overdose, it is crucial to seek immediate medical attention. Contact your local emergency services or go to the nearest emergency room. Be sure to inform the medical professionals about the medication involved and the dosage taken.

What other information should I know?

• Kineret is usually administered as a subcutaneous injection (under the skin) and should be administered as directed by your healthcare provider. Follow the instructions carefully.
• Inform your healthcare provider about any other medications, supplements, or medical conditions you have before starting Kineret, as it may interact with certain drugs or worsen specific conditions.
• Kineret can lower your immune system’s ability to fight infections. Contact your healthcare provider if you experience signs of infection, such as fever, chills, or persistent sore throat.
• Regular monitoring and blood tests may be required during Kineret treatment to evaluate its effectiveness and detect any potential side effects.
• If you miss a dose, contact your healthcare provider for guidance. Do not take a double dose to make up for a missed one.

Remember, this information is a general overview, and it’s essential to consult your healthcare provider or pharmacist for specific instructions, advice, and any concerns related to the storage, disposal, or use of Kineret.