WARNING

Kadian is an extended-release formulation of the opioid pain medication morphine. While it can be effective in managing severe pain, it also carries several risks and potential side effects. Here are some of the risks associated with taking Kadian:

• Addiction and dependence: Kadian belongs to the opioid class of drugs, which are known to be highly addictive. Prolonged use can lead to physical and psychological dependence, making it challenging to stop using the medication without experiencing withdrawal symptoms.
• Respiratory depression: Kadian can suppress the respiratory system, leading to slow and shallow breathing. This effect can be dangerous, especially when taking high doses or combining Kadian with other sedatives or alcohol.
• Central nervous system depression: Kadian can cause drowsiness, dizziness, confusion, and impaired coordination. These effects can increase the risk of accidents, falls, and other injuries, particularly in elderly individuals.
• Constipation: Opioids, including Kadian, commonly cause constipation. It is important to take appropriate measures, such as increasing fluid intake and using stool softeners, to manage this side effect.
• Nausea and vomiting: Kadian may cause gastrointestinal disturbances, including nausea and vomiting, particularly when initiating treatment. These symptoms can often be managed by taking the medication with food.
• Hormonal effects: Prolonged use of opioids like Kadian can disrupt the normal production of hormones, including testosterone and cortisol, which may lead to various endocrine problems.
• Interactions with other substances: Kadian can interact with other medications, especially sedatives, tranquilizers, and alcohol, resulting in increased sedation, respiratory depression, and even overdose.
• Risk of overdose: Taking higher doses of Kadian than prescribed or combining it with other central nervous system depressants significantly increases the risk of overdose, which can be life-threatening.

It is crucial to use Kadian under the guidance of a healthcare professional, strictly following the prescribed dosage and duration. Regular monitoring and open communication with your doctor are essential to manage the risks associated with this medication effectively.

Why is this medication prescribed?

Kadian is prescribed to manage moderate to severe chronic pain that requires around-the-clock opioid treatment and cannot be effectively controlled by other pain medications. It is specifically used when continuous, long-term pain relief is necessary.

The extended-release formulation of Kadian allows for a slow and steady release of morphine over an extended period, typically every 12 or 24 hours. This provides consistent pain relief throughout the day and night, reducing the need for frequent dosing.

Kadian is commonly prescribed for conditions such as:

• Chronic back pain: When other non-opioid pain medications and non-pharmacological treatments have not provided adequate relief.
• Cancer-related pain: It can help manage persistent pain associated with advanced stages of cancer.
• Neuropathic pain: Kadian may be used when other treatments for nerve-related pain, such as diabetic neuropathy or post-herpetic neuralgia, have been ineffective.
• Osteoarthritis and rheumatoid arthritis: For patients who have severe joint pain that limits daily activities and has not responded to other therapies.
• Severe musculoskeletal pain: It can be prescribed for pain resulting from injuries, surgeries, or other traumatic conditions.

How should this medicine be used?

Kadian should be used exactly as prescribed by your healthcare provider. It is crucial to follow the recommended dosage, frequency, and duration of use to ensure safe and effective pain management. Here are some general guidelines for using Kadian:

• Dosage: The dosage of Kadian will be determined by your doctor based on factors such as the severity of your pain, your previous opioid exposure, and your individual response to the medication. It is typically initiated at a low dose and gradually increased if needed.
• Administration: Kadian is an extended-release capsule and should be taken orally, swallowed whole with water. Do not crush, chew, or dissolve the capsules, as it can lead to a rapid release of the medication, potentially causing an overdose.
• Timing: Kadian is usually taken once every 12 or 24 hours, depending on the prescribed formulation. Follow the specific instructions provided by your doctor regarding the timing and frequency of doses.
• Avoid alcohol and other sedatives: Do not consume alcohol or take sedatives, tranquilizers, or other medications that depress the central nervous system while using Kadian. Combining these substances can increase the risk of respiratory depression and other dangerous side effects.
• Do not suddenly stop or adjust the dose: Abruptly stopping Kadian or adjusting the dosage without consulting your doctor can lead to withdrawal symptoms and other complications. If you need to discontinue or modify the treatment, it should be done under medical supervision and as per your doctor’s guidance.
• Regular follow-up: Your healthcare provider will monitor your response to Kadian and may adjust the dosage as needed. It is important to attend scheduled appointments and communicate any changes or concerns regarding your pain management.
• Safe storage: Keep Kadian in a secure place, away from children or individuals who might misuse the medication. Store it at room temperature, protected from moisture and light.

Always consult your healthcare provider for personalized instructions on how to use Kadian properly. They will provide detailed guidance based on your specific condition and medical history to optimize pain relief while minimizing the risks.

Other uses for this medicine

Apart from its primary use as a pain medication, there may be other off-label uses for Kadian as determined by a healthcare professional. They would consider various factors such as your medical condition, overall health, and response to other treatments before prescribing Kadian for any alternative use.

What special precautions should I follow?

Regarding precautions, there are several important considerations when using Kadian:

• Allergies: Inform your doctor if you have known allergies to morphine or other opioids, as well as any other significant drug allergies.
• Medical conditions: Disclose your complete medical history to your healthcare provider, particularly if you have a history of respiratory problems, liver or kidney disease, mental health disorders, substance abuse, or a recent head injury.
• Respiratory depression: Kadian can cause respiratory depression, which is characterized by slowed or shallow breathing. It is crucial to use Kadian cautiously, especially in individuals with compromised respiratory function.
• Interactions: Kadian can interact with other medications, including sedatives, tranquilizers, antidepressants, and certain antibiotics. Inform your doctor about all medications, supplements, or herbal products you are taking to avoid potentially harmful interactions.
• Pregnancy and breastfeeding: Kadian should be used with caution during pregnancy or while breastfeeding. It is important to discuss the potential risks and benefits with your healthcare provider.
• Driving and operating machinery: Kadian can cause drowsiness, dizziness, and impaired coordination. Avoid driving or operating heavy machinery until you understand how Kadian affects you.
• Avoid alcohol: Drinking alcohol while taking Kadian can increase the risk of serious side effects, including respiratory depression and sedation.

Always follow your doctor’s instructions and consult them for personalized advice and precautions specific to your situation when using Kadian.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with taking Kadian (extended-release morphine). However, it is generally recommended to take Kadian with food to help reduce the likelihood of nausea or stomach upset. Taking the medication with a small snack or a meal can also help with its absorption and effectiveness.

What should I do if I forget a dose?

If you forget to take a dose of Kadian, the appropriate action to take depends on the timing and instructions provided by your healthcare provider. Here are some general guidelines:

• If it is close to the time for your next scheduled dose: Skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as it can increase the risk of overdose and other adverse effects.
• If there is ample time before your next scheduled dose: Take the missed dose as soon as you remember. However, if it is almost time for your next dose, it is better to skip the missed dose and continue with your regular schedule.

What side effects can this medication cause?

Kadian (extended-release morphine) can cause various side effects, ranging from common and relatively mild to more severe and less common. It’s important to note that not everyone experiences these side effects, and the severity and occurrence may vary from person to person. Some potential side effects of Kadian include:

1. Common side effects (may affect 1% to 10% of users):
   • Nausea and vomiting
   • Constipation
   • Dizziness
   • Drowsiness
   • Headache
   • Dry mouth
   • Itching or skin rash
2. Less common side effects (may affect less than 1% of users):
   • Abdominal pain
   • Loss of appetite
   • Confusion
   • Sweating
   • Difficulty urinating
   • Changes in mood, such as anxiety or depression
   • Respiratory depression (slow and shallow breathing)
   • Hypotension (low blood pressure)
   • Slowed heart rate
3. Serious side effects (rare but potentially severe):
   • Allergic reactions (e.g., hives, swelling, difficulty breathing)
   • Seizures
   • Adrenal insufficiency
   • Serotonin syndrome (if used in combination with certain medications)
   • Withdrawal symptoms upon discontinuation
   • Hormonal changes (e.g., decreased testosterone levels, menstrual irregularities)

If you experience any concerning or severe side effects while taking Kadian, it is important to seek medical attention immediately.

It’s worth noting that this list of side effects is not exhaustive. Different individuals may experience different reactions, and there may be other possible side effects not mentioned here. It is essential to consult your healthcare provider for a comprehensive understanding of potential side effects associated with Kadian, and to report any adverse reactions you may experience during the course of treatment.

What should I know about storage and disposal of this medication?

Storage and disposal of Kadian:

• Storage: Store Kadian at room temperature, away from moisture and light. Keep it in a secure place out of the reach of children and pets.
• Disposal: Properly dispose of unused, expired, or unwanted Kadian capsules. Follow local guidelines or consult with your pharmacist on the safe disposal methods in your area. Do not flush the medication down the toilet or pour it into a drain unless specifically instructed to do so.

In case of emergency/overdose

• If you suspect an overdose or experience severe symptoms such as extreme drowsiness, difficulty breathing, or loss of consciousness, call emergency services immediately (e.g., 911 in the United States) or seek immediate medical attention.
• Inform the medical professionals about the medication you have taken, including the name and dosage of Kadian.
• If possible, have the Kadian packaging or any relevant information readily available for the healthcare providers.

What other information should I know?

• Regular appointments: Attend scheduled appointments with your healthcare provider for monitoring and adjustments in your pain management plan. Keep them updated on your progress, any side effects experienced, or changes in your pain levels.
• Avoid alcohol: It is important to refrain from consuming alcohol while taking Kadian, as it can increase the risk of respiratory depression and other adverse effects.
• Avoid abrupt discontinuation: Do not stop taking Kadian suddenly without consulting your healthcare provider. Abruptly stopping the medication can lead to withdrawal symptoms. If you and your healthcare provider decide to discontinue Kadian, a gradual tapering schedule may be recommended.
• Inform healthcare providers: Ensure that all healthcare providers you see are aware of your use of Kadian. This includes doctors, dentists, and emergency care providers. It is essential to inform them about all medications you are taking to avoid potential interactions and ensure appropriate care.
• Keep an updated list: Maintain an updated list of all your medications, including Kadian, along with their dosages, and share it with healthcare providers during appointments or in case of emergencies.

Remember, the information provided here is not exhaustive. It is essential to carefully read and follow the instructions provided with your Kadian prescription, consult your healthcare provider for personalized advice, and ask any specific questions you may have about the medication.