Why is this medication prescribed?

Adults and children 12 years of age and older who have activated phosphoinositide 3-kinase delta syndrome (APDS; a genetic disorder that reduces the activity of the immune system and can cause recurrent infections, swollen lymph nodes and spleen, and a specific type of lymphoma [a type of blood cancer]) are treated with leniolisib. A group of drugs known as kinase inhibitors includes leniolisib. It functions by obstructing the immune system’s dysfunctional signaling, which enhances immune system performance.

How should this medicine be used?

The oral tablet form of leniolisib is available. It is typically taken twice day, either with or without meals, and roughly 12 hours apart. Leniolisib should be taken every day at roughly the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Follow the medication directions precisely. Never take it in quantities or frequencies other than those recommended by your doctor.

Take another dose of lenioliolisib as soon as you can if you vomit within an hour of taking it. Avoid taking extra leniolisib if you vomit more than an hour after taking it. Maintain your usual dosage routine.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you think this drug may be recommended for other conditions.

What special precautions should I follow?

• If you have any allergies, including to leniolisib, other medications, or any of the substances in leniolisib tablets, let your doctor and pharmacist know right away. Request an ingredient list from your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter medications, vitamins, herbal items, nutritional supplements, and any drugs you are now taking or intend to take. Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects.
• Liniolisib may interact with the following over-the-counter or herbal products: Saint John’s Wort. Prior to beginning lenioliolisib therapy, make sure to inform your healthcare professional that you are taking this drug. Without consulting your doctor, do not start taking this medicine while taking leniolisib.
• Inform your doctor if you now have or ever had liver issues.
• In case you are nursing or intend to, let your doctor know. As well as for one week following your last dose, you shouldn’t breastfeed while taking leniolisib.
• Without first consulting your doctor, avoid getting any shots.
• Inform your doctor if you are expecting a child or if you intend to do so. Before using leniolisib, you must perform a pregnancy test. While taking lenioliolisib, you shouldn’t get pregnant. Throughout your lenioliolisib treatment and for a week following your last dose, you should use reliable birth control to avoid getting pregnant. Consult your doctor about effective birth control options for you. Call your physician right away if you conceive while taking leniolisib. The fetus could suffer from lenoliolisib’s side effects.

What special dietary instructions should I follow?

Maintain your regular diet unless your doctor instructs you otherwise.

What should I do if I forget a dose?

When you recall, immediately take the missed dose. On the other hand, omit the missed dose and carry on with your regular dosing plan if it is less than 6 hours until your next dose. If you miss a dose, don’t take a second one to make up for it.

What side effects can this medication cause?

There may be adverse effects from leniolisib. Any of these symptoms that are severe or do not go away should be discussed with your doctor:

• Headache
• Nasal blockage and a runny nose
• Itching and dry skin
• Rash that is either red or scaly
• Diarrhea
• Tiredness
• Back or neck ache
• Hair fall
• Fever
• Rapid heart rate

Leniolisib may also have additional negative effects. If you have any strange side effects while taking this medicine, call your doctor right away.

What should I know about storage and disposal of this medication?

Store this medication out of children’s reach in the tightly closed, original container. It should not be kept in the bathroom. Store it at room temperature, away from sources of extreme heat and moisture.

All medications should be kept out of the sight and reach of children, as many of the containers (such as weekly pill containers and those for eye drops, lotions, patches, and inhalers) are not child-resistant and are simple for small children to open. Always lock safety caps and put the medication in a secure spot right away, up high and out of young children’s sight and reach, to prevent poisoning.

In order to prevent pets, kids, and other people from ingesting leftover pharmaceuticals, they should be disposed of in a specific manner. This drug should not, however, be flushed down the toilet. A medicine take-back program is the preferable method for getting rid of your medication. For information about take-back initiatives in your neighborhood, speak with your pharmacist or get in touch with the waste/recycling department of your city.

In case of emergency/overdose

In case of overdose, call the poison control helpline. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Do not miss any of your doctor’s appointments.

You should keep a written record of every drug you take, including prescription and nonprescription (over-the-counter) medications, vitamins, minerals, and other dietary supplements. Every time you see a doctor or are admitted to the hospital, you should carry this list with you. Additionally, it is crucial to have this knowledge on hand in case of emergency.