WARNING

While Daprodustat can be beneficial for the treatment of anemia associated with chronic kidney disease (CKD), there are potential risks and side effects associated with its use. Here is a brief overview of some of the risks:

• Cardiovascular Risks: Daprodustat may increase the risk of cardiovascular events such as heart attack, stroke, and heart failure. Individuals with a history of cardiovascular disease or those at higher risk may require careful monitoring during treatment.
• Blood Pressure Changes: Daprodustat can cause increases or decreases in blood pressure. Blood pressure should be regularly monitored, and adjustments to antihypertensive medications may be necessary.
• Blood Clots: There is a potential risk of blood clot formation with daprodustat. If you experience symptoms such as chest pain, shortness of breath, leg swelling, or sudden severe headache, it is important to seek medical attention promptly.
• Worsening of Kidney Function: Daprodustat may lead to a decline in kidney function or worsen existing kidney problems. Close monitoring of kidney function is crucial during treatment.
• Allergic Reactions: Some individuals may develop allergic reactions to daprodustat, which can manifest as skin rash, itching, swelling, or difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.
• Other Side Effects: Common side effects of daprodustat include diarrhea, nausea, vomiting, headache, dizziness, muscle spasms, and joint pain. Inform your healthcare provider if these side effects become severe or persistent.

It’s important to note that this is not an exhaustive list of all potential risks associated with daprodustat. Every individual may respond differently to the medication, and the risks and benefits should be carefully evaluated by a healthcare professional before initiating treatment. If you have any concerns or questions, it is recommended to consult your doctor or pharmacist.

Why is this medication prescribed?

Daprodustat was an investigational drug that was being developed for the treatment of anemia associated with chronic kidney disease (CKD). Anemia is a condition characterized by a decrease in the number of red blood cells or a decrease in the amount of hemoglobin, which can lead to symptoms such as fatigue, weakness, and shortness of breath. Daprodustat belongs to a class of medications known as hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PH inhibitors). These drugs work by increasing the production of erythropoietin, a hormone that stimulates the production of red blood cells in the bone marrow. By increasing erythropoietin levels, Daprodustat aims to improve red blood cell production and alleviate anemia in patients with CKD.

How should this medicine be used?

The dosing and usage instructions for daprodustat should be determined by a qualified healthcare professional, such as a doctor or pharmacist, who is familiar with your specific medical condition. However, here are some general guidelines:

• Follow Prescribed Dosage: Take daprodustat exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your doctor.
• Oral Administration: Daprodustat is typically available as an oral tablet. It should be taken once daily, preferably at the same time each day.
• Individualized Dosage: The specific dosage of daprodustat will vary depending on factors such as your hemoglobin levels, response to treatment, and other medical conditions. Your doctor will determine the appropriate starting dose and may adjust it over time based on your individual needs.
• Regular Monitoring: Regular blood tests will be necessary to monitor your hemoglobin levels and adjust the dosage of daprodustat accordingly. This allows your healthcare provider to optimize your treatment and avoid potential side effects.
• Food Interactions: Daprodustat can be taken with or without food. However, certain medications or supplements that interact with daprodustat may need to be taken at a different time to ensure maximum effectiveness.
• Adhere to Medical Advice: It is important to follow any additional instructions provided by your doctor or pharmacist. They may advise you on dietary restrictions, lifestyle modifications, and potential drug interactions to ensure the safe and effective use of daprodustat.

Other uses for this medicine

Daprodustat is not widely known or approved for any other uses beyond anemia associated with CKD. It’s always important to consult with your healthcare provider for specific information on approved uses of daprodustat.

What special precautions should I follow?

Regarding special precautions, it’s crucial to follow the guidance of your healthcare provider. However, here are some general precautions that may apply:

• Medical History: Inform your healthcare provider about your complete medical history, including any past or current medical conditions, especially cardiovascular disease, blood clotting disorders, liver disease, or any other relevant conditions.
• Medications and Supplements: Provide a comprehensive list of all medications, supplements, and herbal products you are currently taking or plan to take while on daprodustat. Some medications or supplements may interact with daprodustat and require adjustments or monitoring.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of daprodustat with your doctor. The use of daprodustat during pregnancy or breastfeeding is not well-established, and caution is advised.
• Allergic Reactions: Inform your healthcare provider about any known allergies or hypersensitivity reactions you may have had to medications or other substances in the past.
• Monitoring: Regular monitoring of your hemoglobin levels, blood pressure, and kidney function will be necessary during treatment with daprodustat. Adhere to the recommended monitoring schedule and attend follow-up appointments as advised by your healthcare provider.
• Driving and Operating Machinery: Daprodustat may cause dizziness or other side effects that can impair your ability to drive or operate machinery. If you experience these effects, use caution and avoid such activities until you know how the medication affects you.

These precautions are general in nature, and your healthcare provider will provide you with specific instructions based on your individual circumstances. Always consult with your doctor or pharmacist for personalized advice and guidance on the use of daprodustat and any precautions you should take.

What special dietary instructions should I follow?

Daprodustat is a medication used for the treatment of anemia in patients with chronic kidney disease. It is important to follow the dietary instructions provided by your healthcare provider while taking daprodustat. However, I must mention that I do not have access to specific prescribing information or the latest updates on medications. Therefore, it is crucial to consult your healthcare provider or pharmacist for personalized and up-to-date instructions regarding daprodustat and any other medications you may be taking.

What should I do if I forget a dose?

Regarding forgetting a dose of daprodustat, it is generally recommended to take the missed dose as soon as you remember it, unless it is close to the time for your next scheduled dose. In that case, it is advisable to skip the missed dose and continue with your regular dosing schedule. It is important not to take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, it is best to consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Daprodustat is a medication used for the treatment of anemia associated with chronic kidney disease (CKD). Like any medication, it can cause side effects. Common side effects of daprodustat include:

• Nausea and vomiting
• Diarrhea
• Upper respiratory tract infection
• Headache
• Dizziness
• Fatigue
• Itching or skin rash
• Muscle or joint pain
• Swelling in the legs or feet (peripheral edema)
• High blood pressure (hypertension)

These are not all the possible side effects of daprodustat. Some individuals may experience other side effects, and it’s important to consult a healthcare professional for a comprehensive list of potential adverse effects. Additionally, some side effects may be severe or require immediate medical attention. If you experience any unusual or severe symptoms while taking daprodustat, it’s important to contact your healthcare provider as soon as possible.

What should I know about storage and disposal of this medication?

Storage:

• Keep daprodustat in its original container or packaging, tightly closed.
• Store it at room temperature, away from direct sunlight, heat, and moisture.
• Follow any specific storage instructions provided by the manufacturer or on the medication label.

Disposal:

• It is important to dispose of medications properly to prevent accidental ingestion by others.
• Do not flush daprodustat down the toilet or pour it down the drain unless specifically instructed to do so.
• Consult your local pharmacy, healthcare provider, or waste management facility to inquire about approved methods of medication disposal in your area.

In case of emergency/overdose

In case of emergency or overdose, it is important to seek immediate medical assistance. Contact your local emergency services or a poison control center right away. Be sure to inform them about the medication you have taken, the dosage, and any symptoms you may be experiencing. If possible, have the medication packaging or information readily available.

What other information should I know?

It is essential to be aware of any potential drug interactions or side effects associated with daprodustat. Discuss with your healthcare provider or pharmacist about any other medications, supplements, or herbal products you are taking to avoid any potential interactions. Additionally, familiarize yourself with the common side effects of daprodustat and report any unusual or severe symptoms to your healthcare provider.

Remember, the information provided here is not a substitute for professional medical advice. Always consult your healthcare provider or pharmacist for personalized guidance on storage, disposal, emergency situations, and any other specific concerns you may have regarding daprodustat.