Why is this medication prescribed?

Adults who have endometrial cancer (cancer that starts in the lining of the uterus) that has advanced or returned after receiving treatment with another chemotherapy drug may take the injection dostarlimab-gxly. Adults who were previously treated unsuccessfully with another chemotherapeutic drug and have no other effective treatment alternatives may also use dostarlimab-gxly injection to treat a specific form of solid tumor that has progressed to other areas of their bodies. A group of drugs known as monoclonal antibodies includes dostarlimab-gxly injection. It operates by impeding a specific protein’s function in cancer cells. This aids in slowing the growth of the tumor and bolsters the immune system’s ability to combat cancer cells.

How should this medicine be used?

Dostarlimab-gxly injection is available as a solution (liquid) that a doctor or nurse can administer intravenously (into a vein) over the course of 30 minutes at a hospital or infusion center. Typically, it is administered once every three weeks for four cycles and then once every six weeks for whatever long your doctor advises you continue therapy.

During an infusion, dostarlimab-gxly injection may result in serious or perhaps fatal side effects. While you are receiving the infusion, a doctor or nurse will keep a careful eye on you to make sure you are not experiencing a dangerous pharmaceutical reaction. Any of the following symptoms that could appear during the infusion should be reported right away to your doctor or nurse: chills, flushing, shaking, dizziness, shortness of breath, wheezing, fever, itching, rash, back or neck discomfort, or feeling faint.

Depending on how you react to the drug and any side effects you have, your doctor may reduce the rate of your infusion, cease your dostarlimab-gxly injectable treatment permanently or temporarily, or administer additional medication. Tell your doctor how you are feeling as you receive treatment.

When you start receiving treatment with dostarlimab-gxly injection and each time you refill your prescription, your doctor or pharmacist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, thoroughly read the material, then consult your physician or pharmacist.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you think this drug may be recommended for other conditions.

What special precautions should I follow?

• If you have an allergy to dostarlimab-gxly, any other drugs, or any of the ingredients in dostarlimab-gxly injection, notify your doctor right away. For a list of the ingredients, consult your pharmacist or the Medication Guide.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter medications, vitamins, herbal items, nutritional supplements, and any drugs you are now taking or intend to take. Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects.
• Inform your doctor if you have undergone bone marrow or organ transplantation, as well as if you are undergoing or have undergone chest radiation therapy; an autoimmune illness like Crohn’s disease, which is characterized by the immune system attacking the lining of the digestive tract and causing discomfort, diarrhea, weight loss, and fever, either lupus, in which the immune system assaults several tissues and organs, including the skin, joints, blood, and kidneys, or ulcerative colitis, a disorder that produces swelling and ulcers in the lining of the colon (large intestine) and rectum; any condition that affects your nervous system, such as myasthenia gravis (a nervous system disorder that results in muscle weakness) or Guillain-Barré syndrome (a condition that causes weakness, tingling, and potentially paralysis due to sudden nerve damage); any form of lung disease or breathing issues; thyroid issues; or liver disease.
• Inform your doctor if you are expecting a child or if you intend to do so. Before receiving dostarlimab-gxly, you must perform a pregnancy test. While having dostarlimab-gxly injection and for at least 4 months following your final dose, you shouldn’t get pregnant. Dostarlimab-gxly injection should not be used if you are pregnant. Call your doctor right away. The fetus could suffer from a dostarlimab-gxly injection.
• Inform your doctor if you are currently nursing or intend to do so. For four months following your final dosage of dostarlimab-gxly injection, you shouldn’t breastfeed.

What special dietary instructions should I follow?

Maintain your regular diet unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Call your doctor as soon as you can if you are unable to keep a scheduled appointment to receive dostarlimab-gxly injection.

What side effects can this medication cause?

Dostarlimab-gxly might have unwanted effects. If any of these symptoms are severe or do not go away, consult your doctor:

• Nausea
• Constipation
• Fatigue
• Joint or muscle ache

There can be major negative effects. Call your doctor right away or seek emergency medical attention if you have any of these symptoms or those in the HOW section.

• Chest pain, a cough, or breathlessness
• Diarrhea; more frequent bowel motions; bloody or mucusy stools; black, tarry, or sticky stools; or soreness or discomfort in the stomach area
• Yellowing of the skin or eyes, dark urine, easy bleeding or bruising, appetite loss, severe nausea or vomiting, low energy, or pain on the right side of the stomach region
• Headaches, particularly ones that are unusual or persistent
• Mood or behavioral changes (loss of sex desire, impatience, or forgetfulness)
• Voice getting deeper or sounding hoarse
• Weight fluctuations (gain or decrease)
• Weakness
• Hair fall
• Nausea or fainting
• Vision alterations
• Increased perspiration
• More frequent urination
• Increased light sensitivity
• Rapid heart rate
• Feeling thirstier orhungerier than normal
• Being chilly
• Blood in the urine, ankle edema, change in urine volume or color, or appetite loss
• Pale skin or breathing difficulty
• Itching, rash, blisters, sores, or ulcers on the skin; sores or ulcers in the mouth, nose, throat, or genital region; Swollen lymph nodes, flu-like symptoms, or a fever
• Diarrhea, stomach ache, or a rash
• Swelling of the lymph nodes, a rash or sensitive lumps on the skin, a cough, shortness of breath, changes in eyesight, or eye pain
• Nausea, vomiting, stiff neck, memory issues, fever, weak muscles, balance issues, confusion, or seizures
• Hallucinations (the perception of unreal objects or sounds)

Dostarlimab-gxly could have other negative effects. If you have any strange side effects while taking this medicine, call your doctor right away.

What other information should I know?

Maintain all scheduled times with your physician and the lab. To determine how your body is responding to dostarlimab-gxly, your doctor will request a number of lab tests. To determine whether dostarlimab-gxly can be used to treat your cancer, your doctor will have a lab test done before you start your therapy.

All inquiries regarding dostarlimab-gxly should be directed to your pharmacist.

You should keep a written record of every drug you take, including prescription and nonprescription (over-the-counter) medications, vitamins, minerals, and other dietary supplements. Every time you see a doctor or are admitted to the hospital, you should carry this list with you. Additionally, it is crucial to have this knowledge on hand in case of emergency.