Why is this medication prescribed?

Jakafi (generic name: ruxolitinib) is prescribed for the treatment of certain blood disorders, primarily myelofibrosis and polycythemia vera. Here’s a breakdown of why Jakafi is prescribed for these conditions:

• Myelofibrosis: Myelofibrosis is a rare bone marrow disorder characterized by the abnormal production and accumulation of fibrous tissue in the bone marrow. This leads to the replacement of healthy bone marrow cells with scar tissue, causing symptoms such as enlarged spleen, anemia, fatigue, night sweats, and bone pain. Jakafi is prescribed to manage intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis. Jakafi helps to reduce the size of the spleen and alleviate symptoms associated with myelofibrosis.
• Polycythemia Vera: Polycythemia vera is a chronic blood cancer characterized by the overproduction of red blood cells in the bone marrow. This results in thickened blood, increased risk of blood clots, and other complications. Jakafi is prescribed for adults with polycythemia vera who have had an inadequate response to or cannot tolerate hydroxyurea, which is the standard therapy for this condition. Jakafi helps to normalize blood cell counts and reduce the risk of complications associated with polycythemia vera.

In both myelofibrosis and polycythemia vera, Jakafi works by inhibiting certain enzymes called Janus-associated kinases (JAK1 and JAK2), which are involved in the abnormal cell signaling pathways associated with these blood disorders. By targeting these enzymes, Jakafi helps to regulate cell growth and reduce the symptoms and complications of myelofibrosis and polycythemia vera.

How should this medicine be used?

Jakafi (ruxolitinib) should be used as directed by a healthcare professional. Here are some general guidelines on how Jakafi is typically used:

• Dosage: The specific dosage of Jakafi and the treatment duration will depend on the individual’s condition, response to treatment, and other factors. The healthcare professional will determine the appropriate starting dose and make any necessary adjustments throughout the course of treatment.
• Administration: Jakafi is available in tablet form and is usually taken orally. The tablets should be swallowed whole with a glass of water, and they can be taken with or without food.
• Regular Monitoring: During treatment with Jakafi, regular monitoring of blood counts and liver function is typically recommended. This helps the healthcare provider assess the effectiveness of the medication and detect any potential side effects.
• Compliance: It is important to take Jakafi exactly as prescribed by the healthcare professional. Do not modify the dosage or stop taking the medication without consulting your doctor.
• Missed Dose: If a dose of Jakafi is missed, it should be taken as soon as possible unless it is close to the time for the next scheduled dose. In such cases, the missed dose should be skipped, and the regular dosing schedule should be resumed. Do not double the dose to make up for a missed one.

Remember, the specific instructions for using Jakafi may vary depending on the individual’s condition and the healthcare provider’s recommendations. It is essential to follow the prescribed dosage and administration instructions provided by the healthcare professional and seek their guidance for any concerns or questions regarding the use of Jakafi.

Other uses for this medicine

Jakafi (ruxolitinib) is a medication primarily used for the treatment of certain types of bone marrow disorders, including myelofibrosis and polycythemia vera. However, it may have potential uses beyond its approved indications, and its off-label use should be discussed with a healthcare professional.

What special precautions should I follow?

As for special precautions associated with Jakafi, here are some general considerations. However, please remember that specific precautions may vary depending on individual circumstances, and it is essential to follow your doctor’s instructions:

• Medical history: Inform your doctor about your complete medical history, including any previous or existing medical conditions, such as infections, liver problems, or kidney disease.
• Pregnancy and breastfeeding: Discuss the potential risks and benefits of using Jakafi if you are pregnant, planning to become pregnant, or breastfeeding. The medication’s safety during pregnancy or breastfeeding is not well established, and caution is advised.
• Interactions with other medications: Inform your doctor about all the medications, supplements, or herbal products you are currently taking. Jakafi may interact with certain medications, including strong CYP3A4 inhibitors or inducers, immunosuppressive drugs, or live vaccines.
• Monitoring: Your doctor may recommend regular blood tests to monitor your blood counts, liver function, and cholesterol levels during Jakafi treatment.
• Infections: Jakafi may increase the risk of developing certain infections. Inform your doctor immediately if you experience any signs of infection, such as fever, chills, cough, or flu-like symptoms.
• Bleeding: Jakafi may increase the risk of bleeding. Report any unusual bleeding or bruising to your doctor.
• Surgery: If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking Jakafi.
• Vaccinations: Discuss with your doctor which vaccinations are safe and appropriate for you while taking Jakafi, as some vaccines may be contraindicated.

These are general precautions, and it’s important to consult your doctor for comprehensive guidance and recommendations specific to your situation. Your healthcare provider will consider your individual medical history and condition before determining the appropriate precautions for you.

What special dietary instructions should I follow?

Regarding dietary instructions for Jakafi, it is typically recommended to take this medication with food to minimize stomach discomfort. Eating a balanced diet that includes a variety of nutritious foods is generally beneficial for overall health.

What should I do if I forget a dose?

If you forget to take a dose of Jakafi, it’s best to take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, it’s generally advised to skip the missed dose and continue with your regular dosing schedule. It’s important not to take a double dose to make up for the missed one. If you have any concerns or questions about missed doses, it’s best to contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Jakafi (ruxolitinib) is a medication that is used to treat certain blood disorders, including myelofibrosis and polycythemia vera. While Jakafi can be effective in managing these conditions, like any medication, it can cause side effects. Common side effects of Jakafi may include:

• Anemia (low red blood cell count)
• Thrombocytopenia (low platelet count)
• Neutropenia (low white blood cell count)
• Headache
• Dizziness
• Fatigue
• Diarrhea
• Nausea
• Abdominal pain
• Constipation
• Vomiting
• Muscle spasms
• Weight gain
• Increased cholesterol levels
• Respiratory tract infections
• Urinary tract infections
• Upper respiratory tract infections
• Bruising or bleeding
• Rash or other skin reactions
• Elevated liver function tests

It’s important to note that not all individuals will experience these side effects, and some may experience different or additional side effects. It is recommended to discuss any concerns or potential side effects with a healthcare professional before starting Jakafi or while taking the medication.

What should I know about storage and disposal of this medication?

Storage:

• Keep Jakafi in its original container, tightly closed, and out of reach of children.
• Store Jakafi at room temperature, away from excessive heat or moisture.
• Do not freeze Jakafi or expose it to extreme temperatures.

Disposal:

• Do not dispose of Jakafi in household trash or flush it down the toilet unless specifically instructed to do so.
• Follow the disposal instructions provided by your healthcare provider or local pharmacy.
• If you are unsure about the proper disposal method, consult your healthcare provider or pharmacist for guidance.

In case of emergency/overdose

• In case of an emergency or suspected overdose, call your local emergency services or go to the nearest emergency room immediately.
• Inform the healthcare professionals about the medication taken, the dosage, and the time of ingestion.
• Do not induce vomiting unless instructed to do so by a medical professional.

What other information should I know?

• Always take Jakafi exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking it without consulting your doctor.
• Inform your healthcare provider about any other medications, supplements, or herbal products you are taking before starting Jakafi, as it may interact with certain substances.
• Attend regular check-ups and laboratory tests as advised by your doctor to monitor your response to the medication.
• Inform your healthcare provider if you experience any severe or persistent side effects while taking Jakafi.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using Jakafi with your healthcare provider.

It’s essential to follow your healthcare provider’s instructions and consult them for personalized information regarding the storage, disposal, and emergency procedures for Jakafi, as they can provide the most accurate guidance based on your specific situation.