WARNING

Invega Hafyera is a medication used in the treatment of schizophrenia in adults. Like any other medication, it carries certain risks and side effects. Here are some of the potential risks associated with taking Invega Hafyera:

• Neuroleptic Malignant Syndrome (NMS): In rare cases, Invega Hafyera can cause a serious condition called NMS. Symptoms may include high fever, muscle stiffness, confusion, irregular heartbeat, and changes in blood pressure. Immediate medical attention is required if these symptoms occur.
• Tardive Dyskinesia (TD): In some cases, long-term use of Invega Hafyera can lead to tardive dyskinesia, a condition characterized by involuntary movements, such as facial grimacing, tongue protrusion, and repetitive chewing or sucking motions. This condition may be irreversible, even after discontinuing the medication.
• Metabolic Changes: Invega Hafyera can cause metabolic changes, including weight gain, increased blood sugar levels, and increased cholesterol and triglyceride levels. Regular monitoring of weight, blood sugar, and lipid levels is recommended during treatment.
• Orthostatic Hypotension: Invega Hafyera can cause a drop in blood pressure, particularly when standing up from a sitting or lying position. This may result in dizziness or fainting. Taking precautions while changing positions can help minimize this risk.
• Other Side Effects: Additional common side effects of Invega Hafyera may include drowsiness, restlessness, anxiety, headache, constipation, dry mouth, and blurred vision. It is important to consult a healthcare professional if any bothersome or severe side effects occur.

It is crucial to work closely with a healthcare provider when taking Invega Hafyera. They can monitor your progress, adjust the dosage if necessary, and help manage any potential risks or side effects.

Why is this medication prescribed?

Invega Hafyera is prescribed for the treatment of schizophrenia in adults. Schizophrenia is a chronic mental disorder characterized by disturbances in thinking, perception, emotions, and behavior. The goal of treatment with Invega Hafyera, an antipsychotic medication, is to reduce or control the symptoms associated with schizophrenia.

Invega Hafyera contains two active ingredients: paliperidone palmitate and risperidone. Paliperidone palmitate is an extended-release formulation that provides a sustained release of paliperidone, the active metabolite of risperidone. It works by blocking the effects of certain neurotransmitters in the brain, primarily dopamine and serotonin, which helps to normalize brain function and alleviate the symptoms of schizophrenia.

Invega Hafyera is specifically indicated for adults with schizophrenia who require long-term maintenance treatment. It is administered by injection once every three months, providing continuous medication levels throughout the treatment period. This long-acting formulation helps to improve medication adherence and reduce the risk of relapse.

How should this medicine be used?

Invega Hafyera should be used exactly as prescribed by your healthcare provider. It is an extended-release injectable medication administered by a healthcare professional. Here are some general guidelines for the use of Invega Hafyera:

• Administration: Invega Hafyera is given as an intramuscular injection in the deltoid muscle of the upper arm or the gluteal muscle in the buttocks. The injection is typically administered once every three months.
• Dosage: The dosage of Invega Hafyera is determined by your healthcare provider based on your individual needs and response to treatment. It is important to follow the prescribed dosage schedule and not alter the dose without consulting your healthcare provider.
• Compliance: It is crucial to receive each injection of Invega Hafyera as scheduled to maintain a consistent level of medication in your body. Missing doses may increase the risk of relapse or other complications.
• Storage: Invega Hafyera injections should be stored in a refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze the medication. Prior to administration, the injection should be brought to room temperature for about 15 minutes.
• Additional Medications: Depending on your individual treatment plan, your healthcare provider may prescribe additional medications to supplement the effects of Invega Hafyera or to manage specific symptoms. It is important to follow all prescribed medications and inform your healthcare provider about any other medications or supplements you are taking.
• Regular Check-ups: Regularly scheduled appointments with your healthcare provider are important to monitor your progress, assess the effectiveness of the medication, and manage any potential side effects or concerns.

It is crucial to communicate openly with your healthcare provider regarding your treatment, any changes in your condition, or any concerns you may have. They can provide specific instructions and guidance based on your individual needs and help ensure the safe and effective use of Invega Hafyera.

Other uses for this medicine

Invega Hafyera is primarily prescribed for the treatment of schizophrenia in adults and its long-term maintenance. However, it is important to note that medications should only be used for the purposes approved by regulatory authorities and as directed by a healthcare professional. Off-label uses of Invega Hafyera may exist, but they should be discussed and prescribed by a qualified healthcare provider.

What special precautions should I follow?

Regarding special precautions, there are several important considerations when taking Invega Hafyera. These precautions include:

• Allergic Reactions: Inform your healthcare provider if you have a known allergy to paliperidone, risperidone, or any other ingredients in Invega Hafyera. Allergic reactions may include symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Elderly Population: Older adults may be more sensitive to the side effects of Invega Hafyera, such as dizziness, drowsiness, or orthostatic hypotension. Close monitoring and adjustments to the dosage may be necessary.
• Metabolic Changes: Invega Hafyera may lead to metabolic changes, including weight gain, increased blood sugar levels, and alterations in lipid levels. Regular monitoring of weight, blood glucose, and lipid profiles is recommended.
• Cardiovascular Risks: Invega Hafyera may increase the risk of cardiovascular events such as heart attack or stroke, particularly in elderly individuals with dementia-related psychosis. This medication is not approved for use in patients with dementia-related psychosis.
• Pregnancy and Breastfeeding: The safety of Invega Hafyera during pregnancy and breastfeeding is not well-established. It is important to discuss the potential risks and benefits with a healthcare professional if you are pregnant, planning to become pregnant, or breastfeeding.
• Other Medical Conditions: Inform your healthcare provider about any pre-existing medical conditions, such as liver or kidney problems, cardiovascular disorders, seizures, or a history of neuroleptic malignant syndrome.

It is crucial to follow the instructions provided by your healthcare provider, including dosage, timing, and any additional precautions or recommendations specific to your situation. Regular check-ups and communication with your healthcare team are important for monitoring your progress and managing any potential risks associated with Invega Hafyera.

What special dietary instructions should I follow?

There are no specific dietary instructions for Invega Hafyera. However, it is generally recommended to follow a healthy and balanced diet while taking any medication. Eating a nutritious diet can support overall health and well-being.

What should I do if I forget a dose?

If you forget to take a dose of Invega Hafyera, it is important to contact your healthcare provider for guidance. They can provide specific instructions based on your situation. In general, the missed dose should be taken as soon as you remember, unless it is close to the time for your next scheduled dose. It is not recommended to double the dose to make up for a missed one. It’s important to follow your healthcare provider’s instructions regarding missed doses to maintain the effectiveness of the medication and reduce the risk of relapse or other complications.

What side effects can this medication cause?

Invega Hafyera, like any medication, can cause side effects. Not everyone will experience these side effects, and their severity can vary from person to person. Here are some of the common side effects associated with Invega Hafyera:

• Extrapyramidal Symptoms (EPS): These symptoms can include Parkinsonism (tremors, stiffness, slow movements), dystonia (involuntary muscle contractions), akathisia (restlessness and inability to sit still), and tardive dyskinesia (involuntary repetitive movements). These side effects may occur more frequently with higher doses.
• Sedation and Drowsiness: Invega Hafyera can cause drowsiness, which may impair your ability to concentrate or perform tasks that require alertness. It is important to avoid activities such as driving or operating heavy machinery if you experience excessive drowsiness.
• Weight Gain: Invega Hafyera can lead to weight gain in some individuals. It is important to maintain a healthy diet and engage in regular physical activity to help manage weight while taking this medication.
• Metabolic Changes: Invega Hafyera may cause metabolic changes, including increased blood sugar levels, weight gain, and changes in cholesterol and triglyceride levels. Regular monitoring of these parameters is recommended.
• Orthostatic Hypotension: Invega Hafyera can cause a drop in blood pressure when standing up, resulting in dizziness or lightheadedness. It is important to rise slowly from a sitting or lying position to minimize this effect.
• Gastrointestinal Effects: In some cases, Invega Hafyera may cause constipation, nausea, and dry mouth. Staying adequately hydrated and maintaining a high-fiber diet can help alleviate these symptoms.
• Other Common Side Effects: Additional common side effects may include headache, anxiety, restlessness, blurred vision, and abnormal dreams.

It is important to note that not all individuals will experience these side effects, and some may experience side effects not listed here. If you are concerned about any side effects while taking Invega Hafyera, it is recommended to consult your healthcare provider. They can provide guidance, monitor your progress, and address any concerns you may have.

What should I know about storage and disposal of this medication?

• Storage: Invega Hafyera injections should be stored in a refrigerator between 2°C to 8°C (36°F to 46°F). Keep the medication in its original packaging until it is time for administration. Do not freeze the medication. Protect it from light and moisture.
• Disposal: It is important to dispose of unused or expired Invega Hafyera medication properly. Consult your healthcare provider or local pharmacy for guidance on how to safely dispose of the medication. Do not flush the medication down the toilet or throw it in the regular trash unless instructed to do so.

In case of emergency/overdose

• Emergency: If you or someone else experiences a severe reaction or a life-threatening emergency, such as difficulty breathing, chest pain, seizures, or loss of consciousness, call emergency services immediately (911 in the United States) or seek urgent medical attention.
• Overdose: If you suspect an overdose of Invega Hafyera, contact your local poison control center or go to the nearest emergency room. Symptoms of an overdose may include drowsiness, agitation, rapid heartbeat, tremors, muscle stiffness, and changes in blood pressure.

What other information should I know?

• Regular Monitoring: It is important to attend regular follow-up appointments with your healthcare provider to monitor your progress, assess the effectiveness of the medication, and manage any potential side effects or concerns.
• Medication Adherence: It is crucial to take Invega Hafyera as prescribed by your healthcare provider and adhere to the recommended dosing schedule. Missing doses or altering the dosage without medical supervision may affect the effectiveness of the treatment.
• Interactions: Inform your healthcare provider about all the medications, supplements, or herbal products you are taking. Some medications may interact with Invega Hafyera and affect its efficacy or increase the risk of side effects.
• Allergies: If you have a known allergy to paliperidone, risperidone, or any other ingredients in Invega Hafyera, inform your healthcare provider. Allergic reactions can be serious and require immediate medical attention.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of taking Invega Hafyera with your healthcare provider. The safety of this medication during pregnancy and breastfeeding is not well-established.

Always consult your healthcare provider or pharmacist for personalized guidance and additional information specific to your situation.