Why is this medication prescribed?

Inqovi (decitabine and cedazuridine) is a prescription medication used to treat adults with myelodysplastic syndromes (MDS), including chronic myelomonocytic leukemia (CMML). Myelodysplastic syndromes are a group of disorders characterized by abnormal production and maturation of blood cells in the bone marrow. Inqovi works by inhibiting the DNA methyltransferases, enzymes that are involved in the abnormal DNA methylation patterns observed in MDS.

How should this medicine be used?

Inqovi comes in tablet form and is taken orally. It is usually prescribed as a 28-day treatment cycle, with the tablets taken once daily for the first 21 days of the cycle. The recommended dosage may vary depending on individual factors such as your overall health, the specific type and stage of your condition, and other medications you may be taking.

It’s important to take Inqovi exactly as prescribed by your doctor. Swallow the tablets whole with water, and avoid crushing, chewing, or splitting them unless instructed otherwise. You can take Inqovi with or without food.

If you miss a dose, contact your healthcare provider for guidance. Do not take a double dose to make up for a missed one.

It’s crucial to keep your healthcare provider informed about any side effects or concerns you may experience while taking Inqovi. They will be able to provide you with personalized instructions and advice based on your specific situation.

Remember, this information is a general overview, and it’s important to consult with your healthcare provider for detailed instructions and guidance on the appropriate use of Inqovi for your condition.

Other uses for this medicine

Inqovi (decitabine and cedazuridine) is primarily prescribed for the treatment of myelodysplastic syndromes (MDS), including chronic myelomonocytic leukemia (CMML). However, medications may be prescribed off-label for uses that are not specifically approved by regulatory authorities. It’s best to consult with a healthcare professional for the most up-to-date and accurate information regarding the uses of Inqovi.

What special precautions should I follow?

Regarding special precautions, it’s important to consider the following:

• Allergic reactions: If you are allergic to decitabine, cedazuridine, or any other ingredients in Inqovi, you should not take the medication.
• Bone marrow suppression: Inqovi can cause bone marrow suppression, which may result in a decrease in blood cell counts (white blood cells, red blood cells, and platelets). Regular blood tests are necessary to monitor your blood cell counts during treatment.
• Renal impairment: Inqovi should be used with caution in individuals with moderate to severe renal impairment. Dose adjustments may be necessary based on your kidney function.
• Hepatic impairment: Inqovi should be used with caution in individuals with moderate to severe hepatic impairment. Dose adjustments may be necessary based on your liver function.
• Pregnancy and breastfeeding: Inqovi can harm an unborn baby, so it should be avoided during pregnancy unless the potential benefits outweigh the risks. It is not known if Inqovi passes into breast milk, and its use is not recommended while breastfeeding.
• Interactions with other medications: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as certain drugs may interact with Inqovi and affect its effectiveness or increase the risk of side effects.

These are some general precautions associated with Inqovi, but it’s essential to consult with your healthcare provider or refer to the medication’s prescribing information for a comprehensive list of precautions, potential side effects, and drug interactions specific to your situation.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with taking Inqovi (decitabine and cedazuridine). Generally, you can take Inqovi with or without food. However, it’s always a good idea to consult with your healthcare provider or refer to the medication’s prescribing information for any specific dietary instructions that may apply to your individual case.

What should I do if I forget a dose?

If you forget to take a dose of Inqovi, it’s important to contact your healthcare provider for guidance. They will be able to provide you with specific instructions based on your treatment plan. In general, it’s recommended not to take a double dose to make up for a missed one. Instead, follow your healthcare provider’s instructions on how to proceed and continue with your regular dosing schedule.

What side effects can this medication cause?

Inqovi (decitabine and cedazuridine) may cause side effects in some individuals. It’s important to note that not all people will experience these side effects, and their severity can vary. Common side effects of Inqovi can include:

• Nausea
• Vomiting
• Diarrhea
• Fatigue
• Constipation
• Decreased appetite
• Anemia (low red blood cell count)
• Low platelet count (thrombocytopenia)
• Low white blood cell count (neutropenia)
• Fever
• Rash or itching
• Swelling in the arms, legs, hands, or feet
• Shortness of breath

These are not all the possible side effects of Inqovi. Other less common but more severe side effects may occur. It’s important to seek medical attention if you experience any unusual or severe symptoms while taking Inqovi.

To get the most accurate and up-to-date information about the potential side effects of Inqovi, it’s recommended to consult with your healthcare provider or refer to the medication’s prescribing information. They can provide personalized guidance based on your individual circumstances.

What should I know about storage and disposal of this medication?

Storage and disposal: It is important to follow the specific storage instructions provided with Inqovi or as advised by your healthcare provider or pharmacist. Generally, medications should be stored at room temperature, away from direct sunlight, moisture, and heat. Keep the medication out of reach of children and pets.

When it comes to disposal, it is recommended to follow local regulations or guidelines for the proper disposal of unused or expired medications. You can consult with your pharmacist or local waste management authorities for guidance on the safe disposal of Inqovi.

In case of emergency/overdose

In case of emergency/overdose: If you believe you or someone else may have overdosed on Inqovi, or if you are experiencing severe or life-threatening symptoms, immediately contact emergency services or go to the nearest emergency room. It is also important to inform the medical professionals about the medication taken and the dosage.

What other information should I know?

• Keep a list of all the medications you are currently taking and share it with your healthcare provider. This includes prescription drugs, over-the-counter medications, herbal supplements, and vitamins. Some medications may interact with Inqovi, so it’s important to have an updated list.
• Attend all scheduled appointments with your healthcare provider for blood tests and check-ups. Regular monitoring is necessary to assess the effectiveness of Inqovi and to manage any potential side effects.
• Inform your healthcare provider if you have any pre-existing medical conditions, such as liver or kidney problems, as well as any known allergies or sensitivities.
• Follow your healthcare provider’s instructions regarding any necessary dose adjustments, changes in treatment schedule, or other medications that may be needed during your Inqovi treatment.
• Do not share Inqovi with others, as it is prescribed specifically for your condition and may not be suitable for others.

Please note that the information provided here is for general knowledge and should not replace the specific instructions and advice given by your healthcare provider.