Why is this medication prescribed?

Inlyta (generic name: axitinib) is a prescription medication that is primarily used in the treatment of advanced renal cell carcinoma (RCC), which is the most common type of kidney cancer in adults. It belongs to a class of medications called tyrosine kinase inhibitors (TKIs), which work by blocking certain proteins called tyrosine kinases. These proteins are involved in the growth and spread of cancer cells.

Inlyta is specifically indicated for the treatment of advanced RCC after the failure of one prior systemic therapy. It is used when the cancer has spread to other parts of the body or cannot be surgically removed. Inlyta helps to slow down or stop the growth of cancer cells and may shrink the size of tumors, thereby potentially prolonging the patient’s life and improving their quality of life.

How should this medicine be used?

Here is some general information about the use of Inlyta:

• Dosage: The recommended starting dose of Inlyta for most patients is 5 mg taken orally twice daily (morning and evening) with or without food. However, the actual dosage may vary depending on factors such as the individual’s overall health, tolerance to the medication, and the specific cancer being treated. The healthcare provider may adjust the dosage as needed based on the patient’s response to treatment and any side effects experienced.
• Swallowing: Inlyta tablets should be swallowed whole with a glass of water. They should not be crushed, chewed, or broken before swallowing.
• Duration of treatment: The duration of Inlyta treatment can vary depending on the individual’s condition and response to therapy. It is typically continued as long as the cancer does not progress or until unacceptable side effects occur.
• Follow-up appointments: Regular follow-up appointments with the healthcare provider are important to monitor the progress of the treatment, assess any side effects, and make any necessary adjustments to the dosage or treatment plan.
• Interaction with other medications: It is crucial to inform the healthcare provider about any other medications, including over-the-counter drugs, supplements, or herbal products, being taken. Some medications may interact with Inlyta and affect its effectiveness or increase the risk of side effects.

It’s important to note that the above information is a general overview and does not replace the specific instructions provided by a healthcare professional. If you have been prescribed Inlyta, it is essential to consult with your doctor or pharmacist for precise dosing instructions and any additional guidance specific to your situation.

Other uses for this medicine

While Inlyta is primarily indicated for these specific types of cancer, it is possible that healthcare providers may prescribe it for off-label uses based on their clinical judgment and the patient’s individual circumstances. Off-label use refers to the use of a medication for a purpose other than what it has been approved for by regulatory authorities. These decisions are typically made on a case-by-case basis and require careful evaluation of the potential risks and benefits.

What special precautions should I follow?

Regarding precautions, it is crucial to follow the guidance provided by your healthcare provider and read the medication’s prescribing information for specific details. However, here are some general precautions associated with the use of Inlyta:

• Medical history: Inform your healthcare provider about any underlying medical conditions you have or have had in the past, such as liver problems, high blood pressure, bleeding disorders, heart disease, or thyroid problems.
• Pregnancy and breastfeeding: Inlyta can cause harm to unborn babies, so it is important to discuss the potential risks with your healthcare provider if you are pregnant or planning to become pregnant. Additionally, it is not recommended to breastfeed while taking Inlyta, as it may pass into breast milk and harm the nursing infant.
• Drug interactions: Certain medications, including over-the-counter drugs, herbal supplements, and prescription medications, can interact with Inlyta, potentially affecting its efficacy or increasing the risk of side effects. Inform your healthcare provider about all the medications and supplements you are taking to ensure safe use.
• Bleeding risk: Inlyta may increase the risk of bleeding. Inform your healthcare provider if you have a history of bleeding disorders or if you are taking blood-thinning medications.
• High blood pressure: Inlyta can raise blood pressure, so regular monitoring and management of blood pressure levels are important during treatment.
• Liver function: Inlyta may affect liver function. Regular liver function tests are typically conducted during treatment to monitor for any potential liver problems.

These are just a few general precautions associated with Inlyta. Always consult with your healthcare provider for personalized advice and comprehensive information based on your specific medical condition and treatment plan.

What special dietary instructions should I follow?

When it comes to dietary instructions for Inlyta, it’s typically recommended to take the medication on an empty stomach, at least 1 to 2 hours before or after a meal. This is because food can affect the absorption of the medication in your body. However, individual instructions may vary, so it’s best to consult your healthcare provider for personalized guidance.

What should I do if I forget a dose?

If you forget to take a dose of Inlyta, it’s important to take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, you should skip the missed dose and resume your regular dosing schedule. It’s generally not advised to take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, it’s best to consult your healthcare provider for guidance.

What side effects can this medication cause?

Here are some common and serious side effects associated with Inlyta:

Common side effects:

• Diarrhea
• High blood pressure (hypertension)
• Fatigue or weakness
• Loss of appetite
• Nausea and vomiting
• Hoarseness or voice changes
• Hand-foot syndrome (pain, redness, swelling, or blisters on the palms of the hands or soles of the feet)
• Headache
• Weight loss
• Changes in taste

Serious side effects (which require immediate medical attention):

• Severe bleeding or hemorrhage
• Heart problems, such as heart attack, heart failure, or chest pain
• High blood pressure crisis (severe hypertension)
• Liver problems, including liver failure
• Severe allergic reactions (rash, itching, swelling, severe dizziness, difficulty breathing)
• Seizures or convulsions
• Severe or persistent diarrhea
• Blood clots in the arteries or veins
• Thyroid problems (excessive or inadequate production of thyroid hormones)
• Impaired wound healing

It’s important to note that this is not an exhaustive list of side effects, and individual experiences may vary. If you are prescribed Inlyta, it’s essential to discuss any potential side effects and concerns with your healthcare provider. They can provide more specific information based on your medical history and individual circumstances.

What should I know about storage and disposal of this medication?

Storage:

• Keep Inlyta in its original container and store it at room temperature, away from excessive heat, moisture, and direct light.
• Do not store the medication in the bathroom or any other area with high humidity.
• Keep Inlyta out of the reach of children and pets.

Disposal:

• Do not flush Inlyta down the toilet or pour it down the drain unless specifically instructed to do so.
• Ask your healthcare provider or pharmacist for instructions on the proper disposal of unused or expired medication.
• Follow any local regulations or guidelines for medication disposal in your area.

In case of emergency/overdose

In case of emergency or overdose, it is crucial to seek immediate medical attention. Contact your local emergency services or go to the nearest emergency room. Additionally, you can reach out to a poison control center at 1-800-222-1222 (United States) or the equivalent number in your country.

What other information should I know?

• Dosage and Administration: Follow your healthcare provider’s instructions regarding the dosage and schedule of Inlyta. Do not change the dose or stop taking the medication without consulting your doctor.
• Potential Side Effects: Inlyta may cause various side effects, including high blood pressure, diarrhea, fatigue, decreased appetite, nausea, hand-foot syndrome (redness, swelling, and pain in the palms of the hands and soles of the feet), voice changes, and others. Inform your doctor if you experience any persistent or severe side effects.
• Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as Inlyta can interact with certain drugs and substances.
• Medical History: Discuss your medical history, including any previous or current health conditions, with your doctor before starting Inlyta treatment.
• Pregnancy and Breastfeeding: Inlyta may cause harm to an unborn baby, so it is important to inform your doctor if you are pregnant or planning to become pregnant. It is not recommended to breastfeed while taking Inlyta, as it may pass into breast milk and harm the nursing baby.
• Regular Monitoring: Your healthcare provider will monitor your blood pressure, liver function, and other relevant parameters regularly during your treatment with Inlyta.

Always consult your healthcare provider or pharmacist for personalized guidance and complete information about Inlyta. They can provide you with the most up-to-date information and address any specific concerns you may have.