WARNING

Infliximab is a medication that belongs to a class of drugs called tumor necrosis factor (TNF) inhibitors. It is used to treat various inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, ulcerative colitis, psoriasis, and ankylosing spondylitis. While Infliximab can be effective in managing these conditions, it also carries certain risks. Here are some of the potential risks associated with taking Infliximab injections:

• Increased susceptibility to infections: Infliximab can suppress the immune system, making the body more susceptible to infections. This includes serious infections such as tuberculosis (TB), fungal infections, and bacterial infections. It is important to be vigilant for signs of infection while on Infliximab and to promptly seek medical attention if any symptoms arise.
• Allergic reactions: Some individuals may experience allergic reactions to Infliximab. Symptoms can range from mild reactions like skin rash and itching to severe reactions including difficulty breathing, chest tightness, and anaphylaxis, a life-threatening condition. Immediate medical attention is necessary if an allergic reaction occurs.
• Increased risk of malignancies: There is a slightly higher risk of certain types of cancers, particularly lymphomas, in individuals receiving Infliximab or other TNF inhibitors. The overall risk, however, is generally considered to be low. Regular monitoring and consultation with a healthcare provider are important to assess and manage this risk.
• Heart-related risks: Infliximab use has been associated with an increased risk of heart failure, especially in individuals with pre-existing heart conditions. It is important for individuals with heart conditions to discuss the potential risks and benefits of Infliximab with their healthcare provider.
• Hepatitis B reactivation: Infliximab can cause a reactivation of hepatitis B in individuals who have had previous exposure to the virus. This can result in serious liver problems. It is crucial for individuals to be screened for hepatitis B before starting Infliximab treatment.
• Blood disorders: In rare cases, Infliximab may cause blood disorders such as low white blood cell count or low platelet count. Regular blood tests may be necessary to monitor these parameters during treatment.

It is important to note that these risks are not exhaustive, and the actual risks may vary depending on individual factors and the specific condition being treated. It is essential to consult with a healthcare professional before starting Infliximab or any other medication to fully understand the potential risks and benefits.

Why is this medication prescribed?

Infliximab is a medication that is prescribed for various medical conditions, primarily those involving inflammation and autoimmune diseases. It belongs to a class of drugs called tumor necrosis factor (TNF) inhibitors. Infliximab works by suppressing the activity of TNF, a substance in the body that triggers inflammation.

Here are some of the conditions for which Infliximab Injection may be prescribed:

• Rheumatoid Arthritis: Infliximab is used to treat moderate to severe rheumatoid arthritis, a chronic inflammatory disease that affects the joints, causing pain, swelling, and stiffness.
• Crohn’s Disease: Infliximab is approved for the treatment of moderate to severe Crohn’s disease, an inflammatory bowel disease that primarily affects the gastrointestinal tract. It helps reduce symptoms such as abdominal pain, diarrhea, and weight loss.
• Ulcerative Colitis: Infliximab is used to treat moderate to severe ulcerative colitis, another form of inflammatory bowel disease. It helps reduce symptoms and induce remission in patients who have not responded to other treatments.
• Psoriasis: Infliximab may be prescribed for severe cases of plaque psoriasis, a chronic skin condition characterized by raised, red patches covered with silvery scales. It helps reduce the inflammation and severity of symptoms.
• Ankylosing Spondylitis: Infliximab is used to treat ankylosing spondylitis, a type of arthritis that primarily affects the spine. It helps reduce pain, stiffness, and inflammation in the joints and spine.
• Psoriatic Arthritis: Infliximab can be prescribed for psoriatic arthritis, a condition that combines the symptoms of arthritis and psoriasis. It helps reduce joint inflammation and improve symptoms.

How should this medicine be used?

Infliximab is a medication used to treat certain inflammatory conditions, such as rheumatoid arthritis, Crohn’s disease, ulcerative colitis, psoriasis, and ankylosing spondylitis. It is usually administered as an intravenous (IV) infusion, which means it is delivered directly into a vein.

Here are some general steps involved in using Infliximab:

• Preparation: The medication is typically prepared by a healthcare professional. They will calculate the appropriate dosage based on factors such as body weight and the condition being treated.
• Administration: The infusion is usually performed in a healthcare setting, such as a hospital or an infusion center. A healthcare professional will start an IV line, usually in your arm, to deliver the medication into your bloodstream.
• Timing and frequency: The frequency of Infliximab infusions can vary depending on the condition being treated. Your doctor will determine the appropriate dosing schedule for your specific situation. Infusions are often administered at regular intervals, such as every 4 to 8 weeks.
• Monitoring: During the infusion, healthcare professionals will closely monitor your vital signs and watch for any potential side effects or adverse reactions. The duration of the infusion can vary but may take several hours.

It’s important to follow your doctor’s instructions and attend all scheduled appointments for Infliximab infusions. If you have any questions or concerns about how to use this medication, it’s best to consult with your healthcare provider for personalized advice and guidance.

Other uses for this medicine

Infliximab injection may also be used in the treatment of other autoimmune and inflammatory conditions, such as psoriatic arthritis, hidradenitis suppurativa, uveitis, and pediatric inflammatory bowel disease. However, the specific use of Infliximab should be determined by a healthcare professional based on individual patient factors and medical history.

What special precautions should I follow?

When it comes to special precautions, it’s crucial to consult with your healthcare provider or refer to the prescribing information for a comprehensive understanding. However, here are some general precautions associated with Infliximab injection:

• Infections: Infliximab can lower your body’s ability to fight infections. Before starting treatment, your doctor will assess your medical history for any existing or recent infections. Inform your doctor if you have any signs of infection during treatment, such as fever, cough, or flu-like symptoms.
• Tuberculosis (TB): Infliximab can increase the risk of developing tuberculosis or reactivating a latent TB infection. Prior to starting treatment, your doctor may perform tests to check for TB. Inform your doctor if you have a history of TB or have been in close contact with someone who has TB.
• Allergic reactions: Some individuals may experience allergic reactions to Infliximab. Be sure to inform your doctor if you have any known allergies, especially to other biologic medications or components of Infliximab. Seek immediate medical attention if you experience symptoms of an allergic reaction, such as hives, difficulty breathing, or swelling of the face or throat.
• Immunizations: It is generally recommended to complete all necessary immunizations before starting Infliximab treatment. Live vaccines should be avoided while on Infliximab due to the potential for an inadequate immune response. Consult your doctor regarding appropriate immunization schedules and vaccines.
• Other medical conditions: Inform your doctor about any existing medical conditions, such as heart disease, liver disease, or nervous system disorders, as Infliximab may have specific considerations or potential risks in these cases.

These are just a few precautions associated with Infliximab injection, and there may be additional considerations depending on your specific situation. It’s essential to have a detailed discussion with your healthcare provider about your medical history, potential risks, and benefits before starting Infliximab treatment.

What special dietary instructions should I follow?

Here are some general dietary guidelines that can be beneficial for individuals receiving Infliximab or any other immunosuppressive medication:

• Eat a Balanced Diet: Include a variety of fruits, vegetables, whole grains, lean proteins, and healthy fats in your meals. A balanced diet helps provide essential nutrients and supports overall health.
• Stay Hydrated: Drink an adequate amount of water throughout the day to stay hydrated. Water is important for various bodily functions and helps maintain overall well-being.
• Limit Alcohol Consumption: Alcohol may interact with medications and potentially increase the risk of side effects. It’s advisable to limit or avoid alcohol consumption while on Infliximab or consult your healthcare provider for specific guidance.
• Discuss Supplements: If you’re considering taking any dietary supplements or vitamins, it’s important to consult your healthcare provider. They can advise you on the safety and potential interactions with your medication.

What should I do if I forget a dose?

Regarding missed doses of Infliximab, it’s crucial to follow your healthcare provider’s instructions. If you forget a dose, contact your healthcare provider or the medical facility where you receive your treatment. They will provide guidance on whether a makeup dose is necessary and when it should be scheduled. It’s important not to administer the medication without proper medical advice.

What side effects can this medication cause?

Like any medication, it can cause side effects in some individuals. Here are some potential side effects associated with infliximab injection:

• Infusion reactions: The most common side effect is an infusion reaction, which can occur during or shortly after the infusion. Symptoms may include fever, chills, headache, dizziness, nausea, chest pain, shortness of breath, rash, or itching. Infusion reactions can range from mild to severe, and in rare cases, they can be life-threatening.
• Infections: Infliximab can increase the risk of infections. This may include respiratory infections, urinary tract infections, sinus infections, or skin infections. Serious infections, such as pneumonia or sepsis, are also possible. It is important to notify your doctor if you develop any signs of infection, such as fever, persistent cough, or unusual discharge.
• Allergic reactions: Some individuals may experience allergic reactions to infliximab, which can manifest as hives, itching, swelling, or difficulty breathing. If you have a known allergy to infliximab or its components, it is important to inform your healthcare provider before starting the treatment.
• Increased risk of malignancies: There may be a slightly increased risk of certain types of cancers, such as lymphoma or skin cancer, in patients treated with infliximab. However, the overall risk remains relatively low.
• Blood disorders: Infliximab can affect blood cell counts, leading to a decrease in white blood cells, red blood cells, or platelets. This can increase the risk of infections, anemia, or bleeding. Regular blood tests may be conducted to monitor your blood cell counts during treatment.
• Hepatitis B reactivation: If you have a history of hepatitis B infection, infliximab can reactivate the virus. This can cause serious liver problems. Therefore, your doctor may screen you for hepatitis B before starting treatment with infliximab.
• Heart failure: In rare cases, infliximab may worsen or lead to heart failure. If you have a history of heart disease or heart failure, it is essential to discuss the potential risks with your doctor.

It’s important to note that not everyone will experience these side effects, and many individuals tolerate infliximab well. Your healthcare provider will monitor you closely during treatment and discuss the potential risks and benefits with you before starting infliximab therapy. If you have any concerns or experience any unusual symptoms, it is recommended to consult your healthcare provider.

What should I know about storage and disposal of this medication?

Storage of Infliximab Injection:

• Infliximab injections should be stored in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F).
• Do not freeze the medication. Freezing may cause the medication to become ineffective, and it should not be used if it has been frozen.
• Keep the medication in its original packaging until you are ready to use it.
• Protect the medication from light by keeping it in the original carton or using an opaque bag.

Disposal of Infliximab Injection:

• Do not dispose of Infliximab in household trash or flush it down the toilet unless specifically instructed to do so.
• Consult your healthcare provider, pharmacist, or local waste disposal authority for proper disposal guidelines.
• They will provide you with information about special waste disposal programs or collection sites in your area.

In case of emergency/overdose

• If you suspect an overdose or have concerns about the effects of Infliximab, seek immediate medical attention or contact your local emergency services.
• It is important to have the original packaging or container with you, as it will provide necessary information for healthcare professionals.

What other information should I know?

• Always follow the instructions provided by your healthcare provider for the administration of Infliximab injections.
• Inform your healthcare provider about any medications, supplements, or herbal products you are currently taking or planning to take, as they may interact with Infliximab.
• Report any side effects or adverse reactions to your healthcare provider promptly.
• Keep all scheduled appointments for monitoring and follow-up with your healthcare provider.

Remember, the information provided here is a general guideline. For specific instructions and any concerns about Infliximab storage, disposal, or emergencies, it is best to consult with your healthcare provider or pharmacist who can provide you with the most accurate and up-to-date information based on your individual circumstances.