Why is this medication prescribed?

Inclisiran injection is prescribed for the treatment of high cholesterol levels in adults. It is specifically used for individuals who have familial hypercholesterolemia (a genetic condition that causes high cholesterol) or have atherosclerotic cardiovascular disease (narrowing or blockage of blood vessels due to the buildup of cholesterol and other substances).

Inclisiran is a medication that belongs to a class of drugs known as PCSK9 inhibitors. It works by reducing the production of low-density lipoprotein cholesterol (LDL-C), commonly referred to as “bad cholesterol.” By lowering LDL-C levels, Inclisiran helps to decrease the risk of cardiovascular events such as heart attacks and strokes.

Unlike other medications used to treat high cholesterol, which are taken orally on a daily basis, Inclisiran is administered as an injection. It is typically given as a series of injections, usually every six months, to maintain a consistent reduction in LDL-C levels.

How should this medicine be used?

Inclisiran injection is administered as a subcutaneous injection, which means it is injected under the skin. Here is a general guideline on how Inclisiran should be used:

• Inclisiran is typically administered by a healthcare professional, such as a doctor or nurse, in a clinical setting. They will provide you with the necessary instructions and demonstrate the proper technique for self-administration if needed.
• The injection site for Inclisiran is usually the upper outer arm or the abdomen. Your healthcare provider will advise you on the specific injection site.
• Before administering the injection, wash your hands thoroughly with soap and water to maintain proper hygiene.
• Ensure that the Inclisiran injection is at room temperature. If refrigerated, you may need to leave it at room temperature for a short period to warm up before use. Do not heat the injection or use a microwave to warm it.
• Check the medication packaging to ensure it is not expired, and inspect the solution for any particles or discoloration. If the medication appears unusual, do not use it and consult your healthcare provider.
• Clean the injection site with an alcohol swab and allow it to dry.
• Use the prefilled syringe provided with Inclisiran. Remove the cap from the needle but avoid touching the needle to maintain sterility.
• Pinch a fold of skin at the injection site, hold the syringe like a pencil, and insert the needle into the skin at a 45-degree angle.
• Slowly push the plunger down to inject the medication. Once the injection is complete, remove the needle from the skin.
• Apply gentle pressure to the injection site with a clean cotton ball or sterile gauze to help stop any bleeding.
• Dispose of the used syringe and needle in a sharps container as directed by your healthcare provider.

It is essential to follow the specific instructions provided by your healthcare professional or the medication’s prescribing information. They can provide personalized guidance on the dosage, injection technique, and any additional precautions or considerations based on your individual needs.

Other uses for this medicine

Inclisiran injection is primarily used for the treatment of high cholesterol levels in individuals with familial hypercholesterolemia or atherosclerotic cardiovascular disease. Inclisiran is not approved for any other uses. However, it’s important to consult with a healthcare professional or refer to updated medical resources to stay informed about any new uses or developments regarding Inclisiran.

What special precautions should I follow?

Regarding special precautions for Inclisiran injection, here are a few important considerations:

• Allergies: Inform your healthcare provider if you have any known allergies, especially to Inclisiran or any of its components. Allergic reactions to medications can be serious and may require immediate medical attention.
• Medication Interactions: It’s crucial to provide your healthcare provider with a comprehensive list of all the medications, supplements, and herbal products you are currently taking. Certain medications may interact with Inclisiran and affect its efficacy or increase the risk of side effects.
• Pregnancy and breastfeeding: The safety and effectiveness of Inclisiran in pregnant or breastfeeding individuals have not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using Inclisiran with your healthcare provider.
• Liver or kidney problems: Inform your healthcare provider if you have any pre-existing liver or kidney conditions. Inclisiran may require dosage adjustments or close monitoring in individuals with impaired liver or kidney function.
• Side effects: While Inclisiran is generally well-tolerated, it can still cause side effects. Common side effects may include injection site reactions (such as pain, redness, or swelling), flu-like symptoms, headache, and back pain. If you experience any persistent or severe side effects, contact your healthcare provider.
• Regular monitoring: Your healthcare provider may periodically monitor your cholesterol levels and liver function while you are receiving Inclisiran treatment. This helps ensure the medication is effective and does not cause any adverse effects.

It’s crucial to consult with a healthcare professional for personalized advice and guidance regarding the use of Inclisiran. They can provide comprehensive information based on your specific medical history, current medications, and individual circumstances.

What special dietary instructions should I follow?

Inclisiran injection does not typically require specific dietary instructions. However, it’s important to maintain a healthy lifestyle and follow a balanced diet as recommended by your healthcare provider. A heart-healthy diet that is low in saturated fats, trans fats, and cholesterol can complement the effects of Inclisiran in managing high cholesterol levels. Your healthcare provider or a registered dietitian can provide personalized dietary recommendations based on your individual needs and health goals.

What should I do if I forget a dose?

If you forget a dose of Inclisiran, it is important to contact your healthcare provider or follow the specific instructions provided to you. In general, it is recommended to adhere to the prescribed dosing schedule as closely as possible to maintain the desired therapeutic effect. Missing a dose may impact the consistency of cholesterol reduction, so it’s important to inform your healthcare provider about any missed doses and follow their guidance. They may provide instructions on when and how to administer the missed dose or adjust the subsequent dosing schedule. Avoid doubling the dose to make up for a missed one unless specifically advised by your healthcare provider.

What side effects can this medication cause?

Inclisiran injection is generally well-tolerated, but like any medication, it can cause side effects in some individuals. Here are some common side effects associated with Inclisiran:

• Injection site reactions: This can include pain, redness, itching, swelling, or bruising at the injection site. These reactions are usually mild and resolve on their own.
• Flu-like symptoms: Some individuals may experience symptoms such as fever, chills, muscle aches, fatigue, or headache after receiving Inclisiran. These symptoms are generally transient and resolve without specific treatment.
• Back pain: Inclisiran has been associated with reports of back pain in some individuals. This side effect is usually mild to moderate in intensity.

It’s important to note that not everyone will experience these side effects, and some individuals may not experience any side effects at all. Additionally, there may be other less common or rare side effects that are not listed here. If you experience any persistent or bothersome side effects or have any concerns, it’s essential to contact your healthcare provider for further evaluation and guidance.

In case of severe allergic reactions (e.g., difficulty breathing, swelling of the face or throat, hives, or rash), it is important to seek immediate medical attention, as these can be signs of a serious allergic reaction.

Remember, this is not an exhaustive list of side effects, and it’s crucial to consult with your healthcare provider or refer to the medication’s prescribing information for a comprehensive list of potential side effects associated with Inclisiran.

What should I know about storage and disposal of this medication?

Storage:

• Inclisiran should be stored in the refrigerator between 2°C to 8°C (36°F to 46°F).
• Do not freeze Inclisiran. If the medication accidentally freezes, it should be discarded.
• Keep Inclisiran in its original packaging or container until ready for use to protect it from light.

Disposal:

• Unused or expired Inclisiran should be disposed of properly.
• Follow local regulations or guidelines for the disposal of medications. You can consult your healthcare provider or pharmacist for specific instructions.
• Do not dispose of Inclisiran in household waste or flush it down the toilet unless instructed to do so.

In case of emergency/overdose

• In case of an emergency or suspected overdose, immediately contact emergency services or go to the nearest emergency room.
• It’s helpful to bring the medication packaging or any remaining Inclisiran with you to the emergency facility to provide accurate information to healthcare professionals.

What other information should I know?

• Inclisiran is a prescription medication, and it’s important to follow your healthcare provider’s instructions regarding its use, dosing, and administration.
• Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking to avoid potential drug interactions.
• Attend regular follow-up appointments with your healthcare provider to monitor the effectiveness of Inclisiran and to address any concerns or questions you may have.

It’s always advisable to consult with your healthcare provider or refer to the medication’s prescribing information for the most accurate and up-to-date information regarding storage, disposal, emergency procedures, and any other specific instructions related to Inclisiran.