Why is this medication prescribed?

Imfinzi is a prescription medication that contains the active ingredient durvalumab. It belongs to a class of drugs called immune checkpoint inhibitors. Imfinzi is primarily prescribed for the treatment of certain types of cancer.

Imfinzi is commonly used for the following indications:

• Non-Small Cell Lung Cancer (NSCLC): Imfinzi is approved to treat locally advanced, unresectable NSCLC in patients whose cancer has not progressed after receiving chemotherapy and radiation therapy.
• Small Cell Lung Cancer (SCLC): Imfinzi is prescribed for extensive-stage small cell lung cancer in combination with chemotherapy.
• Bladder Cancer: Imfinzi is used to treat advanced or metastatic bladder cancer that has not progressed during or after platinum-containing chemotherapy.
• Esophageal Cancer: Imfinzi is approved for the treatment of locally advanced, unresectable esophageal cancer in patients whose cancer has not progressed after receiving chemotherapy and radiation therapy.
• Other Cancers: Imfinzi may also be used in clinical trials or under special circumstances for the treatment of other types of cancer, such as head and neck cancer, hepatocellular carcinoma, and ovarian cancer.

How should this medicine be used?

Imfinzi (generic name: durvalumab) is an immunotherapy drug used for the treatment of certain types of cancer. It is commonly used in the treatment of non-small cell lung cancer (NSCLC) and bladder cancer.

Here are some general guidelines for the use of Imfinzi:

• Administration: Imfinzi is typically given as an intravenous (IV) infusion, which means it is delivered directly into a vein through a needle or catheter. The infusion is usually administered by a healthcare professional in a clinic or hospital setting.
• Treatment Schedule: The dosing schedule and duration of Imfinzi treatment can vary depending on the specific type and stage of cancer being treated. Your healthcare provider will determine the appropriate treatment plan for you.
• Follow-up Treatment: Imfinzi treatment is often given in cycles, with a period of active treatment followed by a rest period. It is important to attend all scheduled treatment sessions and follow-up appointments as directed by your healthcare provider.
• Side Effects Management: Imfinzi can cause side effects, some of which may be serious. Common side effects include fatigue, rash, itching, cough, nausea, diarrhea, and decreased appetite. It is important to report any side effects to your healthcare provider promptly. They can provide guidance on managing side effects and may adjust your treatment if necessary.
• Other Medications: Inform your healthcare provider about any other medications, including over-the-counter drugs and supplements, that you are taking. Certain medications may interact with Imfinzi, so it’s important to disclose your complete medication history.

Remember, these are general guidelines, and your healthcare provider will provide specific instructions tailored to your individual needs. It is essential to consult with a healthcare professional for accurate and personalized information regarding the appropriate use of Imfinzi.

Other uses for this medicine

Imfinzi (durvalumab) is primarily approved for the treatment of certain types of cancer, specifically non-small cell lung cancer (NSCLC) and bladder cancer. However, clinical trials and research are ongoing to explore the potential use of Imfinzi in other cancer types and conditions. It’s important to note that using Imfinzi for any other purpose beyond its approved indications should only be done under the supervision and guidance of a healthcare professional.

What special precautions should I follow?

Regarding special precautions, here are some important points to consider when using Imfinzi:

• Allergies: Inform your healthcare provider if you have any known allergies to durvalumab or any other ingredients in Imfinzi. This medication may contain inactive ingredients that can cause allergic reactions or other adverse effects.
• Immune-related side effects: Imfinzi works by activating the immune system, which can lead to immune-related side effects. These may include inflammation of various organs or systems in the body, such as the lungs, liver, intestines, endocrine glands, skin, and kidneys. It is crucial to report any new or unusual symptoms to your healthcare provider promptly.
• Infections: Imfinzi can increase the risk of infections, including bacterial, viral, and fungal infections. Before starting Imfinzi, inform your healthcare provider about any existing infections or a history of recurrent infections. If you develop signs of infection, such as fever, chills, cough, or pain during urination, notify your healthcare provider immediately.
• Pre-existing medical conditions: Discuss your medical history with your healthcare provider, especially if you have or have had autoimmune disorders, organ transplantation, or any other significant medical conditions. These factors may influence the decision to use Imfinzi or require close monitoring during treatment.
• Pregnancy and breastfeeding: The effects of Imfinzi on pregnancy and breastfeeding are not well-established. It is important to inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the potential risks and benefits of using Imfinzi in these situations need to be carefully considered.
• Other medications: Inform your healthcare provider about all the medications, including prescription and over-the-counter drugs, supplements, and herbal products, that you are taking. Certain medications may interact with Imfinzi, potentially affecting its efficacy or increasing the risk of side effects.

These are general precautions, and it is essential to consult with your healthcare provider for personalized advice and to discuss any specific concerns or considerations before using Imfinzi.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Imfinzi (durvalumab) usage. However, it is generally recommended to maintain a healthy and balanced diet to support overall well-being and immune function. Eating a nutritious diet that includes a variety of fruits, vegetables, whole grains, lean proteins, and adequate hydration is beneficial for your overall health during cancer treatment.

What should I do if I forget a dose?

If you happen to forget a dose of Imfinzi, it’s important to contact your healthcare provider or the medical team overseeing your treatment as soon as possible. They can provide guidance on how to proceed based on your specific situation. It’s generally recommended not to double the dose to make up for the missed one. Your healthcare provider will help you determine the best course of action, which may involve rescheduling the missed dose or adjusting the treatment schedule accordingly.

What side effects can this medication cause?

It’s always recommended to discuss potential side effects with your healthcare provider before starting treatment with Imfinzi. Here are some common side effects associated with Imfinzi:

• Fatigue: Feeling tired or experiencing a lack of energy is a common side effect of immunotherapy drugs like Imfinzi.
• Skin reactions: Skin rash, itching, and dryness are possible side effects. In some cases, more severe skin reactions such as blistering or peeling may occur.
• Digestive system issues: Nausea, vomiting, diarrhea, and loss of appetite are potential gastrointestinal side effects of Imfinzi.
• Respiratory problems: Coughing, shortness of breath, and inflammation of the lungs (pneumonitis) can occur. It is important to notify your healthcare provider if you experience any breathing difficulties.
• Endocrine system effects: Imfinzi can cause hormonal imbalances and affect the function of various endocrine glands, leading to symptoms such as thyroid dysfunction or changes in blood sugar levels.
• Liver problems: Imfinzi may cause liver inflammation (hepatitis) and abnormal liver function test results.
• Kidney problems: In rare cases, Imfinzi can lead to inflammation of the kidneys (nephritis) and changes in kidney function.
• Infections: As Imfinzi affects the immune system, it can increase the risk of infections, including respiratory, urinary tract, and skin infections.
• Musculoskeletal pain: Joint pain, muscle pain, and back pain have been reported as side effects of Imfinzi.

It’s important to promptly report any side effects to your healthcare provider, as they can provide guidance on managing these effects and determine if any adjustments to your treatment plan are necessary. They will evaluate the risks and benefits of continuing treatment with Imfinzi and take appropriate measures to ensure your well-being.

What should I know about storage and disposal of this medication?

• Storage: Imfinzi is typically stored in a healthcare setting such as a clinic or hospital. It is usually stored in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). It should be protected from light and kept in its original packaging until ready for use. Do not freeze Imfinzi.
• Disposal: Proper disposal of unused or expired Imfinzi should be done in accordance with local regulations and guidelines. It is recommended to consult with your healthcare provider or pharmacist for specific instructions on how to safely dispose of the medication.

In case of emergency/overdose

In case of an emergency or overdose, it is important to seek immediate medical attention. Contact your local emergency services or go to the nearest emergency room. Provide them with information about the medication you have taken, including the name (Imfinzi or durvalumab) and the dose if possible.

What other information should I know?

• Regular monitoring: Your healthcare provider will closely monitor your progress and response to Imfinzi treatment. This may involve regular check-ups, blood tests, imaging studies, and other assessments to evaluate the effectiveness of the medication and monitor for any potential side effects.
• Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking. Certain medications may interact with Imfinzi and affect its effectiveness or increase the risk of side effects. It’s important to disclose your complete medication history to your healthcare provider.
• Vaccinations: Discuss with your healthcare provider whether it is appropriate to receive vaccines while undergoing treatment with Imfinzi. Some vaccines may be recommended or required before starting Imfinzi treatment, while others may need to be avoided during treatment.
• Follow-up appointments: Attend all scheduled appointments with your healthcare provider as part of your ongoing care. These appointments are important for monitoring your treatment progress, managing any side effects, and adjusting your treatment plan if necessary.
• Supportive care: Your healthcare provider may recommend additional supportive care measures to manage side effects and optimize your well-being during treatment. This may include medications, lifestyle modifications, and supportive therapies.

Remember, it is crucial to follow the instructions and guidance provided by your healthcare provider regarding the storage, disposal, administration, and any other specific instructions related to your treatment with Imfinzi. They can provide you with the most accurate and up-to-date information tailored to your individual needs.