WARNING

While Ibsrela (tenapanor) is generally well-tolerated, like any medication, it carries some potential risks and side effects. It’s important to be aware of these risks when considering treatment with Ibsrela. Here is a brief overview:

• Diarrhea: The most common side effect of Ibsrela is diarrhea, which may occur in a significant number of individuals taking the medication. This diarrhea can be severe in some cases. It’s important to discuss any persistent or severe diarrhea with your healthcare provider.
• Dehydration: Diarrhea caused by Ibsrela can potentially lead to dehydration if fluid loss is not adequately managed. It’s important to maintain proper hydration by drinking enough fluids while taking Ibsrela and seeking medical attention if signs of dehydration occur, such as excessive thirst, dry mouth, dizziness, or decreased urination.
• Hypotension (low blood pressure): Ibsrela may cause a decrease in blood pressure, leading to symptoms such as dizziness or lightheadedness. If you experience these symptoms, it’s important to sit or lie down and consult your healthcare provider.
• Gastrointestinal side effects: Ibsrela may cause other gastrointestinal side effects, including abdominal pain, bloating, flatulence (gas), and nausea. If these side effects persist or become bothersome, inform your healthcare provider.
• Allergic reactions: While rare, some individuals may experience allergic reactions to Ibsrela. Seek immediate medical attention if you develop symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s important to note that this is not an exhaustive list of all possible risks and side effects associated with Ibsrela. Different individuals may react differently to the medication, and there may be other rare or uncommon side effects. It’s essential to discuss any concerns or questions about the risks and benefits of Ibsrela with your healthcare provider, as they can provide personalized information based on your specific medical history and circumstances.

Why is this medication prescribed?

Ibsrela is prescribed for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults. IBS is a chronic gastrointestinal disorder characterized by abdominal pain, bloating, and changes in bowel habits. IBS-C specifically refers to a subtype of IBS in which constipation is the predominant symptom.

Ibsrela contains the active ingredient tenapanor, which is a selective inhibitor of the sodium/hydrogen exchanger 3 (NHE3) in the intestines. By inhibiting NHE3, Ibsrela reduces the absorption of dietary sodium in the intestines. This leads to increased levels of sodium in the intestines, which, in turn, increases the secretion of water into the bowel. The increased water in the bowel helps soften the stools and promotes more regular bowel movements, thereby relieving constipation associated with IBS-C.

How should this medicine be used?

Ibsrela should be used as directed by your healthcare provider. Here are some general guidelines for the use of Ibsrela:

• Dosage: The typical recommended dosage of Ibsrela is 50 milligrams (mg) twice daily. Your healthcare provider will determine the appropriate dosage for you based on your specific condition and response to treatment. It’s important to take Ibsrela exactly as prescribed and not exceed the recommended dose.
• Timing: Ibsrela should be taken with food. It’s usually recommended to take one tablet in the morning and one tablet in the evening, approximately 12 hours apart. Follow your prescribed dosing schedule carefully.
• Swallowing the tablets: Take the Ibsrela tablets whole with a glass of water. Do not crush, chew, or break the tablets, as this may affect the way the medication is absorbed in your body.
• Duration of use: Continue taking Ibsrela for as long as your healthcare provider recommends, even if you start feeling better. It’s important to follow the prescribed treatment plan to effectively manage your symptoms.
• Other medications: Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and any herbal supplements. They can advise you on potential interactions or precautions to be aware of when taking Ibsrela alongside other medications.
• Follow-up appointments: Regularly communicate with your healthcare provider about your progress while taking Ibsrela. They may want to assess your response to the medication and make any necessary adjustments to your treatment plan.

Remember, these guidelines are general and may vary based on individual circumstances. Always follow the specific instructions provided by your healthcare provider for the most accurate and appropriate use of Ibsrela.

Other uses for this medicine

Ibsrela (tenapanor) is primarily prescribed for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults and is not approved for other uses. Its mechanism of action specifically targets the symptoms associated with IBS-C.

What special precautions should I follow?

When it comes to special precautions, here are some important points to consider:

• Allergies: Inform your healthcare provider if you have any known allergies to tenapanor or any other medications. It’s crucial to disclose any previous allergic reactions to medications or any other substances to ensure your safety while taking Ibsrela.
• Medical conditions: Discuss your medical history with your healthcare provider, especially if you have any significant pre-existing medical conditions. This includes conditions such as kidney disease, low blood pressure, gastrointestinal blockage, or any other digestive disorders. Your healthcare provider will assess whether Ibsrela is suitable for you or if any adjustments to the dosage or treatment plan are necessary.
• Pregnancy and breastfeeding: The safety of Ibsrela during pregnancy and breastfeeding has not been established. It’s important to inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. They can weigh the potential risks and benefits and determine the most appropriate course of action.
• Drug interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are currently taking. Certain medications may interact with Ibsrela, potentially affecting its efficacy or increasing the risk of side effects. It’s important to disclose this information to your healthcare provider to prevent any potential drug interactions.
• Pediatric use: The safety and efficacy of Ibsrela in individuals under 18 years of age have not been established. Ibsrela is intended for use in adults with IBS-C only.
• Adverse effects: If you experience severe diarrhea, signs of dehydration, low blood pressure, or any other concerning symptoms while taking Ibsrela, contact your healthcare provider for guidance.

It’s essential to follow your healthcare provider’s instructions and recommendations regarding Ibsrela. They will consider your individual medical history and circumstances to ensure the medication is prescribed and used safely and effectively.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with taking Ibsrela (tenapanor). However, it’s generally recommended to take Ibsrela with food to optimize absorption and minimize the potential for gastrointestinal side effects. Following a healthy and balanced diet, including an adequate intake of fiber and fluids, may also help in managing your symptoms of irritable bowel syndrome with constipation (IBS-C).

What should I do if I forget a dose?

If you forget to take a dose of Ibsrela, take it as soon as you remember, unless it’s close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Ibsrela (tenapanor) may cause several side effects. Not everyone who takes Ibsrela will experience these side effects, and the severity and frequency of side effects can vary among individuals. Here are some common side effects associated with Ibsrela:

• Diarrhea: Diarrhea is the most common side effect of Ibsrela. It can occur in a significant number of individuals taking the medication. In some cases, the diarrhea can be severe. If you experience persistent or severe diarrhea while taking Ibsrela, it’s important to inform your healthcare provider.
• Abdominal pain: Some individuals may experience abdominal pain or discomfort as a side effect of Ibsrela. If the pain is severe or persists, it’s important to seek medical advice.
• Bloating and gas: Ibsrela may cause bloating and increased gas production in some individuals. These symptoms are usually mild to moderate.
• Nausea: Nausea is a possible side effect of Ibsrela. If you experience persistent or severe nausea, it’s important to inform your healthcare provider.
• Hypotension (low blood pressure): Ibsrela may cause a decrease in blood pressure, leading to symptoms such as dizziness or lightheadedness. If you experience these symptoms, it’s important to sit or lie down and consult your healthcare provider.
• Allergic reactions: Although rare, some individuals may experience allergic reactions to Ibsrela. Signs of an allergic reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you develop any of these symptoms.

It’s important to note that this is not an exhaustive list of all possible side effects of Ibsrela. Other side effects may occur. If you have any concerns about side effects while taking Ibsrela, it’s best to consult your healthcare provider. They can provide you with more detailed information and guidance based on your individual circumstances.

What should I know about storage and disposal of this medication?

Storage and disposal:

• Store Ibsrela at room temperature, away from excessive heat, moisture, and direct light.
• Keep the medication in its original container and make sure it is tightly closed.
• Keep Ibsrela out of reach of children and pets.
• Do not use Ibsrela after the expiration date printed on the packaging. If you have expired or unused medication, consult your pharmacist or local waste disposal authorities for proper disposal instructions.

In case of emergency/overdose

• In case of an emergency or suspected overdose, call your local emergency services immediately or seek medical attention.
• If possible, provide healthcare professionals with information about the medication, dosage, and the time it was taken.

What other information should I know?

• Ibsrela is prescribed for your specific condition and should not be shared with others.
• Attend all scheduled appointments with your healthcare provider to monitor your progress and discuss any concerns or questions you may have.
• Inform all healthcare professionals involved in your care, including dentists and surgeons, about your use of Ibsrela.
• Some individuals may experience a response to Ibsrela within the first week of treatment, while others may take longer to see improvement. It’s important to follow your prescribed treatment plan and communicate with your healthcare provider about your progress.
• Keep a record of any side effects or changes in symptoms you experience while taking Ibsrela and discuss them with your healthcare provider during follow-up visits.

It’s important to consult your healthcare provider or pharmacist for specific guidance regarding the storage, disposal, and emergency procedures for Ibsrela. They can provide you with the most accurate and up-to-date information based on your individual circumstances.