WARNING

While Herceptin Hylecta can be an effective treatment for HER2-positive breast cancer, it does come with potential risks and side effects. It’s important to note that not all individuals will experience these risks, and some side effects may be more common or severe than others. Here are some of the potential risks associated with taking Herceptin Hylecta:

• Heart problems: Herceptin Hylecta may cause heart-related side effects, including a decrease in heart function or heart failure. It is important to monitor cardiac function before and during treatment to minimize the risk of these complications.
• Infusion-related reactions: Like other medications given by injection, Herceptin Hylecta can cause infusion-related reactions, which may include fever, chills, nausea, vomiting, headache, allergic reactions, and difficulty breathing. These reactions can occur during or after the injection and may vary in severity.
• Pulmonary toxicity: Rarely, Herceptin Hylecta has been associated with lung problems, including inflammation of the lungs or fluid accumulation in the lungs. Symptoms may include cough, shortness of breath, and difficulty breathing.
• Reduced blood cell counts: Herceptin Hylecta may cause a decrease in certain blood cell counts, such as red blood cells, white blood cells, and platelets. This can increase the risk of infections, anemia, and bleeding. Regular blood tests are necessary to monitor these counts during treatment.
• Potential harm to the fetus: Herceptin Hylecta can be harmful to a developing fetus, so it is not recommended for use during pregnancy. Appropriate contraception methods should be used during treatment and for a certain period afterward.

It’s essential to discuss these risks and potential side effects with your healthcare provider before starting Herceptin Hylecta. They will be able to provide personalized information based on your specific medical history and assess the benefits and risks of the treatment in your particular case.

Why is this medication prescribed?

Herceptin Hylecta is prescribed as a treatment for certain types of breast cancer. It is specifically used in patients who have HER2-positive early breast cancer or HER2-positive metastatic breast cancer. HER2-positive breast cancer is a type of breast cancer in which the cancer cells have an overexpression of a protein called human epidermal growth factor receptor 2 (HER2).

Herceptin Hylecta contains trastuzumab, which is a monoclonal antibody that targets and binds to the HER2 protein on cancer cells. By binding to HER2, Herceptin Hylecta inhibits the growth and spread of cancer cells, leading to tumor shrinkage and improved survival rates.

The medication is administered as a subcutaneous injection, meaning it is injected into the fatty tissue just beneath the skin. The injection is given every three weeks under the skin of the thigh or the back of the upper arm. The dosage and treatment schedule may vary depending on the specific condition being treated and the individual patient’s response to the medication.

How should this medicine be used?

Herceptin Hylecta is a medication used for the treatment of breast cancer that is human epidermal growth factor receptor 2 (HER2)-positive. It is a combination therapy that includes trastuzumab, a monoclonal antibody targeting HER2, and hyaluronidase, an enzyme that helps in the delivery of trastuzumab.

Herceptin Hylecta is typically administered as a subcutaneous injection, which means it is injected just under the skin. The injection is given in the thigh or abdomen area by a healthcare professional. The recommended dosage and treatment schedule may vary depending on the specific circumstances and the instructions provided by the prescribing healthcare provider. It is essential to follow the prescribed dose and schedule as directed.

Other uses for this medicine

Herceptin Hylecta is primarily used for the treatment of HER2-positive breast cancer. However, it is important to note that the information provided here is based on the knowledge cutoff of September 2021, and there may have been updates or new indications since then. It’s always best to consult with a healthcare professional for the most up-to-date and accurate information regarding the uses of any medication.

What special precautions should I follow?

As for special precautions, it’s important to follow the guidelines and instructions provided by your healthcare provider when taking Herceptin Hylecta. Here are some general precautions to consider:

• Cardiac monitoring: Herceptin Hylecta may affect heart function. Before starting treatment, your doctor may perform cardiac assessments, including a baseline evaluation of your heart function using tests such as an echocardiogram or a multigated acquisition (MUGA) scan. Regular cardiac monitoring may also be required during treatment.
• Pregnancy and breastfeeding: Herceptin Hylecta can be harmful to a developing fetus, so it is not recommended during pregnancy. Effective contraception should be used during treatment and for a certain period afterward. It is also advised to avoid breastfeeding while receiving Herceptin Hylecta, as it may be excreted in breast milk.
• Allergic reactions: Inform your healthcare provider about any known allergies or sensitivities you have before starting Herceptin Hylecta. Serious allergic reactions to the medication, though rare, can occur. Seek immediate medical attention if you experience signs of an allergic reaction, such as difficulty breathing, rash, itching, or swelling.
• Other medical conditions: Inform your healthcare provider about any pre-existing medical conditions or ongoing treatments you have. Certain conditions, such as a history of heart disease or lung problems, may require additional monitoring or adjustments in your treatment plan.
• Other medications: Inform your doctor about all medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some medications may interact with Herceptin Hylecta and affect its effectiveness or increase the risk of side effects.

These are general precautions, and specific recommendations may vary depending on individual circumstances. It’s crucial to have open and honest communication with your healthcare provider, who will provide personalized guidance and ensure the safe and effective use of Herceptin Hylecta in your case.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Herceptin Hylecta. However, it’s generally recommended to maintain a healthy and balanced diet to support your overall well-being and immune system.

What should I do if I forget a dose?

If you forget a dose of Herceptin Hylecta, it’s important to contact your healthcare provider or the prescribing doctor for guidance. They will be able to provide specific instructions based on your situation. It’s generally not advisable to take extra doses to make up for a missed one without medical supervision.

What side effects can this medication cause?

Herceptin Hylecta is a combination medication used for the treatment of HER2-positive breast cancer. It contains trastuzumab, which is a monoclonal antibody targeting the HER2 protein, and hyaluronidase, an enzyme that helps the medication to be absorbed more easily.

Like any medication, Herceptin Hylecta can cause side effects. The most common side effects reported with Herceptin Hylecta include:

• Injection site reactions: These may include pain, swelling, redness, itching, or rash at the site of injection.
• Fever: Some individuals may experience fever as a side effect of Herceptin Hylecta.
• Nausea and vomiting: These gastrointestinal symptoms may occur but are usually mild to moderate.
• Diarrhea: Herceptin Hylecta can cause diarrhea in some patients.
• Headache: Headaches have been reported as a side effect, although they are usually mild.
• Fatigue: Feeling tired or experiencing fatigue is a common side effect of Herceptin Hylecta.
• Muscle and joint pain: Some individuals may experience muscle or joint pain as a result of the medication.
• Upper respiratory tract infection: Infections such as the common cold or flu-like symptoms may occur.
• Low white blood cell count: Herceptin Hylecta can affect the production of white blood cells, which are important for fighting infections. This can increase the risk of infections.
• Heart-related side effects: Herceptin Hylecta, like other HER2-targeted therapies, can cause heart problems such as decreased heart function, congestive heart failure, and irregular heart rhythms. These side effects are relatively rare but can be serious. Monitoring of heart function is usually done before and during treatment.

What should I know about storage and disposal of this medication?

• Storage: Herceptin Hylecta should be stored in the refrigerator between 36°F and 46°F (2°C and 8°C). Do not freeze the medication. Keep it in the original carton to protect it from light.
• Handling: Herceptin Hylecta should be handled with care. It is important to follow proper aseptic techniques when preparing and administering the medication to minimize the risk of contamination.
• Disposal: Unused or expired Herceptin Hylecta should be disposed of properly. Do not flush it down the toilet or pour it into drains. Consult your healthcare provider, pharmacist, or local waste disposal authority for specific instructions on how to safely dispose of the medication.

In case of emergency/overdose

In case of an emergency or overdose with Herceptin Hylecta, it is essential to seek immediate medical attention. Contact your local emergency services or go to the nearest emergency room. Be sure to provide all relevant information about the medication and the situation to the healthcare professionals.

What other information should I know?

It’s important to be aware of the following additional information:

• Allergies: Inform your healthcare provider if you are allergic to trastuzumab or any other ingredients in Herceptin Hylecta. This medication may contain inactive ingredients that can cause allergic reactions or other problems.
• Precautions: Discuss any pre-existing medical conditions or ongoing treatments with your healthcare provider before using Herceptin Hylecta. Certain conditions or medications may interact with Herceptin Hylecta, potentially causing complications.
• Side Effects: Herceptin Hylecta may cause side effects, which can vary from person to person. Common side effects may include fever, chills, headache, nausea, diarrhea, fatigue, muscle or joint pain, and injection site reactions. Report any severe or persistent side effects to your healthcare provider.
• Pregnancy and breastfeeding: Herceptin Hylecta may cause harm to a developing fetus, so it is important to inform your healthcare provider if you are pregnant or planning to become pregnant. It is also not recommended to breastfeed while receiving Herceptin Hylecta.
• Drug Interactions: Inform your healthcare provider about all medications, including prescription, over-the-counter, and herbal products, that you are currently taking. Some drugs may interact with Herceptin Hylecta, potentially affecting its effectiveness or increasing the risk of side effects.

Remember to always follow your healthcare provider’s instructions regarding the storage, administration, and disposal of Herceptin Hylecta. If you have any further questions or concerns, consult with your healthcare provider or pharmacist for more personalized information.